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The map label for this gene is glxR [H]

Identifier: 50086085

GI number: 50086085

Start: 3002148

End: 3003023

Strand: Direct

Name: glxR [H]

Synonym: ACIAD3074

Alternate gene names: 50086085

Gene position: 3002148-3003023 (Clockwise)

Preceding gene: 50086084

Following gene: 50086086

Centisome position: 83.42

GC content: 44.63

Gene sequence:

>876_bases
ATGCGTTTTGATCGTCACACGCCTATTGCTTTTATCGGGATGGGTTTAATGGGTAGCCGCATGGCGACACGACTGGTTCA
GGCAGGTTTTTCTGTGGCTGTTTGGAATCGAACACAAAGCGCATGTGATGTTTTACTCGATATGGGTGCACAAGCCCTGA
GTCTTGAAAAAATTGCAGATTATCCTGTTATTTTGATGTGCTTGGCAGATGATCAGGCCGTAAATCATGTGTATGAACAA
GTTCATCACCTTGTACGTCCTCAACAGATTATTGTGGATTTTTCTAGCTTGTCTGTAAACCAAACCAAATATCTGGCCGA
CCGTGCTCAGCAGCAGCAAGCCATCTGGATTGATTCTCCTGTTTCAGGTGGAACCTCAGGCGCAGAACAAGGAACGCTGG
TCATTTTTGCAGGCGGTAATGAAAGTACGATTCAAGATCTAGGCTTAATTTATAACGTACTTTCACAGCGTGTGACACGC
ATGGGAGATACAGGAACAGGTCAGGCAACCAAAATATGCAATCAACTAATTGTGGCTGCAAACAGTGCTTTAATCGCTGA
AGCTGTAGCACTTGCACATCGTGCAGGTGTTGACACAACACTATTGGCACCTGCATTAGCCAATGGCTTTGCCGACTCCA
AACCCTTTCAAATTTTGGCGCCACGTATGGCACGACAAATTTTTGAGCCTGTGCAATGGAAAGTGCAAACGCTCGCCAAA
GATTTAAATAATGCTGTTGAGCTGGCAACGCATTATGCGCTAGATATCCCTGTTGCACATCAGGCTCTACATCAGTTACA
CAGCCACCAACAAAACGGCTATGCGCAAAGTGATTTAGCTACTATGATCAAACAAGTAGAAGATCAAGATCAATAA

Upstream 100 bases:

>100_bases
AGTTATTATTGGGTAAAAATAGTCGACTCGCGCGACAAAAGGACAAACATCCCGAAGTAGAGTTTTTGCCTCGTCAATAT
CAATAATCAAGGATTACATT

Downstream 100 bases:

>100_bases
AAAGTAAGGAAATACATGATGAGTCAGCTTGCAGTCAATCTGTCCATGATATTTACAGAGTCACCTTTAATTGAACGCTT
TGCATTAGCGCATCAGTATG

Product: 3-hydroxyisobutyrate dehydrogenase or 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MRFDRHTPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEKIADYPVILMCLADDQAVNHVYEQ
VHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTR
MGDTGTGQATKICNQLIVAANSALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAK
DLNNAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIKQVEDQDQ

Sequences:

>Translated_291_residues
MRFDRHTPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEKIADYPVILMCLADDQAVNHVYEQ
VHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTR
MGDTGTGQATKICNQLIVAANSALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAK
DLNNAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIKQVEDQDQ
>Mature_291_residues
MRFDRHTPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEKIADYPVILMCLADDQAVNHVYEQ
VHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTR
MGDTGTGQATKICNQLIVAANSALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAK
DLNNAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIKQVEDQDQ

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=299, Percent_Identity=27.7591973244147, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI40556376, Length=264, Percent_Identity=26.5151515151515, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=31.6901408450704, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI145693186, Length=275, Percent_Identity=28.3636363636364, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=24.1379310344828, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789092, Length=291, Percent_Identity=25.4295532646048, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17557316, Length=200, Percent_Identity=26.5, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24655230, Length=200, Percent_Identity=35, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19922568, Length=200, Percent_Identity=35, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28574115, Length=288, Percent_Identity=22.5694444444444, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31653; Mature: 31653

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDRHTPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEKIAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHCC
YPVILMCLADDQAVNHVYEQVHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSP
CCEEEEEECCCHHHHHHHHHHHHHHCCHHHEEEHHHCCCCHHHHHHHHHHCCCEEEEECC
VSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
NSALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAK
CHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DLNNAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIKQVEDQDQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRFDRHTPIAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALSLEKIAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHCC
YPVILMCLADDQAVNHVYEQVHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSP
CCEEEEEECCCHHHHHHHHHHHHHHCCHHHEEEHHHCCCCHHHHHHHHHHCCCEEEEECC
VSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVAA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
NSALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQWKVQTLAK
CHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DLNNAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLATMIKQVEDQDQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]