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The map label for this gene is nhaA [H]

Identifier: 50085707

GI number: 50085707

Start: 2590013

End: 2591029

Strand: Reverse

Name: nhaA [H]

Synonym: ACIAD2637

Alternate gene names: 50085707

Gene position: 2591029-2590013 (Counterclockwise)

Preceding gene: 50085709

Following gene: 50085706

Centisome position: 72.0

GC content: 40.71

Gene sequence:

>1017_bases
ATGTCAGATTGGCCACCTAAACCACAAAATGAAGTGCAAAATAGTAATAATAAAACTGGTCAGGAATGGCAGATTTTAGA
GAAAGCTGTTTTGGCCTCTGTCGAGGAACAACGTCGTACTAGACGTTGGGGAATTTTCTTCAAATTTTTGACCTTTCTTT
ATTTGTTATTCGTTTTTGTATTGTTGGGCCGTGGCTGTACAACGTCTGAAAGCTCTGGTGGTACATCAAGTTCAACCGCG
CATCTTGCTGTCGTTAATATTATTGGAACGATTGACTCGAGTAATCAGTCGGTCAATAGTGAAGACACCAACAAAGCACT
TGAACGAGCATTTGAAGCAAAAAATAGTAAAGCTGTCGCCTTGAATATTAATTCACCAGGTGGATCACCTGTTCAATCTG
ATGAAATCTGGCAAGAAATTCGTTATCTGAAAAAACAGCATCCAGACAAGAAAGTCTATGCTGTAATTGGTGATATGGGC
GCTTCAGGTGCGTACTATATTGCTTCTGCGGCTGATGAAATTATTGTCAATCCATCAAGTTTGGTGGGTTCTATTGGTGT
GATTATGCCGAATTATGGCATCACTGGATTGGCGCAAAAATTAGGAATTGAAGACCGTACACTGACTTCAGGCTCAAATA
AAGATATCTTGAGTATGACAAAACCGGTTAATCCTGCTCAACGTGAACACATTCAGTCTGTACTGGATAATGTGCATGCT
CATTTTATTAACGCGGTAAAAGAAGGGCGTGGTACACGTTTAAAATCGAACGACCCAGCTATTTTTTCAGGTTTATTCTG
GACAGGCGAGCAAGCCATCCAACTGGGTGTGGCTGACCGTACAGGTAATTTGGATACCTTGATGCGCGAGCTTAAAGTTG
AAAATAAAGTGAACTATACCATTGAGCGTAGCCCATTTGAGTCTATTTTAGGAAAAATGGGATCAGAGTTGGGGCAGGGG
ATCAGTCAGTCTGTTTCTCAACAATTAAAAACTGAACAACAGGCTAAATTACAGTAG

Upstream 100 bases:

>100_bases
ATCGGATAAAAATATTATAAGTTAAATTATAACGATTAAACAGTTTTTACCGATTCAGTGTATATAATGGCAGTGTTTTT
AACTTTTTGGGTTATTTTTT

Downstream 100 bases:

>100_bases
ATCTAAACGCTATGCAGAATAAACCGATCATTCATTTTGCGCATGCCAATGGTGTACCGTCCAAAGTATACCAAAAGCTC
TTTGATCAATTAAGCGATCA

Product: protease; signal peptide peptidase sppA

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSDWPPKPQNEVQNSNNKTGQEWQILEKAVLASVEEQRRTRRWGIFFKFLTFLYLLFVFVLLGRGCTTSESSGGTSSSTA
HLAVVNIIGTIDSSNQSVNSEDTNKALERAFEAKNSKAVALNINSPGGSPVQSDEIWQEIRYLKKQHPDKKVYAVIGDMG
ASGAYYIASAADEIIVNPSSLVGSIGVIMPNYGITGLAQKLGIEDRTLTSGSNKDILSMTKPVNPAQREHIQSVLDNVHA
HFINAVKEGRGTRLKSNDPAIFSGLFWTGEQAIQLGVADRTGNLDTLMRELKVENKVNYTIERSPFESILGKMGSELGQG
ISQSVSQQLKTEQQAKLQ

Sequences:

>Translated_338_residues
MSDWPPKPQNEVQNSNNKTGQEWQILEKAVLASVEEQRRTRRWGIFFKFLTFLYLLFVFVLLGRGCTTSESSGGTSSSTA
HLAVVNIIGTIDSSNQSVNSEDTNKALERAFEAKNSKAVALNINSPGGSPVQSDEIWQEIRYLKKQHPDKKVYAVIGDMG
ASGAYYIASAADEIIVNPSSLVGSIGVIMPNYGITGLAQKLGIEDRTLTSGSNKDILSMTKPVNPAQREHIQSVLDNVHA
HFINAVKEGRGTRLKSNDPAIFSGLFWTGEQAIQLGVADRTGNLDTLMRELKVENKVNYTIERSPFESILGKMGSELGQG
ISQSVSQQLKTEQQAKLQ
>Mature_337_residues
SDWPPKPQNEVQNSNNKTGQEWQILEKAVLASVEEQRRTRRWGIFFKFLTFLYLLFVFVLLGRGCTTSESSGGTSSSTAH
LAVVNIIGTIDSSNQSVNSEDTNKALERAFEAKNSKAVALNINSPGGSPVQSDEIWQEIRYLKKQHPDKKVYAVIGDMGA
SGAYYIASAADEIIVNPSSLVGSIGVIMPNYGITGLAQKLGIEDRTLTSGSNKDILSMTKPVNPAQREHIQSVLDNVHAH
FINAVKEGRGTRLKSNDPAIFSGLFWTGEQAIQLGVADRTGNLDTLMRELKVENKVNYTIERSPFESILGKMGSELGQGI
SQSVSQQLKTEQQAKLQ

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=227, Percent_Identity=28.6343612334802, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787527, Length=219, Percent_Identity=26.027397260274, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 37032; Mature: 36901

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDWPPKPQNEVQNSNNKTGQEWQILEKAVLASVEEQRRTRRWGIFFKFLTFLYLLFVFV
CCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGRGCTTSESSGGTSSSTAHLAVVNIIGTIDSSNQSVNSEDTNKALERAFEAKNSKAVA
HHCCCCCCCCCCCCCCCCCHHEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
LNINSPGGSPVQSDEIWQEIRYLKKQHPDKKVYAVIGDMGASGAYYIASAADEIIVNPSS
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCEEECCHH
LVGSIGVIMPNYGITGLAQKLGIEDRTLTSGSNKDILSMTKPVNPAQREHIQSVLDNVHA
HHHHHHHEECCCCHHHHHHHHCCCCCEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHH
HFINAVKEGRGTRLKSNDPAIFSGLFWTGEQAIQLGVADRTGNLDTLMRELKVENKVNYT
HHHHHHHHCCCCCCCCCCCCEEEHHEECCCHHHEEECCCCCCCHHHHHHHHHHHCCCCEE
IERSPFESILGKMGSELGQGISQSVSQQLKTEQQAKLQ
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDWPPKPQNEVQNSNNKTGQEWQILEKAVLASVEEQRRTRRWGIFFKFLTFLYLLFVFV
CCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGRGCTTSESSGGTSSSTAHLAVVNIIGTIDSSNQSVNSEDTNKALERAFEAKNSKAVA
HHCCCCCCCCCCCCCCCCCHHEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
LNINSPGGSPVQSDEIWQEIRYLKKQHPDKKVYAVIGDMGASGAYYIASAADEIIVNPSS
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCEEECCHH
LVGSIGVIMPNYGITGLAQKLGIEDRTLTSGSNKDILSMTKPVNPAQREHIQSVLDNVHA
HHHHHHHEECCCCHHHHHHHHCCCCCEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHH
HFINAVKEGRGTRLKSNDPAIFSGLFWTGEQAIQLGVADRTGNLDTLMRELKVENKVNYT
HHHHHHHHCCCCCCCCCCCCEEEHHEECCCHHHEEECCCCCCCHHHHHHHHHHHCCCCEE
IERSPFESILGKMGSELGQGISQSVSQQLKTEQQAKLQ
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA