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The map label for this gene is groEL [H]

Identifier: 50085881

GI number: 50085881

Start: 2775302

End: 2776936

Strand: Reverse

Name: groEL [H]

Synonym: ACIAD2838

Alternate gene names: 50085881

Gene position: 2776936-2775302 (Counterclockwise)

Preceding gene: 50085882

Following gene: 50085879

Centisome position: 77.17

GC content: 45.32

Gene sequence:

>1635_bases
ATGTCAGCTAAAGACGTAAAATTTGGTGATTCAGCGCGTTCAAAAATGATCGCAGGTGTAAACGTTCTTGCAGATGCAGT
GAAAGTAACACTGGGCCCTAAAGGCCGTAACGTGGTCATCGACCGTTCTTTTGGTGCACCGCACATTACAAAAGATGGTG
TAACGGTTGCGAAAGAAATCACGCTTAAAGATAAATTTGAGAACATGGGTGCGCAATTGGTACGTGAAGTATCAAGCAAA
ACCAACGACATCGCGGGTGATGGTACAACAACTGCAACTGTACTTGCTCAAGCGATCTTGAACGAAGGGATCAAATCAGT
GACTGCTGGTATGAACCCGATGGATCTTAAACGCGGAATCGACATTGCAGTAAGAGCTGTGGTTGAAAACATTCGCGCAA
CAGCTAAACCTGCTGACGATTTCAAAGCAATTGAGCAAGTGGGTTCGATTTCTGCAAACTCTGACGAGACTGTAGGTAAA
TTGATTGCTCAAGCGATGGAAAAAGTGGGCAAAGAAGGCGTGATCACTGTTGAAGAAGGTTCAGGCTTTGAAGACGCACT
TGATGTTGTAGAAGGTATGCAGTTTGACCGCGGTTATATCTCGCCATACTTTGCAAACAAGCAAGATACGCTAACTGCTG
AGCTTGAAAACCCGTTCATTCTTCTTGTTGATAAAAAAATCAGCAACATTCGTGAACTAATCACGACTTTAGAAGCAGTT
GCAAAAACGGGTAAACCACTTTTGATTATTGCTGAAGATGTTGAAGGCGAAGCGCTTGCAACACTTGTTGTCAACAACAT
GCGCGGTATTATCAAAGTATGTGCGGTAAAAGCACCTGGCTTTGGTGACCGTCGTAAAGCAATGCTACAAGACATCGCGA
TCTTGACTGGTGCTACTGTAATTTCTGAAGAAGTGGGCATGTCACTTGAGCAAGCATCACTGCAAGATTTGGGTACTGCG
CATAAAATCACGGTATCGAAAGAAAACACAGTGATTGTTGATGGTGCTGGTGATGCCAATGCGATTGCAGAACGTGTTCA
GCAGATTCGTGCGCAAATTGAAGAATCAACTTCTGAATACGACAAAGAAAAACTTCAAGAACGCGTAGCAAAACTTGCTG
GCGGTGTTGCAGTGATCAAAATCGGTGCTGCGACTGAAGTTGAAATGAAAGAGAAGAAAGACCGTGTAGACGATGCGCTT
CATGCGACACGTGCTGCGGTTGAAGAGGGTGTAGTTGCAGGTGGTGGTGTTGCACTGGTTCGTGCAGTCAACTCACTTGA
CGGCTTAACTGGCGCAAATGATGACCAAACTGTTGGTATCAACATTTTACGCCGTGCGATTGAAGCACCACTTCGTCAAA
TCGTATCGAATGCAGGCGATGAGCCATCTGTTGTCATCAATGCAGTGAAAGCAGGTGAAGGTAACTATGGTTACAACGCT
GCAACAGGTGTGTATGGCGATATGCTTGAAATGGGTATCCTTGATCCAGCGAAAGTAACGCGTTCTGCACTTGAGCATGC
TGCATCTGTTGCAGGCTTGATGTTGACCACTGAGGCGATGATCACTGATATTCCAGAAGATAAACCAGCTATGCCTGATA
TGGGCGGCATGGGTGGTATGGGCGGTATGATGTAA

Upstream 100 bases:

>100_bases
CATGAAAGAATCTGACATTTTAGCTGTTCTTGAAGGCTAAATTTCACTTAACTCATTGATAAATCAGATCAAGCATTGAT
AGAAAAATTTGGAGTATAGA

Downstream 100 bases:

>100_bases
TACCGACTATATCGTCCCGATTTCATATAGGATCGGGATCGAATATTTAAAAAGACCGTGAGCCTGCTCACGGTCTTTTT
TTATAATGATTTTGGCTTTG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEITLKDKFENMGAQLVREVSSK
TNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVRAVVENIRATAKPADDFKAIEQVGSISANSDETVGK
LIAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELITTLEAV
AKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQASLQDLGTA
HKITVSKENTVIVDGAGDANAIAERVQQIRAQIEESTSEYDKEKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDAL
HATRAAVEEGVVAGGGVALVRAVNSLDGLTGANDDQTVGINILRRAIEAPLRQIVSNAGDEPSVVINAVKAGEGNYGYNA
ATGVYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTEAMITDIPEDKPAMPDMGGMGGMGGMM

Sequences:

>Translated_544_residues
MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEITLKDKFENMGAQLVREVSSK
TNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVRAVVENIRATAKPADDFKAIEQVGSISANSDETVGK
LIAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELITTLEAV
AKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQASLQDLGTA
HKITVSKENTVIVDGAGDANAIAERVQQIRAQIEESTSEYDKEKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDAL
HATRAAVEEGVVAGGGVALVRAVNSLDGLTGANDDQTVGINILRRAIEAPLRQIVSNAGDEPSVVINAVKAGEGNYGYNA
ATGVYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTEAMITDIPEDKPAMPDMGGMGGMGGMM
>Mature_543_residues
SAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEITLKDKFENMGAQLVREVSSKT
NDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVRAVVENIRATAKPADDFKAIEQVGSISANSDETVGKL
IAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELITTLEAVA
KTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQASLQDLGTAH
KITVSKENTVIVDGAGDANAIAERVQQIRAQIEESTSEYDKEKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDALH
ATRAAVEEGVVAGGGVALVRAVNSLDGLTGANDDQTVGINILRRAIEAPLRQIVSNAGDEPSVVINAVKAGEGNYGYNAA
TGVYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTEAMITDIPEDKPAMPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=50.6641366223909, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=50.6641366223909, Blast_Score=536, Evalue=1e-152,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=75.0943396226415, Blast_Score=800, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.6068052930057, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=52.132701421801, Blast_Score=221, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=55.893536121673, Blast_Score=576, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=28.3950617283951, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=50.9505703422053, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=50.9505703422053, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=51.1450381679389, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=51.1450381679389, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=51.1450381679389, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=43.1734317343173, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=39.2120075046904, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=39.2120075046904, Blast_Score=353, Evalue=2e-97,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57172; Mature: 57041

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCHHHHHH
TLKDKFENMGAQLVREVSSKTNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DIAVRAVVENIRATAKPADDFKAIEQVGSISANSDETVGKLIAQAMEKVGKEGVITVEEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELITTLEAV
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHH
AKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEVGMSLEQASLQDLGTAHKITVSKENTVIVDGAGDANAIAERVQQIRAQIEESTSEY
HHHHHCCCHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DKEKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAVNSLDGLTGANDDQTVGINILRRAIEAPLRQIVSNAGDEPSVVINAVKAGEGNYGYNA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ATGVYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTEAMITDIPEDKPAMPDMGGMGGM
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGMM
CCCC
>Mature Secondary Structure 
SAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCHHHHHH
TLKDKFENMGAQLVREVSSKTNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DIAVRAVVENIRATAKPADDFKAIEQVGSISANSDETVGKLIAQAMEKVGKEGVITVEEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELITTLEAV
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHH
AKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEVGMSLEQASLQDLGTAHKITVSKENTVIVDGAGDANAIAERVQQIRAQIEESTSEY
HHHHHCCCHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DKEKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAVNSLDGLTGANDDQTVGINILRRAIEAPLRQIVSNAGDEPSVVINAVKAGEGNYGYNA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ATGVYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTEAMITDIPEDKPAMPDMGGMGGM
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGMM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA