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The map label for this gene is manA [H]

Identifier: 50841502

GI number: 50841502

Start: 8304

End: 9491

Strand: Direct

Name: manA [H]

Synonym: PPA0008

Alternate gene names: 50841502

Gene position: 8304-9491 (Clockwise)

Preceding gene: 50841501

Following gene: 50841503

Centisome position: 0.32

GC content: 58.59

Gene sequence:

>1188_bases
ATGCGTGCACTGACAGGACAGGTCCAGCATTACGACTGGGGATCCGCTGACGCCATTCCCGCCATCCTTGGGACTAGACC
CGATGGCACCCCGTGGGCCGAGTACTGGCTGGGAGCCCACCCCAAAGCTCCATCGGCCCTACCGGACGGCACACCTCTGG
ATCAGTGGTTGACACATCACCCCGACGAGCTGGGAGCTGGGAGCCGCGAGGCCTTCGGTGACCGTCTGCCTTTTTTGCTG
AAAATCCTGTCTGCCAATCATGCCCTGAGTATCCAGGCTCACCCTTCACGGGAACAGGCCGAGAAGGGGTTCGCCGCCGA
GAACGAAGCAGGGGTTCCCCTTGATGCCCCCAACCGTATCTTTCGTGACGACTGGCCCAAGCCCGAGATGATCGTCGCCC
TTACTGATTTCGATGCCCTGTGTGGGTTCCGCGATCCATCCTCGTCCCTGGTATTGCTATCGGGTCTGGGTGAAGTCGAT
GGACTGAACGAGGTGCTGACACCACTGAGCCAAAACGATGGCCTGGCCACGCTCGTGGCGGCAGTGCTGTCAGGTGACGA
CGATGTGACTCCGGTCGTCAAAAGGGTCGTGTCTGCCTCTCGCGCCTACCTCAATGACGGTGCAGATGAAGACGTCCGCA
GCCTAGCCACCACCGCCGTCGAGCTGTGGGAGGACCATCCCGGAGACCCGTCCATTCTTGTCGCTCTGCTGATGAACCGG
GTGCGATTGGCTCCCGGTCAGCAAATTCACCTGTGCGCCGGAAGTATGCACGCCTATCTTGGTGGCACTGGTGTGGAAAT
TATGGCTAATTCTGACAATGTTTTGCGTGGTGGTCTGACGAGCAAGTACATCGACGTCAAGGCCTTATTAGACCACGCCA
ACATGACTCCTGAGCCGTGCGTTGGTGAGTATGCTCAGCAAATATCTCCAGGAGTCGGCGTGTATCACACTACGTTCCCG
GAATTCCGGCTTTGGGGGCTTGAAGGGCACAATGATGTCCTCGACCTTCCTGCTACCGAACTAGGGCGAATTCTTCTTGT
AACAGAGGGCCAGTTAGTGGCCCACTGCGGTACTGACGATTGCGAATTAAGCCGTGGCCAATCCGTCTGGTTGCCTGCCG
GGGACGAGGTGAAAGTGACTGGTCAAGGACGTGGATTCCTGGCAAGTGCTGGGGTAGGGGACTCCTGA

Upstream 100 bases:

>100_bases
TTAAGTACTTCGCGTCGTCGTGGAAGTCGTGGTACTCACAATCGTCGGGACTGTCCTCACCTAGGTGACTCGAGCCCAAC
CAACGTGATGAAATCTAACC

Downstream 100 bases:

>100_bases
ATGGAAGGTGGCATAACGCTGCTGACGTCGTGACCCCCCACTCGGTACCGGTAGTCGGGTGAGGGGGTCGAATCGCTCAC
AGGCCCCCTCAACGTCCATC

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MRALTGQVQHYDWGSADAIPAILGTRPDGTPWAEYWLGAHPKAPSALPDGTPLDQWLTHHPDELGAGSREAFGDRLPFLL
KILSANHALSIQAHPSREQAEKGFAAENEAGVPLDAPNRIFRDDWPKPEMIVALTDFDALCGFRDPSSSLVLLSGLGEVD
GLNEVLTPLSQNDGLATLVAAVLSGDDDVTPVVKRVVSASRAYLNDGADEDVRSLATTAVELWEDHPGDPSILVALLMNR
VRLAPGQQIHLCAGSMHAYLGGTGVEIMANSDNVLRGGLTSKYIDVKALLDHANMTPEPCVGEYAQQISPGVGVYHTTFP
EFRLWGLEGHNDVLDLPATELGRILLVTEGQLVAHCGTDDCELSRGQSVWLPAGDEVKVTGQGRGFLASAGVGDS

Sequences:

>Translated_395_residues
MRALTGQVQHYDWGSADAIPAILGTRPDGTPWAEYWLGAHPKAPSALPDGTPLDQWLTHHPDELGAGSREAFGDRLPFLL
KILSANHALSIQAHPSREQAEKGFAAENEAGVPLDAPNRIFRDDWPKPEMIVALTDFDALCGFRDPSSSLVLLSGLGEVD
GLNEVLTPLSQNDGLATLVAAVLSGDDDVTPVVKRVVSASRAYLNDGADEDVRSLATTAVELWEDHPGDPSILVALLMNR
VRLAPGQQIHLCAGSMHAYLGGTGVEIMANSDNVLRGGLTSKYIDVKALLDHANMTPEPCVGEYAQQISPGVGVYHTTFP
EFRLWGLEGHNDVLDLPATELGRILLVTEGQLVAHCGTDDCELSRGQSVWLPAGDEVKVTGQGRGFLASAGVGDS
>Mature_395_residues
MRALTGQVQHYDWGSADAIPAILGTRPDGTPWAEYWLGAHPKAPSALPDGTPLDQWLTHHPDELGAGSREAFGDRLPFLL
KILSANHALSIQAHPSREQAEKGFAAENEAGVPLDAPNRIFRDDWPKPEMIVALTDFDALCGFRDPSSSLVLLSGLGEVD
GLNEVLTPLSQNDGLATLVAAVLSGDDDVTPVVKRVVSASRAYLNDGADEDVRSLATTAVELWEDHPGDPSILVALLMNR
VRLAPGQQIHLCAGSMHAYLGGTGVEIMANSDNVLRGGLTSKYIDVKALLDHANMTPEPCVGEYAQQISPGVGVYHTTFP
EFRLWGLEGHNDVLDLPATELGRILLVTEGQLVAHCGTDDCELSRGQSVWLPAGDEVKVTGQGRGFLASAGVGDS

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=413, Percent_Identity=30.5084745762712, Blast_Score=161, Evalue=8e-40,
Organism=Escherichia coli, GI1787899, Length=397, Percent_Identity=32.9974811083123, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17557650, Length=429, Percent_Identity=25.4079254079254, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI71997620, Length=354, Percent_Identity=30.7909604519774, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320839, Length=332, Percent_Identity=31.6265060240964, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI21356061, Length=400, Percent_Identity=30.75, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42109; Mature: 42109

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALTGQVQHYDWGSADAIPAILGTRPDGTPWAEYWLGAHPKAPSALPDGTPLDQWLTHH
CCCCCCCCEECCCCCCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHCC
PDELGAGSREAFGDRLPFLLKILSANHALSIQAHPSREQAEKGFAAENEAGVPLDAPNRI
CHHHCCCCHHHHHCHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCH
FRDDWPKPEMIVALTDFDALCGFRDPSSSLVLLSGLGEVDGLNEVLTPLSQNDGLATLVA
HCCCCCCCCEEEEEECHHHHCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCHHHHHH
AVLSGDDDVTPVVKRVVSASRAYLNDGADEDVRSLATTAVELWEDHPGDPSILVALLMNR
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VRLAPGQQIHLCAGSMHAYLGGTGVEIMANSDNVLRGGLTSKYIDVKALLDHANMTPEPC
HHCCCCCEEEEECCCHHHHCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHCCCCCCCH
VGEYAQQISPGVGVYHTTFPEFRLWGLEGHNDVLDLPATELGRILLVTEGQLVAHCGTDD
HHHHHHHCCCCCCEEECCCCCEEEEECCCCCCEEECCHHHHCEEEEEECCCEEEECCCCC
CELSRGQSVWLPAGDEVKVTGQGRGFLASAGVGDS
CCCCCCCEEEECCCCEEEEEECCCCEEEECCCCCC
>Mature Secondary Structure
MRALTGQVQHYDWGSADAIPAILGTRPDGTPWAEYWLGAHPKAPSALPDGTPLDQWLTHH
CCCCCCCCEECCCCCCCCCHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHCC
PDELGAGSREAFGDRLPFLLKILSANHALSIQAHPSREQAEKGFAAENEAGVPLDAPNRI
CHHHCCCCHHHHHCHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCH
FRDDWPKPEMIVALTDFDALCGFRDPSSSLVLLSGLGEVDGLNEVLTPLSQNDGLATLVA
HCCCCCCCCEEEEEECHHHHCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCHHHHHH
AVLSGDDDVTPVVKRVVSASRAYLNDGADEDVRSLATTAVELWEDHPGDPSILVALLMNR
HHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VRLAPGQQIHLCAGSMHAYLGGTGVEIMANSDNVLRGGLTSKYIDVKALLDHANMTPEPC
HHCCCCCEEEEECCCHHHHCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHCCCCCCCH
VGEYAQQISPGVGVYHTTFPEFRLWGLEGHNDVLDLPATELGRILLVTEGQLVAHCGTDD
HHHHHHHCCCCCCEEECCCCCEEEEECCCCCCEEECCHHHHCEEEEEECCCEEEECCCCC
CELSRGQSVWLPAGDEVKVTGQGRGFLASAGVGDS
CCCCCCCEEEECCCCEEEEEECCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]