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The map label for this gene is ppiA

Identifier: 50086590

GI number: 50086590

Start: 3565216

End: 3565782

Strand: Reverse

Name: ppiA

Synonym: ACIAD3647

Alternate gene names: 50086590

Gene position: 3565782-3565216 (Counterclockwise)

Preceding gene: 50086591

Following gene: 50086585

Centisome position: 99.09

GC content: 37.57

Gene sequence:

>567_bases
ATGCTTAAACGAGTCGCGATAGTTCTGGGTGGATTATTGATTAGTGCACATGCTTTAGCAAATACCATGGTTGAGATGAA
AACCAATCTGGGAAATATAGAAATTGAGCTTTACAACAATAAAGCACCGATCTCAGCGAAAAACTTTGAAAGCTATGTCA
AAAATAATTTCTACAATGGCACTATTTTTCATCGCGTCATTCCAAATTTCATGATTCAAGGAGGTGGTTTTGAAACCAAT
ATGAAAGAGAAGGCGACTGCTGCACCTATCAAAAATGAGGCGTCAAATGGCTTGGCAAATACTCGCGGCACATTGGCAAT
GGCAAGAACCAGTAATCCCGATTCAGCAACCAGCCAGTTTTTTATCAATGTTGCAGATAACAACTTCTTAAATGCTTCAC
GTACAGATGCAGGTTATGCAGTATTTGGCAAGGTAATTAAAGGCATGGATGTCGTCGATAAAATTGCGAATGTACCTACA
AGTACCTATGGTATGCATCAAAATGTACCTAAACAACCTGTGAAAATTATAAGTGTACAAATTAAGAGCATTAATACAGC
AAAATAA

Upstream 100 bases:

>100_bases
TATTTGAAGAAATAGTATCAAATACACAATTAAAACAAGAGAGTAGACAGTTTATGCTATGTTAAGTCACTTATGATAAA
AGAAGTTAACAGGATAACGA

Downstream 100 bases:

>100_bases
CCAAGAAATAAAAATGACATATTTTTCTTTTATAATTAGAACCTTGTGATCATTTTTACCTTAAAAAGCACCATGTTGGT
GCGCAAAAATAGAACACTCG

Product: peptidyl-prolyl cis-trans isomerase precursor (PPIase)

Products: NA

Alternate protein names: PPIase; Rotamase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MLKRVAIVLGGLLISAHALANTMVEMKTNLGNIEIELYNNKAPISAKNFESYVKNNFYNGTIFHRVIPNFMIQGGGFETN
MKEKATAAPIKNEASNGLANTRGTLAMARTSNPDSATSQFFINVADNNFLNASRTDAGYAVFGKVIKGMDVVDKIANVPT
STYGMHQNVPKQPVKIISVQIKSINTAK

Sequences:

>Translated_188_residues
MLKRVAIVLGGLLISAHALANTMVEMKTNLGNIEIELYNNKAPISAKNFESYVKNNFYNGTIFHRVIPNFMIQGGGFETN
MKEKATAAPIKNEASNGLANTRGTLAMARTSNPDSATSQFFINVADNNFLNASRTDAGYAVFGKVIKGMDVVDKIANVPT
STYGMHQNVPKQPVKIISVQIKSINTAK
>Mature_188_residues
MLKRVAIVLGGLLISAHALANTMVEMKTNLGNIEIELYNNKAPISAKNFESYVKNNFYNGTIFHRVIPNFMIQGGGFETN
MKEKATAAPIKNEASNGLANTRGTLAMARTSNPDSATSQFFINVADNNFLNASRTDAGYAVFGKVIKGMDVVDKIANVPT
STYGMHQNVPKQPVKIISVQIKSINTAK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain

Homologues:

Organism=Homo sapiens, GI7706339, Length=157, Percent_Identity=36.3057324840764, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI22547212, Length=161, Percent_Identity=33.5403726708075, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI7657473, Length=161, Percent_Identity=33.5403726708075, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI22547215, Length=156, Percent_Identity=34.6153846153846, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI5454154, Length=159, Percent_Identity=36.4779874213836, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI19557636, Length=139, Percent_Identity=34.5323741007194, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI24308049, Length=160, Percent_Identity=34.375, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI64276486, Length=128, Percent_Identity=38.28125, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI310110104, Length=135, Percent_Identity=35.5555555555556, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI310129267, Length=134, Percent_Identity=34.3283582089552, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI310120620, Length=134, Percent_Identity=34.3283582089552, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=36.9230769230769, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI5174637, Length=177, Percent_Identity=31.638418079096, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789763, Length=183, Percent_Identity=57.9234972677596, Blast_Score=211, Evalue=3e-56,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=61.7283950617284, Blast_Score=198, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71980590, Length=138, Percent_Identity=38.4057971014493, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=157, Percent_Identity=36.3057324840764, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=138, Percent_Identity=38.4057971014493, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71997782, Length=125, Percent_Identity=36.8, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=145, Percent_Identity=33.7931034482759, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532643, Length=161, Percent_Identity=32.9192546583851, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17565860, Length=167, Percent_Identity=32.3353293413174, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=160, Percent_Identity=30, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17552782, Length=173, Percent_Identity=32.3699421965318, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17566266, Length=152, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=152, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=136, Percent_Identity=35.2941176470588, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=157, Percent_Identity=34.3949044585987, Blast_Score=78, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321848, Length=155, Percent_Identity=37.4193548387097, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320359, Length=135, Percent_Identity=32.5925925925926, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=159, Percent_Identity=35.8490566037736, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17986117, Length=174, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19922376, Length=156, Percent_Identity=31.4102564102564, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24586038, Length=160, Percent_Identity=34.375, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922912, Length=161, Percent_Identity=34.1614906832298, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45549139, Length=146, Percent_Identity=36.3013698630137, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24652460, Length=152, Percent_Identity=28.9473684210526, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664125, Length=133, Percent_Identity=38.3458646616541, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357783, Length=133, Percent_Identity=38.3458646616541, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357249, Length=160, Percent_Identity=30, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPIA_ACIAD (P42693)

Other databases:

- EMBL:   X74839
- EMBL:   CR543861
- PIR:   S50205
- RefSeq:   YP_048100.1
- ProteinModelPortal:   P42693
- SMR:   P42693
- STRING:   P42693
- GeneID:   2879809
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3647
- NMPDR:   fig|62977.3.peg.3293
- eggNOG:   COG0652
- HOGENOM:   HBG610621
- OMA:   FYINQAD
- PhylomeDB:   P42693
- ProtClustDB:   CLSK707952
- BioCyc:   ASP62977:ACIAD3647-MONOMER
- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130
- Gene3D:   G3DSA:2.40.100.10
- PRINTS:   PR00153

Pfam domain/function: PF00160 Pro_isomerase; SSF50891 CSA_PPIase

EC number: =5.2.1.8

Molecular weight: Translated: 20399; Mature: 20399

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS00170 CSA_PPIASE_1; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRVAIVLGGLLISAHALANTMVEMKTNLGNIEIELYNNKAPISAKNFESYVKNNFYNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCC
TIFHRVIPNFMIQGGGFETNMKEKATAAPIKNEASNGLANTRGTLAMARTSNPDSATSQF
CHHHHHHHHHEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEE
FINVADNNFLNASRTDAGYAVFGKVIKGMDVVDKIANVPTSTYGMHQNVPKQPVKIISVQ
EEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
IKSINTAK
EECCCCCC
>Mature Secondary Structure
MLKRVAIVLGGLLISAHALANTMVEMKTNLGNIEIELYNNKAPISAKNFESYVKNNFYNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCC
TIFHRVIPNFMIQGGGFETNMKEKATAAPIKNEASNGLANTRGTLAMARTSNPDSATSQF
CHHHHHHHHHEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEE
FINVADNNFLNASRTDAGYAVFGKVIKGMDVVDKIANVPTSTYGMHQNVPKQPVKIISVQ
EEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
IKSINTAK
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7948017