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The map label for this gene is uvrB [H]

Identifier: 50364873

GI number: 50364873

Start: 73663

End: 75510

Strand: Direct

Name: uvrB [H]

Synonym: Mfl058

Alternate gene names: 50364873

Gene position: 73663-75510 (Clockwise)

Preceding gene: 50364872

Following gene: 50364874

Centisome position: 9.29

GC content: 29.11

Gene sequence:

>1848_bases
ATGGCAAATATAATTAAAGAAATTAATAAACCAACTTTAGTTCTTGCACATAACAAAACTTTAGCTATGCAATTGTATTA
TGAGTTGATGGAATTCTTTCCTAATAATAGAGTTGAGTATTTTGTTTCAAATTTCGACTTCTTTCAACCTGAAGCATATA
AGCCTGCGACTGATTTATATATTAATAAAGATGCCAGAATTAATATGGAACTTGATATGTTGAGAATGAGCGCTATGAAT
GCATTATCAATTTCTAATGACACAATAGTAGTTGCATCTGTTGCCGCAATATATCCATCACAAGATCCTGTTCAATATGC
ATCAAGTTTTTTTGAATTGAAAACTGGGCAAAAATTTTCTAAAAGAGAATTATTAACATATTTAGTTAAAACAGGATATA
CAAGAAACGACATTGAAAATTCACCAGGTACTTTTAGTGTAAAAGGTGATGTTATAAAAGTAGTTCCAGGATGATCTTTA
TCAGCTATGTATCGTTTTTCATTATTTGATGATCATATAGAAATGATAGACATGTTAAATGTTGTAACGGGGGCTTTAAT
TGAAAGAATCTCAACTGTTACAATATATCCTGCTCAAGCTTATGTGACACCTGAAGATAAGTTAAAACAAGCTTGCTTGA
ACATAAGAGAAGAACTTGCGGTTAGAGTTAAAGAATTAAAAGAAGAAGGAAAACTATTAGAAGCAGAAAGATTAGATCAA
AGAACAAGATATGATTTAGAAAGTTTAGAAGAGTTTGGATTTTGTAGTGGTATTGAAAATTATTCTGCACACTTAGATTT
TAGAGCGCCAGGAGAGACCCCATATACTTTATTAGATTATTTTAAAGGAGATTTTTTAACTATAATTGATGAATCACACA
TAATGGTTTCTCAAGTTAGAGGTATGTATAATACTGATAGAAGTAGAAAACAAACTCTTGTAGAGTATGGTTTTAGATTG
CCTTCAGCATTAGATAATAGACCTTTAAATTTTGAAGAATTTACAGGAAAATTAAAACAAGTAATTTATACATCAGCTAC
ACCAGGTGATTATGAATTAGAACTTGTTAATCATGAAGTTGTTGAACAAATTATTAGACCAACGGGTTTATTAGATCCAG
TAATCGAAGTTAAAAAAACAGAAGGTCAAATAGAAGATATAATTGAACAAATTCATGAAAGAAAAAAAGTAAATGAAAAG
GTATTTATTACAACTTTAACAATTAGAATGAGTGAAGATTTAACAAGTTACTTACAAGAAAGAAATATTAAAGTAGCATA
TTTACATTCAGAATTAAAAACACTTGAAAGAAGCGATATTTTAAATGATCTTAGAAGAGGCGTTTATGATGCTGTTGTTG
GAGTTAACTTATTACGTGAAGGGTTGGATTTACCTGAAGTGAGTTTAGTTTGTGTTCTAGATGCAGATAAACAAGGTTTT
TTAAGAAATACAAAATCACTAATTCAAACAGCTGGTAGAGCTGCTAGAAATGCTAATGGTAAAGTTATTTTTTATGCAGA
TACAATTTCAACATCAATGCAAGAAGCTATGGATGAAACAAATCGTAGACGAGAAATTCAACAAGCTTACAATAAAGAAC
ATAATATAACTCCAGTAACTATAACAAAGAAAATCAATCAATCAACTTTAAGTGAAGCAACTAAAAAAGAACTTGAAAAA
ATTAAAAAACAAAAAACTGCAAAAGGCAAAAAAGAAGCTTATCAAAAAACAATTGATGATATTAGAGCTGAAATGATTCA
AGCAGCAAAGGATTTAGATTTTGAAAAAGCAGCAGTTTTAAGAGATACAATAATTGAACTAGAAGCTAAGAAAAGTGAGG
TAAAATAA

Upstream 100 bases:

>100_bases
AGATCAACCCAAAGCAATTGAAAAATTATTAAAAGGTTTAAAAGAAAATAAAAAACACCAAGTTCTTTTAGGTGCTACTG
GAACTGGTAAAACATTCACA

Downstream 100 bases:

>100_bases
TGGAAAATAAAATAGTAATAAAAGGTGCAAGAGAAAACAATTTAAAAAACGTTGACTTAGAAATACCAAAAAATAAGCTA
GTTGTTTTTACTGGATTAAG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MANIIKEINKPTLVLAHNKTLAMQLYYELMEFFPNNRVEYFVSNFDFFQPEAYKPATDLYINKDARINMELDMLRMSAMN
ALSISNDTIVVASVAAIYPSQDPVQYASSFFELKTGQKFSKRELLTYLVKTGYTRNDIENSPGTFSVKGDVIKVVPGWSL
SAMYRFSLFDDHIEMIDMLNVVTGALIERISTVTIYPAQAYVTPEDKLKQACLNIREELAVRVKELKEEGKLLEAERLDQ
RTRYDLESLEEFGFCSGIENYSAHLDFRAPGETPYTLLDYFKGDFLTIIDESHIMVSQVRGMYNTDRSRKQTLVEYGFRL
PSALDNRPLNFEEFTGKLKQVIYTSATPGDYELELVNHEVVEQIIRPTGLLDPVIEVKKTEGQIEDIIEQIHERKKVNEK
VFITTLTIRMSEDLTSYLQERNIKVAYLHSELKTLERSDILNDLRRGVYDAVVGVNLLREGLDLPEVSLVCVLDADKQGF
LRNTKSLIQTAGRAARNANGKVIFYADTISTSMQEAMDETNRRREIQQAYNKEHNITPVTITKKINQSTLSEATKKELEK
IKKQKTAKGKKEAYQKTIDDIRAEMIQAAKDLDFEKAAVLRDTIIELEAKKSEVK

Sequences:

>Translated_615_residues
MANIIKEINKPTLVLAHNKTLAMQLYYELMEFFPNNRVEYFVSNFDFFQPEAYKPATDLYINKDARINMELDMLRMSAMN
ALSISNDTIVVASVAAIYPSQDPVQYASSFFELKTGQKFSKRELLTYLVKTGYTRNDIENSPGTFSVKGDVIKVVPG*SL
SAMYRFSLFDDHIEMIDMLNVVTGALIERISTVTIYPAQAYVTPEDKLKQACLNIREELAVRVKELKEEGKLLEAERLDQ
RTRYDLESLEEFGFCSGIENYSAHLDFRAPGETPYTLLDYFKGDFLTIIDESHIMVSQVRGMYNTDRSRKQTLVEYGFRL
PSALDNRPLNFEEFTGKLKQVIYTSATPGDYELELVNHEVVEQIIRPTGLLDPVIEVKKTEGQIEDIIEQIHERKKVNEK
VFITTLTIRMSEDLTSYLQERNIKVAYLHSELKTLERSDILNDLRRGVYDAVVGVNLLREGLDLPEVSLVCVLDADKQGF
LRNTKSLIQTAGRAARNANGKVIFYADTISTSMQEAMDETNRRREIQQAYNKEHNITPVTITKKINQSTLSEATKKELEK
IKKQKTAKGKKEAYQKTIDDIRAEMIQAAKDLDFEKAAVLRDTIIELEAKKSEVK
>Mature_614_residues
ANIIKEINKPTLVLAHNKTLAMQLYYELMEFFPNNRVEYFVSNFDFFQPEAYKPATDLYINKDARINMELDMLRMSAMNA
LSISNDTIVVASVAAIYPSQDPVQYASSFFELKTGQKFSKRELLTYLVKTGYTRNDIENSPGTFSVKGDVIKVVPG*SLS
AMYRFSLFDDHIEMIDMLNVVTGALIERISTVTIYPAQAYVTPEDKLKQACLNIREELAVRVKELKEEGKLLEAERLDQR
TRYDLESLEEFGFCSGIENYSAHLDFRAPGETPYTLLDYFKGDFLTIIDESHIMVSQVRGMYNTDRSRKQTLVEYGFRLP
SALDNRPLNFEEFTGKLKQVIYTSATPGDYELELVNHEVVEQIIRPTGLLDPVIEVKKTEGQIEDIIEQIHERKKVNEKV
FITTLTIRMSEDLTSYLQERNIKVAYLHSELKTLERSDILNDLRRGVYDAVVGVNLLREGLDLPEVSLVCVLDADKQGFL
RNTKSLIQTAGRAARNANGKVIFYADTISTSMQEAMDETNRRREIQQAYNKEHNITPVTITKKINQSTLSEATKKELEKI
KKQKTAKGKKEAYQKTIDDIRAEMIQAAKDLDFEKAAVLRDTIIELEAKKSEVK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=620, Percent_Identity=50.1612903225806, Blast_Score=610, Evalue=1e-176,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 70213; Mature: 70082

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIIKEINKPTLVLAHNKTLAMQLYYELMEFFPNNRVEYFVSNFDFFQPEAYKPATDLY
CCCHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEE
INKDARINMELDMLRMSAMNALSISNDTIVVASVAAIYPSQDPVQYASSFFELKTGQKFS
ECCCCEEEEHHHHHHHHHHHHEECCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHCCCCHH
KRELLTYLVKTGYTRNDIENSPGTFSVKGDVIKVVPGSLSAMYRFSLFDDHIEMIDMLNV
HHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
VTGALIERISTVTIYPAQAYVTPEDKLKQACLNIREELAVRVKELKEEGKLLEAERLDQR
HHHHHHHHHHEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TRYDLESLEEFGFCSGIENYSAHLDFRAPGETPYTLLDYFKGDFLTIIDESHIMVSQVRG
HHCCHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHH
MYNTDRSRKQTLVEYGFRLPSALDNRPLNFEEFTGKLKQVIYTSATPGDYELELVNHEVV
HHCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHEECCCCCCEEEEECCHHHH
EQIIRPTGLLDPVIEVKKTEGQIEDIIEQIHERKKVNEKVFITTLTIRMSEDLTSYLQER
HHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHC
NIKVAYLHSELKTLERSDILNDLRRGVYDAVVGVNLLREGLDLPEVSLVCVLDADKQGFL
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHH
RNTKSLIQTAGRAARNANGKVIFYADTISTSMQEAMDETNRRREIQQAYNKEHNITPVTI
HHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TKKINQSTLSEATKKELEKIKKQKTAKGKKEAYQKTIDDIRAEMIQAAKDLDFEKAAVLR
ECHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DTIIELEAKKSEVK
HHHHHHHHHHCCCC
>Mature Secondary Structure 
ANIIKEINKPTLVLAHNKTLAMQLYYELMEFFPNNRVEYFVSNFDFFQPEAYKPATDLY
CCHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEE
INKDARINMELDMLRMSAMNALSISNDTIVVASVAAIYPSQDPVQYASSFFELKTGQKFS
ECCCCEEEEHHHHHHHHHHHHEECCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHCCCCHH
KRELLTYLVKTGYTRNDIENSPGTFSVKGDVIKVVPGSLSAMYRFSLFDDHIEMIDMLNV
HHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
VTGALIERISTVTIYPAQAYVTPEDKLKQACLNIREELAVRVKELKEEGKLLEAERLDQR
HHHHHHHHHHEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TRYDLESLEEFGFCSGIENYSAHLDFRAPGETPYTLLDYFKGDFLTIIDESHIMVSQVRG
HHCCHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHH
MYNTDRSRKQTLVEYGFRLPSALDNRPLNFEEFTGKLKQVIYTSATPGDYELELVNHEVV
HHCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHEECCCCCCEEEEECCHHHH
EQIIRPTGLLDPVIEVKKTEGQIEDIIEQIHERKKVNEKVFITTLTIRMSEDLTSYLQER
HHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHC
NIKVAYLHSELKTLERSDILNDLRRGVYDAVVGVNLLREGLDLPEVSLVCVLDADKQGFL
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHH
RNTKSLIQTAGRAARNANGKVIFYADTISTSMQEAMDETNRRREIQQAYNKEHNITPVTI
HHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TKKINQSTLSEATKKELEKIKKQKTAKGKKEAYQKTIDDIRAEMIQAAKDLDFEKAAVLR
ECHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DTIIELEAKKSEVK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA