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The map label for this gene is hemH

Identifier: 50086247

GI number: 50086247

Start: 3167492

End: 3168514

Strand: Reverse

Name: hemH

Synonym: ACIAD3255

Alternate gene names: 50086247

Gene position: 3168514-3167492 (Counterclockwise)

Preceding gene: 50086248

Following gene: 50086246

Centisome position: 88.05

GC content: 42.72

Gene sequence:

>1023_bases
ATGCCGATTTTCCCTAAACCGAAAGTTACGGTGATTTTGGCAAATTTGGGAACACCTGATGTACCCACTGCATCTGCAGT
GAGAGCATTTCTAAAACAGTTTCTTTCCGATCAGCGTGTGATTGAAATTCCGAAATTACTTTGGAAAATTATTCTATATA
GTTTTGTGCTGCCTTTTCGCCCTAAGCGTGTTGCACATGCATATGCAAGTGTATGGGGGCAAGATTCACCAATGCGTGAG
ATTCTGTTTGCGCAAACCGATGCTTTAAAGCGACAGTTAATTTCGCATTACCCACAGCTTGATCTCAATATTGTTCCAGC
CATGACTTATGGAAATCCAGGGGTTCAGCATATTTTGAAAGATCTGGCTGCATCACCGCAGGAACATGTGATTCTATTGC
CATTATTTCCTCAATATTCTGCTACATCTACCGCACCGCTTTATGATGCATTTGCCAACTGGATACCCAAGCAAAGACAT
TTACCGGGCTTGACTATTATTAAGGATTATTATCGCCATCCTGTGTTTATTCAGGCGCTGGTCAGTAGTGTGCAGCGATT
TCAGCAACAACATGGCAAGCCTCAAAAATTACTCATGTCATTTCACGGGATTCCTCAGCCTTATGCTGATAAGGGTGATC
CTTATGCAGATCGTTGTCGTGAAACTGCTCGATTGGTCGCAAAACAACTTGGACTTACACCTGATGATTGGGCGATCAGT
TTTCAATCCAGATTTGGTAAACAAGAATGGGTCAAACCTTATACAGATGAATTGTTGACAACATGGGCAGCCAATGGAAT
TAAATCGGTACAGATCTTGAGTCCAGCATTTTCGGCAGATTGCCTGGAAACCTTGGAAGAGCTCGAAATTCAAAATGCCG
AATTGTTTCTTGAGGCGGGTGGTACAAGTTACCAGTATATTCCAGCATTGAATACTTCCGTTGAGCATCTGGAGCTATTG
CGTCAATTGTTACAGGCACATCTGGATGCACTCAATTACAGTCTGGCCTATTCGGCACATTAA

Upstream 100 bases:

>100_bases
CGAAATTTTCAATTAAATTCTAATTCATATTCCAATTTATAAATCTGACTGAAACCTGTTACAGTTCATGCAATGATAGA
TTTTTGCAATAGGACACGAT

Downstream 100 bases:

>100_bases
TTTAAGGAGAATTTGATGTTGCAAGTAAAAATTGTTCCTGTAACAGCATTTGCCCAAAACTGTTCGATTTTGTGGGACAG
TGAATCAAAAGAAGCCGTAT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MPIFPKPKVTVILANLGTPDVPTASAVRAFLKQFLSDQRVIEIPKLLWKIILYSFVLPFRPKRVAHAYASVWGQDSPMRE
ILFAQTDALKRQLISHYPQLDLNIVPAMTYGNPGVQHILKDLAASPQEHVILLPLFPQYSATSTAPLYDAFANWIPKQRH
LPGLTIIKDYYRHPVFIQALVSSVQRFQQQHGKPQKLLMSFHGIPQPYADKGDPYADRCRETARLVAKQLGLTPDDWAIS
FQSRFGKQEWVKPYTDELLTTWAANGIKSVQILSPAFSADCLETLEELEIQNAELFLEAGGTSYQYIPALNTSVEHLELL
RQLLQAHLDALNYSLAYSAH

Sequences:

>Translated_340_residues
MPIFPKPKVTVILANLGTPDVPTASAVRAFLKQFLSDQRVIEIPKLLWKIILYSFVLPFRPKRVAHAYASVWGQDSPMRE
ILFAQTDALKRQLISHYPQLDLNIVPAMTYGNPGVQHILKDLAASPQEHVILLPLFPQYSATSTAPLYDAFANWIPKQRH
LPGLTIIKDYYRHPVFIQALVSSVQRFQQQHGKPQKLLMSFHGIPQPYADKGDPYADRCRETARLVAKQLGLTPDDWAIS
FQSRFGKQEWVKPYTDELLTTWAANGIKSVQILSPAFSADCLETLEELEIQNAELFLEAGGTSYQYIPALNTSVEHLELL
RQLLQAHLDALNYSLAYSAH
>Mature_339_residues
PIFPKPKVTVILANLGTPDVPTASAVRAFLKQFLSDQRVIEIPKLLWKIILYSFVLPFRPKRVAHAYASVWGQDSPMREI
LFAQTDALKRQLISHYPQLDLNIVPAMTYGNPGVQHILKDLAASPQEHVILLPLFPQYSATSTAPLYDAFANWIPKQRHL
PGLTIIKDYYRHPVFIQALVSSVQRFQQQHGKPQKLLMSFHGIPQPYADKGDPYADRCRETARLVAKQLGLTPDDWAISF
QSRFGKQEWVKPYTDELLTTWAANGIKSVQILSPAFSADCLETLEELEIQNAELFLEAGGTSYQYIPALNTSVEHLELLR
QLLQAHLDALNYSLAYSAH

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=337, Percent_Identity=22.8486646884273, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI60499021, Length=337, Percent_Identity=22.8486646884273, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1786681, Length=321, Percent_Identity=43.613707165109, Blast_Score=294, Evalue=6e-81,
Organism=Drosophila melanogaster, GI17864156, Length=339, Percent_Identity=23.8938053097345, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24651774, Length=263, Percent_Identity=23.574144486692, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_ACIAD (Q6F7N0)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047757.1
- ProteinModelPortal:   Q6F7N0
- STRING:   Q6F7N0
- GeneID:   2879992
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3255
- NMPDR:   fig|62977.3.peg.2950
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- PhylomeDB:   Q6F7N0
- ProtClustDB:   CLSK2307544
- BioCyc:   ASP62977:ACIAD3255-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 38457; Mature: 38326

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIFPKPKVTVILANLGTPDVPTASAVRAFLKQFLSDQRVIEIPKLLWKIILYSFVLPFR
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
PKRVAHAYASVWGQDSPMREILFAQTDALKRQLISHYPQLDLNIVPAMTYGNPGVQHILK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
DLAASPQEHVILLPLFPQYSATSTAPLYDAFANWIPKQRHLPGLTIIKDYYRHPVFIQAL
HHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHH
VSSVQRFQQQHGKPQKLLMSFHGIPQPYADKGDPYADRCRETARLVAKQLGLTPDDWAIS
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHEEH
FQSRFGKQEWVKPYTDELLTTWAANGIKSVQILSPAFSADCLETLEELEIQNAELFLEAG
HHHHCCHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEC
GTSYQYIPALNTSVEHLELLRQLLQAHLDALNYSLAYSAH
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
PIFPKPKVTVILANLGTPDVPTASAVRAFLKQFLSDQRVIEIPKLLWKIILYSFVLPFR
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
PKRVAHAYASVWGQDSPMREILFAQTDALKRQLISHYPQLDLNIVPAMTYGNPGVQHILK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
DLAASPQEHVILLPLFPQYSATSTAPLYDAFANWIPKQRHLPGLTIIKDYYRHPVFIQAL
HHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHH
VSSVQRFQQQHGKPQKLLMSFHGIPQPYADKGDPYADRCRETARLVAKQLGLTPDDWAIS
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHEEH
FQSRFGKQEWVKPYTDELLTTWAANGIKSVQILSPAFSADCLETLEELEIQNAELFLEAG
HHHHCCHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEC
GTSYQYIPALNTSVEHLELLRQLLQAHLDALNYSLAYSAH
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA