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The map label for this gene is hyi [H]

Identifier: 50086086

GI number: 50086086

Start: 3003039

End: 3003836

Strand: Direct

Name: hyi [H]

Synonym: ACIAD3075

Alternate gene names: 50086086

Gene position: 3003039-3003836 (Clockwise)

Preceding gene: 50086085

Following gene: 50086087

Centisome position: 83.45

GC content: 43.48

Gene sequence:

>798_bases
ATGATGAGTCAGCTTGCAGTCAATCTGTCCATGATATTTACAGAGTCACCTTTAATTGAACGCTTTGCATTAGCGCATCA
GTATGGATTTCAGCATGTTGAAATCCAGTTTCCGTATGAGCTCTCTATTGAGGAGATCCAGACTCAATTGGCTCAATACA
ATTTGAGTTTATGTCTGATCAATGTTCCCGCAGGCGACCTGATGCAAGGTGGTGATGGTCTGGCTGGCATACCAGGTCAA
GAACAGGCTTTTGCACAAGCATTACAACAAGCCGTTGAGTATGCCACTGCGTTAAATGTTCCACGGGTGAATATTCTCGC
TGGCAAACAACCGGTTGATACAGACCTGCTGCCTTGCTTGAATACACTAGCCAGTAATCTCAAATTTGCATGTGAGCGTT
TGACTGAACACGGTATTGAGCCCGTTTTTGAGATGATCAATGGTACAGATATGCCACGCTTCTTGGTTCAGAACATTGCT
CAGGCGCAAGAAATGCTAGAAGCTGTAAGGCACCCTGCTCTCAAGATGCAATATGATTGTTACCATATGGCCATGATGGG
CGAAGATGTGCTCGCAGGCTTAAAAGAAAATATCGGTCAGATCGGACATATTCAATTTGCAGACTGTCCTGGACGTCACG
AACCAGATACTGCGCAAATCCACTTTAATGAAATTTTTCAATGGATACAGCAAAGCACTTATCAAGGTTATATTGCGGCT
GAATATCGACCTCAATCCAGCTCAGCGCAATCTTTTGCGTGGAAAAACAAATATTTCGCAAATGATGTAAATAGCTAG

Upstream 100 bases:

>100_bases
TCAGTTACACAGCCACCAACAAAACGGCTATGCGCAAAGTGATTTAGCTACTATGATCAAACAAGTAGAAGATCAAGATC
AATAAAAAGTAAGGAAATAC

Downstream 100 bases:

>100_bases
TTAAATGCATGTTTCTTTTTTAAACAATTTTTTTCAATATCATCTTCGATCAAAAATTGAAATTTGGACGTAAAGACGCT
ATATTAAACAATGAGTAATT

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MMSQLAVNLSMIFTESPLIERFALAHQYGFQHVEIQFPYELSIEEIQTQLAQYNLSLCLINVPAGDLMQGGDGLAGIPGQ
EQAFAQALQQAVEYATALNVPRVNILAGKQPVDTDLLPCLNTLASNLKFACERLTEHGIEPVFEMINGTDMPRFLVQNIA
QAQEMLEAVRHPALKMQYDCYHMAMMGEDVLAGLKENIGQIGHIQFADCPGRHEPDTAQIHFNEIFQWIQQSTYQGYIAA
EYRPQSSSAQSFAWKNKYFANDVNS

Sequences:

>Translated_265_residues
MMSQLAVNLSMIFTESPLIERFALAHQYGFQHVEIQFPYELSIEEIQTQLAQYNLSLCLINVPAGDLMQGGDGLAGIPGQ
EQAFAQALQQAVEYATALNVPRVNILAGKQPVDTDLLPCLNTLASNLKFACERLTEHGIEPVFEMINGTDMPRFLVQNIA
QAQEMLEAVRHPALKMQYDCYHMAMMGEDVLAGLKENIGQIGHIQFADCPGRHEPDTAQIHFNEIFQWIQQSTYQGYIAA
EYRPQSSSAQSFAWKNKYFANDVNS
>Mature_265_residues
MMSQLAVNLSMIFTESPLIERFALAHQYGFQHVEIQFPYELSIEEIQTQLAQYNLSLCLINVPAGDLMQGGDGLAGIPGQ
EQAFAQALQQAVEYATALNVPRVNILAGKQPVDTDLLPCLNTLASNLKFACERLTEHGIEPVFEMINGTDMPRFLVQNIA
QAQEMLEAVRHPALKMQYDCYHMAMMGEDVLAGLKENIGQIGHIQFADCPGRHEPDTAQIHFNEIFQWIQQSTYQGYIAA
EYRPQSSSAQSFAWKNKYFANDVNS

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=264, Percent_Identity=32.1969696969697, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI300068964, Length=244, Percent_Identity=32.7868852459016, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1786718, Length=257, Percent_Identity=37.3540856031128, Blast_Score=183, Evalue=8e-48,
Organism=Escherichia coli, GI1789095, Length=257, Percent_Identity=34.2412451361868, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17552022, Length=253, Percent_Identity=32.8063241106719, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17530883, Length=265, Percent_Identity=28.6792452830189, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29691; Mature: 29691

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSQLAVNLSMIFTESPLIERFALAHQYGFQHVEIQFPYELSIEEIQTQLAQYNLSLCLI
CCCHHHHHHHEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCEEEEEE
NVPAGDLMQGGDGLAGIPGQEQAFAQALQQAVEYATALNVPRVNILAGKQPVDTDLLPCL
ECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
NTLASNLKFACERLTEHGIEPVFEMINGTDMPRFLVQNIAQAQEMLEAVRHPALKMQYDC
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
YHMAMMGEDVLAGLKENIGQIGHIQFADCPGRHEPDTAQIHFNEIFQWIQQSTYQGYIAA
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEE
EYRPQSSSAQSFAWKNKYFANDVNS
EECCCCCCCHHHHHCCCHHCCCCCC
>Mature Secondary Structure
MMSQLAVNLSMIFTESPLIERFALAHQYGFQHVEIQFPYELSIEEIQTQLAQYNLSLCLI
CCCHHHHHHHEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCEEEEEE
NVPAGDLMQGGDGLAGIPGQEQAFAQALQQAVEYATALNVPRVNILAGKQPVDTDLLPCL
ECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
NTLASNLKFACERLTEHGIEPVFEMINGTDMPRFLVQNIAQAQEMLEAVRHPALKMQYDC
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
YHMAMMGEDVLAGLKENIGQIGHIQFADCPGRHEPDTAQIHFNEIFQWIQQSTYQGYIAA
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEE
EYRPQSSSAQSFAWKNKYFANDVNS
EECCCCCCCHHHHHCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]