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The map label for this gene is ilvC

Identifier: 50086106

GI number: 50086106

Start: 3024495

End: 3025511

Strand: Reverse

Name: ilvC

Synonym: ACIAD3102

Alternate gene names: 50086106

Gene position: 3025511-3024495 (Counterclockwise)

Preceding gene: 50086107

Following gene: 50086105

Centisome position: 84.07

GC content: 43.07

Gene sequence:

>1017_bases
ATGCAAATTTTTTACGATAAAGATTGTGACTTATCAATCATCCAAGGCAAAAAAGTAGCAATTATTGGTTACGGTTCACA
AGGTCACGCGCATGCGCTTAACCTGAAAGATTCTGGTGTTGATGTAACTGTAGGTTTACGTGCAAATTCAGCATCTTGGA
AAAAAGCTGAAAATGCGGGCCTTAAAGTTGCTGAAGTACCTGAAGCTGTGAAACAAGCTGACTTGGTCATGATTTTGACT
CCAGATGAGTTTCAGTCACAACTTTACCGTGATGTAATTGAGCCAAACATCAAAGAAGGTGCAACCTTAGCATTTGCACA
CGGTTTCTCGGTTCTTTATAACCAAGTTGTTCCACGTCAAGATCTTGACGTGATTATGGTTGCACCAAAAGCACCAGGTC
ATACGGTTCGTTCTGAATTCCAACGTGGTTCAGGTGTACCTGATCTGATTGCAATTCATCAAGATGCTTCAGGTAATGCA
CGTAATGTTGCATTGTCTTACGCGTCAGGTGTTGGTGGTGGCCGTACTGGTATCATCGAGACTTCATTCCGTGAAGAAAC
TGAAACTGACTTGTTCGGTGAGCAAGCAGTACTCTGTGGTGGTGCGGTTGAATTGGTTAAAATGGGCTTCGAAACTTTGG
TTGAAGCGGGTTATTCACCAGAAATGGCATACTTCGAATGCTTGCACGAGCTTAAGTTGATTGTTGACTTGATGTTCGAA
GGCGGTATTGCGGACATGAACTACTCTGTATCAAACAATGCTGAGTATGGCGAATATGTGACTGGTGTTGAAGTCATCAA
TGAACAGTCTCGTGAAGCGATGCGTAATGCACTTAAACGTATTCAATCTGGCGAATACGCGAAAATGTTCATTCAGGAAG
GTGCGCTGAACTATCCGTCAATGACTGCGCGTCGTCGTCAAAATGCAGCACACGGTATTGAAGTAACAGGTTCGAAATTG
CGTGCGATGATGCCTTGGATTCAAGCCAACAAAATCGTGGACAAAGAAAAGAACTAA

Upstream 100 bases:

>100_bases
CCATTTTAGAAGTGGTTCGCTCAGGTGTATCGGGTATCGCGCGCGGCGAAAAAGTATTAAGTATTTAAACCAAATTAACG
TATTTTAGCGGAGAAAACAG

Downstream 100 bases:

>100_bases
GTTTTTTCTTTAGTGAAAATCCTGTCATTTGGCAGGATTTTTTTTATCACTTTGATTTAATTATGTGATTTATTTCATGA
AATATGCAAAATATCGTGTT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MQIFYDKDCDLSIIQGKKVAIIGYGSQGHAHALNLKDSGVDVTVGLRANSASWKKAENAGLKVAEVPEAVKQADLVMILT
PDEFQSQLYRDVIEPNIKEGATLAFAHGFSVLYNQVVPRQDLDVIMVAPKAPGHTVRSEFQRGSGVPDLIAIHQDASGNA
RNVALSYASGVGGGRTGIIETSFREETETDLFGEQAVLCGGAVELVKMGFETLVEAGYSPEMAYFECLHELKLIVDLMFE
GGIADMNYSVSNNAEYGEYVTGVEVINEQSREAMRNALKRIQSGEYAKMFIQEGALNYPSMTARRRQNAAHGIEVTGSKL
RAMMPWIQANKIVDKEKN

Sequences:

>Translated_338_residues
MQIFYDKDCDLSIIQGKKVAIIGYGSQGHAHALNLKDSGVDVTVGLRANSASWKKAENAGLKVAEVPEAVKQADLVMILT
PDEFQSQLYRDVIEPNIKEGATLAFAHGFSVLYNQVVPRQDLDVIMVAPKAPGHTVRSEFQRGSGVPDLIAIHQDASGNA
RNVALSYASGVGGGRTGIIETSFREETETDLFGEQAVLCGGAVELVKMGFETLVEAGYSPEMAYFECLHELKLIVDLMFE
GGIADMNYSVSNNAEYGEYVTGVEVINEQSREAMRNALKRIQSGEYAKMFIQEGALNYPSMTARRRQNAAHGIEVTGSKL
RAMMPWIQANKIVDKEKN
>Mature_338_residues
MQIFYDKDCDLSIIQGKKVAIIGYGSQGHAHALNLKDSGVDVTVGLRANSASWKKAENAGLKVAEVPEAVKQADLVMILT
PDEFQSQLYRDVIEPNIKEGATLAFAHGFSVLYNQVVPRQDLDVIMVAPKAPGHTVRSEFQRGSGVPDLIAIHQDASGNA
RNVALSYASGVGGGRTGIIETSFREETETDLFGEQAVLCGGAVELVKMGFETLVEAGYSPEMAYFECLHELKLIVDLMFE
GGIADMNYSVSNNAEYGEYVTGVEVINEQSREAMRNALKRIQSGEYAKMFIQEGALNYPSMTARRRQNAAHGIEVTGSKL
RAMMPWIQANKIVDKEKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=317, Percent_Identity=37.8548895899054, Blast_Score=190, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6323387, Length=255, Percent_Identity=36.4705882352941, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_ACIAD (Q6F821)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047616.1
- ProteinModelPortal:   Q6F821
- SMR:   Q6F821
- STRING:   Q6F821
- GeneID:   2877810
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3102
- NMPDR:   fig|62977.3.peg.2809
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q6F821
- ProtClustDB:   PRK05479
- BioCyc:   ASP62977:ACIAD3102-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36943; Mature: 36943

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIFYDKDCDLSIIQGKKVAIIGYGSQGHAHALNLKDSGVDVTVGLRANSASWKKAENAG
CCEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCEEEEEEEECCCCCCCHHHCCC
LKVAEVPEAVKQADLVMILTPDEFQSQLYRDVIEPNIKEGATLAFAHGFSVLYNQVVPRQ
CCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCC
DLDVIMVAPKAPGHTVRSEFQRGSGVPDLIAIHQDASGNARNVALSYASGVGGGRTGIIE
CCCEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCEEE
TSFREETETDLFGEQAVLCGGAVELVKMGFETLVEAGYSPEMAYFECLHELKLIVDLMFE
CCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGIADMNYSVSNNAEYGEYVTGVEVINEQSREAMRNALKRIQSGEYAKMFIQEGALNYPS
CCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
MTARRRQNAAHGIEVTGSKLRAMMPWIQANKIVDKEKN
HHHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQIFYDKDCDLSIIQGKKVAIIGYGSQGHAHALNLKDSGVDVTVGLRANSASWKKAENAG
CCEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCEEEEEEEECCCCCCCHHHCCC
LKVAEVPEAVKQADLVMILTPDEFQSQLYRDVIEPNIKEGATLAFAHGFSVLYNQVVPRQ
CCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCC
DLDVIMVAPKAPGHTVRSEFQRGSGVPDLIAIHQDASGNARNVALSYASGVGGGRTGIIE
CCCEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCEEE
TSFREETETDLFGEQAVLCGGAVELVKMGFETLVEAGYSPEMAYFECLHELKLIVDLMFE
CCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGIADMNYSVSNNAEYGEYVTGVEVINEQSREAMRNALKRIQSGEYAKMFIQEGALNYPS
CCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
MTARRRQNAAHGIEVTGSKLRAMMPWIQANKIVDKEKN
HHHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA