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The map label for this gene is fadA [H]

Identifier: 50086009

GI number: 50086009

Start: 2919024

End: 2920232

Strand: Direct

Name: fadA [H]

Synonym: ACIAD2988

Alternate gene names: 50086009

Gene position: 2919024-2920232 (Clockwise)

Preceding gene: 50086007

Following gene: 50086010

Centisome position: 81.12

GC content: 45.99

Gene sequence:

>1209_bases
ATGATGAGCGAGGCTTATATCATCGATGCCATCCGCACTCCTCGCGGAAAAGGAAAAAAAGATGGCTCACTTTATGAAGT
AAAACCCATCACGTTACTCACAACATTACTGAATGAACTCCAGCAACGTCATCAACTGGATACAGCCAAAGTAGATGATA
TCGTTTTGGGTTGTGTGACGCCAATTGGTGATCAGGGTGGTGATATTGCCAAAACCGCTGCAATTGCCGCAGGTTGGAAC
GATGATGTGGCTGGGGTGCAAATCAACCGTTTCTGTGCATCGGGTCTGGAAGCAGTCAATCTGGCGGCTCAAAAAGTTCG
TTCTGGTTGGGAAGATGTGGTGGTGGCTGGTGGTGTAGAGTCGATGTCACGAATTCCGATGGGTTCGGATGGTGGCCCTT
GGGCACTTGATCCTGAAACAAATTTAAAGTCTTCTTTTGTGCCACAAGGGATTGGCGCTGACTTAATTGCAACACTGGAT
GGTTATAGTCGCGCAGATGTCGATGCTTTTGCAGTCAGTTCACAACAAAAGGCGGCGGCGGCTCAAGCCAATGGTTATTT
CGATAAATCAATCGTGCCCGTAAAAGATCATTCAGGTGTGATGATTTTAGAAAAAGACGAATTTATCAAAGCCAATACCA
GCGTTGAAGGTTTGGCAAAACTGAATGCCAGCTTTGAAATGATGGGGCAAATGGGCTTTGATGCGGTTGCCTTACAGAAA
TATCCAGAAGCGCAAAAAATTAACCATGTCCATCATGCGGGAAATTCATCGGGCATTGTAGATGGTGCTGCGGTGGTGTT
ATTGGCTTCTGAAAAAGCAGTGAAAGAGCAAGGTTTAAAACCTCGTGCAAAAGTTCTTGCAACTGCATTAGTCGGCACAG
ATCCAACCATTATGTTGACTGGCCCTGCCCCTGCAGCACGTAAAGCTTTACAAAAAGCCGGCTTAACTATTGACGATATC
GATCTCTTTGAAGTGAACGAAGCCTTTGCAGCTGTGGTGATGCGTTTTATCAATGAATTACAGGTGCCAGAAGATAAAGT
CAATGTGAACGGCGGTGCAATTGCCATGGGACATCCATTAGGTGCAACAGGCGCCATGATTTTAGGAACTCTACTGGATG
AATTAGAACGTCAGGGTAAAAAACGGGGCTTAGCCACTTTATGTGTAGGCGGTGGTATGGGTATCGCGACGATCATTGAA
CGAGTGTAA

Upstream 100 bases:

>100_bases
AAAAAACATCATTTGTCTGATGACCTTCTCGTCATTGTCTTGTACTCAAAATCCACTACACTCAAAAGCATAAAAATATT
TTAAGGCCATAAAAGGAAGA

Downstream 100 bases:

>100_bases
GGAGAATCTCATGAGCGCTATTAAATACGAAAAAAACGCTGACAATATTGTAATTCTTACCCTTGATTCATCGGGTCAAT
CTGCAAATACCATGAATGCA

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MMSEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTAKVDDIVLGCVTPIGDQGGDIAKTAAIAAGWN
DDVAGVQINRFCASGLEAVNLAAQKVRSGWEDVVVAGGVESMSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLD
GYSRADVDAFAVSSQQKAAAAQANGYFDKSIVPVKDHSGVMILEKDEFIKANTSVEGLAKLNASFEMMGQMGFDAVALQK
YPEAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQGLKPRAKVLATALVGTDPTIMLTGPAPAARKALQKAGLTIDDI
DLFEVNEAFAAVVMRFINELQVPEDKVNVNGGAIAMGHPLGATGAMILGTLLDELERQGKKRGLATLCVGGGMGIATIIE
RV

Sequences:

>Translated_402_residues
MMSEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTAKVDDIVLGCVTPIGDQGGDIAKTAAIAAGWN
DDVAGVQINRFCASGLEAVNLAAQKVRSGWEDVVVAGGVESMSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLD
GYSRADVDAFAVSSQQKAAAAQANGYFDKSIVPVKDHSGVMILEKDEFIKANTSVEGLAKLNASFEMMGQMGFDAVALQK
YPEAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQGLKPRAKVLATALVGTDPTIMLTGPAPAARKALQKAGLTIDDI
DLFEVNEAFAAVVMRFINELQVPEDKVNVNGGAIAMGHPLGATGAMILGTLLDELERQGKKRGLATLCVGGGMGIATIIE
RV
>Mature_402_residues
MMSEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTAKVDDIVLGCVTPIGDQGGDIAKTAAIAAGWN
DDVAGVQINRFCASGLEAVNLAAQKVRSGWEDVVVAGGVESMSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLD
GYSRADVDAFAVSSQQKAAAAQANGYFDKSIVPVKDHSGVMILEKDEFIKANTSVEGLAKLNASFEMMGQMGFDAVALQK
YPEAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQGLKPRAKVLATALVGTDPTIMLTGPAPAARKALQKAGLTIDDI
DLFEVNEAFAAVVMRFINELQVPEDKVNVNGGAIAMGHPLGATGAMILGTLLDELERQGKKRGLATLCVGGGMGIATIIE
RV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=408, Percent_Identity=37.5, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4501853, Length=388, Percent_Identity=38.4020618556701, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI167614485, Length=424, Percent_Identity=33.4905660377358, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4557237, Length=415, Percent_Identity=31.3253012048193, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4504327, Length=444, Percent_Identity=29.7297297297297, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI194353979, Length=114, Percent_Identity=46.4912280701754, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1787663, Length=423, Percent_Identity=40.4255319148936, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI48994986, Length=408, Percent_Identity=40.4411764705882, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI87082165, Length=414, Percent_Identity=37.6811594202899, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788554, Length=417, Percent_Identity=38.6091127098321, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788683, Length=428, Percent_Identity=27.3364485981308, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI133906874, Length=371, Percent_Identity=38.0053908355795, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI25147385, Length=412, Percent_Identity=32.5242718446602, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535921, Length=413, Percent_Identity=29.7820823244552, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=404, Percent_Identity=29.4554455445545, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17551802, Length=447, Percent_Identity=26.8456375838926, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=35.3233830845771, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6325229, Length=421, Percent_Identity=34.916864608076, Blast_Score=182, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24655093, Length=415, Percent_Identity=40.7228915662651, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI17648125, Length=415, Percent_Identity=35.1807228915663, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24640423, Length=421, Percent_Identity=32.541567695962, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=30.316742081448, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42157; Mature: 42157

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTAKVDDIVLGCVT
CCCCEEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEC
PIGDQGGDIAKTAAIAAGWNDDVAGVQINRFCASGLEAVNLAAQKVRSGWEDVVVAGGVE
CCCCCCCCHHHHHHEECCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHCCCHHEEEECCHH
SMSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLDGYSRADVDAFAVSSQQKAAA
HHHCCCCCCCCCCEEECCCCCCCHHCCCCCCCCHHHHHCCCCCCCCCHHHHHCCHHHHHH
AQANGYFDKSIVPVKDHSGVMILEKDEFIKANTSVEGLAKLNASFEMMGQMGFDAVALQK
HHCCCCCCCCEEEEECCCCEEEEECCCEEECCCCHHHHHHHCCHHHHHHHCCCCHHHHHH
YPEAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQGLKPRAKVLATALVGTDPTIMLT
CCCHHHHHHHHCCCCCCCCCCCEEEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCEEEEE
GPAPAARKALQKAGLTIDDIDLFEVNEAFAAVVMRFINELQVPEDKVNVNGGAIAMGHPL
CCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCEEEECCCC
GATGAMILGTLLDELERQGKKRGLATLCVGGGMGIATIIERV
CCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MMSEAYIIDAIRTPRGKGKKDGSLYEVKPITLLTTLLNELQQRHQLDTAKVDDIVLGCVT
CCCCEEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEC
PIGDQGGDIAKTAAIAAGWNDDVAGVQINRFCASGLEAVNLAAQKVRSGWEDVVVAGGVE
CCCCCCCCHHHHHHEECCCCCCCCCEEHHHHHHCCHHHHHHHHHHHHCCCHHEEEECCHH
SMSRIPMGSDGGPWALDPETNLKSSFVPQGIGADLIATLDGYSRADVDAFAVSSQQKAAA
HHHCCCCCCCCCCEEECCCCCCCHHCCCCCCCCHHHHHCCCCCCCCCHHHHHCCHHHHHH
AQANGYFDKSIVPVKDHSGVMILEKDEFIKANTSVEGLAKLNASFEMMGQMGFDAVALQK
HHCCCCCCCCEEEEECCCCEEEEECCCEEECCCCHHHHHHHCCHHHHHHHCCCCHHHHHH
YPEAQKINHVHHAGNSSGIVDGAAVVLLASEKAVKEQGLKPRAKVLATALVGTDPTIMLT
CCCHHHHHHHHCCCCCCCCCCCEEEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCEEEEE
GPAPAARKALQKAGLTIDDIDLFEVNEAFAAVVMRFINELQVPEDKVNVNGGAIAMGHPL
CCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCEEEECCCC
GATGAMILGTLLDELERQGKKRGLATLCVGGGMGIATIIERV
CCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]