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The map label for this gene is obgE [H]

Identifier: 50085638

GI number: 50085638

Start: 2520898

End: 2522100

Strand: Reverse

Name: obgE [H]

Synonym: ACIAD2561

Alternate gene names: 50085638

Gene position: 2522100-2520898 (Counterclockwise)

Preceding gene: 50085639

Following gene: 50085637

Centisome position: 70.09

GC content: 46.8

Gene sequence:

>1203_bases
ATGCGCTTTGTTGATGAAGCAGTCATTACCGTAGAGGCTGGCGACGGTGGCAATGGCGTGGCCAGTTTTCGCCGTGAAAA
ATTTGTACCATTTGGTGGTCCAGATGGTGGAGATGGTGGGCGTGGCGGCAGTGTCTATATTCAGGCAGATGATGACACTG
GGACGCTGGTTGACTATCGTTATACCCGTAAATTCCGTGCTGAACGTGGTAAAAATGGCGCAGGCGCAAACTGTACAGGC
CGCGGTGGCGAAGATGTTGTACTTAAAGTACCTGTAGGCACAACCATTGTCGATGTAGAGTCAGGCGATATTATTGGTGA
CTTGGTTGAAGATGGCCAGCGTGTCATGGTTGCCACTGGCGGTGATGGTGGCTTGGGAAATACGCACTTTAAATCATCGA
CCAACCGTTCTCCACGTAAGTTTACAACGGGTGTCAAAGGCGAATTCCGCGAGATTCGTTTAGAGCTTAAAGTACTTGCA
GATGTGGGGCTATTGGGAATGCCGAATGCAGGTAAATCGACCTTCATTCGTGCAGTCAGCGCAGCAAAACCAAAAGTTGC
AGATTATCCGTTTACAACGATGGTTCCAAATTTAGGCGTTGTAGATGCAGACCGTCATCGTTCGTTTGTCATGGCGGATA
TTCCTGGTCTGATTGAAGGTGCAGCAGAAGGTGCTGGACTGGGGATTCGTTTCCTTAAGCACTTGGCACGTACCCGTATT
TTGCTGCACATTGTAGATGTTCAGCCAATTGATGGTTCTGACCCAGTACATAATGCTAAAGCGATTGTAGGTGAGTTGAA
AAAATTCTCTCCAACACTTGCAGAACTTCCAGTGGTACTTGTACTGAACAAGCTTGATCAGATTGATGAAGCAAATCGTG
AAGAATGGTGTCAACACATTCTGACTGAGCTTGAGTGGACTGGTCCAGTGTTCCGTACTTCTGGCTTATTGCTTGAAGGA
ACCAAAGAGGTTGTCTATTACCTCATGGATCAGATTGAACAACAGCGTGAGCTTGAAGCTGAAGATCCTGAATATGCACG
AAAAGTGAAAGCATTCCGTGAGCAGCTTGAAGCAGAAACACGTGAACAAACCATCGCAGCAAAAGAAGCATACCGAGCTA
TGCGTAAAGCACAGCGTGAAGCAGATCAGGATGATGATTTTGACGATGATGATGACGAAGTGGAAGTAATTTACGTTCGT
TAA

Upstream 100 bases:

>100_bases
GCATTGCAGCAGTCACTGATAAATAGTCTGATTTTCTATTCGAGAAATCTATTAAAATATGGCAGAATAGGCGGTTTTAG
AGATTTTAGAGGATTGGCAA

Downstream 100 bases:

>100_bases
GTAGAACTCGAGGAAAAAATGATAGAAGTGATCGATGGGCAACGACAGCTCAAGGCGTGCAAACGTATCGTTGTTAAAAT
CGGATCATCTCTACTGACAG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MRFVDEAVITVEAGDGGNGVASFRREKFVPFGGPDGGDGGRGGSVYIQADDDTGTLVDYRYTRKFRAERGKNGAGANCTG
RGGEDVVLKVPVGTTIVDVESGDIIGDLVEDGQRVMVATGGDGGLGNTHFKSSTNRSPRKFTTGVKGEFREIRLELKVLA
DVGLLGMPNAGKSTFIRAVSAAKPKVADYPFTTMVPNLGVVDADRHRSFVMADIPGLIEGAAEGAGLGIRFLKHLARTRI
LLHIVDVQPIDGSDPVHNAKAIVGELKKFSPTLAELPVVLVLNKLDQIDEANREEWCQHILTELEWTGPVFRTSGLLLEG
TKEVVYYLMDQIEQQRELEAEDPEYARKVKAFREQLEAETREQTIAAKEAYRAMRKAQREADQDDDFDDDDDEVEVIYVR

Sequences:

>Translated_400_residues
MRFVDEAVITVEAGDGGNGVASFRREKFVPFGGPDGGDGGRGGSVYIQADDDTGTLVDYRYTRKFRAERGKNGAGANCTG
RGGEDVVLKVPVGTTIVDVESGDIIGDLVEDGQRVMVATGGDGGLGNTHFKSSTNRSPRKFTTGVKGEFREIRLELKVLA
DVGLLGMPNAGKSTFIRAVSAAKPKVADYPFTTMVPNLGVVDADRHRSFVMADIPGLIEGAAEGAGLGIRFLKHLARTRI
LLHIVDVQPIDGSDPVHNAKAIVGELKKFSPTLAELPVVLVLNKLDQIDEANREEWCQHILTELEWTGPVFRTSGLLLEG
TKEVVYYLMDQIEQQRELEAEDPEYARKVKAFREQLEAETREQTIAAKEAYRAMRKAQREADQDDDFDDDDDEVEVIYVR
>Mature_400_residues
MRFVDEAVITVEAGDGGNGVASFRREKFVPFGGPDGGDGGRGGSVYIQADDDTGTLVDYRYTRKFRAERGKNGAGANCTG
RGGEDVVLKVPVGTTIVDVESGDIIGDLVEDGQRVMVATGGDGGLGNTHFKSSTNRSPRKFTTGVKGEFREIRLELKVLA
DVGLLGMPNAGKSTFIRAVSAAKPKVADYPFTTMVPNLGVVDADRHRSFVMADIPGLIEGAAEGAGLGIRFLKHLARTRI
LLHIVDVQPIDGSDPVHNAKAIVGELKKFSPTLAELPVVLVLNKLDQIDEANREEWCQHILTELEWTGPVFRTSGLLLEG
TKEVVYYLMDQIEQQRELEAEDPEYARKVKAFREQLEAETREQTIAAKEAYRAMRKAQREADQDDDFDDDDDEVEVIYVR

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=304, Percent_Identity=39.8026315789474, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI111955139, Length=241, Percent_Identity=41.0788381742739, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI111955063, Length=133, Percent_Identity=39.8496240601504, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1789574, Length=362, Percent_Identity=57.7348066298343, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1787454, Length=100, Percent_Identity=35, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=332, Percent_Identity=37.6506024096386, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17552324, Length=306, Percent_Identity=30.718954248366, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17509631, Length=128, Percent_Identity=35.15625, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=179, Percent_Identity=34.0782122905028, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319281, Length=128, Percent_Identity=33.59375, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129375, Length=299, Percent_Identity=40.4682274247492, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24585318, Length=293, Percent_Identity=38.5665529010239, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24640873, Length=129, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24640877, Length=129, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24640875, Length=129, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 43801; Mature: 43801

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVDEAVITVEAGDGGNGVASFRREKFVPFGGPDGGDGGRGGSVYIQADDDTGTLVDYR
CCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEHH
YTRKFRAERGKNGAGANCTGRGGEDVVLKVPVGTTIVDVESGDIIGDLVEDGQRVMVATG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHCCCCEEEEEEC
GDGGLGNTHFKSSTNRSPRKFTTGVKGEFREIRLELKVLADVGLLGMPNAGKSTFIRAVS
CCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTMVPNLGVVDADRHRSFVMADIPGLIEGAAEGAGLGIRFLKHLARTRI
HCCCCCCCCCHHHHCCCCCCEECCCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHHEE
LLHIVDVQPIDGSDPVHNAKAIVGELKKFSPTLAELPVVLVLNKLDQIDEANREEWCQHI
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHH
LTELEWTGPVFRTSGLLLEGTKEVVYYLMDQIEQQRELEAEDPEYARKVKAFREQLEAET
HHHHCCCCCEEECCCEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
REQTIAAKEAYRAMRKAQREADQDDDFDDDDDEVEVIYVR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MRFVDEAVITVEAGDGGNGVASFRREKFVPFGGPDGGDGGRGGSVYIQADDDTGTLVDYR
CCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEHH
YTRKFRAERGKNGAGANCTGRGGEDVVLKVPVGTTIVDVESGDIIGDLVEDGQRVMVATG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHCCCCEEEEEEC
GDGGLGNTHFKSSTNRSPRKFTTGVKGEFREIRLELKVLADVGLLGMPNAGKSTFIRAVS
CCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTMVPNLGVVDADRHRSFVMADIPGLIEGAAEGAGLGIRFLKHLARTRI
HCCCCCCCCCHHHHCCCCCCEECCCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHHEE
LLHIVDVQPIDGSDPVHNAKAIVGELKKFSPTLAELPVVLVLNKLDQIDEANREEWCQHI
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHH
LTELEWTGPVFRTSGLLLEGTKEVVYYLMDQIEQQRELEAEDPEYARKVKAFREQLEAET
HHHHCCCCCEEECCCEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
REQTIAAKEAYRAMRKAQREADQDDDFDDDDDEVEVIYVR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA