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The map label for this gene is rnc

Identifier: 50085655

GI number: 50085655

Start: 2538979

End: 2539671

Strand: Reverse

Name: rnc

Synonym: ACIAD2581

Alternate gene names: 50085655

Gene position: 2539671-2538979 (Counterclockwise)

Preceding gene: 50085656

Following gene: 50085654

Centisome position: 70.57

GC content: 40.69

Gene sequence:

>693_bases
TTGATCAAAACTCAGTCCAAGCTCAGTGATCCTCGATTACAGAGTCGGATCGGTTATGAGTTTAAGCAGTTGGAACTACT
TCAACTCGCGTTGACTCACCGGTCTGTTAGCCATAAATACAATTATGAGCGCCTAGAGTTTCTGGGCGATTCATTGTTGG
GGATGATTATTGCCAATTATCTCTATCAAGCCTATCCGCATGAAAATGAAGGCCGTTTGACGCGTATGAGAGCGACTCTC
GTTCGTCAGGAGGCACTTGGTAAGATTGCAAATGATTTGAAACTTAGTCGCTGTTTAATATTAAGCACGGGTGAATTAAA
ATCAGGGGGACATCATCGTGAGTCGATTCTTGCCGATACGGTCGAAGCGATTATTGGTGCGATTTATGTCGATAGTAATG
ATTTGAATTTATTAAAAAATATTGTACTAAAATGGTATATACCATATTTAGATCATATTGAACCAACGGATCAGTTAAAA
GATCCAAAATCACGCTTACAAGAGTATTTACAAGCACGTAAAAAACCTCTCCCTGTTTACGAGGTTGTAGATATTCAAGG
TGATGCACCAAACCAGCACTTTAAAGTGGTATGCTTAGTTGAAGGATTACCACGTGTGATGGGTGAGGGCTCAAGTCGTC
GTTTTGCAGAGCAAACAGCAGCGGCGGAAATTTTAAAGTTATTGGAGCAGTAA

Upstream 100 bases:

>100_bases
GTTACCATTAACAAAGGTGGTTTACATATCGTAAAACAGTATGAAGTGAGGAAGTCTTTCTTGCTGAATATTGATTTAGT
GTTAAAGTTTGAGAAAAGTT

Downstream 100 bases:

>100_bases
GTTGCATGTCGATGCATTCTGATCAAGTCAATCCAGATTCTCATGAGAACAATGACGAAACTCAATCACCAAATATGATT
GATCAATTTTTTAGCGCTGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MIKTQSKLSDPRLQSRIGYEFKQLELLQLALTHRSVSHKYNYERLEFLGDSLLGMIIANYLYQAYPHENEGRLTRMRATL
VRQEALGKIANDLKLSRCLILSTGELKSGGHHRESILADTVEAIIGAIYVDSNDLNLLKNIVLKWYIPYLDHIEPTDQLK
DPKSRLQEYLQARKKPLPVYEVVDIQGDAPNQHFKVVCLVEGLPRVMGEGSSRRFAEQTAAAEILKLLEQ

Sequences:

>Translated_230_residues
MIKTQSKLSDPRLQSRIGYEFKQLELLQLALTHRSVSHKYNYERLEFLGDSLLGMIIANYLYQAYPHENEGRLTRMRATL
VRQEALGKIANDLKLSRCLILSTGELKSGGHHRESILADTVEAIIGAIYVDSNDLNLLKNIVLKWYIPYLDHIEPTDQLK
DPKSRLQEYLQARKKPLPVYEVVDIQGDAPNQHFKVVCLVEGLPRVMGEGSSRRFAEQTAAAEILKLLEQ
>Mature_230_residues
MIKTQSKLSDPRLQSRIGYEFKQLELLQLALTHRSVSHKYNYERLEFLGDSLLGMIIANYLYQAYPHENEGRLTRMRATL
VRQEALGKIANDLKLSRCLILSTGELKSGGHHRESILADTVEAIIGAIYVDSNDLNLLKNIVLKWYIPYLDHIEPTDQLK
DPKSRLQEYLQARKKPLPVYEVVDIQGDAPNQHFKVVCLVEGLPRVMGEGSSRRFAEQTAAAEILKLLEQ

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=223, Percent_Identity=28.2511210762332, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI155030234, Length=223, Percent_Identity=28.2511210762332, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788920, Length=219, Percent_Identity=56.62100456621, Blast_Score=227, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17506883, Length=203, Percent_Identity=31.5270935960591, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193202651, Length=203, Percent_Identity=31.5270935960591, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17137682, Length=227, Percent_Identity=29.0748898678414, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_ACIAD (Q6F9C2)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047165.1
- ProteinModelPortal:   Q6F9C2
- SMR:   Q6F9C2
- STRING:   Q6F9C2
- GeneID:   2879534
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2581
- NMPDR:   fig|62977.3.peg.2358
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q6F9C2
- ProtClustDB:   PRK00102
- BioCyc:   ASP62977:ACIAD2581-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26271; Mature: 26271

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTQSKLSDPRLQSRIGYEFKQLELLQLALTHRSVSHKYNYERLEFLGDSLLGMIIANY
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LYQAYPHENEGRLTRMRATLVRQEALGKIANDLKLSRCLILSTGELKSGGHHRESILADT
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHH
VEAIIGAIYVDSNDLNLLKNIVLKWYIPYLDHIEPTDQLKDPKSRLQEYLQARKKPLPVY
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCCCEE
EVVDIQGDAPNQHFKVVCLVEGLPRVMGEGSSRRFAEQTAAAEILKLLEQ
EEEECCCCCCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKTQSKLSDPRLQSRIGYEFKQLELLQLALTHRSVSHKYNYERLEFLGDSLLGMIIANY
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LYQAYPHENEGRLTRMRATLVRQEALGKIANDLKLSRCLILSTGELKSGGHHRESILADT
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHH
VEAIIGAIYVDSNDLNLLKNIVLKWYIPYLDHIEPTDQLKDPKSRLQEYLQARKKPLPVY
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCCCEE
EVVDIQGDAPNQHFKVVCLVEGLPRVMGEGSSRRFAEQTAAAEILKLLEQ
EEEECCCCCCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA