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The map label for this gene is cycA [H]

Identifier: 50085730

GI number: 50085730

Start: 2615880

End: 2617292

Strand: Reverse

Name: cycA [H]

Synonym: ACIAD2662

Alternate gene names: 50085730

Gene position: 2617292-2615880 (Counterclockwise)

Preceding gene: 50085733

Following gene: 50085729

Centisome position: 72.73

GC content: 40.84

Gene sequence:

>1413_bases
ATGTCAAATGAAATGCACGGTCAACCTTCTGGAGAAGGTGAGCTTTCGAGAAGCTTATCCAATCGACATTTGCAACTCAT
TGCAATTGGCGGCGCAATTGGTACAGGATTATTCATGGGTTCGGGTAAGACGATTAGTCTGGCTGGCCCATCTATTCTTT
TTATTTACCTGATTATTGGTGTTATGGTGTTTTTTGTCATGCGCGCGCTTGGCGAGTTACTCTTATCCAATCTTCAATAT
AAGTCATTTATTGATTTCTCGACTGATTTGATTGGACCTTGGGCAGGCTATTTTGTCGGCTGGACCTATTGGTTGTGTTG
GATCACGATTGGTATCGCAGACTTATCTGCCATTATTTATTATTTGCAATTTTTCAATAATGGTATGCCCTTTACACCAA
CTGAAGGGGCAATGATCAGTGTCGCTGCAATTTTCTTTATCATGGGGCTTAATCTCATGACGGTTAAATTGTTTGGCGAG
CTTGAATTCTGGTTTGCCATGATCAAGATTACTGCAATTGTGGTTTTGATTTTGGTAGGACTCTGGATGATCTTCACAGG
CTTTACCTCCACCAGTGGTGAAGTGGCTTCATTTACCCATTTGTGGGCCAATGGCGGGTTTTTCCCAACAGGCATGCATG
GCTTCCTGGCGGGCTTCCAGATTGCGATCTTTGCTTTCGTTGGTGTTGAGTTGGTTGGGACCACTGCTGCAGAAACCAAG
AACCCTGAAATTAACTTACCTAAAGCGGTGAACTCGATCCCAATTCGTATCATTATTTTCTATGTACTGGCACTACTTAT
TGTGATGTCGGTGACACCATGGAATCGGATTGATCCAAATATTAGCCCATTTGTAAATTTGTTTAGTCAGGCAGGTATTG
CTGCTGCTGCCATTATCATGAATTTGGTGGTACTTTCTTCAGTCATGTCATCTATGAACAGCGGTGTATTTTCAACCAGC
CGTATGTTGTTCGGTTTGTCTAAAGAGAAGCAAGCACCTCAAGCATTTGGTGCATTAAATAAAGGTCGCGTTCCTGCAAA
TGCGCTGTATTTTTCAACTGTATGTTTACTGCTAGGTGCGGCTTTACAATACGTTGTTCCAAATACGGTTGAAGCCTTTA
CACTGGCAACGACTTTATCAACGATTTTATTTATCTGCGTATGGCTCATGATTATTTGGAGCTATATGGTGTATTACAAA
AAACGTCCAGAGTTACATGCAAAATCAATCTTCAAATTACCAGGTGGTCTATTTACCTGCTGGATCCTGATTATCTTTTT
TGTAGGTATGATTTATGTTCTGTCATTGGAACCAGATACGATGAAAGCTTTGATGGTAAGTCCAATCTGGCTGGTTATTT
TAGTGATTGGTTACTTCGGTTTTTACAAACCAAGGTTAAAATCTAAGAAATAA

Upstream 100 bases:

>100_bases
TTATTTCCAAGAATATTGAATAAATGCCGAAATAATCTTTTTTATTTTGAGCATTTTGGGCTAATTTTGAAATACAAAAT
TTGAGAGTTGAAAAAAAACA

Downstream 100 bases:

>100_bases
TTGAAAAAACGCCAGTCGATGACTGGCGTTTTTTTTTAGATCATTCTAAGCTTTGTGGTTTTCCACTTTGGTCATTAATT
TGATCACGGTATAATCTGTC

Product: D-alanine/D-serine/glycine transport protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSNEMHGQPSGEGELSRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYLIIGVMVFFVMRALGELLLSNLQY
KSFIDFSTDLIGPWAGYFVGWTYWLCWITIGIADLSAIIYYLQFFNNGMPFTPTEGAMISVAAIFFIMGLNLMTVKLFGE
LEFWFAMIKITAIVVLILVGLWMIFTGFTSTSGEVASFTHLWANGGFFPTGMHGFLAGFQIAIFAFVGVELVGTTAAETK
NPEINLPKAVNSIPIRIIIFYVLALLIVMSVTPWNRIDPNISPFVNLFSQAGIAAAAIIMNLVVLSSVMSSMNSGVFSTS
RMLFGLSKEKQAPQAFGALNKGRVPANALYFSTVCLLLGAALQYVVPNTVEAFTLATTLSTILFICVWLMIIWSYMVYYK
KRPELHAKSIFKLPGGLFTCWILIIFFVGMIYVLSLEPDTMKALMVSPIWLVILVIGYFGFYKPRLKSKK

Sequences:

>Translated_470_residues
MSNEMHGQPSGEGELSRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYLIIGVMVFFVMRALGELLLSNLQY
KSFIDFSTDLIGPWAGYFVGWTYWLCWITIGIADLSAIIYYLQFFNNGMPFTPTEGAMISVAAIFFIMGLNLMTVKLFGE
LEFWFAMIKITAIVVLILVGLWMIFTGFTSTSGEVASFTHLWANGGFFPTGMHGFLAGFQIAIFAFVGVELVGTTAAETK
NPEINLPKAVNSIPIRIIIFYVLALLIVMSVTPWNRIDPNISPFVNLFSQAGIAAAAIIMNLVVLSSVMSSMNSGVFSTS
RMLFGLSKEKQAPQAFGALNKGRVPANALYFSTVCLLLGAALQYVVPNTVEAFTLATTLSTILFICVWLMIIWSYMVYYK
KRPELHAKSIFKLPGGLFTCWILIIFFVGMIYVLSLEPDTMKALMVSPIWLVILVIGYFGFYKPRLKSKK
>Mature_469_residues
SNEMHGQPSGEGELSRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYLIIGVMVFFVMRALGELLLSNLQYK
SFIDFSTDLIGPWAGYFVGWTYWLCWITIGIADLSAIIYYLQFFNNGMPFTPTEGAMISVAAIFFIMGLNLMTVKLFGEL
EFWFAMIKITAIVVLILVGLWMIFTGFTSTSGEVASFTHLWANGGFFPTGMHGFLAGFQIAIFAFVGVELVGTTAAETKN
PEINLPKAVNSIPIRIIIFYVLALLIVMSVTPWNRIDPNISPFVNLFSQAGIAAAAIIMNLVVLSSVMSSMNSGVFSTSR
MLFGLSKEKQAPQAFGALNKGRVPANALYFSTVCLLLGAALQYVVPNTVEAFTLATTLSTILFICVWLMIIWSYMVYYKK
RPELHAKSIFKLPGGLFTCWILIIFFVGMIYVLSLEPDTMKALMVSPIWLVILVIGYFGFYKPRLKSKK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=348, Percent_Identity=24.7126436781609, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI181337167, Length=347, Percent_Identity=21.9020172910663, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790653, Length=460, Percent_Identity=60.2173913043478, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1786302, Length=470, Percent_Identity=38.5106382978723, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1786789, Length=452, Percent_Identity=38.716814159292, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1786602, Length=459, Percent_Identity=38.1263616557734, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI48994972, Length=439, Percent_Identity=37.8132118451025, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI87081915, Length=454, Percent_Identity=35.9030837004405, Blast_Score=285, Evalue=7e-78,
Organism=Escherichia coli, GI1789017, Length=373, Percent_Identity=34.0482573726542, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1788480, Length=349, Percent_Identity=38.10888252149, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI87081708, Length=406, Percent_Identity=33.0049261083744, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17533459, Length=409, Percent_Identity=23.4718826405868, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17568033, Length=347, Percent_Identity=24.4956772334294, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=401, Percent_Identity=23.4413965087282, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=349, Percent_Identity=26.0744985673352, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=497, Percent_Identity=29.5774647887324, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324924, Length=460, Percent_Identity=30.8695652173913, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6320772, Length=374, Percent_Identity=32.8877005347594, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=456, Percent_Identity=28.7280701754386, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322892, Length=349, Percent_Identity=30.945558739255, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6324059, Length=423, Percent_Identity=29.3144208037825, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6321629, Length=434, Percent_Identity=28.5714285714286, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=452, Percent_Identity=26.9911504424779, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324553, Length=351, Percent_Identity=29.6296296296296, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6320717, Length=420, Percent_Identity=26.4285714285714, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319543, Length=456, Percent_Identity=24.1228070175439, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6321053, Length=434, Percent_Identity=26.9585253456221, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319824, Length=443, Percent_Identity=24.8306997742664, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319608, Length=434, Percent_Identity=26.9585253456221, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=479, Percent_Identity=29.0187891440501, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319542, Length=486, Percent_Identity=25.1028806584362, Blast_Score=116, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320251, Length=415, Percent_Identity=24.8192771084337, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6320364, Length=501, Percent_Identity=23.5528942115768, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24668806, Length=397, Percent_Identity=22.9219143576826, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356285, Length=397, Percent_Identity=22.9219143576826, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24668802, Length=397, Percent_Identity=22.9219143576826, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221512776, Length=337, Percent_Identity=21.9584569732938, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24666159, Length=337, Percent_Identity=21.9584569732938, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24667468, Length=441, Percent_Identity=20.8616780045351, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51799; Mature: 51667

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEMHGQPSGEGELSRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYLIIG
CCCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHHHH
VMVFFVMRALGELLLSNLQYKSFIDFSTDLIGPWAGYFVGWTYWLCWITIGIADLSAIIY
HHHHHHHHHHHHHHHHCCCHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLQFFNNGMPFTPTEGAMISVAAIFFIMGLNLMTVKLFGELEFWFAMIKITAIVVLILVG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWMIFTGFTSTSGEVASFTHLWANGGFFPTGMHGFLAGFQIAIFAFVGVELVGTTAAETK
HHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
NPEINLPKAVNSIPIRIIIFYVLALLIVMSVTPWNRIDPNISPFVNLFSQAGIAAAAIIM
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
NLVVLSSVMSSMNSGVFSTSRMLFGLSKEKQAPQAFGALNKGRVPANALYFSTVCLLLGA
HHHHHHHHHHHHCCCCHHHHHHHHCCCHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
ALQYVVPNTVEAFTLATTLSTILFICVWLMIIWSYMVYYKKRPELHAKSIFKLPGGLFTC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHH
WILIIFFVGMIYVLSLEPDTMKALMVSPIWLVILVIGYFGFYKPRLKSKK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SNEMHGQPSGEGELSRSLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILFIYLIIG
CCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHHHHHH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HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]