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The map label for this gene is mutL [H]

Identifier: 50085465

GI number: 50085465

Start: 2334119

End: 2336080

Strand: Reverse

Name: mutL [H]

Synonym: ACIAD2375

Alternate gene names: 50085465

Gene position: 2336080-2334119 (Counterclockwise)

Preceding gene: 50085466

Following gene: 50085464

Centisome position: 64.92

GC content: 42.2

Gene sequence:

>1962_bases
ATGCATAATGATGCCGTTCAGATTCATCGAATTCATACCCTCGATCCCGCACTTGCAAACCAGATTGCAGCTGGTGAGGT
AATTGAGCGCCCAGCATCTGTTGTTAAAGAGCTATTAGAAAATGCAATTGATGCAGGTGCAACTGAACTAATTATACGGG
TTGCACAAGGTGGTTCGACGCTGATCGAAATTATTGATAATGGTTTGGGTATTCATCCTGATGATTTACCTTTGGCCGTG
ATGCGTCATGCAACCAGCAAAATTAAAACTCCTGAAGATCTGCATGCCATTGTGAGTCTAGGATTTCGTGGTGAGGCTTT
AGCATCCATTGCGGCAGTCTCACGGCTATCCTTAATGAGTAGTCAAACAGATGATGGCGTTGGTTATCAGGTTGAAGTGA
ATGGAACGGCATTTGATCACCAGGAAATCCAGGCAATTGCACTTCGAAAGGGTACACACATCCGTGTTCAGGATTTATTT
TTTAATGTACCCGCACGCCGTAAATTTTTAAAAAAACCATCAACCGAATTTGGACATATTGAAGAAATTGTAAGACGTTT
GGCACTGACACATTTTGAGATTCGTTTTGTACTTGAGCATAACGATCAAATTAAACTGAATCTTCCTATAGCAGACAGTG
GCGTTTTGCGGTTCCAACGTGTCCAGCAATTACTCGGACAACAGTTTACCCAGAATGCATATTGGCTGGATACAGAAAGT
ATTTCAATGCGCTTATCTGGTTGGTTAGGACATCCTTCTGATGCACGTTCACAGGCAGATTTGCAATATGTTTATGTGAA
TGGTCGTATTGTCAAAGATAAAACAATCTCTCATGCCTTACGTATGGCTTATGATGGAATTCTGCATGGACATCAATATT
CGGCTTACCTACTGTTTCTCGAAGTCGATCCAGACCAGGTCGATGTCAATGTTCATCCAACCAAACATGAAATCCGTTTT
TTGAATCAGCGCGAAGTACATGAGTTTGTAAGGCATCATGCCAAGGAAACATTGGCACAATTTCAAACGGCAAGTGCAGA
TCTGGCTCAAGCCATGAAAAGCAATGAACCCAAAGATATTCTACGCGATCAACCGAAGCACCAAGAGCAGTTTTCGTTGC
ATCGTACAGATGCAACAGAAAATCCAGTAGTGAACAGGGCAGAAGACACGCAGATAGAATATCGAAAAGAACTGTCGACG
GATTTACTCACCGAGTTCAACGCCAGCCGCCCCAAAACGGTTGAGTATTCTACACGTATGCCAGTGCGTGATCCTGTACA
GCTCAATAATGCATTAAAAACCTATTTAGCACCGTTAAGAGAAGAATCTGGATCGGCGATTACAGCATCATCGGATGTTG
TTTCTGGAGTCGACGAGTTTCCTCTTGGCGTTGCAATTGCCCAGTTACATGGTATTTATATTTTGGCTCAAAATACTGAA
GGTCTGATTATTGTAGATATGCATGCTGCACACGAGCGTATTCTGCTGCAACAAATGAAAGCTGCTTGGGATAAGCCTGA
ATTTTGGATTTCACAGCAATTATTGATTCCCAAGATAATAAGCATTACCAGAATGCAGGCTTCACGTATTGAAGATTTAA
AATCTCAGTTACTCAGACTGGGGTTAGATATTGATCAGTATGGTGATGAGCAAGCAATTGTGCGAGGTGTTCCAGCAATT
TTGCAAAAAGCAAATTTTGAAAAACTGATACCTGAACTATTGCACGATCTCGATCCGAATGATGAAGCACAGGCGTTATT
ACAAAAAAGAGATACCATATTGGCAGGTATGGCGTGTCATGGTGCTGTACGGGCACATCGTATGCTCAGTCTTTCTGAAA
TGAATGCACTGTTACGTCAGATGGAGCAAACTGAATTTGCTAGCCAATGTAACCATGGTCGTCCTACATGGCGCGCATTT
CCACTTCATCAACTTGATAAGCTTTTTGCTCGAGGAGAATAA

Upstream 100 bases:

>100_bases
GTCATTCAAATTGAAAAATCTGAAGATGATGTGCAGCGTTTTATTACATTCAGTCTAGAAAATGCTGCGTTGTACGAGTG
TCTGAAGGAAAAATTGTAAT

Downstream 100 bases:

>100_bases
TTCAAAATGTCATCGACTTTACCCGTCATTAATTTAATGGGGCCTACTGCAAGCGGGAAAACCGCTTTGGCGTGTGAACT
CTATGAACGGGGTCATTTTG

Product: enzyme in methyl-directed mismatch repair, stimulates binding of Vsr and MutS to heteroduplex DNA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MHNDAVQIHRIHTLDPALANQIAAGEVIERPASVVKELLENAIDAGATELIIRVAQGGSTLIEIIDNGLGIHPDDLPLAV
MRHATSKIKTPEDLHAIVSLGFRGEALASIAAVSRLSLMSSQTDDGVGYQVEVNGTAFDHQEIQAIALRKGTHIRVQDLF
FNVPARRKFLKKPSTEFGHIEEIVRRLALTHFEIRFVLEHNDQIKLNLPIADSGVLRFQRVQQLLGQQFTQNAYWLDTES
ISMRLSGWLGHPSDARSQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQYSAYLLFLEVDPDQVDVNVHPTKHEIRF
LNQREVHEFVRHHAKETLAQFQTASADLAQAMKSNEPKDILRDQPKHQEQFSLHRTDATENPVVNRAEDTQIEYRKELST
DLLTEFNASRPKTVEYSTRMPVRDPVQLNNALKTYLAPLREESGSAITASSDVVSGVDEFPLGVAIAQLHGIYILAQNTE
GLIIVDMHAAHERILLQQMKAAWDKPEFWISQQLLIPKIISITRMQASRIEDLKSQLLRLGLDIDQYGDEQAIVRGVPAI
LQKANFEKLIPELLHDLDPNDEAQALLQKRDTILAGMACHGAVRAHRMLSLSEMNALLRQMEQTEFASQCNHGRPTWRAF
PLHQLDKLFARGE

Sequences:

>Translated_653_residues
MHNDAVQIHRIHTLDPALANQIAAGEVIERPASVVKELLENAIDAGATELIIRVAQGGSTLIEIIDNGLGIHPDDLPLAV
MRHATSKIKTPEDLHAIVSLGFRGEALASIAAVSRLSLMSSQTDDGVGYQVEVNGTAFDHQEIQAIALRKGTHIRVQDLF
FNVPARRKFLKKPSTEFGHIEEIVRRLALTHFEIRFVLEHNDQIKLNLPIADSGVLRFQRVQQLLGQQFTQNAYWLDTES
ISMRLSGWLGHPSDARSQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQYSAYLLFLEVDPDQVDVNVHPTKHEIRF
LNQREVHEFVRHHAKETLAQFQTASADLAQAMKSNEPKDILRDQPKHQEQFSLHRTDATENPVVNRAEDTQIEYRKELST
DLLTEFNASRPKTVEYSTRMPVRDPVQLNNALKTYLAPLREESGSAITASSDVVSGVDEFPLGVAIAQLHGIYILAQNTE
GLIIVDMHAAHERILLQQMKAAWDKPEFWISQQLLIPKIISITRMQASRIEDLKSQLLRLGLDIDQYGDEQAIVRGVPAI
LQKANFEKLIPELLHDLDPNDEAQALLQKRDTILAGMACHGAVRAHRMLSLSEMNALLRQMEQTEFASQCNHGRPTWRAF
PLHQLDKLFARGE
>Mature_653_residues
MHNDAVQIHRIHTLDPALANQIAAGEVIERPASVVKELLENAIDAGATELIIRVAQGGSTLIEIIDNGLGIHPDDLPLAV
MRHATSKIKTPEDLHAIVSLGFRGEALASIAAVSRLSLMSSQTDDGVGYQVEVNGTAFDHQEIQAIALRKGTHIRVQDLF
FNVPARRKFLKKPSTEFGHIEEIVRRLALTHFEIRFVLEHNDQIKLNLPIADSGVLRFQRVQQLLGQQFTQNAYWLDTES
ISMRLSGWLGHPSDARSQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQYSAYLLFLEVDPDQVDVNVHPTKHEIRF
LNQREVHEFVRHHAKETLAQFQTASADLAQAMKSNEPKDILRDQPKHQEQFSLHRTDATENPVVNRAEDTQIEYRKELST
DLLTEFNASRPKTVEYSTRMPVRDPVQLNNALKTYLAPLREESGSAITASSDVVSGVDEFPLGVAIAQLHGIYILAQNTE
GLIIVDMHAAHERILLQQMKAAWDKPEFWISQQLLIPKIISITRMQASRIEDLKSQLLRLGLDIDQYGDEQAIVRGVPAI
LQKANFEKLIPELLHDLDPNDEAQALLQKRDTILAGMACHGAVRAHRMLSLSEMNALLRQMEQTEFASQCNHGRPTWRAF
PLHQLDKLFARGE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=333, Percent_Identity=33.6336336336336, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI4505911, Length=319, Percent_Identity=28.8401253918495, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=28.6585365853659, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI4505913, Length=335, Percent_Identity=28.0597014925373, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI310128478, Length=335, Percent_Identity=28.0597014925373, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=27.4447949526814, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI263191589, Length=239, Percent_Identity=27.6150627615063, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI91992162, Length=265, Percent_Identity=29.811320754717, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI91992160, Length=265, Percent_Identity=29.811320754717, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI310128480, Length=288, Percent_Identity=26.7361111111111, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1790612, Length=575, Percent_Identity=36.5217391304348, Blast_Score=320, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI71991825, Length=326, Percent_Identity=32.2085889570552, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=27.4725274725275, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=357, Percent_Identity=31.9327731092437, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=354, Percent_Identity=28.8135593220339, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=282, Percent_Identity=23.4042553191489, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=195, Percent_Identity=28.2051282051282, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136968, Length=344, Percent_Identity=34.593023255814, Blast_Score=185, Evalue=9e-47,
Organism=Drosophila melanogaster, GI17136970, Length=355, Percent_Identity=27.3239436619718, Blast_Score=104, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 73541; Mature: 73541

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNDAVQIHRIHTLDPALANQIAAGEVIERPASVVKELLENAIDAGATELIIRVAQGGST
CCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHH
LIEIIDNGLGIHPDDLPLAVMRHATSKIKTPEDLHAIVSLGFRGEALASIAAVSRLSLMS
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SQTDDGVGYQVEVNGTAFDHQEIQAIALRKGTHIRVQDLFFNVPARRKFLKKPSTEFGHI
CCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEHHHHCCCCHHHHHHCCCCCCCHHH
EEIVRRLALTHFEIRFVLEHNDQIKLNLPIADSGVLRFQRVQQLLGQQFTQNAYWLDTES
HHHHHHHHHHHEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECHH
ISMRLSGWLGHPSDARSQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQYSAYLLFL
HHEEEECCCCCCCCCCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHCCCEEEEEEEEE
EVDPDQVDVNVHPTKHEIRFLNQREVHEFVRHHAKETLAQFQTASADLAQAMKSNEPKDI
EECCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LRDQPKHQEQFSLHRTDATENPVVNRAEDTQIEYRKELSTDLLTEFNASRPKTVEYSTRM
HCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
PVRDPVQLNNALKTYLAPLREESGSAITASSDVVSGVDEFPLGVAIAQLHGIYILAQNTE
CCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCCHHCCHHHHHHHHCCEEEEEECCC
GLIIVDMHAAHERILLQQMKAAWDKPEFWISQQLLIPKIISITRMQASRIEDLKSQLLRL
CEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLDIDQYGDEQAIVRGVPAILQKANFEKLIPELLHDLDPNDEAQALLQKRDTILAGMACH
CCCHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GAVRAHRMLSLSEMNALLRQMEQTEFASQCNHGRPTWRAFPLHQLDKLFARGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHCCC
>Mature Secondary Structure
MHNDAVQIHRIHTLDPALANQIAAGEVIERPASVVKELLENAIDAGATELIIRVAQGGST
CCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHH
LIEIIDNGLGIHPDDLPLAVMRHATSKIKTPEDLHAIVSLGFRGEALASIAAVSRLSLMS
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
SQTDDGVGYQVEVNGTAFDHQEIQAIALRKGTHIRVQDLFFNVPARRKFLKKPSTEFGHI
CCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEHHHHCCCCHHHHHHCCCCCCCHHH
EEIVRRLALTHFEIRFVLEHNDQIKLNLPIADSGVLRFQRVQQLLGQQFTQNAYWLDTES
HHHHHHHHHHHEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECHH
ISMRLSGWLGHPSDARSQADLQYVYVNGRIVKDKTISHALRMAYDGILHGHQYSAYLLFL
HHEEEECCCCCCCCCCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHCCCEEEEEEEEE
EVDPDQVDVNVHPTKHEIRFLNQREVHEFVRHHAKETLAQFQTASADLAQAMKSNEPKDI
EECCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LRDQPKHQEQFSLHRTDATENPVVNRAEDTQIEYRKELSTDLLTEFNASRPKTVEYSTRM
HCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
PVRDPVQLNNALKTYLAPLREESGSAITASSDVVSGVDEFPLGVAIAQLHGIYILAQNTE
CCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCCHHCCHHHHHHHHCCEEEEEECCC
GLIIVDMHAAHERILLQQMKAAWDKPEFWISQQLLIPKIISITRMQASRIEDLKSQLLRL
CEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLDIDQYGDEQAIVRGVPAILQKANFEKLIPELLHDLDPNDEAQALLQKRDTILAGMACH
CCCHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GAVRAHRMLSLSEMNALLRQMEQTEFASQCNHGRPTWRAFPLHQLDKLFARGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA