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The map label for this gene is fadB1 [H]

Identifier: 50084967

GI number: 50084967

Start: 1827314

End: 1828090

Strand: Direct

Name: fadB1 [H]

Synonym: ACIAD1820

Alternate gene names: 50084967

Gene position: 1827314-1828090 (Clockwise)

Preceding gene: 50084966

Following gene: 50084968

Centisome position: 50.78

GC content: 46.85

Gene sequence:

>777_bases
ATGCTAAATCAATTAATTAAAACCGAAATCTCTCAGCATGTGGCGGTGGTTACGCTCAATAATCCACCCGTCAATGCCCA
GTCTCGCGAGTTTGTTGAAGAGCTCATCAGCGTATTTGATGAGTTAAATGATACGCCCGAAGTGCGTGTGATTGTACTAA
CGGGGCAGGGCAAAGTTTTTTCTGCCGGTGCAGATATCAAATCACGCGGCAATGTCGGAGAGATTCCAGGAGAAACCTAT
CGACATTTGCGCCGTACCCGTGAAGTCGGCTTTTGTATTATGGAATCGAACAAGCCCGTCATTGCCGCTGTCAATGGTCC
TGCTTTAGGTGCTGGATTGGGCTTGGTACTGTGTTCAGACATTATTCTGGCCTCAGAAAATGCTGTATTTGGTTTGCCTG
AAATTGATATTGGGCTAATGGGTGGGGTGCGTCATACCATGCGCTTATTTCCACATTCATTAACACGTCGAATGGTACTT
TCAGGCTATCGAGTAACAGCAGCAGAATTATACCGTCGCGGCATTATCGAGGCGTGTACCACGCCTGATCAACTCATGGA
AGAAGCATTGGCAATCGCGCACAGTATTGCCAGTAAGAGTCCAGCAGCATTGAAGCTGGCCAAACGTGCCATCAATACGG
TCGAAACCATGGGGCTCAAGGAGGGGTATCGATTTGAGCAAAATCTCACGGTTGAAATGACTCGTCACGAAGATTCTAAA
GAGGCGATGCGTGCGTTTTTAGAAAAACGTCAACCTGTATTTAAGGATAGCGTGTAA

Upstream 100 bases:

>100_bases
CAGTCAATCTGGCGGCCTCGCTGGGCGATGCAGAAAGCTTAAGACTTCAGTTTATCGAAATGGAACGTGCCGCCTAGGCG
CTGCAATAAAGGAATACAAT

Downstream 100 bases:

>100_bases
TGACAAACTGGAATGCATTATCAGACGACGAGTTTCGTCAGATTTTTAGAGATTGGGTACTTGAAAATTGCCCAGAATCG
CTACGGTATATGCGCAAGCA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MLNQLIKTEISQHVAVVTLNNPPVNAQSREFVEELISVFDELNDTPEVRVIVLTGQGKVFSAGADIKSRGNVGEIPGETY
RHLRRTREVGFCIMESNKPVIAAVNGPALGAGLGLVLCSDIILASENAVFGLPEIDIGLMGGVRHTMRLFPHSLTRRMVL
SGYRVTAAELYRRGIIEACTTPDQLMEEALAIAHSIASKSPAALKLAKRAINTVETMGLKEGYRFEQNLTVEMTRHEDSK
EAMRAFLEKRQPVFKDSV

Sequences:

>Translated_258_residues
MLNQLIKTEISQHVAVVTLNNPPVNAQSREFVEELISVFDELNDTPEVRVIVLTGQGKVFSAGADIKSRGNVGEIPGETY
RHLRRTREVGFCIMESNKPVIAAVNGPALGAGLGLVLCSDIILASENAVFGLPEIDIGLMGGVRHTMRLFPHSLTRRMVL
SGYRVTAAELYRRGIIEACTTPDQLMEEALAIAHSIASKSPAALKLAKRAINTVETMGLKEGYRFEQNLTVEMTRHEDSK
EAMRAFLEKRQPVFKDSV
>Mature_258_residues
MLNQLIKTEISQHVAVVTLNNPPVNAQSREFVEELISVFDELNDTPEVRVIVLTGQGKVFSAGADIKSRGNVGEIPGETY
RHLRRTREVGFCIMESNKPVIAAVNGPALGAGLGLVLCSDIILASENAVFGLPEIDIGLMGGVRHTMRLFPHSLTRRMVL
SGYRVTAAELYRRGIIEACTTPDQLMEEALAIAHSIASKSPAALKLAKRAINTVETMGLKEGYRFEQNLTVEMTRHEDSK
EAMRAFLEKRQPVFKDSV

