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The map label for this gene is panC

Identifier: 50086072

GI number: 50086072

Start: 2986931

End: 2987776

Strand: Reverse

Name: panC

Synonym: ACIAD3060

Alternate gene names: 50086072

Gene position: 2987776-2986931 (Counterclockwise)

Preceding gene: 50086073

Following gene: 50086071

Centisome position: 83.03

GC content: 42.91

Gene sequence:

>846_bases
ATGAAAACCGAAACCACGATTCAGGGATTAACCGCGTCACTCAATCCTGCACGTACAACACGCAAGATTATTGGTTTTGT
GCCAACGATGGGTAATTTGCATCAAGGTCATCTCAATTTAGTTCGTGAAGCAAAAAAACTCTGTGATATTGTCGTGGTCA
GCATTTTCGTCAATCCGATCCAGTTTGGAGAAGGTGAAGATTTTGAAAATTACCCACGTACACTTGAGCAGGATAGCCAT
CTACTTGCAGATGTAGGCTGTGATATTATTTTTGCGCCTTCAGTCGAACAAATGTATGGTAAACATCCACGTCTCACCAA
TATTTCTGTGGCTGATATTACCGATGATCTTTGCGGTCAATCACGTCCTGGACATTTTGACGGTGTAGCCGTTGTCGTCA
CCAAACTATTCAATATTGTGCAGCCGAATGTCGCATTTTTTGGCCAGAAGGATTATCAGCAACTTGCTGTCATCCGCCAG
TTGGTACAGGATTTGAATTTGCCGATTGATATTATCGGTGTGCCGATTGCGCGAGATCATGATGGACTGGCATTGAGTTC
AAGAAATGGTTATTTGTCTGAAGCAGAACGTCAGATTGCGCCTACCATTTATCAGTCATTAAAATTGGCGGAACAGCAAC
TCCATCAAGGTGTTGAGTTGGTAGATGTATTGGATGAGTTAAAGTTTCGATTGACAGCCGCAGGCTTCGTTGTTGATTAT
GTTGAGGCGCGCCAGCCCAATTTACAGCCAATTGCGCAATTTGATCGTGATCTGGTACTTTTTGTTGCTGCAAAGCTGGG
TAAGACACGACTCATTGATAATTTACAGGTTAAGTTGAAGGCATAA

Upstream 100 bases:

>100_bases
AGAGACTGCAATTGTAGATGCATTTAAGGCATATCATGCTGCTGTACAAGACCAGTCATTTCCTGCACGAGAACATACAT
TTCAGGTAGAGCTGTAATTT

Downstream 100 bases:

>100_bases
TTTCGAAAGGACAGCCATGCCATGAAACGTATTCTTATCGTCACAGGTCAATCAGGGTCTGGAAAATCTTCGGCATTACA
GGTGCTTGAAGATTTAGGCT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKTETTIQGLTASLNPARTTRKIIGFVPTMGNLHQGHLNLVREAKKLCDIVVVSIFVNPIQFGEGEDFENYPRTLEQDSH
LLADVGCDIIFAPSVEQMYGKHPRLTNISVADITDDLCGQSRPGHFDGVAVVVTKLFNIVQPNVAFFGQKDYQQLAVIRQ
LVQDLNLPIDIIGVPIARDHDGLALSSRNGYLSEAERQIAPTIYQSLKLAEQQLHQGVELVDVLDELKFRLTAAGFVVDY
VEARQPNLQPIAQFDRDLVLFVAAKLGKTRLIDNLQVKLKA

Sequences:

>Translated_281_residues
MKTETTIQGLTASLNPARTTRKIIGFVPTMGNLHQGHLNLVREAKKLCDIVVVSIFVNPIQFGEGEDFENYPRTLEQDSH
LLADVGCDIIFAPSVEQMYGKHPRLTNISVADITDDLCGQSRPGHFDGVAVVVTKLFNIVQPNVAFFGQKDYQQLAVIRQ
LVQDLNLPIDIIGVPIARDHDGLALSSRNGYLSEAERQIAPTIYQSLKLAEQQLHQGVELVDVLDELKFRLTAAGFVVDY
VEARQPNLQPIAQFDRDLVLFVAAKLGKTRLIDNLQVKLKA
>Mature_281_residues
MKTETTIQGLTASLNPARTTRKIIGFVPTMGNLHQGHLNLVREAKKLCDIVVVSIFVNPIQFGEGEDFENYPRTLEQDSH
LLADVGCDIIFAPSVEQMYGKHPRLTNISVADITDDLCGQSRPGHFDGVAVVVTKLFNIVQPNVAFFGQKDYQQLAVIRQ
LVQDLNLPIDIIGVPIARDHDGLALSSRNGYLSEAERQIAPTIYQSLKLAEQQLHQGVELVDVLDELKFRLTAAGFVVDY
VEARQPNLQPIAQFDRDLVLFVAAKLGKTRLIDNLQVKLKA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=265, Percent_Identity=47.1698113207547, Blast_Score=237, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6322046, Length=220, Percent_Identity=44.5454545454545, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_ACIAD (Q6F855)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047582.1
- ProteinModelPortal:   Q6F855
- SMR:   Q6F855
- STRING:   Q6F855
- GeneID:   2880498
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3060
- NMPDR:   fig|62977.3.peg.2775
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q6F855
- ProtClustDB:   PRK00380
- BioCyc:   ASP62977:ACIAD3060-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31209; Mature: 31209

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 154-154 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTETTIQGLTASLNPARTTRKIIGFVPTMGNLHQGHLNLVREAKKLCDIVVVSIFVNPI
CCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QFGEGEDFENYPRTLEQDSHLLADVGCDIIFAPSVEQMYGKHPRLTNISVADITDDLCGQ
CCCCCCCHHHCCHHHHCCCHHHHHCCCCEEECCCHHHHCCCCCCCCCCCHHHCCHHHHCC
SRPGHFDGVAVVVTKLFNIVQPNVAFFGQKDYQQLAVIRQLVQDLNLPIDIIGVPIARDH
CCCCCCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCEECCC
DGLALSSRNGYLSEAERQIAPTIYQSLKLAEQQLHQGVELVDVLDELKFRLTAAGFVVDY
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VEARQPNLQPIAQFDRDLVLFVAAKLGKTRLIDNLQVKLKA
HHHCCCCCCHHHHHCHHHHHHHHHHHCHHHHHCCCEEEEEC
>Mature Secondary Structure
MKTETTIQGLTASLNPARTTRKIIGFVPTMGNLHQGHLNLVREAKKLCDIVVVSIFVNPI
CCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QFGEGEDFENYPRTLEQDSHLLADVGCDIIFAPSVEQMYGKHPRLTNISVADITDDLCGQ
CCCCCCCHHHCCHHHHCCCHHHHHCCCCEEECCCHHHHCCCCCCCCCCCHHHCCHHHHCC
SRPGHFDGVAVVVTKLFNIVQPNVAFFGQKDYQQLAVIRQLVQDLNLPIDIIGVPIARDH
CCCCCCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCEEEEECCEECCC
DGLALSSRNGYLSEAERQIAPTIYQSLKLAEQQLHQGVELVDVLDELKFRLTAAGFVVDY
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VEARQPNLQPIAQFDRDLVLFVAAKLGKTRLIDNLQVKLKA
HHHCCCCCCHHHHHCHHHHHHHHHHHCHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA