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The map label for this gene is merR1 [H]

Identifier: 50086549

GI number: 50086549

Start: 3517500

End: 3518018

Strand: Reverse

Name: merR1 [H]

Synonym: ACIAD3599

Alternate gene names: 50086549

Gene position: 3518018-3517500 (Counterclockwise)

Preceding gene: 50086551

Following gene: 50086548

Centisome position: 97.76

GC content: 39.69

Gene sequence:

>519_bases
ATGTTTGATGCTTTGGGGGTTCGTGATGATGACAGCAGCCAGCCATTTGCAATTTCCTTAACTTTAGATAAGCTGATTAA
AAAGGCTGGAGTCACTCCAAGGTCAAGTCTGATGATGAAATATTTAATTGGCGAACTTTCAAAAAAATCGCATATCTCTG
TCGATAGCATTCGTTTTTATGAAAAGCGTGGACTATTACAAGCACCACAACGTGCACCAAACAATTATCGTTATTATGAT
GATCAGGCACTGGATCAGTTAATTTTTATACGGCACTGCCGCGAGCTCGGCATGTCATTGAATGAAATTCAGGCATTACA
TCAGTTGCTCCAACATCCTGAACAACAATGCAACGTTATTGATCAGGCCATTGAGGAGCATCTCGAACATATTAATCAAA
AAATTAGACAGTTTGAAACCTTTAAAATTCAGCTCGAACAGTTGCGTGAGCGTTGCCAGTCCAATAGCACCATTGATCAC
TGTAAAATTGTTCAAACGCTGAAAGAACACGACCATTGA

Upstream 100 bases:

>100_bases
CATAAAGAGGTTGAACCGATATGCGCGCCACCGAATACTTCAATAAAAAACATGCCCAGATTAAGCAACAGTGCAATCCA
TAGAGCAATTTTAAATTTCG

Downstream 100 bases:

>100_bases
AGCTTCATATTTAAATCATTGGATCAAAACTTTTTGGAAATATGCGGTAAAACAAAACTACATTTTCACAGCAATATCTT
AAGTCTGATTTTCTTATGCT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MFDALGVRDDDSSQPFAISLTLDKLIKKAGVTPRSSLMMKYLIGELSKKSHISVDSIRFYEKRGLLQAPQRAPNNYRYYD
DQALDQLIFIRHCRELGMSLNEIQALHQLLQHPEQQCNVIDQAIEEHLEHINQKIRQFETFKIQLEQLRERCQSNSTIDH
CKIVQTLKEHDH

Sequences:

>Translated_172_residues
MFDALGVRDDDSSQPFAISLTLDKLIKKAGVTPRSSLMMKYLIGELSKKSHISVDSIRFYEKRGLLQAPQRAPNNYRYYD
DQALDQLIFIRHCRELGMSLNEIQALHQLLQHPEQQCNVIDQAIEEHLEHINQKIRQFETFKIQLEQLRERCQSNSTIDH
CKIVQTLKEHDH
>Mature_172_residues
MFDALGVRDDDSSQPFAISLTLDKLIKKAGVTPRSSLMMKYLIGELSKKSHISVDSIRFYEKRGLLQAPQRAPNNYRYYD
DQALDQLIFIRHCRELGMSLNEIQALHQLLQHPEQQCNVIDQAIEEHLEHINQKIRQFETFKIQLEQLRERCQSNSTIDH
CKIVQTLKEHDH

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=132, Percent_Identity=31.0606060606061, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786695, Length=125, Percent_Identity=29.6, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 20156; Mature: 20156

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDALGVRDDDSSQPFAISLTLDKLIKKAGVTPRSSLMMKYLIGELSKKSHISVDSIRFY
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
EKRGLLQAPQRAPNNYRYYDDQALDQLIFIRHCRELGMSLNEIQALHQLLQHPEQQCNVI
HHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHH
DQAIEEHLEHINQKIRQFETFKIQLEQLRERCQSNSTIDHCKIVQTLKEHDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFDALGVRDDDSSQPFAISLTLDKLIKKAGVTPRSSLMMKYLIGELSKKSHISVDSIRFY
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
EKRGLLQAPQRAPNNYRYYDDQALDQLIFIRHCRELGMSLNEIQALHQLLQHPEQQCNVI
HHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHH
DQAIEEHLEHINQKIRQFETFKIQLEQLRERCQSNSTIDHCKIVQTLKEHDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]