Click here to switch to the map view.

The map label for this gene is mmgC [H]

Identifier: 50085334

GI number: 50085334

Start: 2198574

End: 2199719

Strand: Reverse

Name: mmgC [H]

Synonym: ACIAD2226

Alternate gene names: 50085334

Gene position: 2199719-2198574 (Counterclockwise)

Preceding gene: 50085335

Following gene: 50085331

Centisome position: 61.13

GC content: 42.84

Gene sequence:

>1146_bases
ATGTTAGCTTACGATGCTGAACTAGAGTTATTTCGCGATAATTTTAAACGTTACCTGAAAGAGCATATTGCACCGCACTA
TGAGCAATGGGAACGTGAAGGTATCATGCCACGCTCGGTCTGGAACAGCTTGGGTGAAAATGGCTTTTTGTGTGTAGATA
TGCCAGAAGAATATGGTGGCTATGGTGTCCCGACATATTATTCTTTGATGCTGGTTGAAGAATCTGCCCGTGCAGGATAT
GGAGCATTATCTACAGCAATCTCTTGCCATTCTGAGATTGCAGCACCGTATATTCTTCATATTGGAACGGAACAACAGAA
ACAACACTGGTTAAGTAAAATGGTCACGGGTGAAGTGGTCGGGGCGATTGGGATGACTGAGCCAGGTGCAGGTTCTGATT
TGCAAGCAATGAGAACGAGTGCCATATTGCAAGATGATCATTATGTGCTAAATGGTTCTAAAACATTTATTTCAAATGGT
CAACATGCTGATTTAGTGGTATTGGCTGTAAAAACAGACCCACAAGCCAGAGCCAAAGGCGTTTCATTAATGTTGGTCGA
TACCCATCTGGATGGTTTCAAAAAAGGTACCAATCTGGATAAGATCGGGTTGCATTCTCAGGATACCTCAGAACTATTTT
TTGATCATGTCAAAGTGCCAAAAGATCAGTTACTTGGTCAGGCTGGGCAGGGGTTTGCTTATCTCATGCAAGAGTTGCCA
AGAGAAAGAACCGCAATTGCGGCAACGGCGTTAGGTGCAATACGTGGTGCTATTGATGTTGCCACGGCGTATATCCAGGA
GCGTCAAGCTTTTGGCCAAGCCATTGCGAGCTTTCAAAATACCCGTTTTGTGATGGCACAAGCAAAAATTGATGAGTTGG
CTACAGCTGCATTCTATGAGCGTAATGTCAGTTTGTATCAAGAAGGCAAGCTGGATGTCGAAACGGCTGCTGCGCTAAAA
AGCTTTAGTACAGATATGCAAATGAAAGTTGCAGATAACTTGTTACAGTTATTTGGCGGTTATGGCTATATGACTGAATA
TCCAATTTCACGTTTCTTTGTCGATGCGCGAATCCAGCGTATTTATGGTGGAACAAATGAAATTATGAAAGAGATTGTAG
CGCGTGGAATTTTAGGAAAGTCCTAA

Upstream 100 bases:

>100_bases
GTGCGTTCATGTGTTTTGATCATTGTTGACATGACAGGGTGCATAAAACTGATTAGCATGCAGATATGAAATATTCAAAA
CAATAAAGAGGATTCATTAA

Downstream 100 bases:

>100_bases
TTATAAACCGATACAGCGTGCTGGAAGCTGATAACAATATCAGCTCCAGCGTGTTTATAGACGCAATACTTTAAGGGTTT
CATTCAGGAACTGTGGAAGT

Product: acyl coenzyme A dehydrogenase (HcaD-like)

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MLAYDAELELFRDNFKRYLKEHIAPHYEQWEREGIMPRSVWNSLGENGFLCVDMPEEYGGYGVPTYYSLMLVEESARAGY
GALSTAISCHSEIAAPYILHIGTEQQKQHWLSKMVTGEVVGAIGMTEPGAGSDLQAMRTSAILQDDHYVLNGSKTFISNG
QHADLVVLAVKTDPQARAKGVSLMLVDTHLDGFKKGTNLDKIGLHSQDTSELFFDHVKVPKDQLLGQAGQGFAYLMQELP
RERTAIAATALGAIRGAIDVATAYIQERQAFGQAIASFQNTRFVMAQAKIDELATAAFYERNVSLYQEGKLDVETAAALK
SFSTDMQMKVADNLLQLFGGYGYMTEYPISRFFVDARIQRIYGGTNEIMKEIVARGILGKS

Sequences:

>Translated_381_residues
MLAYDAELELFRDNFKRYLKEHIAPHYEQWEREGIMPRSVWNSLGENGFLCVDMPEEYGGYGVPTYYSLMLVEESARAGY
GALSTAISCHSEIAAPYILHIGTEQQKQHWLSKMVTGEVVGAIGMTEPGAGSDLQAMRTSAILQDDHYVLNGSKTFISNG
QHADLVVLAVKTDPQARAKGVSLMLVDTHLDGFKKGTNLDKIGLHSQDTSELFFDHVKVPKDQLLGQAGQGFAYLMQELP
RERTAIAATALGAIRGAIDVATAYIQERQAFGQAIASFQNTRFVMAQAKIDELATAAFYERNVSLYQEGKLDVETAAALK
SFSTDMQMKVADNLLQLFGGYGYMTEYPISRFFVDARIQRIYGGTNEIMKEIVARGILGKS
>Mature_381_residues
MLAYDAELELFRDNFKRYLKEHIAPHYEQWEREGIMPRSVWNSLGENGFLCVDMPEEYGGYGVPTYYSLMLVEESARAGY
GALSTAISCHSEIAAPYILHIGTEQQKQHWLSKMVTGEVVGAIGMTEPGAGSDLQAMRTSAILQDDHYVLNGSKTFISNG
QHADLVVLAVKTDPQARAKGVSLMLVDTHLDGFKKGTNLDKIGLHSQDTSELFFDHVKVPKDQLLGQAGQGFAYLMQELP
RERTAIAATALGAIRGAIDVATAYIQERQAFGQAIASFQNTRFVMAQAKIDELATAAFYERNVSLYQEGKLDVETAAALK
SFSTDMQMKVADNLLQLFGGYGYMTEYPISRFFVDARIQRIYGGTNEIMKEIVARGILGKS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=41.1140583554377, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI226958412, Length=369, Percent_Identity=32.520325203252, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI226958414, Length=337, Percent_Identity=33.2344213649852, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI4557233, Length=370, Percent_Identity=31.6216216216216, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=32.2666666666667, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI187960098, Length=369, Percent_Identity=32.520325203252, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI4557231, Length=369, Percent_Identity=32.520325203252, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI7656849, Length=363, Percent_Identity=31.129476584022, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI76496475, Length=380, Percent_Identity=33.1578947368421, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4557235, Length=380, Percent_Identity=33.1578947368421, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI21361497, Length=388, Percent_Identity=29.8969072164948, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI4503943, Length=381, Percent_Identity=28.6089238845144, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI7669494, Length=353, Percent_Identity=28.6118980169972, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI211971008, Length=291, Percent_Identity=29.553264604811, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI48976061, Length=291, Percent_Identity=29.553264604811, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI38505218, Length=293, Percent_Identity=24.5733788395904, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87081958, Length=362, Percent_Identity=32.5966850828729, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1786223, Length=391, Percent_Identity=26.8542199488491, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI87081702, Length=271, Percent_Identity=25.0922509225092, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=32.2834645669291, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17508101, Length=360, Percent_Identity=31.1111111111111, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17570075, Length=374, Percent_Identity=32.0855614973262, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17534899, Length=365, Percent_Identity=32.0547945205479, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=31.7333333333333, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17506239, Length=369, Percent_Identity=30.3523035230352, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=32.7077747989276, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=30.4, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17569725, Length=373, Percent_Identity=29.7587131367292, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71990804, Length=296, Percent_Identity=33.7837837837838, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71985184, Length=347, Percent_Identity=31.700288184438, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=32.4561403508772, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71982178, Length=266, Percent_Identity=28.1954887218045, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71985192, Length=254, Percent_Identity=33.8582677165354, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=367, Percent_Identity=28.8828337874659, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562446, Length=292, Percent_Identity=27.0547945205479, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=25.2066115702479, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=278, Percent_Identity=27.3381294964029, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=278, Percent_Identity=27.3381294964029, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=31.3513513513514, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=31.1345646437995, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=31.7333333333333, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24660351, Length=365, Percent_Identity=29.3150684931507, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24666513, Length=370, Percent_Identity=28.3783783783784, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI281363737, Length=342, Percent_Identity=32.1637426900585, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI19920834, Length=376, Percent_Identity=30.3191489361702, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42171; Mature: 42171

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAYDAELELFRDNFKRYLKEHIAPHYEQWEREGIMPRSVWNSLGENGFLCVDMPEEYGG
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHCCCCCEEEEECCHHHCC
YGVPTYYSLMLVEESARAGYGALSTAISCHSEIAAPYILHIGTEQQKQHWLSKMVTGEVV
CCCCHHHEEEEEECHHCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
GAIGMTEPGAGSDLQAMRTSAILQDDHYVLNGSKTFISNGQHADLVVLAVKTDPQARAKG
HHCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCEECCCCCCEEEEEEEECCCHHHHCC
VSLMLVDTHLDGFKKGTNLDKIGLHSQDTSELFFDHVKVPKDQLLGQAGQGFAYLMQELP
CEEEEEECCCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCC
RERTAIAATALGAIRGAIDVATAYIQERQAFGQAIASFQNTRFVMAQAKIDELATAAFYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHH
RNVSLYQEGKLDVETAAALKSFSTDMQMKVADNLLQLFGGYGYMTEYPISRFFVDARIQR
CCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYGGTNEIMKEIVARGILGKS
HHCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLAYDAELELFRDNFKRYLKEHIAPHYEQWEREGIMPRSVWNSLGENGFLCVDMPEEYGG
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHCCCCCEEEEECCHHHCC
YGVPTYYSLMLVEESARAGYGALSTAISCHSEIAAPYILHIGTEQQKQHWLSKMVTGEVV
CCCCHHHEEEEEECHHCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
GAIGMTEPGAGSDLQAMRTSAILQDDHYVLNGSKTFISNGQHADLVVLAVKTDPQARAKG
HHCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCEECCCCCCEEEEEEEECCCHHHHCC
VSLMLVDTHLDGFKKGTNLDKIGLHSQDTSELFFDHVKVPKDQLLGQAGQGFAYLMQELP
CEEEEEECCCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCC
RERTAIAATALGAIRGAIDVATAYIQERQAFGQAIASFQNTRFVMAQAKIDELATAAFYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHH
RNVSLYQEGKLDVETAAALKSFSTDMQMKVADNLLQLFGGYGYMTEYPISRFFVDARIQR
CCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYGGTNEIMKEIVARGILGKS
HHCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]