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The map label for this gene is adhA [C]

Identifier: 50086320

GI number: 50086320

Start: 3241694

End: 3242725

Strand: Reverse

Name: adhA [C]

Synonym: ACIAD3339

Alternate gene names: 50086320

Gene position: 3242725-3241694 (Counterclockwise)

Preceding gene: 50086325

Following gene: 50086319

Centisome position: 90.11

GC content: 42.64

Gene sequence:

>1032_bases
ATGGGAAGTTTAATGAAAGCTGCAGTAGTCACTGCTTTTAATCAACCGTTAGAGATCAAGGATGTAGAAATACCGAAAGT
TACTTCAGGCAAAGTATTGGTGAAGATGATTGCAACGGGAGTCTGTCATACCGATTTACACGCTATGCACGGTGATTGGC
CGATCAAACCCAGTCTCCCTTTCATTCCTGGACACGAAGGTGTAGGTGAGGTGGTCGAAATTGGAGAAGGCATTACACAC
TTAAAAATTGGCGATACAGTGGGTGTTCCTTGGTTATATTCGGCATGTGGTCATTGTGACCATTGTTACGCCGGCTGGGA
AACATTATGTAAGCAACAGCAAAACTCTGGTTACTCTGTAAATGGTAGTTTTGCAGAATACTGTCTGGCCGATGGCGAAT
ATGTTGGAGTGATTCCTGAGGGCGTAGATTTACTTGAAATCGCGCCAATTTTATGTGCAGGGGTAACTGTATATAAAGGT
TTAAAAATGACAGAAGCCAAAACTGGTGATTGGGTTGCAATTTCTGGTATTGGTGGCTTAGGTCATGTTGCCGTACAGTA
TGCAAAAACGATGGGCTTTAATGTGGTTGCAATTGATGTAGATGACAGCAAATTGGAACTTGCCAAACAGTTAGGTGCAG
ATGTGGGAATCAATGCACTTAAAGTTGATGTAAAAGAAGAGGTCCTAAAAGCGACAGGTGAAGGTTGTCATGGGGTATTG
GTGACTGCTGTTTCTCCTAAGGCTTTTGAACAGGCAGTATCCGTTGTACGACGTGGTGGAACCATGGTTTTAAACGGCTT
ACCACCAGGTAAATTTGACCTTTCAATTTTTGATATGGTGCTGGATGGAATCACCGTGCGTGGTTCGATTGTAGGAACTC
GGCTGGATCTGAAAGAAGCGTTGGATATTGCAGCGCGTGGAAAAGTAAAAGCACATATTAGCGTAGAACCCCTAGAAAAT
ATCAATGATATTTTTGAGCGAATGGAACAGGGTAAAATTGATGGACGTATTGTGATTGACCTTAAACTCTAA

Upstream 100 bases:

>100_bases
TAACCTACCAAACTCCTACCTTATTGGACTTATCTTATTTTAATTGAGAATCATTCTTACATATGGTTCTTAATTCTTAA
AAATACACGGAGATAATAAA

Downstream 100 bases:

>100_bases
GTTAAATAGTTTAATTAGAACCAGTCTTTAAGGCTGGTTTTATAATTTTTAAGGCGATGAAATAAAATCAGTATTTGTGA
CTATCATCCATCATATAGGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MGSLMKAAVVTAFNQPLEIKDVEIPKVTSGKVLVKMIATGVCHTDLHAMHGDWPIKPSLPFIPGHEGVGEVVEIGEGITH
LKIGDTVGVPWLYSACGHCDHCYAGWETLCKQQQNSGYSVNGSFAEYCLADGEYVGVIPEGVDLLEIAPILCAGVTVYKG
LKMTEAKTGDWVAISGIGGLGHVAVQYAKTMGFNVVAIDVDDSKLELAKQLGADVGINALKVDVKEEVLKATGEGCHGVL
VTAVSPKAFEQAVSVVRRGGTMVLNGLPPGKFDLSIFDMVLDGITVRGSIVGTRLDLKEALDIAARGKVKAHISVEPLEN
INDIFERMEQGKIDGRIVIDLKL

Sequences:

>Translated_343_residues
MGSLMKAAVVTAFNQPLEIKDVEIPKVTSGKVLVKMIATGVCHTDLHAMHGDWPIKPSLPFIPGHEGVGEVVEIGEGITH
LKIGDTVGVPWLYSACGHCDHCYAGWETLCKQQQNSGYSVNGSFAEYCLADGEYVGVIPEGVDLLEIAPILCAGVTVYKG
LKMTEAKTGDWVAISGIGGLGHVAVQYAKTMGFNVVAIDVDDSKLELAKQLGADVGINALKVDVKEEVLKATGEGCHGVL
VTAVSPKAFEQAVSVVRRGGTMVLNGLPPGKFDLSIFDMVLDGITVRGSIVGTRLDLKEALDIAARGKVKAHISVEPLEN
INDIFERMEQGKIDGRIVIDLKL
>Mature_342_residues
GSLMKAAVVTAFNQPLEIKDVEIPKVTSGKVLVKMIATGVCHTDLHAMHGDWPIKPSLPFIPGHEGVGEVVEIGEGITHL
KIGDTVGVPWLYSACGHCDHCYAGWETLCKQQQNSGYSVNGSFAEYCLADGEYVGVIPEGVDLLEIAPILCAGVTVYKGL
KMTEAKTGDWVAISGIGGLGHVAVQYAKTMGFNVVAIDVDDSKLELAKQLGADVGINALKVDVKEEVLKATGEGCHGVLV
TAVSPKAFEQAVSVVRRGGTMVLNGLPPGKFDLSIFDMVLDGITVRGSIVGTRLDLKEALDIAARGKVKAHISVEPLENI
NDIFERMEQGKIDGRIVIDLKL

