Click here to switch to the map view.

The map label for this gene is mdcD [C]

Identifier: 50084907

GI number: 50084907

Start: 1762460

End: 1763311

Strand: Direct

Name: mdcD [C]

Synonym: ACIAD1756

Alternate gene names: 50084907

Gene position: 1762460-1763311 (Clockwise)

Preceding gene: 50084906

Following gene: 50084908

Centisome position: 48.98

GC content: 42.84

Gene sequence:

>852_bases
ATGGCTGATATTGATTACTTACTCAATAAACAAAGTTTTATCGAGATGGATGCACGTGAGCGCGCCAAATCTCTATTTGA
TCTGAATAGCTGTAAGGAATTACTCGATCCTTTTGCAGGTGTAATGTCTCCTTGGTTACTTAGACAAAATATCGTACCTC
AAGCGGACGATGGCGTTGTGGTCATGAAAGGATTCATCGAACAGCAACCCGCTGTGGTTATTTCTGTTGAAGGCAGTTTT
CAAGGAGGCAGTTTGGGCGAGGTAGGCGGTGCCAAAATTGCAGGTGCACTTGAGCTTGCAATTGAAGATAACTGTAATCA
TATTCCAACCCGAGCAATTCTGTTACTTGAAACTGGTGGGGTACGCTTGCAGGAAGCCAATTTGGGACTCGCAGCAATTG
CTGAAATCCATTCTGCAATCGTTGAACTTCGTCATTATCAACCTGTCATTGGTGTTATAGCGGGAAGCGTAGGATGCTTT
GGCGGAATGTCGATCGCTGCGGGATTATGTAGTTATCTCATCATGACCCAAGAAGGTCGTTTAGGACTAAATGGCCCTCA
AGTGATTGAACAGGAAGCTGGTATTGATGAATATAATGCCAAAGATCGTCCTTTCATCTGGAGTATTACGGGCGGAGAGC
AGCGTTTTGCTAGTGGATTGATCGATGCTTATGTTGAAGATGACCGTGAACTCATAAAACAAAAGGTGATTGCGTATATT
CAACAAGGTATTCCTCAGGTTCAGCGTAGTACGCAGTCTACATTTTATTTGTCTAAACTCTTTCAGCTCGATACGTCAGA
TCAAATTTTGCCTGTAGATGTTAGAAAATTATATCAAGGAGAACAGGCATGA

Upstream 100 bases:

>100_bases
GAACAGGACATGCCTGCGGTGCATATGGATATTCATGATTTTGGTGCCACACCTGGCGTTGTCAGATTACGACTTGAACA
GGCATTTGAGGAGGTGTTAC

Downstream 100 bases:

>100_bases
ACATGGATGTCAATGCAGTAAAAAATTCGACCAGAGGTAAACACTGGTTCAACTTGCTAACACAGGGCTTTAATTTGATT
GCGAGTGGTATCGATTCACT

Product: malonate decarboxylase subunit beta

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MADIDYLLNKQSFIEMDARERAKSLFDLNSCKELLDPFAGVMSPWLLRQNIVPQADDGVVVMKGFIEQQPAVVISVEGSF
QGGSLGEVGGAKIAGALELAIEDNCNHIPTRAILLLETGGVRLQEANLGLAAIAEIHSAIVELRHYQPVIGVIAGSVGCF
GGMSIAAGLCSYLIMTQEGRLGLNGPQVIEQEAGIDEYNAKDRPFIWSITGGEQRFASGLIDAYVEDDRELIKQKVIAYI
QQGIPQVQRSTQSTFYLSKLFQLDTSDQILPVDVRKLYQGEQA

Sequences:

>Translated_283_residues
MADIDYLLNKQSFIEMDARERAKSLFDLNSCKELLDPFAGVMSPWLLRQNIVPQADDGVVVMKGFIEQQPAVVISVEGSF
QGGSLGEVGGAKIAGALELAIEDNCNHIPTRAILLLETGGVRLQEANLGLAAIAEIHSAIVELRHYQPVIGVIAGSVGCF
GGMSIAAGLCSYLIMTQEGRLGLNGPQVIEQEAGIDEYNAKDRPFIWSITGGEQRFASGLIDAYVEDDRELIKQKVIAYI
QQGIPQVQRSTQSTFYLSKLFQLDTSDQILPVDVRKLYQGEQA
>Mature_282_residues
ADIDYLLNKQSFIEMDARERAKSLFDLNSCKELLDPFAGVMSPWLLRQNIVPQADDGVVVMKGFIEQQPAVVISVEGSFQ
GGSLGEVGGAKIAGALELAIEDNCNHIPTRAILLLETGGVRLQEANLGLAAIAEIHSAIVELRHYQPVIGVIAGSVGCFG
GMSIAAGLCSYLIMTQEGRLGLNGPQVIEQEAGIDEYNAKDRPFIWSITGGEQRFASGLIDAYVEDDRELIKQKVIAYIQ
QGIPQVQRSTQSTFYLSKLFQLDTSDQILPVDVRKLYQGEQA

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG0777

COG function: function code I; Acetyl-CoA carboxylase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Escherichia coli, GI1788655, Length=190, Percent_Identity=30.5263157894737, Blast_Score=74, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 30831; Mature: 30699

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50980 COA_CT_NTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIDYLLNKQSFIEMDARERAKSLFDLNSCKELLDPFAGVMSPWLLRQNIVPQADDGVV
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VMKGFIEQQPAVVISVEGSFQGGSLGEVGGAKIAGALELAIEDNCNHIPTRAILLLETGG
EEEHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCEEEEEEECCC
VRLQEANLGLAAIAEIHSAIVELRHYQPVIGVIAGSVGCFGGMSIAAGLCSYLIMTQEGR
CEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LGLNGPQVIEQEAGIDEYNAKDRPFIWSITGGEQRFASGLIDAYVEDDRELIKQKVIAYI
CCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQGIPQVQRSTQSTFYLSKLFQLDTSDQILPVDVRKLYQGEQA
HHCCHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHCCCCCC
>Mature Secondary Structure 
ADIDYLLNKQSFIEMDARERAKSLFDLNSCKELLDPFAGVMSPWLLRQNIVPQADDGVV
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VMKGFIEQQPAVVISVEGSFQGGSLGEVGGAKIAGALELAIEDNCNHIPTRAILLLETGG
EEEHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCEEEEEEECCC
VRLQEANLGLAAIAEIHSAIVELRHYQPVIGVIAGSVGCFGGMSIAAGLCSYLIMTQEGR
CEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LGLNGPQVIEQEAGIDEYNAKDRPFIWSITGGEQRFASGLIDAYVEDDRELIKQKVIAYI
CCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQGIPQVQRSTQSTFYLSKLFQLDTSDQILPVDVRKLYQGEQA
HHCCHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]