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The map label for this gene is ppx [H]

Identifier: 50086049

GI number: 50086049

Start: 2965523

End: 2967043

Strand: Reverse

Name: ppx [H]

Synonym: ACIAD3036

Alternate gene names: 50086049

Gene position: 2967043-2965523 (Counterclockwise)

Preceding gene: 50086053

Following gene: 50086048

Centisome position: 82.45

GC content: 43.85

Gene sequence:

>1521_bases
ATGGCTGACTTTTTGATAGATGAAGAATTACTTGCTGCCATCGATATGGGGTCGAACAGTTTTCACTTAGCCATTGCACG
TGTAGATCATGGGGAAGTTAAGAAAGTGGCTTCTATGTCAGAAAAGGTTCAGCTTGCAGCGGGACTTGATGAAAATAAAA
ATTTGACTGAAGCTGCTCAGCAACGTGGTTTGGCTTGTCTGGCACGGTTTGTGGGACGTTTAAGTTCTGTACAGCCAAAT
CGTTTGCGTATTGTGGCAACCAACGCATTGCGTCAGGCTAAAAATGGACACGAGTTTATTCAGCGTGCTGCCGAAATTTT
ACCCAAACCGATTGAGATTATTGCAGGACGTGAAGAAGCACGTCTGATTTATCTGGGGGTTTCACACACCATGGCCAATG
GTGGCCGTCGACTGGTGGTAGACATCGGTGGGGGGTCGACCGAGTTTATTATTGGTGAAGAATTTGAGCCGATTCAGACT
GAATCCTTGCAAATGGGCTGTGTAGCGTATACCAAAGCTTATTTTGCAGATGGTGATATTAGCTCGAAAGTATTTGATAA
GGCGGTGGTGGCCGCGCGCAAAGAATTATCAGCCATTGCCAATATTTATAAAGCTGAAGGCTGGGATACGGTTGTTGGTT
CGAGTGGAACGATTAAAGCTGCCAAACAGATTATGGTGAATATGGGGCTGAGCGATGAGCAAGAGAATGTCACGCGTGAA
GGTCTGGAAAAGTTAAAAGATCGATTAATCAAGTTTAAGCATGTGTCTGAAATTGATTTTGAAGGTCTAAAAGATGATCG
TCGAGCAGTTTTGCCAGCTGGGTTGGCAATTTTGTACGCAGTCTTTGAAGTGTTGAATATCGATAAGCTGGCTTATTCAG
ATGGTGCATTACGTGAAGGTGTTATGTACGACTTGCTTGGACGTTTCAAGCATGAAGACATCCGCGACCGCAGTGTTCAA
GCACTGATGGGACGTTATAATGCCGATCTCAAACAGGCAGAACGTGTGGTAAATACTGCTCAACATTTGTTTGATGATGT
CGCACACAAGCTAGATTTAGTGAGTGAAGACAGTGACTTATTGCGTCGTGCAGCGTATTTACATGAAATTGGCTTGGCCA
TCAGTCATGGCGGATATCATCGTCATGGTGCATATTTATTGCAACATTCCGATATTCCTGGCTTTTCACAAATTGATCAA
AATCATCTGGCACATTTGGTAGCCCACCATCGCCGCAAGCTACGCAACGACAGTAAAAATGACGTATTAAAGGTAGGCGG
TACCAAGCTACTTTACCTATGTTTGCTGCTTCGCCTTGCTGTTTTACTCAATCATAGTCGCAGTGATCAGATGCTTCCTG
CCATTGAATTAAGCATTGTAAATGATCAACAATGGCAGCTTAGCGTTTCTGGTGATGCCAAACAATGGCCATTGCTGGTT
GCCGATTTGCACGATGAGCAAGAGCAATTTAAGCACTGGGACATTGAGTTGAATATTCAGTCGGAAAAATTTATCGATTA
A

Upstream 100 bases:

>100_bases
TTGAGTGGTAAACACTCTGAAAATGAGCCGAAATATGGCTTTTCAATTGTATATATGTGAATTAATCTTAGCGTGAATTT
TATAAAGGTTTATATCAATA

Downstream 100 bases:

>100_bases
CTCGATTTGGTTAATTTAGGGATAATGCTCGACTTATGAAAAATAAAGCTGCTCAGTCTAAAGCGTGGACAACGGTTCAA
ATTGCACGACATCCAGATCG

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MADFLIDEELLAAIDMGSNSFHLAIARVDHGEVKKVASMSEKVQLAAGLDENKNLTEAAQQRGLACLARFVGRLSSVQPN
RLRIVATNALRQAKNGHEFIQRAAEILPKPIEIIAGREEARLIYLGVSHTMANGGRRLVVDIGGGSTEFIIGEEFEPIQT
ESLQMGCVAYTKAYFADGDISSKVFDKAVVAARKELSAIANIYKAEGWDTVVGSSGTIKAAKQIMVNMGLSDEQENVTRE
GLEKLKDRLIKFKHVSEIDFEGLKDDRRAVLPAGLAILYAVFEVLNIDKLAYSDGALREGVMYDLLGRFKHEDIRDRSVQ
ALMGRYNADLKQAERVVNTAQHLFDDVAHKLDLVSEDSDLLRRAAYLHEIGLAISHGGYHRHGAYLLQHSDIPGFSQIDQ
NHLAHLVAHHRRKLRNDSKNDVLKVGGTKLLYLCLLLRLAVLLNHSRSDQMLPAIELSIVNDQQWQLSVSGDAKQWPLLV
ADLHDEQEQFKHWDIELNIQSEKFID

Sequences:

>Translated_506_residues
MADFLIDEELLAAIDMGSNSFHLAIARVDHGEVKKVASMSEKVQLAAGLDENKNLTEAAQQRGLACLARFVGRLSSVQPN
RLRIVATNALRQAKNGHEFIQRAAEILPKPIEIIAGREEARLIYLGVSHTMANGGRRLVVDIGGGSTEFIIGEEFEPIQT
ESLQMGCVAYTKAYFADGDISSKVFDKAVVAARKELSAIANIYKAEGWDTVVGSSGTIKAAKQIMVNMGLSDEQENVTRE
GLEKLKDRLIKFKHVSEIDFEGLKDDRRAVLPAGLAILYAVFEVLNIDKLAYSDGALREGVMYDLLGRFKHEDIRDRSVQ
ALMGRYNADLKQAERVVNTAQHLFDDVAHKLDLVSEDSDLLRRAAYLHEIGLAISHGGYHRHGAYLLQHSDIPGFSQIDQ
NHLAHLVAHHRRKLRNDSKNDVLKVGGTKLLYLCLLLRLAVLLNHSRSDQMLPAIELSIVNDQQWQLSVSGDAKQWPLLV
ADLHDEQEQFKHWDIELNIQSEKFID
>Mature_505_residues
ADFLIDEELLAAIDMGSNSFHLAIARVDHGEVKKVASMSEKVQLAAGLDENKNLTEAAQQRGLACLARFVGRLSSVQPNR
LRIVATNALRQAKNGHEFIQRAAEILPKPIEIIAGREEARLIYLGVSHTMANGGRRLVVDIGGGSTEFIIGEEFEPIQTE
SLQMGCVAYTKAYFADGDISSKVFDKAVVAARKELSAIANIYKAEGWDTVVGSSGTIKAAKQIMVNMGLSDEQENVTREG
LEKLKDRLIKFKHVSEIDFEGLKDDRRAVLPAGLAILYAVFEVLNIDKLAYSDGALREGVMYDLLGRFKHEDIRDRSVQA
LMGRYNADLKQAERVVNTAQHLFDDVAHKLDLVSEDSDLLRRAAYLHEIGLAISHGGYHRHGAYLLQHSDIPGFSQIDQN
HLAHLVAHHRRKLRNDSKNDVLKVGGTKLLYLCLLLRLAVLLNHSRSDQMLPAIELSIVNDQQWQLSVSGDAKQWPLLVA
DLHDEQEQFKHWDIELNIQSEKFID

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=487, Percent_Identity=42.9158110882957, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI48994966, Length=493, Percent_Identity=38.5395537525355, Blast_Score=337, Evalue=2e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56434; Mature: 56303

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFLIDEELLAAIDMGSNSFHLAIARVDHGEVKKVASMSEKVQLAAGLDENKNLTEAAQ
CCCCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHH
QRGLACLARFVGRLSSVQPNRLRIVATNALRQAKNGHEFIQRAAEILPKPIEIIAGREEA
HHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCCCCC
RLIYLGVSHTMANGGRRLVVDIGGGSTEFIIGEEFEPIQTESLQMGCVAYTKAYFADGDI
EEEEEEEHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
SSKVFDKAVVAARKELSAIANIYKAEGWDTVVGSSGTIKAAKQIMVNMGLSDEQENVTRE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCHHHHHHH
GLEKLKDRLIKFKHVSEIDFEGLKDDRRAVLPAGLAILYAVFEVLNIDKLAYSDGALREG
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VMYDLLGRFKHEDIRDRSVQALMGRYNADLKQAERVVNTAQHLFDDVAHKLDLVSEDSDL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LRRAAYLHEIGLAISHGGYHRHGAYLLQHSDIPGFSQIDQNHLAHLVAHHRRKLRNDSKN
HHHHHHHHHHHHEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
DVLKVGGTKLLYLCLLLRLAVLLNHSRSDQMLPAIELSIVNDQQWQLSVSGDAKQWPLLV
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCEEE
ADLHDEQEQFKHWDIELNIQSEKFID
EECCCCHHHHCCCCEEEEECHHCCCC
>Mature Secondary Structure 
ADFLIDEELLAAIDMGSNSFHLAIARVDHGEVKKVASMSEKVQLAAGLDENKNLTEAAQ
CCCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHH
QRGLACLARFVGRLSSVQPNRLRIVATNALRQAKNGHEFIQRAAEILPKPIEIIAGREEA
HHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCCCCC
RLIYLGVSHTMANGGRRLVVDIGGGSTEFIIGEEFEPIQTESLQMGCVAYTKAYFADGDI
EEEEEEEHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
SSKVFDKAVVAARKELSAIANIYKAEGWDTVVGSSGTIKAAKQIMVNMGLSDEQENVTRE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCHHHHHHH
GLEKLKDRLIKFKHVSEIDFEGLKDDRRAVLPAGLAILYAVFEVLNIDKLAYSDGALREG
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VMYDLLGRFKHEDIRDRSVQALMGRYNADLKQAERVVNTAQHLFDDVAHKLDLVSEDSDL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LRRAAYLHEIGLAISHGGYHRHGAYLLQHSDIPGFSQIDQNHLAHLVAHHRRKLRNDSKN
HHHHHHHHHHHHEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
DVLKVGGTKLLYLCLLLRLAVLLNHSRSDQMLPAIELSIVNDQQWQLSVSGDAKQWPLLV
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCEEE
ADLHDEQEQFKHWDIELNIQSEKFID
EECCCCHHHHCCCCEEEEECHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]