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The map label for this gene is tesB [H]

Identifier: 50086226

GI number: 50086226

Start: 3145034

End: 3145906

Strand: Reverse

Name: tesB [H]

Synonym: ACIAD3231

Alternate gene names: 50086226

Gene position: 3145906-3145034 (Counterclockwise)

Preceding gene: 50086228

Following gene: 50086225

Centisome position: 87.42

GC content: 43.64

Gene sequence:

>873_bases
ATGAATACACTAACCCAAGAACTGGTTGAACTTTTATCTCTAGAAAAGCTGGAAGAGAACCTCTATCGCGGGATGAGCCG
AAATCTGGTGGGGAAGCGCGTATTCGGTGGTCAGGTTCTTGGACAAGCATTAAGAGCTGCGTCATATACGACAGATCGTC
CTGCACATTCATTACATGCTTACTTTCTCTATGGTGGCGATGTTAACGCCCCTATTATTTATGAAGTAGATCCTTTACGT
GATGGTAAAAGTTTTGTGAGTCGTCAGGTTCGCGCTATTCAGCATGGACGTACTATTTTTTCTGCGATGGTTTCTTTTGC
ATCACCAGAAGAAGGGCTTAACTATCAAAATGATATGCCTGATTATCCTGCACCTGAGCAGCTTAAATCTGAAGCGGAGT
TAAAACTGGGGCTGATTGATTTTGTACCTGAAAATGTACGTGCCAGTTTTATGCGTGAACGCCACATAGAGATTCGTCCA
GTTGAGCCAGTTAATCCCTTTCAGCCTCAACCTCAAGCACCGACTAACGCCCACTATATCCGTACCCATGACAAGATCGG
AAAAGCGTTTGACCAGATTGCGCTACACCAGTCTATTGTTGCTTTTTATTCAGACTTTACTTTAATGACAACAGCACTTA
AACCGCATGGTTTAAGCTATCTTTCACCGAGTTTGCAGTGTGCCAGTATAGATCACACCATTTATTTTCATCGTCCGTTA
CGTGCAGATGAATGGATGCTCTACGACATGGATGCCACGGTCAGTGCTGGCTCAAGAGGTTTGAACTTTGGGCGAATGTG
GCAAAATGGATTATTGGTTTGTAGCACCGTACAAGAAGGTTTAATGCGCCTTCGTGAAATTGAAACACAGTAA

Upstream 100 bases:

>100_bases
TTCAGGATATGAAATTCTGAATTTATGGCAAAATAGTTCAAAGATCGCAACTCATTCGATATCGCGCTCATTTTTAATTT
TGACATAGAAAAGGCATTCC

Downstream 100 bases:

>100_bases
TTTCAGCTTATAAATAAAACTCGATTCTTGATCTGGGTCATGTCATATTGCACTTAATCAAATAAAAGAATCGACTTAAA
TATGAGCTTAAATACGCAAA

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MNTLTQELVELLSLEKLEENLYRGMSRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHAYFLYGGDVNAPIIYEVDPLR
DGKSFVSRQVRAIQHGRTIFSAMVSFASPEEGLNYQNDMPDYPAPEQLKSEAELKLGLIDFVPENVRASFMRERHIEIRP
VEPVNPFQPQPQAPTNAHYIRTHDKIGKAFDQIALHQSIVAFYSDFTLMTTALKPHGLSYLSPSLQCASIDHTIYFHRPL
RADEWMLYDMDATVSAGSRGLNFGRMWQNGLLVCSTVQEGLMRLREIETQ

Sequences:

>Translated_290_residues
MNTLTQELVELLSLEKLEENLYRGMSRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHAYFLYGGDVNAPIIYEVDPLR
DGKSFVSRQVRAIQHGRTIFSAMVSFASPEEGLNYQNDMPDYPAPEQLKSEAELKLGLIDFVPENVRASFMRERHIEIRP
VEPVNPFQPQPQAPTNAHYIRTHDKIGKAFDQIALHQSIVAFYSDFTLMTTALKPHGLSYLSPSLQCASIDHTIYFHRPL
RADEWMLYDMDATVSAGSRGLNFGRMWQNGLLVCSTVQEGLMRLREIETQ
>Mature_290_residues
MNTLTQELVELLSLEKLEENLYRGMSRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHAYFLYGGDVNAPIIYEVDPLR
DGKSFVSRQVRAIQHGRTIFSAMVSFASPEEGLNYQNDMPDYPAPEQLKSEAELKLGLIDFVPENVRASFMRERHIEIRP
VEPVNPFQPQPQAPTNAHYIRTHDKIGKAFDQIALHQSIVAFYSDFTLMTTALKPHGLSYLSPSLQCASIDHTIYFHRPL
RADEWMLYDMDATVSAGSRGLNFGRMWQNGLLVCSTVQEGLMRLREIETQ

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=288, Percent_Identity=37.1527777777778, Blast_Score=187, Evalue=8e-48,
Organism=Escherichia coli, GI1786657, Length=272, Percent_Identity=44.1176470588235, Blast_Score=241, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI71988741, Length=304, Percent_Identity=35.8552631578947, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17558508, Length=307, Percent_Identity=36.4820846905537, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17531889, Length=287, Percent_Identity=30.6620209059233, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI115532456, Length=287, Percent_Identity=29.9651567944251, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17531885, Length=287, Percent_Identity=30.6620209059233, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI212645202, Length=290, Percent_Identity=31.3793103448276, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71982224, Length=309, Percent_Identity=28.8025889967638, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322480, Length=304, Percent_Identity=26.6447368421053, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32847; Mature: 32847

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLTQELVELLSLEKLEENLYRGMSRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
YFLYGGDVNAPIIYEVDPLRDGKSFVSRQVRAIQHGRTIFSAMVSFASPEEGLNYQNDMP
EEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCC
DYPAPEQLKSEAELKLGLIDFVPENVRASFMRERHIEIRPVEPVNPFQPQPQAPTNAHYI
CCCCHHHHHCHHHHEEEHHHHCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEE
RTHDKIGKAFDQIALHQSIVAFYSDFTLMTTALKPHGLSYLSPSLQCASIDHTIYFHRPL
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEECCCEEEEECCC
RADEWMLYDMDATVSAGSRGLNFGRMWQNGLLVCSTVQEGLMRLREIETQ
CCCCEEEEECCCCCCCCCCCCCHHHHHHCCEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTLTQELVELLSLEKLEENLYRGMSRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
YFLYGGDVNAPIIYEVDPLRDGKSFVSRQVRAIQHGRTIFSAMVSFASPEEGLNYQNDMP
EEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCC
DYPAPEQLKSEAELKLGLIDFVPENVRASFMRERHIEIRPVEPVNPFQPQPQAPTNAHYI
CCCCHHHHHCHHHHEEEHHHHCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEE
RTHDKIGKAFDQIALHQSIVAFYSDFTLMTTALKPHGLSYLSPSLQCASIDHTIYFHRPL
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEECCCEEEEECCC
RADEWMLYDMDATVSAGSRGLNFGRMWQNGLLVCSTVQEGLMRLREIETQ
CCCCEEEEECCCCCCCCCCCCCHHHHHHCCEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]