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The map label for this gene is adhC [H]

Identifier: 50085020

GI number: 50085020

Start: 1871988

End: 1873097

Strand: Reverse

Name: adhC [H]

Synonym: ACIAD1879

Alternate gene names: 50085020

Gene position: 1873097-1871988 (Counterclockwise)

Preceding gene: 50085021

Following gene: 50085019

Centisome position: 52.05

GC content: 43.69

Gene sequence:

>1110_bases
ATGAAATCACGTGCAGCAGTTGCATTTGGCCCAGGTCAACCTTTACAGATTGTTGAAGTGGATGTCGAACCACCTAAAGC
TGGTGAAGTTCTGATTAAAGTCACCCATTCAGGTGTATGCCATACAGATGCTTTTACCTTATCTGGTGATGATCCTGAAG
GTGTTTTTCCCGCAATTTTAGGACATGAAGGCGCTGGTATTGTTATTGAAGTCGGTGAAGGTGTCACCAGTGTACAACCT
GGCGATCATGTCATTCCGCTTTATACTGCCGAATGTGGTGAATGTTTATTCTGTAAGTCGAATAAAACCAACTTGTGTGT
TTCCGTTCGAGCGACACAGGGGAAAGGTGTGATGCCAGATGGAACGACTCGTTTTTCTTATAACGGCGAACCTATTTATC
ACTATATGGGATGTTCAACTTTTAGCGAATATACCGTTGTGGCAGAAGTATCACTTGCCAAGATTAATCCTGAAGCAAAT
CACGAACAGGTTTGCTTACTTGGCTGTGGTGTAACCACAGGAATTGGTGCTGTGCATAACACTGCTAAAGTTCAGGAAGG
TGATAGTGTTGCCGTCTTTGGTTTAGGTGGTATTGGTTTAGCCGTGGTACAAGGCGCGCGTCAAGCAAAAGCAGGACGCA
TCATTGTTGTAGACATGAACCCAGAAAAATTCGAACTCGCAAAAGAATTTGGTGCGACAGATTTTCTTAATCCAAAAGAT
TATGACAAGCCGATTCAGCAAGTCATTGTTGAAATGACAGGCTGGGGAGTCGATCATTCATTTGAATGTATTGGTAATGT
GAATGTTATGCGTTCGGCATTAGAGTGTGCACATCGTGGTTGGGGTCAATCAGTCATCATTGGGGTTGCTGGTGCGGGAC
AGGAAATTTCAACTCGACCTTTTCAGCTCGTTACAGGACGTAAATGGTTGGGGACTGCTTTTGGTGGTGTCAAAGGGCGT
AGTCAGCTTCCGAAAATGGTTGAAGATGCAATGAAAGGCGACATCCAGCTTGAGCCATTTGTTACGCATACCATGCCGCT
GGATGAAATTAACCATGCATTTGATTTAATGCATGAAGGTAAGTCTATTCGTAGCGTAATTCATTTTTAG

Upstream 100 bases:

>100_bases
CGATGGAGATTCAACAGAGCTTCAGCGCAGTGAAGAACTGATTGAAATTAGTAAAATTCTGAAATCCTATCTCAAGTAAA
CCTTACAAGGAGAAACATCC

Downstream 100 bases:

>100_bases
AATGGATATATATTCATCCTGATTTTTATTTATGAACATCTCAGGGACGAGTGGTCACTGAGATGTTCAATCTTATGAAA
GAGCATCATTAGATGAAGTC

Product: glutathione-dependent formaldehyde dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKSRAAVAFGPGQPLQIVEVDVEPPKAGEVLIKVTHSGVCHTDAFTLSGDDPEGVFPAILGHEGAGIVIEVGEGVTSVQP
GDHVIPLYTAECGECLFCKSNKTNLCVSVRATQGKGVMPDGTTRFSYNGEPIYHYMGCSTFSEYTVVAEVSLAKINPEAN
HEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDMNPEKFELAKEFGATDFLNPKD
YDKPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRPFQLVTGRKWLGTAFGGVKGR
SQLPKMVEDAMKGDIQLEPFVTHTMPLDEINHAFDLMHEGKSIRSVIHF

Sequences:

>Translated_369_residues
MKSRAAVAFGPGQPLQIVEVDVEPPKAGEVLIKVTHSGVCHTDAFTLSGDDPEGVFPAILGHEGAGIVIEVGEGVTSVQP
GDHVIPLYTAECGECLFCKSNKTNLCVSVRATQGKGVMPDGTTRFSYNGEPIYHYMGCSTFSEYTVVAEVSLAKINPEAN
HEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDMNPEKFELAKEFGATDFLNPKD
YDKPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRPFQLVTGRKWLGTAFGGVKGR
SQLPKMVEDAMKGDIQLEPFVTHTMPLDEINHAFDLMHEGKSIRSVIHF
>Mature_369_residues
MKSRAAVAFGPGQPLQIVEVDVEPPKAGEVLIKVTHSGVCHTDAFTLSGDDPEGVFPAILGHEGAGIVIEVGEGVTSVQP
GDHVIPLYTAECGECLFCKSNKTNLCVSVRATQGKGVMPDGTTRFSYNGEPIYHYMGCSTFSEYTVVAEVSLAKINPEAN
HEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDMNPEKFELAKEFGATDFLNPKD
YDKPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRPFQLVTGRKWLGTAFGGVKGR
SQLPKMVEDAMKGDIQLEPFVTHTMPLDEINHAFDLMHEGKSIRSVIHF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=62.6016260162602, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=50.1347708894879, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=49.0616621983914, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=49.3261455525606, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=48.7870619946092, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=47.1389645776567, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=47.3684210526316, Blast_Score=348, Evalue=3e-96,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=46.070460704607, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=46.070460704607, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI156627571, Length=371, Percent_Identity=25.8760107816712, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=84.8238482384824, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI1787863, Length=352, Percent_Identity=28.4090909090909, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87082125, Length=379, Percent_Identity=26.3852242744063, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786825, Length=363, Percent_Identity=26.1707988980716, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI87081918, Length=348, Percent_Identity=31.0344827586207, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788073, Length=366, Percent_Identity=26.5027322404372, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790045, Length=362, Percent_Identity=25.1381215469613, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1790718, Length=333, Percent_Identity=24.9249249249249, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI226510992, Length=365, Percent_Identity=25.2054794520548, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788407, Length=233, Percent_Identity=28.755364806867, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=26.1455525606469, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=57.372654155496, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=57.0666666666667, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=56.8513119533528, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71988145, Length=219, Percent_Identity=32.4200913242009, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=363, Percent_Identity=26.1707988980716, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=172, Percent_Identity=32.5581395348837, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=59.5687331536388, Blast_Score=467, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319621, Length=281, Percent_Identity=30.9608540925267, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=359, Percent_Identity=27.5766016713092, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=348, Percent_Identity=27.8735632183908, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=307, Percent_Identity=28.9902280130293, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=370, Percent_Identity=26.2162162162162, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=370, Percent_Identity=26.2162162162162, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=62.5, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17137530, Length=253, Percent_Identity=28.4584980237154, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17737897, Length=251, Percent_Identity=27.8884462151394, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39364; Mature: 39364

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAVAFGPGQPLQIVEVDVEPPKAGEVLIKVTHSGVCHTDAFTLSGDDPEGVFPAIL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCCCHHHC
GHEGAGIVIEVGEGVTSVQPGDHVIPLYTAECGECLFCKSNKTNLCVSVRATQGKGVMPD
CCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCC
GTTRFSYNGEPIYHYMGCSTFSEYTVVAEVSLAKINPEANHEQVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCHHHCCCHHCC
TAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDMNPEKFELAKEFGATDFLNPKD
CCEECCCCCEEEEEECCHHHHHHHCCHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCC
YDKPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRP
CHHHHHHHHHHHHCCCCCCCHHEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRKWLGTAFGGVKGRSQLPKMVEDAMKGDIQLEPFVTHTMPLDEINHAFDLMHEG
EEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCEEEECCCHHHHHHHHHHHHCC
KSIRSVIHF
HHHHHHHCC
>Mature Secondary Structure
MKSRAAVAFGPGQPLQIVEVDVEPPKAGEVLIKVTHSGVCHTDAFTLSGDDPEGVFPAIL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCCCHHHC
GHEGAGIVIEVGEGVTSVQPGDHVIPLYTAECGECLFCKSNKTNLCVSVRATQGKGVMPD
CCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCC
GTTRFSYNGEPIYHYMGCSTFSEYTVVAEVSLAKINPEANHEQVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCHHHCCCHHCC
TAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIIVVDMNPEKFELAKEFGATDFLNPKD
CCEECCCCCEEEEEECCHHHHHHHCCHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCC
YDKPIQQVIVEMTGWGVDHSFECIGNVNVMRSALECAHRGWGQSVIIGVAGAGQEISTRP
CHHHHHHHHHHHHCCCCCCCHHEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRKWLGTAFGGVKGRSQLPKMVEDAMKGDIQLEPFVTHTMPLDEINHAFDLMHEG
EEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECCEEEECCCHHHHHHHHHHHHCC
KSIRSVIHF
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]