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The map label for this gene is theD [H]

Identifier: 50841601

GI number: 50841601

Start: 132955

End: 134664

Strand: Direct

Name: theD [H]

Synonym: PPA0110

Alternate gene names: 50841601

Gene position: 132955-134664 (Clockwise)

Preceding gene: 50841588

Following gene: 50841602

Centisome position: 5.19

GC content: 64.15

Gene sequence:

>1710_bases
GTGTTCGGTCAGTTTTCAGCGGCGGAGCGCACGTCGTGGTGGGGTGGCATACTGGCCCATGGACACGGGGTGCGCCTCGG
TGGCGCTGAGATCACACCCGTGGAACCTGATCTAGTTCGTACTGGCGAAGGGATGTCCGAGATGACCATTAGTGATGCGC
TTGCCGAGCGGGGAACAATTCCCCGCGTCCTGTCAATTGCGGGTACCGATCCGTCCGGGGGAGCTGGCACCGCAGCCGAC
ACCAAATCGATCATCGCGGCAGGTGGATATGCGATGGCTGTCGTCACCTCCTTGGTGGCCCAGAACACCGAAGGGGTGCG
CGCCATCCACACCCCGCCGACCGACTTCCTGGTCCAGCAACTGGCCGCTGTCAGCGATGACGTGAGAATCGACGCCGTCA
AAACCGGGATGCTCGGCACCGCTGAGATCGTTGACGCGGTTGCGACCTTCCTCGACGAGCATCGACCGCTGGTAGTCGTC
GTCGATCCGGTAATGGTCGCCACCAGCGGGGACCGCCTCCTTGCCCCCGACGCAGAGGCTGCCATGCGCGAGTTTTGTCG
CCGCGCGACCGTCATCACCCCGAATATTCCGGAGCTCGCGGTGCTGTGCCAGAGCGAGCCGGCGACGACCCCGGAGCAGG
CCGTGGAGCAGGCTCGTCGGTGGGCGGCTGAGACGGGAGCGGCCGTCGTCGTCAAGACCGGGCATTTGAATTCGCAGCGG
GTCGACAATATGTGGGTGACGACGGAAGGAGCAATGCACGTCGCCCCGGCGGCGCGGGTGGAGACGACCAACACCCACGG
TACCGGGTGCTCACTGTCCTCAGCCTTGGCGACCCGGTTGGGTGCCGGTGACACCCCGGGGGATGCCCTGGCGTGGGTCA
CCGACTGGCTGCACGAGGCGATTCAGTACGGGTCGGCGCTGAACGTCGGTAAGGGTCACGGCCCGGTGGACCACTCCCAT
CGAGCACGTCGGCTGGCCGAGGACGCTTCAGCAGTGGCGTGGTTCGCGCCCATCGACCCATTGGAATCTCCACAAGGGTT
GGTTGTATCGGCTGAGCCTGCACCGGACGCGGTGGTTGCTCCAGCCGGGCCATGGACGACGGCCCTGTGGCAAGCAAGTG
GGGACATCGCGCGTCGCATTGAGGACTCGGATTTTGTTGCCGTTCTCGTCGACGGCACCTTGTCGAAGCCGGCCTTCGAG
TTCTACCTGGGGCAAGATGCTCAGTACCTCACCTACTATTCACGAGCTTTGGCATCCTTGGCGGCTCGTGCTGTCGACCC
GGAGGAGTCAGTGTGGTGGGCGCAGTCCTCTCAGGCGTGTCTTGTGGAGGAGGCAGAACTGCACCGCTCTTGGCTAGGGG
ATCACATCGACGTGGTTGCCGGGCCGGTGACCTTGGCCTACACGGACTTCCTGCTGGCCCGGGCATTGGGTGACGACTAC
GTCGTCGGTACGGCAGCGGTACTGCCTTGTTTCTGGCTTTATGCACACTTGGGTGCCAAGGTTCCGCACGTTCCCGACGA
CCACCCTTACGCCTCATGGTTGCAGACCTATGGGGATCCCGAGTTCGTCGAGGGGGCGTCACACACCATCGGTCTGGTGG
AGAAAGCCTTCCAGAACGCCTCCGCCGTCACCAGGGCTCGCGCTGCCCACGCCTACCTGACGGCCTGCCGTCACGAATTG
GAGTTCTTCGACCAAGCTTTGCGGGTCTGA

