Click here to switch to the map view.

The map label for this gene is htrB

Identifier: 50812291

GI number: 50812291

Start: 3384070

End: 3385446

Strand: Reverse

Name: htrB

Synonym: BSU33000

Alternate gene names: 50812291

Gene position: 3385446-3384070 (Counterclockwise)

Preceding gene: 255767752

Following gene: 16080347

Centisome position: 80.31

GC content: 47.28

Gene sequence:

>1377_bases
ATGGATTATCGACGTGATGGCCAAAACGATCAACATCAAACTGAACCTTCACATACAGAACAGCAGAATACAGAAAACCA
GAAGCTGATTGGACATTCTGAACAAGAATTGCTTGACGCGCCTGTGTCGTATGAAGCGGGACGGCAGGAAACGGCTTCTG
CTTTAGAAATGGAAAAGCAAGAAACGGCTGTGAAAAAAGAAAAGAAACGGAGAGCCGCATGGCTGAGCCCGATTTTAGGC
GGTATTATCGGCGGGGGCCTCATGCTTGGCATCGCGCCTTATCTGCCGTCAGACCAAAATCAGGCGACCGAAACCGCTTC
CGCAAATAAACAGGTGCAGTCTGATAATTTTACAACGGCGCCGATAACGAACGCATCAAACATCGCTGATATGGTAGAGG
ATTTAGAGCCTACGATTGTCGGAATCTCAAATATCCAAACCTCTCAAAATAACACATTCGGCACGGGAGGAGGCTCCAGC
TCAGAAAGTGAAAGCGGAACCGGGTCAGGTGTTATTTTCAAAAAAGACAGCGATAAAGCGTATATCATTACAAACAACCA
TGTCGTTGAAGGCGCGAACAAGCTGACTGTTACGCTATACAACGGAGAAACGGAAACTGCCAAGCTTGTCGGCAGCGATA
CCATTACTGATTTGGCAGTTTTGGAAATCAGCGGCAAGAATGTAAAAAAAGTGGCGAGCTTTGGTGACTCTTCACAGCTG
CGCACTGGCGAAAAGGTAATCGCTATCGGTAACCCGCTCGGACAGCAGTTTTCCGGTACAGTGACACAAGGTATCATTAG
CGGACTGAACCGGACAATTGATGTGGATACAACACAGGGGACGGTGGAAATGAACGTGCTGCAAACCGATGCAGCGATCA
ATCCGGGGAACAGCGGAGGCCCATTAATCAATGCAAGCGGCCAGGTCATCGGCATCAACAGCTTGAAGGTGAGCGAAAGC
GGCGTGGAATCACTTGGATTTGCGATCCCAAGCAATGATGTCGAGCCGATTGTTGACCAGCTGCTGCAAAACGGGAAGGT
GGACCGTCCGTTTTTAGGCGTGCAGATGATTGACATGTCACAAGTTCCTGAAACCTATCAGGAAAATACGCTCGGCCTGT
TTGGAGATCAATTGGGCAAAGGTGTTTATGTAAAAGAAGTTCAAGCAAATTCGCCGGCAGAAAAAGCAGGTATTAAATCT
GAGGATGTCATTGTCAAACTAAACGGTAAAGACGTGGAAAGCAGTGCGGATATCCGTCAGATCCTTTACAAAGACTTAAA
AGTCGGAGATAAAACAACAATCCAAGTGCTGCGAAAGGGAAAAACGAAAACGTTGAACGCAACACTGACCAAGCAGACAG
AAAGCAGTTCAAGCTAA

Upstream 100 bases:

>100_bases
TTTGGTGCTTTGCTTTTCTCCTCATTATTGGGACAATTGAACTTGTACATGCGATGAATATGTAACGATAAATGAATAAC
CGTTAAAGGAGTGTAAGAAC

Downstream 100 bases:

>100_bases
GAAAAAACAAAAAGCTGAACCCGATTAAGGTTCAGCTTTTTTGTTACCCTAAATAAGAGGAAAGCATCCACACTTGTTTT
TCAACTTCTTCAATTAATCC

Product: HtrA-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSYEAGRQETASALEMEKQETAVKKEKKRRAAWLSPILG
GIIGGGLMLGIAPYLPSDQNQATETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS
SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDLAVLEISGKNVKKVASFGDSSQL
RTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVDTTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSES
GVESLGFAIPSNDVEPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSPAEKAGIKS
EDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLTKQTESSSS

Sequences:

>Translated_458_residues
MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSYEAGRQETASALEMEKQETAVKKEKKRRAAWLSPILG
GIIGGGLMLGIAPYLPSDQNQATETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS
SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDLAVLEISGKNVKKVASFGDSSQL
RTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVDTTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSES
GVESLGFAIPSNDVEPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSPAEKAGIKS
EDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLTKQTESSSS
>Mature_458_residues
MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSYEAGRQETASALEMEKQETAVKKEKKRRAAWLSPILG
GIIGGGLMLGIAPYLPSDQNQATETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS
SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDLAVLEISGKNVKKVASFGDSSQL
RTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVDTTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSES
GVESLGFAIPSNDVEPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSPAEKAGIKS
EDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLTKQTESSSS

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain

Homologues:

Organism=Homo sapiens, GI4506141, Length=318, Percent_Identity=34.2767295597484, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI22129776, Length=314, Percent_Identity=35.9872611464968, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI24308541, Length=344, Percent_Identity=32.8488372093023, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI7019477, Length=334, Percent_Identity=32.6347305389222, Blast_Score=133, Evalue=4e-31,
Organism=Escherichia coli, GI1786356, Length=297, Percent_Identity=39.3939393939394, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789629, Length=286, Percent_Identity=37.0629370629371, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1789630, Length=297, Percent_Identity=37.7104377104377, Blast_Score=146, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24646839, Length=412, Percent_Identity=29.8543689320388, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YVTA_BACSU (Q9R9I1)

Other databases:

- EMBL:   AF188296
- EMBL:   Z93941
- EMBL:   Z93941
- EMBL:   AL009126
- PIR:   E70048
- PIR:   F70048
- RefSeq:   NP_391180.2
- ProteinModelPortal:   Q9R9I1
- SMR:   Q9R9I1
- EnsemblBacteria:   EBBACT00000002731
- GeneID:   935935
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU33000
- GenoList:   BSU33000
- GeneTree:   EBGT00050000001145
- HOGENOM:   HBG585708
- OMA:   MNVLQTD
- ProtClustDB:   CLSK887151
- BioCyc:   BSUB:BSU33000-MONOMER
- GO:   GO:0006508
- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940
- PRINTS:   PR00834
- SMART:   SM00228

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin; SSF50156 PDZ; SSF50494 Pept_Ser_Cys

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48718; Mature: 48718

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50106 PDZ; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: ACT_SITE 187-187 ACT_SITE 217-217 ACT_SITE 298-298

Signals:

None

Transmembrane regions:

HASH(0x11222654)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSYEAGRQETASALEMEKQ
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
ETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQATETASANKQVQSDNFTTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCEEC
PITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSSSESESGTGSGVIFKKDSDKA
CCCCHHHHHHHHHHCCCEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCE
YIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDLAVLEISGKNVKKVASFGDSSQL
EEEECCEEECCCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHCCCCCCC
RTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVDTTQGTVEMNVLQTDAAINPGNSGG
CCCCEEEEECCCCCCHHCCHHHHHHHHHCCCEEEEECCCCEEEEEEEEECCCCCCCCCCC
PLINASGQVIGINSLKVSESGVESLGFAIPSNDVEPIVDQLLQNGKVDRPFLGVQMIDMS
CEEECCCCEEEECEEECCHHCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECHH
QVPETYQENTLGLFGDQLGKGVYVKEVQANSPAEKAGIKSEDVIVKLNGKDVESSADIRQ
HCCHHHHHCCCHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHH
ILYKDLKVGDKTTIQVLRKGKTKTLNATLTKQTESSSS
HHHHHHCCCCHHHHHHHHCCCCEEEEEEEEECCCCCCH
>Mature Secondary Structure
MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSYEAGRQETASALEMEKQ
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
ETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQATETASANKQVQSDNFTTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCEEC
PITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSSSESESGTGSGVIFKKDSDKA
CCCCHHHHHHHHHHCCCEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCE
YIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDLAVLEISGKNVKKVASFGDSSQL
EEEECCEEECCCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHCCCCCCC
RTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVDTTQGTVEMNVLQTDAAINPGNSGG
CCCCEEEEECCCCCCHHCCHHHHHHHHHCCCEEEEECCCCEEEEEEEEECCCCCCCCCCC
PLINASGQVIGINSLKVSESGVESLGFAIPSNDVEPIVDQLLQNGKVDRPFLGVQMIDMS
CEEECCCCEEEECEEECCHHCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECHH
QVPETYQENTLGLFGDQLGKGVYVKEVQANSPAEKAGIKSEDVIVKLNGKDVESSADIRQ
HCCHHHHHCCCHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHH
ILYKDLKVGDKTTIQVLRKGKTKTLNATLTKQTESSSS
HHHHHHCCCCHHHHHHHHCCCCEEEEEEEEECCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10692364; 9353931; 9384377; 10568751; 11133960