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The map label for this gene is folE2

Identifier: 50084892

GI number: 50084892

Start: 1747804

End: 1748688

Strand: Reverse

Name: folE2

Synonym: ACIAD1740

Alternate gene names: 50084892

Gene position: 1748688-1747804 (Counterclockwise)

Preceding gene: 50084893

Following gene: 50084891

Centisome position: 48.59

GC content: 36.72

Gene sequence:

>885_bases
ATGAATGCTCAACTTCCCGATGTATCAGTCTCACAGCTTCCTTGCAATTTATCCCCTTTAAATTGGGTGGGCATGCAACA
TATAGACTTACCTACTGTGATTGATACGGCAAATCAAACTGTTAATACCAAAGTTGATGTATATGTAAATTTACCCAAAA
GTAGTGTAAAAGGCATTCATATGTCTAGGTTATATCATTTGATTAATCATCTATCCGTATTGAATACGATGTCTATAAAA
TCAGTTCTCAAGCAAATGATAGATAGCCATCAAGATTGTGGAACTACTGCGGCCAAAATTGTATTTAAATTTGATCTGCT
GTTAAAAAGAGATGCTATCGTCAGTACAGCGCTTTCAGGATGGAAAAGTTATCCCGTTATCATTGAGGCCAGTATTATTA
ATGAATTGTTTAATATTGAATACAAACTCGATATAAGTTATTCCTCGACCTGCCCTTGCTCTGCTGCCTTATCAAGGCAA
ATCATTAAGAATGGATTCAAAGCAGATTTTAGTTCTCAAAATTTAATACCCAGTGCAGATATTGAAGCTTGGCTCGAACA
ATACGCGACATTGGCTACACCTCACAGCCAGCGTAGTATTGCAACGGTTGTGGTACAGCCTTTTGATTATGCTCATGATA
TTAATTTTGTCGATTTAATCGATTCAATAGAAAATACACTAAAGACACCAACACAGACTGCGGTTAAACGTGCAGATGAA
CAAGCTTTTGCCAAGTTAAATGGTGAAAATCTTATGTTTGTAGAAGATGCTGCACGCCGCCTTAAAATGCTACTAGATCA
AAAATATAAGTTTTGGTCCGCACAAGTGGTACATCAAGAAAGTCTTCATCCTCATGATGCGATTGCAGTTGCAATATCAT
CTTAA

Upstream 100 bases:

>100_bases
CGCTTGGCCCTGACGGCTGGACTCAAATGTCAAATCCGTTTGATTGGTCTTAATCACTAAATTTTAATTCTATTTAATCA
CTTATATTGTATAACCTAAT

Downstream 100 bases:

>100_bases
TAATAAGTTTATGTCTTCTTATAGCGTTAAGTTTGAGCCTTAACGCTATATTGTTAATTTTAAATTTATGGTTTTTTGTT
TGCTTTTAAAATTATATTTA

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNAQLPDVSVSQLPCNLSPLNWVGMQHIDLPTVIDTANQTVNTKVDVYVNLPKSSVKGIHMSRLYHLINHLSVLNTMSIK
SVLKQMIDSHQDCGTTAAKIVFKFDLLLKRDAIVSTALSGWKSYPVIIEASIINELFNIEYKLDISYSSTCPCSAALSRQ
IIKNGFKADFSSQNLIPSADIEAWLEQYATLATPHSQRSIATVVVQPFDYAHDINFVDLIDSIENTLKTPTQTAVKRADE
QAFAKLNGENLMFVEDAARRLKMLLDQKYKFWSAQVVHQESLHPHDAIAVAISS

Sequences:

>Translated_294_residues
MNAQLPDVSVSQLPCNLSPLNWVGMQHIDLPTVIDTANQTVNTKVDVYVNLPKSSVKGIHMSRLYHLINHLSVLNTMSIK
SVLKQMIDSHQDCGTTAAKIVFKFDLLLKRDAIVSTALSGWKSYPVIIEASIINELFNIEYKLDISYSSTCPCSAALSRQ
IIKNGFKADFSSQNLIPSADIEAWLEQYATLATPHSQRSIATVVVQPFDYAHDINFVDLIDSIENTLKTPTQTAVKRADE
QAFAKLNGENLMFVEDAARRLKMLLDQKYKFWSAQVVHQESLHPHDAIAVAISS
>Mature_294_residues
MNAQLPDVSVSQLPCNLSPLNWVGMQHIDLPTVIDTANQTVNTKVDVYVNLPKSSVKGIHMSRLYHLINHLSVLNTMSIK
SVLKQMIDSHQDCGTTAAKIVFKFDLLLKRDAIVSTALSGWKSYPVIIEASIINELFNIEYKLDISYSSTCPCSAALSRQ
IIKNGFKADFSSQNLIPSADIEAWLEQYATLATPHSQRSIATVVVQPFDYAHDINFVDLIDSIENTLKTPTQTAVKRADE
QAFAKLNGENLMFVEDAARRLKMLLDQKYKFWSAQVVHQESLHPHDAIAVAISS

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_ACIAD (Q6FBI2)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046402.1
- ProteinModelPortal:   Q6FBI2
- SMR:   Q6FBI2
- STRING:   Q6FBI2
- GeneID:   2878385
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1740
- NMPDR:   fig|62977.3.peg.1664
- eggNOG:   COG1469
- HOGENOM:   HBG466315
- OMA:   FCEDAAR
- ProtClustDB:   PRK13674
- BioCyc:   ASP62977:ACIAD1740-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 32773; Mature: 32773

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQLPDVSVSQLPCNLSPLNWVGMQHIDLPTVIDTANQTVNTKVDVYVNLPKSSVKGIH
CCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEEEEECCHHHHCCHH
MSRLYHLINHLSVLNTMSIKSVLKQMIDSHQDCGTTAAKIVFKFDLLLKRDAIVSTALSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
WKSYPVIIEASIINELFNIEYKLDISYSSTCPCSAALSRQIIKNGFKADFSSQNLIPSAD
CCCCCEEEEHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHH
IEAWLEQYATLATPHSQRSIATVVVQPFDYAHDINFVDLIDSIENTLKTPTQTAVKRADE
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHCCHHHHHHHHHHHHHCCCHHHHHHHHHH
QAFAKLNGENLMFVEDAARRLKMLLDQKYKFWSAQVVHQESLHPHDAIAVAISS
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MNAQLPDVSVSQLPCNLSPLNWVGMQHIDLPTVIDTANQTVNTKVDVYVNLPKSSVKGIH
CCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEEEEECCHHHHCCHH
MSRLYHLINHLSVLNTMSIKSVLKQMIDSHQDCGTTAAKIVFKFDLLLKRDAIVSTALSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
WKSYPVIIEASIINELFNIEYKLDISYSSTCPCSAALSRQIIKNGFKADFSSQNLIPSAD
CCCCCEEEEHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHH
IEAWLEQYATLATPHSQRSIATVVVQPFDYAHDINFVDLIDSIENTLKTPTQTAVKRADE
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHCCHHHHHHHHHHHHHCCCHHHHHHHHHH
QAFAKLNGENLMFVEDAARRLKMLLDQKYKFWSAQVVHQESLHPHDAIAVAISS
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA