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The map label for this gene is accB [H]

Identifier: 50084890

GI number: 50084890

Start: 1745822

End: 1746244

Strand: Reverse

Name: accB [H]

Synonym: ACIAD1737

Alternate gene names: 50084890

Gene position: 1746244-1745822 (Counterclockwise)

Preceding gene: 50084891

Following gene: 50084889

Centisome position: 48.53

GC content: 43.74

Gene sequence:

>423_bases
ATGGATATTCGCAAAATTAAGAAACTCATCGACTTGATGATTGAATCTGACTTACAAGCGATTGAGGTTAAAGAAGGTGA
TCAATCTATCGCTCTAACTCGCCCTACTCCAGTTATTGCGGCTGGTGCGATTGCAGCAGCTCCTGCATCAGCAGCGCCTG
CTGCACCTGCAGTGAAAACTCCACGTGGTGCTGTTGAAACGTCTCCAATGGTTGGCGTATTTTATGCAGCTCCAAGTCCA
GGTGAAGGTCCTTTTGTTAAGGTAGGCCAAACAGTTTCTGCTGGTGAAACATTGGGTATTATCGAAGCAATGAAAATCAT
GAACCCAATCGAAGCAACTCAAAGTGGCGTTGTTGAAGAAATTTTAGTTAAAAATGGTGATGTAATCCAATTTGGTCAAC
CATTATTCCGCTTCCGCGCATAA

Upstream 100 bases:

>100_bases
TTGCGGTTTCGGTGCAAAGGGTTATCACTTTGCACTGGATTATGCCATCCAAAAAATTCAACCATCTACTTAATTCAACA
TGATTTAGGAACATTCACCT

Downstream 100 bases:

>100_bases
TCTCACGGGGATACTTATGTTGCAAAAAGTTTTAATTGCAAACCGTGGTGAAATCGCGTTACGAATTACCCGGGCTTGCA
AAACATTAGGAATCAAGACC

Product: biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP)

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MDIRKIKKLIDLMIESDLQAIEVKEGDQSIALTRPTPVIAAGAIAAAPASAAPAAPAVKTPRGAVETSPMVGVFYAAPSP
GEGPFVKVGQTVSAGETLGIIEAMKIMNPIEATQSGVVEEILVKNGDVIQFGQPLFRFRA

Sequences:

>Translated_140_residues
MDIRKIKKLIDLMIESDLQAIEVKEGDQSIALTRPTPVIAAGAIAAAPASAAPAAPAVKTPRGAVETSPMVGVFYAAPSP
GEGPFVKVGQTVSAGETLGIIEAMKIMNPIEATQSGVVEEILVKNGDVIQFGQPLFRFRA
>Mature_140_residues
MDIRKIKKLIDLMIESDLQAIEVKEGDQSIALTRPTPVIAAGAIAAAPASAAPAAPAVKTPRGAVETSPMVGVFYAAPSP
GEGPFVKVGQTVSAGETLGIIEAMKIMNPIEATQSGVVEEILVKNGDVIQFGQPLFRFRA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=152, Percent_Identity=44.078947368421, Blast_Score=117, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 14568; Mature: 14568

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRKIKKLIDLMIESDLQAIEVKEGDQSIALTRPTPVIAAGAIAAAPASAAPAAPAVKT
CCHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCEEECCHHHCCCCCCCCCCCCCCC
PRGAVETSPMVGVFYAAPSPGEGPFVKVGQTVSAGETLGIIEAMKIMNPIEATQSGVVEE
CCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
ILVKNGDVIQFGQPLFRFRA
HHHCCCCEEEECCHHHHHCC
>Mature Secondary Structure
MDIRKIKKLIDLMIESDLQAIEVKEGDQSIALTRPTPVIAAGAIAAAPASAAPAAPAVKT
CCHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCEEECCHHHCCCCCCCCCCCCCCC
PRGAVETSPMVGVFYAAPSPGEGPFVKVGQTVSAGETLGIIEAMKIMNPIEATQSGVVEE
CCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
ILVKNGDVIQFGQPLFRFRA
HHHCCCCEEEECCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]