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=363, Percent_Identity=30.5785123966942, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI4501933, Length=363, Percent_Identity=29.7520661157025, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI4501929, Length=363, Percent_Identity=29.7520661157025, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI71743840, Length=359, Percent_Identity=27.2980501392758, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI71565154, Length=237, Percent_Identity=31.6455696202532, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI262073058, Length=359, Percent_Identity=27.2980501392758, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=26.3440860215054, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=26.0387811634349, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI156523966, Length=361, Percent_Identity=26.0387811634349, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI22538446, Length=356, Percent_Identity=26.685393258427, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI22538444, Length=356, Percent_Identity=26.685393258427, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI194239674, Length=268, Percent_Identity=24.6268656716418, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI13236495, Length=268, Percent_Identity=24.6268656716418, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI87081918, Length=340, Percent_Identity=48.2352941176471, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1786518, Length=351, Percent_Identity=32.7635327635328, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI87082401, Length=339, Percent_Identity=28.9085545722714, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1790045, Length=289, Percent_Identity=30.7958477508651, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87082125, Length=209, Percent_Identity=31.1004784688995, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786552, Length=364, Percent_Identity=32.6923076923077, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788073, Length=272, Percent_Identity=30.8823529411765, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1787863, Length=315, Percent_Identity=29.2063492063492, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788075, Length=306, Percent_Identity=27.1241830065359, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI226510992, Length=322, Percent_Identity=27.9503105590062, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788407, Length=323, Percent_Identity=28.1733746130031, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790718, Length=286, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786825, Length=371, Percent_Identity=25.0673854447439, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=348, Percent_Identity=40.2298850574713, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17562584, Length=344, Percent_Identity=37.5, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=35.2941176470588, Blast_Score=220, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17562876, Length=332, Percent_Identity=29.5180722891566, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=246, Percent_Identity=32.520325203252, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=344, Percent_Identity=27.3255813953488, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71997431, Length=248, Percent_Identity=32.258064516129, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=219, Percent_Identity=30.5936073059361, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17536829, Length=306, Percent_Identity=24.8366013071895, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=339, Percent_Identity=46.9026548672566, Blast_Score=295, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=47.7064220183486, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=44.3425076452599, Blast_Score=276, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6319621, Length=339, Percent_Identity=42.1828908554572, Blast_Score=273, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6319949, Length=339, Percent_Identity=30.0884955752212, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323980, Length=317, Percent_Identity=29.0220820189274, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=27.3224043715847, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=299, Percent_Identity=29.4314381270903, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=299, Percent_Identity=29.4314381270903, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=330, Percent_Identity=24.8484848484848, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=351, Percent_Identity=24.7863247863248, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=26.6483516483516, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=26.5060240963855, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137530, Length=209, Percent_Identity=30.622009569378, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36471; Mature: 36340

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSLMKAAVVTAFNQPLEIKDVEIPKVTSGKVLVKMIATGVCHTDLHAMHGDWPIKPSLP
CCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
FIPGHEGVGEVVEIGEGITHLKIGDTVGVPWLYSACGHCDHCYAGWETLCKQQQNSGYSV
CCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
NGSFAEYCLADGEYVGVIPEGVDLLEIAPILCAGVTVYKGLKMTEAKTGDWVAISGIGGL
CCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCH
GHVAVQYAKTMGFNVVAIDVDDSKLELAKQLGADVGINALKVDVKEEVLKATGEGCHGVL
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCEEEECHHHHHHHHCCCCCCEEE
VTAVSPKAFEQAVSVVRRGGTMVLNGLPPGKFDLSIFDMVLDGITVRGSIVGTRLDLKEA
EEEECHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCEEEECEEEEEEECHHHH
LDIAARGKVKAHISVEPLENINDIFERMEQGKIDGRIVIDLKL
HHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEEEC
>Mature Secondary Structure 
GSLMKAAVVTAFNQPLEIKDVEIPKVTSGKVLVKMIATGVCHTDLHAMHGDWPIKPSLP
CCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
FIPGHEGVGEVVEIGEGITHLKIGDTVGVPWLYSACGHCDHCYAGWETLCKQQQNSGYSV
CCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
NGSFAEYCLADGEYVGVIPEGVDLLEIAPILCAGVTVYKGLKMTEAKTGDWVAISGIGGL
CCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEECCCCH
GHVAVQYAKTMGFNVVAIDVDDSKLELAKQLGADVGINALKVDVKEEVLKATGEGCHGVL
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCEEEECHHHHHHHHCCCCCCEEE
VTAVSPKAFEQAVSVVRRGGTMVLNGLPPGKFDLSIFDMVLDGITVRGSIVGTRLDLKEA
EEEECHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCEEEECEEEEEEECHHHH
LDIAARGKVKAHISVEPLENINDIFERMEQGKIDGRIVIDLKL
HHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]