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The map label for this gene is dsbB

Identifier: 50086502

GI number: 50086502

Start: 3473090

End: 3473605

Strand: Reverse

Name: dsbB

Synonym: ACIAD3548

Alternate gene names: 50086502

Gene position: 3473605-3473090 (Counterclockwise)

Preceding gene: 50086503

Following gene: 50086500

Centisome position: 96.53

GC content: 43.8

Gene sequence:

>516_bases
ATGCAATGGAGTTATCGCTTCGTAAGTGGTTTATTGGTTCTGGCCAGTATTGTGGGTATGACCTTTGCGTTATATCTAGA
ACATTTTAAAGGTCTGGAGCCTTGTCCATTATGTATCTTCCAGCGTGTCGGACTGATGGCAATGGGCATTGTGGCACTGA
TCGCATTTTTACATAACCCTGTATCGAATGCGTTTAAACGCGTCTATGCGTTTTTGGCGACGCTGGGTATTTTATGGTCT
GTTGGCGTAGCAATACGTCATGTCTGGTTGCAAACCTTACCACCAGATCAAGTACCGAGCTGTGGGCCTGGTTTAAATTA
TTTGCTGGATGCACTACCGCTTAAAACGGTATTACAGCAAGTTTTGCAGGGTTCAGGAGAGTGTGCTGCAATCCATTGGA
CATTTTTGGGGCAGTCATTACCTGTATGGTCGTTGGCTTATTTTAGTCTGATTCTGTTGGTATGTGTGTGGCAGTTGTTA
AGACGTTATCCAGTGATCGTGACCAAGAAAAAATAA

Upstream 100 bases:

>100_bases
GCACAGCAGTCTTTACAACAACAGTATCAACTCGAACAAGAGTCTTCGGTGAGTTTTGAAGATTATCTTGCTCAATTTCG
ATAAAGAATGAGGAATCACC

Downstream 100 bases:

>100_bases
TGGATTGATCAATAAAAAAATCCCGAATGATGCTCAATCATTCGGGATTTTTTTAGTTTGAGAAAATTCGATTTTCATTA
TTCAATGAAAATTATTTTTC

Product: disulfide bond formation protein

Products: glutathione disulfide; Protein dithiol

Alternate protein names: Disulfide oxidoreductase

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MQWSYRFVSGLLVLASIVGMTFALYLEHFKGLEPCPLCIFQRVGLMAMGIVALIAFLHNPVSNAFKRVYAFLATLGILWS
VGVAIRHVWLQTLPPDQVPSCGPGLNYLLDALPLKTVLQQVLQGSGECAAIHWTFLGQSLPVWSLAYFSLILLVCVWQLL
RRYPVIVTKKK

Sequences:

>Translated_171_residues
MQWSYRFVSGLLVLASIVGMTFALYLEHFKGLEPCPLCIFQRVGLMAMGIVALIAFLHNPVSNAFKRVYAFLATLGILWS
VGVAIRHVWLQTLPPDQVPSCGPGLNYLLDALPLKTVLQQVLQGSGECAAIHWTFLGQSLPVWSLAYFSLILLVCVWQLL
RRYPVIVTKKK
>Mature_171_residues
MQWSYRFVSGLLVLASIVGMTFALYLEHFKGLEPCPLCIFQRVGLMAMGIVALIAFLHNPVSNAFKRVYAFLATLGILWS
VGVAIRHVWLQTLPPDQVPSCGPGLNYLLDALPLKTVLQQVLQGSGECAAIHWTFLGQSLPVWSLAYFSLILLVCVWQLL
RRYPVIVTKKK

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein

COG id: COG1495

COG function: function code O; Disulfide bond formation protein DsbB

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DsbB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DSBB_ACIAD (Q6F6X5)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_048012.1
- ProteinModelPortal:   Q6F6X5
- SMR:   Q6F6X5
- STRING:   Q6F6X5
- GeneID:   2879765
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3548
- NMPDR:   fig|62977.3.peg.3205
- eggNOG:   COG1495
- HOGENOM:   HBG637909
- OMA:   WAWARAK
- ProtClustDB:   CLSK707923
- BioCyc:   ASP62977:ACIAD3548-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00286
- InterPro:   IPR003752
- InterPro:   IPR022920

Pfam domain/function: PF02600 DsbB

EC number: 1.8.4.2

Molecular weight: Translated: 19102; Mature: 19102

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1aef8ea4)-; HASH(0x1b4d9b2c)-; HASH(0x1b7880cc)-; HASH(0x1b6e7188)-;

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQWSYRFVSGLLVLASIVGMTFALYLEHFKGLEPCPLCIFQRVGLMAMGIVALIAFLHNP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
VSNAFKRVYAFLATLGILWSVGVAIRHVWLQTLPPDQVPSCGPGLNYLLDALPLKTVLQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VLQGSGECAAIHWTFLGQSLPVWSLAYFSLILLVCVWQLLRRYPVIVTKKK
HHCCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCH
>Mature Secondary Structure
MQWSYRFVSGLLVLASIVGMTFALYLEHFKGLEPCPLCIFQRVGLMAMGIVALIAFLHNP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
VSNAFKRVYAFLATLGILWSVGVAIRHVWLQTLPPDQVPSCGPGLNYLLDALPLKTVLQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VLQGSGECAAIHWTFLGQSLPVWSLAYFSLILLVCVWQLLRRYPVIVTKKK
HHCCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; Protein disulfide

Specific reaction: 2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA