Click here to switch to the map view.

The map label for this gene is yqjI

Identifier: 50812264

GI number: 50812264

Start: 2480750

End: 2482159

Strand: Reverse

Name: yqjI

Synonym: BSU23860

Alternate gene names: 50812264

Gene position: 2482159-2480750 (Counterclockwise)

Preceding gene: 255767518

Following gene: 16079441

Centisome position: 58.88

GC content: 43.97

Gene sequence:

>1410_bases
ATGTCAAAACAACAAATCGGCGTTATCGGACTTGCGGTCATGGGTAAAAATCTGGCTTTAAATATCGAAAGCCGGGGATT
TTCTGTTTCTGTTTACAACAGATCAAGCAGTAAAACTGAGGAGTTTTTACAGGAGGCAAAAGGAAAAAATGTTGTTGGCA
CTTACAGCATTGAAGAATTTGTCCAATCCTTGGAAACACCGCGCAAAATCTTATTAATGGTTAAAGCGGGAACTGCAACA
GATGCGACAATTCAATCTCTTCTTCCTCATCTAGAGAAGGATGATATTTTAATTGACGGCGGTAATACATACTATAAAGA
TACACAGCGCCGTAACAAAGAACTCGCTGAAAGCGGCATTCATTTTATCGGAACAGGCGTTTCCGGCGGAGAAGAAGGAG
CGCTTAAAGGACCTTCTATCATGCCTGGCGGACAAAAAGAAGCACATGAGCTTGTAAAACCGATTCTTGAAGCCATTTCT
GCAAAAGTTGACGGAGAACCTTGTACGACATATATCGGTCCGGACGGCGCCGGCCATTACGTAAAAATGGTGCACAACGG
AATTGAATACGGAGATATGCAGCTGATCTCTGAATCATATTTCATTCTGAAACAGGTGCTGGGCCTTTCTGCTGATGAGC
TTCATGAAGTTTTCGCTGAATGGAATAAAGGTGAGCTTGATAGCTACCTGATTGAGATTACGGCTGACATCTTCACAAAA
AAAGACGAAGAAACAGGCAAACCGCTTGTTGATGTGATTCTTGATAAAGCAGGCCAAAAAGGAACAGGAAAATGGACAAG
CCAAAGCGCACTTGACTTAGGCGTTCCGCTTCCGATTATTACTGAATCTGTATTCGCACGCTTTATCTCAGCTATGAAGG
AAGAGCGTGTAAAAGCGAGCGGACTTCTTTCAGGACCAGAAGTGAAGCCTGTTACAGAAAATAAAGAAGAGCTGATTGAA
GCGGTCAGAAAAGCGTTGTTCATGAGTAAAATCTGTTCATACGCGCAAGGATTTGCCCAAATGAAAGCTGCTTCTGAAGA
ATACAACTGGGATCTGAAATATGGTGAAATCGCTATGATCTTCCGCGGTGGTTGCATCATTCGCGCGGCATTCCTTCAGA
AGATCAAAGAAGCTTACGATCGCGAGCCTGAGCTTGACAACCTGCTTCTTGACAGCTATTTCAAGAATATTGTAGAAAGC
TATCAAGGAGCGCTTCGCCAAGTGATTTCACTTGCAGTTGCCCAAGGTGTGCCGGTGCCATCATTCTCAAGCGCATTAGC
CTACTATGACAGCTACCGCACAGCCGTACTGCCTGCAAACTTAATCCAAGCACAGCGCGACTACTTTGGCGCTCATACTT
ATGAGCGTACTGACAAAGAAGGCATCTTCCATACTGAATGGATGAAGTAA

Upstream 100 bases:

>100_bases
AAAAAAGGGTGAATGTATGGTAATTTCTTTATTATAAATATCATTTTATTTTAATTTAAATTTTAAAATGATTAAACGTT
TGCAGAAGGGACGTTAGAAT

Downstream 100 bases:

>100_bases
TCAATAGAAACCCCCGAAGCTCTTAAGCTTTGGGGGTTTTGTTATTAAGGAGATTGTTATACCTTTGTTCAGCGTAAAAA
AGACCGAAAATGCTTAGTAA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQEAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTAT
DATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS
AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVFAEWNKGELDSYLIEITADIFTK
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIE
AVRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDSYFKNIVES
YQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK

Sequences:

>Translated_469_residues
MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQEAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTAT
DATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS
AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVFAEWNKGELDSYLIEITADIFTK
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIE
AVRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDSYFKNIVES
YQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
>Mature_468_residues
SKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQEAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATD
ATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISA
KVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVFAEWNKGELDSYLIEITADIFTKK
DEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEA
VRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDSYFKNIVESY
QGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=55.7446808510638, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1788341, Length=469, Percent_Identity=70.1492537313433, Blast_Score=691, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=52.6539278131635, Blast_Score=528, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6321695, Length=459, Percent_Identity=54.4662309368192, Blast_Score=523, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=55.5309734513274, Blast_Score=508, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24639279, Length=471, Percent_Identity=56.0509554140127, Blast_Score=514, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGD2_BACSU (P80859)

Other databases:

- EMBL:   D84432
- EMBL:   AL009126
- PIR:   A69964
- RefSeq:   NP_390267.2
- ProteinModelPortal:   P80859
- SMR:   P80859
- EnsemblBacteria:   EBBACT00000002390
- GeneID:   938695
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU23860
- NMPDR:   fig|224308.1.peg.2391
- GenoList:   BSU23860
- GeneTree:   EBGT00050000001992
- HOGENOM:   HBG286913
- OMA:   CIIRAGF
- PhylomeDB:   P80859
- ProtClustDB:   PRK09287
- BioCyc:   BSUB:BSU23860-MONOMER
- BioCyc:   MetaCyc:MONOMER-6842
- BRENDA:   1.1.1.44
- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183
- Gene3D:   G3DSA:1.20.5.320
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PIRSF:   PIRSF000109
- PRINTS:   PR00076
- TIGRFAMs:   TIGR00873

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2; SSF48179 6DGDH_C_like

EC number: =1.1.1.44

Molecular weight: Translated: 51776; Mature: 51644

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00461 6PGD

Important sites: ACT_SITE 182-182 ACT_SITE 189-189 BINDING 102-102 BINDING 102-102 BINDING 190-190 BINDING 260-260 BINDING 287-287 BINDING 446-446 BINDING 452-452

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQEAKGKNVVGTYSIEEF
CCCCCEEEEEHEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHH
VQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
HFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISAKVDGEPCTTYIGPDGAGHY
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
VKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVFAEWNKGELDSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKAS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GLLSGPEVKPVTENKEELIEAVRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
FRGGCIIRAAFLQKIKEAYDREPELDNLLLDSYFKNIVESYQGALRQVISLAVAQGVPVP
EECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
CHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQEAKGKNVVGTYSIEEF
CCCCEEEEEHEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHH
VQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
HFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISAKVDGEPCTTYIGPDGAGHY
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
VKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVFAEWNKGELDSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKAS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GLLSGPEVKPVTENKEELIEAVRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
FRGGCIIRAAFLQKIKEAYDREPELDNLLLDSYFKNIVESYQGALRQVISLAVAQGVPVP
EECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
CHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659