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=247, Percent_Identity=37.246963562753, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI31542718, Length=243, Percent_Identity=29.6296296296296, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI70995211, Length=261, Percent_Identity=27.9693486590038, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI68989263, Length=215, Percent_Identity=30.2325581395349, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI62530384, Length=200, Percent_Identity=27.5, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI37594469, Length=208, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI37594471, Length=208, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI150378541, Length=253, Percent_Identity=26.4822134387352, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4502327, Length=239, Percent_Identity=29.7071129707113, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI221136756, Length=210, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI221136753, Length=210, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI116235487, Length=174, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI221307494, Length=210, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI20127408, Length=193, Percent_Identity=29.0155440414508, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI260274832, Length=196, Percent_Identity=25.5102040816327, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI45643119, Length=171, Percent_Identity=26.9005847953216, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI260275230, Length=171, Percent_Identity=26.9005847953216, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=36.5461847389558, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI221142681, Length=251, Percent_Identity=34.6613545816733, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI87082183, Length=260, Percent_Identity=29.6153846153846, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788597, Length=248, Percent_Identity=27.8225806451613, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787660, Length=258, Percent_Identity=29.8449612403101, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788682, Length=193, Percent_Identity=29.0155440414508, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=251, Percent_Identity=37.0517928286853, Blast_Score=143, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI25145438, Length=259, Percent_Identity=37.0656370656371, Blast_Score=141, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17536985, Length=263, Percent_Identity=27.3764258555133, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=229, Percent_Identity=29.2576419213974, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17534483, Length=265, Percent_Identity=29.0566037735849, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17540306, Length=256, Percent_Identity=27.34375, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=262, Percent_Identity=29.0076335877863, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17549921, Length=250, Percent_Identity=28.4, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI20129971, Length=266, Percent_Identity=35.7142857142857, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24653477, Length=266, Percent_Identity=35.7142857142857, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI19920382, Length=255, Percent_Identity=32.9411764705882, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653139, Length=253, Percent_Identity=30.8300395256917, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19922422, Length=251, Percent_Identity=28.2868525896414, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24654903, Length=165, Percent_Identity=28.4848484848485, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583165, Length=223, Percent_Identity=22.8699551569507, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28371; Mature: 28371

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQLIKTEISQHVAVVTLNNPPVNAQSREFVEELISVFDELNDTPEVRVIVLTGQGKVF
CCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEE
SAGADIKSRGNVGEIPGETYRHLRRTREVGFCIMESNKPVIAAVNGPALGAGLGLVLCSD
ECCCCCCCCCCCCCCCCHHHHHHHHHHHHCEEEEECCCCEEEEECCCCHHHHHHHHHHHH
IILASENAVFGLPEIDIGLMGGVRHTMRLFPHSLTRRMVLSGYRVTAAELYRRGIIEACT
HHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
TPDQLMEEALAIAHSIASKSPAALKLAKRAINTVETMGLKEGYRFEQNLTVEMTRHEDSK
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHH
EAMRAFLEKRQPVFKDSV
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLNQLIKTEISQHVAVVTLNNPPVNAQSREFVEELISVFDELNDTPEVRVIVLTGQGKVF
CCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEE
SAGADIKSRGNVGEIPGETYRHLRRTREVGFCIMESNKPVIAAVNGPALGAGLGLVLCSD
ECCCCCCCCCCCCCCCCHHHHHHHHHHHHCEEEEECCCCEEEEECCCCHHHHHHHHHHHH
IILASENAVFGLPEIDIGLMGGVRHTMRLFPHSLTRRMVLSGYRVTAAELYRRGIIEACT
HHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
TPDQLMEEALAIAHSIASKSPAALKLAKRAINTVETMGLKEGYRFEQNLTVEMTRHEDSK
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHH
EAMRAFLEKRQPVFKDSV
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7751302; 11481430 [H]