Upstream 100 bases:

>100_bases
CTTCGTCGGAAGTTCTCCGGTGAACTTCCGACCAGTTCCCACGATAGCGCTATAACCGCTTAATGGACCCCTGTCAATGA
CTTTTGTAGGAGTTTTACGG

Downstream 100 bases:

>100_bases
CCAACTCGTCAGCACAAAGATTCACATGACCATACTTGTGTCTGTTGCGCGCCGGGCCTCGGCTGGAACGTCGATGCCCT
CTGAGGGACGCGCTGCCCTG

Product: multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase

Products: NA

Alternate protein names: Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MFGQFSAAERTSWWGGILAHGHGVRLGGAEITPVEPDLVRTGEGMSEMTISDALAERGTIPRVLSIAGTDPSGGAGTAAD
TKSIIAAGGYAMAVVTSLVAQNTEGVRAIHTPPTDFLVQQLAAVSDDVRIDAVKTGMLGTAEIVDAVATFLDEHRPLVVV
VDPVMVATSGDRLLAPDAEAAMREFCRRATVITPNIPELAVLCQSEPATTPEQAVEQARRWAAETGAAVVVKTGHLNSQR
VDNMWVTTEGAMHVAPAARVETTNTHGTGCSLSSALATRLGAGDTPGDALAWVTDWLHEAIQYGSALNVGKGHGPVDHSH
RARRLAEDASAVAWFAPIDPLESPQGLVVSAEPAPDAVVAPAGPWTTALWQASGDIARRIEDSDFVAVLVDGTLSKPAFE
FYLGQDAQYLTYYSRALASLAARAVDPEESVWWAQSSQACLVEEAELHRSWLGDHIDVVAGPVTLAYTDFLLARALGDDY
VVGTAAVLPCFWLYAHLGAKVPHVPDDHPYASWLQTYGDPEFVEGASHTIGLVEKAFQNASAVTRARAAHAYLTACRHEL
EFFDQALRV

Sequences:

>Translated_569_residues
MFGQFSAAERTSWWGGILAHGHGVRLGGAEITPVEPDLVRTGEGMSEMTISDALAERGTIPRVLSIAGTDPSGGAGTAAD
TKSIIAAGGYAMAVVTSLVAQNTEGVRAIHTPPTDFLVQQLAAVSDDVRIDAVKTGMLGTAEIVDAVATFLDEHRPLVVV
VDPVMVATSGDRLLAPDAEAAMREFCRRATVITPNIPELAVLCQSEPATTPEQAVEQARRWAAETGAAVVVKTGHLNSQR
VDNMWVTTEGAMHVAPAARVETTNTHGTGCSLSSALATRLGAGDTPGDALAWVTDWLHEAIQYGSALNVGKGHGPVDHSH
RARRLAEDASAVAWFAPIDPLESPQGLVVSAEPAPDAVVAPAGPWTTALWQASGDIARRIEDSDFVAVLVDGTLSKPAFE
FYLGQDAQYLTYYSRALASLAARAVDPEESVWWAQSSQACLVEEAELHRSWLGDHIDVVAGPVTLAYTDFLLARALGDDY
VVGTAAVLPCFWLYAHLGAKVPHVPDDHPYASWLQTYGDPEFVEGASHTIGLVEKAFQNASAVTRARAAHAYLTACRHEL
EFFDQALRV
>Mature_569_residues
MFGQFSAAERTSWWGGILAHGHGVRLGGAEITPVEPDLVRTGEGMSEMTISDALAERGTIPRVLSIAGTDPSGGAGTAAD
TKSIIAAGGYAMAVVTSLVAQNTEGVRAIHTPPTDFLVQQLAAVSDDVRIDAVKTGMLGTAEIVDAVATFLDEHRPLVVV
VDPVMVATSGDRLLAPDAEAAMREFCRRATVITPNIPELAVLCQSEPATTPEQAVEQARRWAAETGAAVVVKTGHLNSQR
VDNMWVTTEGAMHVAPAARVETTNTHGTGCSLSSALATRLGAGDTPGDALAWVTDWLHEAIQYGSALNVGKGHGPVDHSH
RARRLAEDASAVAWFAPIDPLESPQGLVVSAEPAPDAVVAPAGPWTTALWQASGDIARRIEDSDFVAVLVDGTLSKPAFE
FYLGQDAQYLTYYSRALASLAARAVDPEESVWWAQSSQACLVEEAELHRSWLGDHIDVVAGPVTLAYTDFLLARALGDDY
VVGTAAVLPCFWLYAHLGAKVPHVPDDHPYASWLQTYGDPEFVEGASHTIGLVEKAFQNASAVTRARAAHAYLTACRHEL
EFFDQALRV

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thiaminase-2 family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=258, Percent_Identity=44.1860465116279, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324517, Length=546, Percent_Identity=27.8388278388278, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324997, Length=493, Percent_Identity=29.4117647058824, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6325378, Length=488, Percent_Identity=27.2540983606557, Blast_Score=143, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR016084
- InterPro:   IPR013749
- InterPro:   IPR004399
- InterPro:   IPR004305
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF08543 Phos_pyr_kin; PF03070 TENA_THI-4; PF02581 TMP-TENI [H]

EC number: =2.5.1.3; =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 60403; Mature: 60403

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGQFSAAERTSWWGGILAHGHGVRLGGAEITPVEPDLVRTGEGMSEMTISDALAERGTI
CCCCCCCCCCCCCCCHHHCCCCCEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCC
PRVLSIAGTDPSGGAGTAADTKSIIAAGGYAMAVVTSLVAQNTEGVRAIHTPPTDFLVQQ
CCEEEEECCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHH
LAAVSDDVRIDAVKTGMLGTAEIVDAVATFLDEHRPLVVVVDPVMVATSGDRLLAPDAEA
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCEEECCCHHH
AMREFCRRATVITPNIPELAVLCQSEPATTPEQAVEQARRWAAETGAAVVVKTGHLNSQR
HHHHHHHHCEEECCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
VDNMWVTTEGAMHVAPAARVETTNTHGTGCSLSSALATRLGAGDTPGDALAWVTDWLHEA
CCCEEEEECCCEEECCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
IQYGSALNVGKGHGPVDHSHRARRLAEDASAVAWFAPIDPLESPQGLVVSAEPAPDAVVA
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCCCCCEEE
PAGPWTTALWQASGDIARRIEDSDFVAVLVDGTLSKPAFEFYLGQDAQYLTYYSRALASL
CCCCCHHHHHHCCCHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHH
AARAVDPEESVWWAQSSQACLVEEAELHRSWLGDHIDVVAGPVTLAYTDFLLARALGDDY
HHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHCCCCC
VVGTAAVLPCFWLYAHLGAKVPHVPDDHPYASWLQTYGDPEFVEGASHTIGLVEKAFQNA
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHH
SAVTRARAAHAYLTACRHELEFFDQALRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFGQFSAAERTSWWGGILAHGHGVRLGGAEITPVEPDLVRTGEGMSEMTISDALAERGTI
CCCCCCCCCCCCCCCHHHCCCCCEEECCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCC
PRVLSIAGTDPSGGAGTAADTKSIIAAGGYAMAVVTSLVAQNTEGVRAIHTPPTDFLVQQ
CCEEEEECCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHH
LAAVSDDVRIDAVKTGMLGTAEIVDAVATFLDEHRPLVVVVDPVMVATSGDRLLAPDAEA
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCEEECCCHHH
AMREFCRRATVITPNIPELAVLCQSEPATTPEQAVEQARRWAAETGAAVVVKTGHLNSQR
HHHHHHHHCEEECCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
VDNMWVTTEGAMHVAPAARVETTNTHGTGCSLSSALATRLGAGDTPGDALAWVTDWLHEA
CCCEEEEECCCEEECCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
IQYGSALNVGKGHGPVDHSHRARRLAEDASAVAWFAPIDPLESPQGLVVSAEPAPDAVVA
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCCCCCEEE
PAGPWTTALWQASGDIARRIEDSDFVAVLVDGTLSKPAFEFYLGQDAQYLTYYSRALASL
CCCCCHHHHHHCCCHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHH
AARAVDPEESVWWAQSSQACLVEEAELHRSWLGDHIDVVAGPVTLAYTDFLLARALGDDY
HHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHCCCCC
VVGTAAVLPCFWLYAHLGAKVPHVPDDHPYASWLQTYGDPEFVEGASHTIGLVEKAFQNA
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHH
SAVTRARAAHAYLTACRHELEFFDQALRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]