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The map label for this gene is era [H]

Identifier: 50085654

GI number: 50085654

Start: 2537936

End: 2538973

Strand: Reverse

Name: era [H]

Synonym: ACIAD2580

Alternate gene names: 50085654

Gene position: 2538973-2537936 (Counterclockwise)

Preceding gene: 50085655

Following gene: 50085653

Centisome position: 70.55

GC content: 40.94

Gene sequence:

>1038_bases
ATGTCGATGCATTCTGATCAAGTCAATCCAGATTCTCATGAGAACAATGACGAAACTCAATCACCAAATATGATTGATCA
ATTTTTTAGCGCTGCCGGAACGGAAATTCCTTCCGACTTCAGAAGTGGTTTTGTCGCTATTGTCGGACGTCCAAATGTTG
GAAAGTCTACATTGATGAACCACTTGCTTGGACAAAAACTATCCATTACTTCACGTAAGCCGCAAACGACACGTCACAAG
ATTGTAGGTATTGATTCTCGTGAAAAGTCTCAGGCAGTATATGTAGATACGCCAGGGATGCACAAAAAAGAAGTGCGTGC
GATCAACAAAATGATGAATCGTGCTGCACATTCTGCACTTCGTGACGTCAATCTAGTGTTATTTGTGGTCGATATTCATA
AGTGGACACAGAATGATGATTTGGTACTAGAAAAACTGAAAAATGCAGAAATGCCAGTGATTCTTGTGATTAATAAAGTC
GATACGCTTGAAGATAAAAAGAGCTTGTTACCTCTCATTCAAGAGCGTACCAAGCTCATGAATTTTGCAGAAATTATTCC
AGTTTCGGCCTTGCGCGGTGCCAATCTTGATCAATTGCGCGATACTGTAGAAAAATATTTGCCATTTCAGCCACCATTAT
ATTCACTTGATCAAATTACAGATCGTTCAGAGCGTTTTCTTGCCAGCGAAATTATTCGTGAAAAAATCATGCGACAGCTT
GGTGAAGAACTCCCTTATGATTTGACAGTACAAATTGAATCATTTAAGACAGAAGAACCGACCGTCAGTGAAAAGACAGG
GCGCTTAAAACCTGCCTGTACTTATATTGATGCGACGATTTTTGTTGAACGTGCAGGTCAGAAGGCCATTGTGATTGGTG
AAAAGGGCGCGAAATTGAAGCGGATTGGAATGGAAGCGCGTACAGACATGGAAAAAATGTTTGAACAAAAGATCATGCTC
ACGCTTTGGGTGAAAGTCAAAGGTGGTTGGTCTGACGATGAGCGTGCGCTTAAGAGTCTTGGTTATAGCGACATTTAA

Upstream 100 bases:

>100_bases
TTGAAGGATTACCACGTGTGATGGGTGAGGGCTCAAGTCGTCGTTTTGCAGAGCAAACAGCAGCGGCGGAAATTTTAAAG
TTATTGGAGCAGTAAGTTGC

Downstream 100 bases:

>100_bases
AGAGAACACAAGATGACAGTCATGATTCGTTGTATTGCAATACTTGGTTGTGTTTTACTCTTACAAGGATGTATTACCAA
AATCGTGACTGTTCCAGTCA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSMHSDQVNPDSHENNDETQSPNMIDQFFSAAGTEIPSDFRSGFVAIVGRPNVGKSTLMNHLLGQKLSITSRKPQTTRHK
IVGIDSREKSQAVYVDTPGMHKKEVRAINKMMNRAAHSALRDVNLVLFVVDIHKWTQNDDLVLEKLKNAEMPVILVINKV
DTLEDKKSLLPLIQERTKLMNFAEIIPVSALRGANLDQLRDTVEKYLPFQPPLYSLDQITDRSERFLASEIIREKIMRQL
GEELPYDLTVQIESFKTEEPTVSEKTGRLKPACTYIDATIFVERAGQKAIVIGEKGAKLKRIGMEARTDMEKMFEQKIML
TLWVKVKGGWSDDERALKSLGYSDI

Sequences:

>Translated_345_residues
MSMHSDQVNPDSHENNDETQSPNMIDQFFSAAGTEIPSDFRSGFVAIVGRPNVGKSTLMNHLLGQKLSITSRKPQTTRHK
IVGIDSREKSQAVYVDTPGMHKKEVRAINKMMNRAAHSALRDVNLVLFVVDIHKWTQNDDLVLEKLKNAEMPVILVINKV
DTLEDKKSLLPLIQERTKLMNFAEIIPVSALRGANLDQLRDTVEKYLPFQPPLYSLDQITDRSERFLASEIIREKIMRQL
GEELPYDLTVQIESFKTEEPTVSEKTGRLKPACTYIDATIFVERAGQKAIVIGEKGAKLKRIGMEARTDMEKMFEQKIML
TLWVKVKGGWSDDERALKSLGYSDI
>Mature_344_residues
SMHSDQVNPDSHENNDETQSPNMIDQFFSAAGTEIPSDFRSGFVAIVGRPNVGKSTLMNHLLGQKLSITSRKPQTTRHKI
VGIDSREKSQAVYVDTPGMHKKEVRAINKMMNRAAHSALRDVNLVLFVVDIHKWTQNDDLVLEKLKNAEMPVILVINKVD
TLEDKKSLLPLIQERTKLMNFAEIIPVSALRGANLDQLRDTVEKYLPFQPPLYSLDQITDRSERFLASEIIREKIMRQLG
EELPYDLTVQIESFKTEEPTVSEKTGRLKPACTYIDATIFVERAGQKAIVIGEKGAKLKRIGMEARTDMEKMFEQKIMLT
LWVKVKGGWSDDERALKSLGYSDI

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=348, Percent_Identity=25.8620689655172, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1788919, Length=303, Percent_Identity=57.4257425742574, Blast_Score=346, Evalue=1e-96,
Organism=Escherichia coli, GI87082120, Length=166, Percent_Identity=33.7349397590361, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646434, Length=323, Percent_Identity=28.1733746130031, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 39142; Mature: 39010

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMHSDQVNPDSHENNDETQSPNMIDQFFSAAGTEIPSDFRSGFVAIVGRPNVGKSTLMN
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCEEEEEECCCCCHHHHHH
HLLGQKLSITSRKPQTTRHKIVGIDSREKSQAVYVDTPGMHKKEVRAINKMMNRAAHSAL
HHHCCCEECCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
RDVNLVLFVVDIHKWTQNDDLVLEKLKNAEMPVILVINKVDTLEDKKSLLPLIQERTKLM
HHCEEEEEEEEHHHCCCCCHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
NFAEIIPVSALRGANLDQLRDTVEKYLPFQPPLYSLDQITDRSERFLASEIIREKIMRQL
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHH
GEELPYDLTVQIESFKTEEPTVSEKTGRLKPACTYIDATIFVERAGQKAIVIGEKGAKLK
HHHCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCEEEEECCCCCHHH
RIGMEARTDMEKMFEQKIMLTLWVKVKGGWSDDERALKSLGYSDI
HHCCHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
SMHSDQVNPDSHENNDETQSPNMIDQFFSAAGTEIPSDFRSGFVAIVGRPNVGKSTLMN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHCCCEEEEEECCCCCHHHHHH
HLLGQKLSITSRKPQTTRHKIVGIDSREKSQAVYVDTPGMHKKEVRAINKMMNRAAHSAL
HHHCCCEECCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
RDVNLVLFVVDIHKWTQNDDLVLEKLKNAEMPVILVINKVDTLEDKKSLLPLIQERTKLM
HHCEEEEEEEEHHHCCCCCHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
NFAEIIPVSALRGANLDQLRDTVEKYLPFQPPLYSLDQITDRSERFLASEIIREKIMRQL
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHH
GEELPYDLTVQIESFKTEEPTVSEKTGRLKPACTYIDATIFVERAGQKAIVIGEKGAKLK
HHHCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCEEEEECCCCCHHH
RIGMEARTDMEKMFEQKIMLTLWVKVKGGWSDDERALKSLGYSDI
HHCCHHHHHHHHHHHHHEEEEEEEEEECCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA