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The map label for this gene is tadA [H]

Identifier: 50085441

GI number: 50085441

Start: 2312018

End: 2312542

Strand: Reverse

Name: tadA [H]

Synonym: ACIAD2350

Alternate gene names: 50085441

Gene position: 2312542-2312018 (Counterclockwise)

Preceding gene: 50085442

Following gene: 50085440

Centisome position: 64.26

GC content: 41.9

Gene sequence:

>525_bases
ATGAGTCTCTCCGACACTTTTAATGATGAATACTGGATGCAGCTTGCTTACGAGCAAGCTGTACGCGCAGCCGAACACAA
CGAAGTTCCTGTAGGGGCTGTAATTGTGAGTCAAAACAAAGTTATTGGTTCTGGCTATAATGCGCCAATTACCCTGAATG
ATCCTACAGCTCATGCAGAAATTCGTGCAATTCGTATGGCTTGTGAATCTGTTAAGAATTATCGTTTACCTGAAGATGCA
ACCTTATATGTTACCTTAGAGCCATGTACCATGTGTGTAGGTGCCTTGGTCCATGCACGCATTCATCGTGTTGTTTTTGC
AACAACAGAGCCTAAGGCGGGCTCTTTAGTAAGCGCAAGGCAATTATTGAATATGGGATATTACAATCATAAATTTTTAA
TTGAACACGGGTGTATGCAGGCACAATGTTCTAAACAGCTCAGCGACTTTTTTAGAAAACGTCGTGAACAAAAACGTGAG
CTCAGACAACAATACATTGCGACTTCTGAAAATCCGCAGACTTGA

Upstream 100 bases:

>100_bases
AGGATTTAAGTTTGAAAGGTATTCTAGGTGATAATCCTCCTGTTACTACAATTCAAAGCTGGAACGATTTGTTAAAACAC
TATGGTATCATTTAGTTCAA

Downstream 100 bases:

>100_bases
TTTGCTCCACTGACATTTATTTAAGGCTGTTTTTACCTTGCTTGAGATCATTAAATCTATTAATTTGTGCTGACAATATT
TATTGTCAATAAGGTGACAA

Product: deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MSLSDTFNDEYWMQLAYEQAVRAAEHNEVPVGAVIVSQNKVIGSGYNAPITLNDPTAHAEIRAIRMACESVKNYRLPEDA
TLYVTLEPCTMCVGALVHARIHRVVFATTEPKAGSLVSARQLLNMGYYNHKFLIEHGCMQAQCSKQLSDFFRKRREQKRE
LRQQYIATSENPQT

Sequences:

>Translated_174_residues
MSLSDTFNDEYWMQLAYEQAVRAAEHNEVPVGAVIVSQNKVIGSGYNAPITLNDPTAHAEIRAIRMACESVKNYRLPEDA
TLYVTLEPCTMCVGALVHARIHRVVFATTEPKAGSLVSARQLLNMGYYNHKFLIEHGCMQAQCSKQLSDFFRKRREQKRE
LRQQYIATSENPQT
>Mature_173_residues
SLSDTFNDEYWMQLAYEQAVRAAEHNEVPVGAVIVSQNKVIGSGYNAPITLNDPTAHAEIRAIRMACESVKNYRLPEDAT
LYVTLEPCTMCVGALVHARIHRVVFATTEPKAGSLVSARQLLNMGYYNHKFLIEHGCMQAQCSKQLSDFFRKRREQKREL
RQQYIATSENPQT

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=114, Percent_Identity=36.8421052631579, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI145693172, Length=151, Percent_Identity=51.6556291390728, Blast_Score=159, Evalue=9e-41,
Organism=Escherichia coli, GI1786616, Length=156, Percent_Identity=34.6153846153846, Blast_Score=67, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554608, Length=122, Percent_Identity=39.344262295082, Blast_Score=93, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17541138, Length=117, Percent_Identity=35.8974358974359, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555996, Length=126, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 19739; Mature: 19608

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSDTFNDEYWMQLAYEQAVRAAEHNEVPVGAVIVSQNKVIGSGYNAPITLNDPTAHAE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCCEEECCCCCHHH
IRAIRMACESVKNYRLPEDATLYVTLEPCTMCVGALVHARIHRVVFATTEPKAGSLVSAR
HHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHH
QLLNMGYYNHKFLIEHGCMQAQCSKQLSDFFRKRREQKRELRQQYIATSENPQT
HHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SLSDTFNDEYWMQLAYEQAVRAAEHNEVPVGAVIVSQNKVIGSGYNAPITLNDPTAHAE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCCEEECCCCCHHH
IRAIRMACESVKNYRLPEDATLYVTLEPCTMCVGALVHARIHRVVFATTEPKAGSLVSAR
HHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHH
QLLNMGYYNHKFLIEHGCMQAQCSKQLSDFFRKRREQKRELRQQYIATSENPQT
HHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]