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The map label for this gene is dxs

Identifier: 50086242

GI number: 50086242

Start: 3162500

End: 3164422

Strand: Reverse

Name: dxs

Synonym: ACIAD3247

Alternate gene names: 50086242

Gene position: 3164422-3162500 (Counterclockwise)

Preceding gene: 50086246

Following gene: 50086241

Centisome position: 87.93

GC content: 45.92

Gene sequence:

>1923_bases
TTGCCACATATGTTGTATACCGAAATTCCAACTCACCGTCCTGTTACGCCATTGTTAGATGAGATCGATCATCCTCAACA
ATTACGTCAGCTCGAACAAAGCCAACTCACACAAGTGGCCGATGAGTTGCGTCAGTTTATTTTATATGCGGCAGGTCAAA
GTGGGGGGCACTTTGGTGCCAATCTGGGCGTGATTGAACTCACTGTTGCATTGCATTACTGCTTTAATACGCCACATGAT
CGTTTGATCTGGGACGTGGGTCATCAGGCTTATCCGCATAAGGTGCTTACAGGCCGTCGTGAACAGTTAATGACGATTCG
TGCTCAACATGGCCTAGCTGCTTTTCCCGCACGTGAAGAGTCGGTGTTTGATACCTTTGGGGTGGGGCATTCCTCGACTG
CAATTTCAGCGGGTTTAGGTATGTCTTTGGCTCGTCGCTATCAGCAAAATCCATGCGAAGTCGTGTGCATTGTCGGTGAT
GGTGCCATGACAGCAGGTATGGCATTTGAAGCCATGAATGATGCCGTTGCCCATGATGCCGATCTTATGGTGGTGCTGAA
TGACAATGATATGTCTATTTCATGTAGTACAGGTGGTTTTGCTAGGCATCTTGCTGCCATATGGGAAAAAGGTCAGTTAG
TCAATATTGATGAACATGGCGAAGCCTATGTTCAGCCTCATCCAAAGTGGACCTATAACTCTCGCTTACATCAATCTGCA
ACCGATGCGGCAGATAACCTGTTTAAAGCGATTGGGTTTGATTATTTCGGTCCGTTCGATGGTCATGATGTTGAACATCT
GGTGCATGTATTCAATGCGCTCAAAAAACGTCAGGGCCCACGTTTAATCCATATTTATACCAAAAAAGGCAAGGGCTTCG
AACCTGCCGAAGCAGACCCAATTACGTATCATGCAATCACCAAAATTACGCCTGTATCAATTGCACCCGTAAAAAAATCA
CCACCAAAATATTCAGATGTTTTTGGTCAGTGGTTGTGTGATGAAGCTGCGCAAGATGATCGTCTTTTGGCTATCACGCC
AGCAATGTGTGAAGGTTCTGGCATGGTCAAATTTGCCAAGCAGTATCCTGAGCGTTTTTTTGATGTTGCAATTGCTGAGC
AACATGCAGTTACTTTGGCCGCAGGAATGGCCTGTGAAGGGTTAAAGCCTGTCGTTGCAATTTACTCGACCTTTTTACAG
CGTGGTTATGATCAGTTGATTCATGATGTTGCCTTGCAAAATCTGGATGTAACATTTGGCATTGATCGTGCTGGACTGGT
CGGTGAGGATGGCCCAACACATGCGGGCGCTTATGATTATGCTTATATGCGGACCATTCCAAATCTGGTAATTATGGCGC
CTAAAGACGAAAATGAATGTCGTCAGATGCTACATACGGCGTATGACTTTAACGGTCCAGCAGCCGTACGATATCCTCGT
GGCGCAGGCTTGGGTGTGGAGATCCAGCAGGAGCTGACCAAGCTTGAAATTGGTAAAGCCGAGATGGTCTTACAATGTCA
TCCAGAGCATGATGAACACATTACAATTTTAGCTTTTGGTAGCCGTGTATCAGTTGCTATGGAGGCTGCACAGCAGTTGG
CGCAGCTTCATGATATTGGAATTACAGTCGTCAATATGCGCTTTGTGAAGCCGCTAGACGAACAAATCATTCGTGATCTT
GCGGAGCGGACCCAGCTTTTTGTGACTATAGAAGAACATGCAGTAATGGCAGGTGCAGGTAGCGCGGTCAATGAATATCT
GGCCAAAGCACAAATTATGAAACCAACGCTTAATCTTGGCTTGCCCGATACCTTTATGGCACAAGCTACGCATACGCAAA
TGCTCAAGAATTGTGGTCTTGACGCAGAAGGTATTCAAGCTTCGATAGAAAAGGTTTGGTTAAGGATTGTTCAGGCTGTT
TAG

Upstream 100 bases:

>100_bases
CTGCATCGTTAGAAATGTGGCTGATTGAAGGTGATTTTATTCGATTTGAAGATCGGATTCCCATTTACCCAGCTTAGGAT
TTGCCAGGCTTAAGAAGGCT

Downstream 100 bases:

>100_bases
TTGGCTGCTTTAAAAAAACGAATATTTTTTACCAAAAGGCGCGTTGATTTGATAGAATTAGCGCGCTTTTATGCATTATT
CTTTGTCAAAATCTTCAAAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MPHMLYTEIPTHRPVTPLLDEIDHPQQLRQLEQSQLTQVADELRQFILYAAGQSGGHFGANLGVIELTVALHYCFNTPHD
RLIWDVGHQAYPHKVLTGRREQLMTIRAQHGLAAFPAREESVFDTFGVGHSSTAISAGLGMSLARRYQQNPCEVVCIVGD
GAMTAGMAFEAMNDAVAHDADLMVVLNDNDMSISCSTGGFARHLAAIWEKGQLVNIDEHGEAYVQPHPKWTYNSRLHQSA
TDAADNLFKAIGFDYFGPFDGHDVEHLVHVFNALKKRQGPRLIHIYTKKGKGFEPAEADPITYHAITKITPVSIAPVKKS
PPKYSDVFGQWLCDEAAQDDRLLAITPAMCEGSGMVKFAKQYPERFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQ
RGYDQLIHDVALQNLDVTFGIDRAGLVGEDGPTHAGAYDYAYMRTIPNLVIMAPKDENECRQMLHTAYDFNGPAAVRYPR
GAGLGVEIQQELTKLEIGKAEMVLQCHPEHDEHITILAFGSRVSVAMEAAQQLAQLHDIGITVVNMRFVKPLDEQIIRDL
AERTQLFVTIEEHAVMAGAGSAVNEYLAKAQIMKPTLNLGLPDTFMAQATHTQMLKNCGLDAEGIQASIEKVWLRIVQAV

Sequences:

>Translated_640_residues
MPHMLYTEIPTHRPVTPLLDEIDHPQQLRQLEQSQLTQVADELRQFILYAAGQSGGHFGANLGVIELTVALHYCFNTPHD
RLIWDVGHQAYPHKVLTGRREQLMTIRAQHGLAAFPAREESVFDTFGVGHSSTAISAGLGMSLARRYQQNPCEVVCIVGD
GAMTAGMAFEAMNDAVAHDADLMVVLNDNDMSISCSTGGFARHLAAIWEKGQLVNIDEHGEAYVQPHPKWTYNSRLHQSA
TDAADNLFKAIGFDYFGPFDGHDVEHLVHVFNALKKRQGPRLIHIYTKKGKGFEPAEADPITYHAITKITPVSIAPVKKS
PPKYSDVFGQWLCDEAAQDDRLLAITPAMCEGSGMVKFAKQYPERFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQ
RGYDQLIHDVALQNLDVTFGIDRAGLVGEDGPTHAGAYDYAYMRTIPNLVIMAPKDENECRQMLHTAYDFNGPAAVRYPR
GAGLGVEIQQELTKLEIGKAEMVLQCHPEHDEHITILAFGSRVSVAMEAAQQLAQLHDIGITVVNMRFVKPLDEQIIRDL
AERTQLFVTIEEHAVMAGAGSAVNEYLAKAQIMKPTLNLGLPDTFMAQATHTQMLKNCGLDAEGIQASIEKVWLRIVQAV
>Mature_639_residues
PHMLYTEIPTHRPVTPLLDEIDHPQQLRQLEQSQLTQVADELRQFILYAAGQSGGHFGANLGVIELTVALHYCFNTPHDR
LIWDVGHQAYPHKVLTGRREQLMTIRAQHGLAAFPAREESVFDTFGVGHSSTAISAGLGMSLARRYQQNPCEVVCIVGDG
AMTAGMAFEAMNDAVAHDADLMVVLNDNDMSISCSTGGFARHLAAIWEKGQLVNIDEHGEAYVQPHPKWTYNSRLHQSAT
DAADNLFKAIGFDYFGPFDGHDVEHLVHVFNALKKRQGPRLIHIYTKKGKGFEPAEADPITYHAITKITPVSIAPVKKSP
PKYSDVFGQWLCDEAAQDDRLLAITPAMCEGSGMVKFAKQYPERFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQR
GYDQLIHDVALQNLDVTFGIDRAGLVGEDGPTHAGAYDYAYMRTIPNLVIMAPKDENECRQMLHTAYDFNGPAAVRYPRG
AGLGVEIQQELTKLEIGKAEMVLQCHPEHDEHITILAFGSRVSVAMEAAQQLAQLHDIGITVVNMRFVKPLDEQIIRDLA
ERTQLFVTIEEHAVMAGAGSAVNEYLAKAQIMKPTLNLGLPDTFMAQATHTQMLKNCGLDAEGIQASIEKVWLRIVQAV

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=557, Percent_Identity=24.4165170556553, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI4507521, Length=557, Percent_Identity=24.4165170556553, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI225637463, Length=505, Percent_Identity=25.7425742574257, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI225637459, Length=505, Percent_Identity=25.7425742574257, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI225637461, Length=505, Percent_Identity=25.7425742574257, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI133778974, Length=554, Percent_Identity=24.5487364620939, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1786622, Length=624, Percent_Identity=51.2820512820513, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=531, Percent_Identity=24.105461393597, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17538422, Length=330, Percent_Identity=24.2424242424242, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319698, Length=279, Percent_Identity=24.7311827956989, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45551847, Length=512, Percent_Identity=25, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550715, Length=512, Percent_Identity=25, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24645119, Length=512, Percent_Identity=25, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24666278, Length=615, Percent_Identity=24.390243902439, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_ACIAD (Q6F7N5)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047752.1
- ProteinModelPortal:   Q6F7N5
- SMR:   Q6F7N5
- STRING:   Q6F7N5
- GeneID:   2879773
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3247
- NMPDR:   fig|62977.3.peg.2945
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q6F7N5
- ProtClustDB:   PRK05444
- BioCyc:   ASP62977:ACIAD3247-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70609; Mature: 70478

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHMLYTEIPTHRPVTPLLDEIDHPQQLRQLEQSQLTQVADELRQFILYAAGQSGGHFGA
CCCCEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLGVIELTVALHYCFNTPHDRLIWDVGHQAYPHKVLTGRREQLMTIRAQHGLAAFPAREE
CCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCEECCCCCH
SVFDTFGVGHSSTAISAGLGMSLARRYQQNPCEVVCIVGDGAMTAGMAFEAMNDAVAHDA
HHHHHHCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
DLMVVLNDNDMSISCSTGGFARHLAAIWEKGQLVNIDEHGEAYVQPHPKWTYNSRLHQSA
CEEEEECCCCCEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCCCCHHHHHH
TDAADNLFKAIGFDYFGPFDGHDVEHLVHVFNALKKRQGPRLIHIYTKKGKGFEPAEADP
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
ITYHAITKITPVSIAPVKKSPPKYSDVFGQWLCDEAAQDDRLLAITPAMCEGSGMVKFAK
EEEEEEHEECCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
QYPERFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLDVTFG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
IDRAGLVGEDGPTHAGAYDYAYMRTIPNLVIMAPKDENECRQMLHTAYDFNGPAAVRYPR
CCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEECCC
GAGLGVEIQQELTKLEIGKAEMVLQCHPEHDEHITILAFGSRVSVAMEAAQQLAQLHDIG
CCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCC
ITVVNMRFVKPLDEQIIRDLAERTQLFVTIEEHAVMAGAGSAVNEYLAKAQIMKPTLNLG
EEEEEEEHHCCHHHHHHHHHHHHHEEEEEEECCEEEECCCHHHHHHHHHHHHHCCHHCCC
LPDTFMAQATHTQMLKNCGLDAEGIQASIEKVWLRIVQAV
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PHMLYTEIPTHRPVTPLLDEIDHPQQLRQLEQSQLTQVADELRQFILYAAGQSGGHFGA
CCCEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLGVIELTVALHYCFNTPHDRLIWDVGHQAYPHKVLTGRREQLMTIRAQHGLAAFPAREE
CCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCEECCCCCH
SVFDTFGVGHSSTAISAGLGMSLARRYQQNPCEVVCIVGDGAMTAGMAFEAMNDAVAHDA
HHHHHHCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
DLMVVLNDNDMSISCSTGGFARHLAAIWEKGQLVNIDEHGEAYVQPHPKWTYNSRLHQSA
CEEEEECCCCCEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCCCCHHHHHH
TDAADNLFKAIGFDYFGPFDGHDVEHLVHVFNALKKRQGPRLIHIYTKKGKGFEPAEADP
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
ITYHAITKITPVSIAPVKKSPPKYSDVFGQWLCDEAAQDDRLLAITPAMCEGSGMVKFAK
EEEEEEHEECCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
QYPERFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLDVTFG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
IDRAGLVGEDGPTHAGAYDYAYMRTIPNLVIMAPKDENECRQMLHTAYDFNGPAAVRYPR
CCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEECCC
GAGLGVEIQQELTKLEIGKAEMVLQCHPEHDEHITILAFGSRVSVAMEAAQQLAQLHDIG
CCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCC
ITVVNMRFVKPLDEQIIRDLAERTQLFVTIEEHAVMAGAGSAVNEYLAKAQIMKPTLNLG
EEEEEEEHHCCHHHHHHHHHHHHHEEEEEEECCEEEECCCHHHHHHHHHHHHHCCHHCCC
LPDTFMAQATHTQMLKNCGLDAEGIQASIEKVWLRIVQAV
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA