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The map label for this gene is sthA [H]

Identifier: 50085375

GI number: 50085375

Start: 2243210

End: 2244625

Strand: Reverse

Name: sthA [H]

Synonym: ACIAD2274

Alternate gene names: 50085375

Gene position: 2244625-2243210 (Counterclockwise)

Preceding gene: 50085379

Following gene: 50085372

Centisome position: 62.37

GC content: 41.53

Gene sequence:

>1416_bases
ATGCCACGTAAAAAAGAGGTCGTTAGTGGGAATTTCGTTAGATACGATGCGGTAATTCTCGGTTCGGGACCTGCGGGTGA
AGGCGCGGCAATGAAGCTGGCAAAATCAGGGAAGCGGGTTGCAATTGTTGATATTCGTGAGCAGTTAGGTGGAAACTGTG
CGCATGTCGGAACAATCCCGAGTAAAGCTTTACGTCAAACTGTATCAAGTATTATTCGTTACCAACGTGATCCAATGTTT
CAAAAAGTGGGTGAATGGAAGAAATTCACCATGAAACAAGTTTTGAGTCATGCACATCGTGTGATTCAGCAACAAGTGGC
TACGCATACTCGATTCTATGATCGTAATAATATTGATGTATTTTATGGTCGCGCTTACATTCAAGACCAAAATACGGTTC
TGGTTTTTACACCTGAAGGTATTAAAGAGTCGATCATATTTGAGCAACTTGTAATTGCAACAGGTAGTCGACCTTATCAG
CCTCAAGGTCTCGATTTTAAACATAAGCGTGTATTCGATTCTGATAAGATTCTCGACTTGGACTATCCGATTCACAAGAT
TATCATTTATGGCGCAGGTGTTATTGGCTGTGAATATGCATCTATTTTTATTGGTTTGAATCACAAAGTTGATCTCATCA
ATACTCAGCATAAACTGCTCAGTTATCTTGATGATGAAATTGCTGATGCGCTGTCTTATCATTTGCGGGAACAGGGCGTT
CTGATCCGTCATAATGAACAAATCGATCATTTGGAAACCCATGATGATTATGTTGTCTTACATCTGCAAAGCGGTAAAAA
AATTAAAGCCGATGCGATTTTGTGGTGTAACGGACGCTCAGGTAATACCGATGGTTTGGGCTTAGAAAATGTAGGCCTGA
AGCCAAATGGCCGGGGCCAGCTGGCGGTCAACGAGAAATACCAGACTGAAGTTGAAAATATTTATGCAGCGGGCGATGTT
GTCGGCTGGCCATCTTTGGCATCTGCTGCATATGACCAAGGGCGCTGTGCTGGTGCAAACATGAGTGGCGAAGAAAATGT
TAAACCAGTGACCGATATCCCGACAGGAATTTACACCATTCCAGAAATTTCATGTTTTGGTAAAACTGAGCAGCAATTAA
CGGAAGAGAAAATTCCTTACGAAGTCGGACAGTCATCTTTCCGTCATTTGGCGCGTGCCCAAATTACAGGCGATACAGTG
GGTGAGCTCAAGATATTATTCCATCGTGATACCTTGGAAATTTTGGGAATCCATTGCTTTGGTAATAATGCATCAGAAAT
TATTCATATTGGTCAAGCAGTGATGCAAAGTCCAAATAATTCTTTGAAGTATTTTATGGAAACGACCTTTAACTATCCAA
CGATGGCTGAGGCTTATCGTGTGGCTGCATTAAATGGTTTAAATCGTTTGTTTTAA

Upstream 100 bases:

>100_bases
GTTATTCCAGAATATAGGCTTGAGAAATACATTATTCGACAGCATAGTAGCCATCATTTATTATAAAATACGTAGATTGA
TTGGATTGAAGGAGCTTTGA

Downstream 100 bases:

>100_bases
AGCATCTTTATCAGTTAAAGCATATAAAAGAAAGCCCGTCATTTGACGGGCTTTTGCGTTGATTCAATTAAGCATTATTA
TTGTTTTTTATTTTTATTAG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MPRKKEVVSGNFVRYDAVILGSGPAGEGAAMKLAKSGKRVAIVDIREQLGGNCAHVGTIPSKALRQTVSSIIRYQRDPMF
QKVGEWKKFTMKQVLSHAHRVIQQQVATHTRFYDRNNIDVFYGRAYIQDQNTVLVFTPEGIKESIIFEQLVIATGSRPYQ
PQGLDFKHKRVFDSDKILDLDYPIHKIIIYGAGVIGCEYASIFIGLNHKVDLINTQHKLLSYLDDEIADALSYHLREQGV
LIRHNEQIDHLETHDDYVVLHLQSGKKIKADAILWCNGRSGNTDGLGLENVGLKPNGRGQLAVNEKYQTEVENIYAAGDV
VGWPSLASAAYDQGRCAGANMSGEENVKPVTDIPTGIYTIPEISCFGKTEQQLTEEKIPYEVGQSSFRHLARAQITGDTV
GELKILFHRDTLEILGIHCFGNNASEIIHIGQAVMQSPNNSLKYFMETTFNYPTMAEAYRVAALNGLNRLF

Sequences:

>Translated_471_residues
MPRKKEVVSGNFVRYDAVILGSGPAGEGAAMKLAKSGKRVAIVDIREQLGGNCAHVGTIPSKALRQTVSSIIRYQRDPMF
QKVGEWKKFTMKQVLSHAHRVIQQQVATHTRFYDRNNIDVFYGRAYIQDQNTVLVFTPEGIKESIIFEQLVIATGSRPYQ
PQGLDFKHKRVFDSDKILDLDYPIHKIIIYGAGVIGCEYASIFIGLNHKVDLINTQHKLLSYLDDEIADALSYHLREQGV
LIRHNEQIDHLETHDDYVVLHLQSGKKIKADAILWCNGRSGNTDGLGLENVGLKPNGRGQLAVNEKYQTEVENIYAAGDV
VGWPSLASAAYDQGRCAGANMSGEENVKPVTDIPTGIYTIPEISCFGKTEQQLTEEKIPYEVGQSSFRHLARAQITGDTV
GELKILFHRDTLEILGIHCFGNNASEIIHIGQAVMQSPNNSLKYFMETTFNYPTMAEAYRVAALNGLNRLF
>Mature_470_residues
PRKKEVVSGNFVRYDAVILGSGPAGEGAAMKLAKSGKRVAIVDIREQLGGNCAHVGTIPSKALRQTVSSIIRYQRDPMFQ
KVGEWKKFTMKQVLSHAHRVIQQQVATHTRFYDRNNIDVFYGRAYIQDQNTVLVFTPEGIKESIIFEQLVIATGSRPYQP
QGLDFKHKRVFDSDKILDLDYPIHKIIIYGAGVIGCEYASIFIGLNHKVDLINTQHKLLSYLDDEIADALSYHLREQGVL
IRHNEQIDHLETHDDYVVLHLQSGKKIKADAILWCNGRSGNTDGLGLENVGLKPNGRGQLAVNEKYQTEVENIYAAGDVV
GWPSLASAAYDQGRCAGANMSGEENVKPVTDIPTGIYTIPEISCFGKTEQQLTEEKIPYEVGQSSFRHLARAQITGDTVG
ELKILFHRDTLEILGIHCFGNNASEIIHIGQAVMQSPNNSLKYFMETTFNYPTMAEAYRVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=473, Percent_Identity=31.2896405919662, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=24.5161290322581, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI22035672, Length=476, Percent_Identity=24.7899159663866, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI33519430, Length=476, Percent_Identity=26.890756302521, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI33519428, Length=476, Percent_Identity=26.890756302521, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI33519426, Length=476, Percent_Identity=26.890756302521, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI148277065, Length=476, Percent_Identity=26.890756302521, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI148277071, Length=476, Percent_Identity=26.890756302521, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=24.3697478991597, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=57.1739130434783, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=27.1334792122538, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI87081717, Length=466, Percent_Identity=29.3991416309013, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1789915, Length=442, Percent_Identity=28.2805429864253, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=455, Percent_Identity=29.8901098901099, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=23.6786469344609, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71983419, Length=336, Percent_Identity=25.8928571428571, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71983429, Length=336, Percent_Identity=25.8928571428571, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982272, Length=452, Percent_Identity=24.1150442477876, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17559934, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=28.6016949152542, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=27.8481012658228, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6325166, Length=442, Percent_Identity=26.0180995475113, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21358499, Length=456, Percent_Identity=29.8245614035088, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24640551, Length=504, Percent_Identity=25.5952380952381, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24640553, Length=491, Percent_Identity=25.6619144602851, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640549, Length=491, Percent_Identity=25.6619144602851, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737741, Length=486, Percent_Identity=24.6913580246914, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 52554; Mature: 52422

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRKKEVVSGNFVRYDAVILGSGPAGEGAAMKLAKSGKRVAIVDIREQLGGNCAHVGTIP
CCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEEHHHHCCCEEEECCCC
SKALRQTVSSIIRYQRDPMFQKVGEWKKFTMKQVLSHAHRVIQQQVATHTRFYDRNNIDV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
FYGRAYIQDQNTVLVFTPEGIKESIIFEQLVIATGSRPYQPQGLDFKHKRVFDSDKILDL
EEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCEEEC
DYPIHKIIIYGAGVIGCEYASIFIGLNHKVDLINTQHKLLSYLDDEIADALSYHLREQGV
CCCCEEEEEECCCEEEEEEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCE
LIRHNEQIDHLETHDDYVVLHLQSGKKIKADAILWCNGRSGNTDGLGLENVGLKPNGRGQ
EEEECCCCCCCCCCCCEEEEEECCCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCE
LAVNEKYQTEVENIYAAGDVVGWPSLASAAYDQGRCAGANMSGEENVKPVTDIPTGIYTI
EEECCHHHHHHHHEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEC
PEISCFGKTEQQLTEEKIPYEVGQSSFRHLARAQITGDTVGELKILFHRDTLEILGIHCF
CCEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEEEE
GNNASEIIHIGQAVMQSPNNSLKYFMETTFNYPTMAEAYRVAALNGLNRLF
CCCHHHHHHHHHHHHHCCCCCCEEHEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRKKEVVSGNFVRYDAVILGSGPAGEGAAMKLAKSGKRVAIVDIREQLGGNCAHVGTIP
CCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEEHHHHCCCEEEECCCC
SKALRQTVSSIIRYQRDPMFQKVGEWKKFTMKQVLSHAHRVIQQQVATHTRFYDRNNIDV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
FYGRAYIQDQNTVLVFTPEGIKESIIFEQLVIATGSRPYQPQGLDFKHKRVFDSDKILDL
EEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCEEEC
DYPIHKIIIYGAGVIGCEYASIFIGLNHKVDLINTQHKLLSYLDDEIADALSYHLREQGV
CCCCEEEEEECCCEEEEEEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCE
LIRHNEQIDHLETHDDYVVLHLQSGKKIKADAILWCNGRSGNTDGLGLENVGLKPNGRGQ
EEEECCCCCCCCCCCCEEEEEECCCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCE
LAVNEKYQTEVENIYAAGDVVGWPSLASAAYDQGRCAGANMSGEENVKPVTDIPTGIYTI
EEECCHHHHHHHHEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEC
PEISCFGKTEQQLTEEKIPYEVGQSSFRHLARAQITGDTVGELKILFHRDTLEILGIHCF
CCEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEEEE
GNNASEIIHIGQAVMQSPNNSLKYFMETTFNYPTMAEAYRVAALNGLNRLF
CCCHHHHHHHHHHHHHCCCCCCEEHEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA