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The map label for this gene is fabG [H]

Identifier: 50085501

GI number: 50085501

Start: 2380001

End: 2380771

Strand: Reverse

Name: fabG [H]

Synonym: ACIAD2416

Alternate gene names: 50085501

Gene position: 2380771-2380001 (Counterclockwise)

Preceding gene: 50085502

Following gene: 50085499

Centisome position: 66.16

GC content: 40.21

Gene sequence:

>771_bases
ATGAAGATTCAGGGAAAACATTTTGTTATTACAGGTGGGGCATCAGGGTTAGGTGCTGCTGTTGCTGAGTATTTGATTAA
ACAGGGTGCAGAAATTAGCCTCATTGATATGAATATAGAAGCAGGCCATGCATTAGTTAAGCTATTAGGAGTAAAAGCGC
AATTTTTTCAACTAGATGTCACCAGTGAAACTCAAGTCGAGCAGTTTTTTATTCAAATGCGAGATCAGGCGATTGAATTG
CAAGGATTAATCAATTGTGCAGGTATAGGGCCCTCTGCAAAAGTTGTAGGAAAAGAAGGCCTACATGATTTGGCACTATT
TAATAAAGTATTAAATATTAATGTTACTGGTTCTTTTAATATGCTGCGTTTTGCTGCCCAAGCCATGAGTACTAATAAAC
TAGATCCGCAAGAAGAAGACCGTGGCGTTATCATTAATACTGCTTCAGTTGCTGCTTTTGATGGTCAAATAGGTCAAGCG
GCTTATGCTGCATCAAAAGGTGCAGTTGTTGCAATGACTTTACCAATTGCACGTGAGTTGGGACGCCATGCGATTCGAGT
CATGACCATCGCACCAGGCATTATGGAAACACCAATGTTAAAAGCTATGCCACAAAATGTACAAGATGCGTTGGGACAAA
TGGTGCCTTATCCTTCACGTTTAGGAAAACCGCAGGAGTTTGCGGCATTGGTCGCACATATTATTGAAAACTCTTATTTA
AATGGAGAAGTGATTCGATTGGATGGTGCAATTCGTATGGCACCAAAATAA

Upstream 100 bases:

>100_bases
CAAAAACTGCAATTGATTTGAGGTTTTTTGAAATTGTATTGAAAAAGAAGAACTTTTACTCTGGTGCAAGAGCGAAATAA
AAATCAATCAGGAAATATGT

Downstream 100 bases:

>100_bases
TGAAAAAGATGATATTTCGATATGCCAAATATTTTATGGGATTTGGCATATGCAGAAATGAATACATATTAGAATATTTT
AAAATATGAAACCCAAAAAT

Product: oxidoreductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MKIQGKHFVITGGASGLGAAVAEYLIKQGAEISLIDMNIEAGHALVKLLGVKAQFFQLDVTSETQVEQFFIQMRDQAIEL
QGLINCAGIGPSAKVVGKEGLHDLALFNKVLNINVTGSFNMLRFAAQAMSTNKLDPQEEDRGVIINTASVAAFDGQIGQA
AYAASKGAVVAMTLPIARELGRHAIRVMTIAPGIMETPMLKAMPQNVQDALGQMVPYPSRLGKPQEFAALVAHIIENSYL
NGEVIRLDGAIRMAPK

Sequences:

>Translated_256_residues
MKIQGKHFVITGGASGLGAAVAEYLIKQGAEISLIDMNIEAGHALVKLLGVKAQFFQLDVTSETQVEQFFIQMRDQAIEL
QGLINCAGIGPSAKVVGKEGLHDLALFNKVLNINVTGSFNMLRFAAQAMSTNKLDPQEEDRGVIINTASVAAFDGQIGQA
AYAASKGAVVAMTLPIARELGRHAIRVMTIAPGIMETPMLKAMPQNVQDALGQMVPYPSRLGKPQEFAALVAHIIENSYL
NGEVIRLDGAIRMAPK
>Mature_256_residues
MKIQGKHFVITGGASGLGAAVAEYLIKQGAEISLIDMNIEAGHALVKLLGVKAQFFQLDVTSETQVEQFFIQMRDQAIEL
QGLINCAGIGPSAKVVGKEGLHDLALFNKVLNINVTGSFNMLRFAAQAMSTNKLDPQEEDRGVIINTASVAAFDGQIGQA
AYAASKGAVVAMTLPIARELGRHAIRVMTIAPGIMETPMLKAMPQNVQDALGQMVPYPSRLGKPQEFAALVAHIIENSYL
NGEVIRLDGAIRMAPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=52.34375, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI83715985, Length=257, Percent_Identity=49.8054474708171, Blast_Score=220, Evalue=9e-58,
Organism=Homo sapiens, GI15277342, Length=261, Percent_Identity=32.183908045977, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=29.0983606557377, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI31542939, Length=262, Percent_Identity=27.4809160305344, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=26.8, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI66933014, Length=256, Percent_Identity=26.5625, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=27.734375, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI59889578, Length=210, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4503817, Length=212, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI32483357, Length=257, Percent_Identity=26.0700389105058, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI224922801, Length=178, Percent_Identity=29.7752808988764, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=28.6274509803922, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=29.9610894941634, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790717, Length=264, Percent_Identity=29.9242424242424, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=31.6, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=25.7692307692308, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=27.6923076923077, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=27.9527559055118, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787905, Length=260, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786812, Length=268, Percent_Identity=26.1194029850746, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=26.6409266409266, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=247, Percent_Identity=47.7732793522267, Blast_Score=227, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17555706, Length=256, Percent_Identity=31.640625, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=29.0196078431373, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=266, Percent_Identity=26.6917293233083, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=207, Percent_Identity=27.0531400966184, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=24.7058823529412, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=275, Percent_Identity=25.0909090909091, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=206, Percent_Identity=30.0970873786408, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=270, Percent_Identity=24.8148148148148, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737361, Length=249, Percent_Identity=51.8072289156626, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=31.9066147859922, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=25.2, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356301, Length=204, Percent_Identity=29.9019607843137, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI23397609, Length=262, Percent_Identity=27.8625954198473, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24643142, Length=262, Percent_Identity=26.3358778625954, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=26.4150943396226, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 27368; Mature: 27368

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIQGKHFVITGGASGLGAAVAEYLIKQGAEISLIDMNIEAGHALVKLLGVKAQFFQLDV
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCEEEEEEEC
TSETQVEQFFIQMRDQAIELQGLINCAGIGPSAKVVGKEGLHDLALFNKVLNINVTGSFN
CCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEECCCCCHHHHHHHHHHEEEEECCCHH
MLRFAAQAMSTNKLDPQEEDRGVIINTASVAAFDGQIGQAAYAASKGAVVAMTLPIAREL
HHHHHHHHHHCCCCCCCCCCCCEEEEECEEEEECCCCCHHHHHCCCCCEEEEEHHHHHHH
GRHAIRVMTIAPGIMETPMLKAMPQNVQDALGQMVPYPSRLGKPQEFAALVAHIIENSYL
HHHHEEEEEECCCHHCCCHHHHCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHCCCC
NGEVIRLDGAIRMAPK
CCEEEEECCEEEECCC
>Mature Secondary Structure
MKIQGKHFVITGGASGLGAAVAEYLIKQGAEISLIDMNIEAGHALVKLLGVKAQFFQLDV
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCEEEEEEEC
TSETQVEQFFIQMRDQAIELQGLINCAGIGPSAKVVGKEGLHDLALFNKVLNINVTGSFN
CCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEECCCCCHHHHHHHHHHEEEEECCCHH
MLRFAAQAMSTNKLDPQEEDRGVIINTASVAAFDGQIGQAAYAASKGAVVAMTLPIAREL
HHHHHHHHHHCCCCCCCCCCCCEEEEECEEEEECCCCCHHHHHCCCCCEEEEEHHHHHHH
GRHAIRVMTIAPGIMETPMLKAMPQNVQDALGQMVPYPSRLGKPQEFAALVAHIIENSYL
HHHHEEEEEECCCHHCCCHHHHCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHCCCC
NGEVIRLDGAIRMAPK
CCEEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]