Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 50084889

GI number: 50084889

Start: 1744417

End: 1745805

Strand: Reverse

Name: accC [H]

Synonym: ACIAD1736

Alternate gene names: 50084889

Gene position: 1745805-1744417 (Counterclockwise)

Preceding gene: 50084890

Following gene: 50084883

Centisome position: 48.51

GC content: 41.76

Gene sequence:

>1389_bases
ATGTTGCAAAAAGTTTTAATTGCAAACCGTGGTGAAATCGCGTTACGAATTACCCGGGCTTGCAAAACATTAGGAATCAA
GACCGTTGGTATCTATTCAGATGCTGACAAAGACTTAATGCATTTACGTTTTGTTGATGAAGCGGTATGTATTGGACCGG
GTGCAAGTAGTGATAGCTATTTAAATATCCCCGCAATTATTACTGCAGCAGAAATCACAGGCGCAGATGCCATCCATCCA
GGTTACGGTTTCCTTTCTGAAAATGCTGAGTTTGCAGAAATTGTCGAAACTTCTGGTTTTATTTTCATTGGTCCACGTCC
AGAACATATCCGCCTCATGGGTAATAAAGTATCTGCGATTATTGCCATGAAAAAAGCTGGTGTTCCAACAGTTCCAGGTT
GTGATCACGCTGTAACCATTCACAACGCGCTTGCAGAAGCAAAAGAGATTGGCTTTCCATTGATTGTCAAAGCTGCTTCT
GGTGGTGGTGGTCGTGGTATGCGTATTGTTGAACGCGTTGATACACTTCTTGAATCTGTTCAGGCAGCACAACGTGACGC
AGAAATGTGGTTTGGTGATGATACGGTCTATATGGAACGTTTCTTACAAAAGCCACGTCATATTGAAGTTCAGGTATTGG
GCGATGGAAATGGTCATGCTGTGCATCTTTACGACCGTGACTGTTCTTTGCAACGCCGCCACCAAAAAGTACTAGAAGAA
GCTCCTGCACCAAATCTTCCAGAGCAAGCACGTGCCGATATTCTAGAAGCATGTGTGAATGCGTGTAAGTTAATGCAATA
CCGCGGCGCTGGTACTTTTGAGTTTCTATTTGAAGATGGTGAATTCTTCTTTATTGAAATGAATACACGTGTTCAGGTAG
AGCATCCTGTTACTGAAATGGTGACAGGAATTGACATTATCGAGCAACAATTGCGTATTGCTGCTGGTCTTGGTTTAGAG
CTTCAACAAGAAGATATTGAAGTTCGTGGTCATGCCATCGAATGCCGTATCAATGCTGAAGATCCAACCACATTTTTGCC
ATCACCAGGTAAAATTGAGACGTTCTATGCGCCAGGTGGAGCGGGTATCCGTTTAGATTCGCATATCTATTCAGGCTATA
GCATTCCACCTTACTATGATTCAATGATTGCAAAACTCATTTCACATGGTAAAGATCGTGAAACGTCAATGGCACGTATG
CGTCAAGCACTGGATGAAACTATTCTCACTGGTGTTAAAACCAATATTCCATTACATAAAGATCTGATCTTACAAGATAA
AAACTTCTTAAAAGAAGCGATGGACATCCATTATCTTGAAAAGCATCTTTTAAAACAATTGGAAGCTGAAAAAGCAGCTC
CAGCAGCTGAAACCACAGAAAAAGCCTAA

Upstream 100 bases:

>100_bases
CAAAGTGGCGTTGTTGAAGAAATTTTAGTTAAAAATGGTGATGTAATCCAATTTGGTCAACCATTATTCCGCTTCCGCGC
ATAATCTCACGGGGATACTT

Downstream 100 bases:

>100_bases
TTCTCTTTGTGGTTTATAAAAAACCCTTATCTATACGATAAGGGTTTTTTTTATTCTGTAGAGATTATGGTAAAACCCTA
CGCAAGGTTGCAAAACACTG

Product: biotin carboxylase (A subunit of acetyl-CoA carboxylase)

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSYLNIPAIITAAEITGADAIHP
GYGFLSENAEFAEIVETSGFIFIGPRPEHIRLMGNKVSAIIAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAAS
GGGGRGMRIVERVDTLLESVQAAQRDAEMWFGDDTVYMERFLQKPRHIEVQVLGDGNGHAVHLYDRDCSLQRRHQKVLEE
APAPNLPEQARADILEACVNACKLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEMVTGIDIIEQQLRIAAGLGLE
LQQEDIEVRGHAIECRINAEDPTTFLPSPGKIETFYAPGGAGIRLDSHIYSGYSIPPYYDSMIAKLISHGKDRETSMARM
RQALDETILTGVKTNIPLHKDLILQDKNFLKEAMDIHYLEKHLLKQLEAEKAAPAAETTEKA

Sequences:

>Translated_462_residues
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSYLNIPAIITAAEITGADAIHP
GYGFLSENAEFAEIVETSGFIFIGPRPEHIRLMGNKVSAIIAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAAS
GGGGRGMRIVERVDTLLESVQAAQRDAEMWFGDDTVYMERFLQKPRHIEVQVLGDGNGHAVHLYDRDCSLQRRHQKVLEE
APAPNLPEQARADILEACVNACKLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEMVTGIDIIEQQLRIAAGLGLE
LQQEDIEVRGHAIECRINAEDPTTFLPSPGKIETFYAPGGAGIRLDSHIYSGYSIPPYYDSMIAKLISHGKDRETSMARM
RQALDETILTGVKTNIPLHKDLILQDKNFLKEAMDIHYLEKHLLKQLEAEKAAPAAETTEKA
>Mature_462_residues
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSYLNIPAIITAAEITGADAIHP
GYGFLSENAEFAEIVETSGFIFIGPRPEHIRLMGNKVSAIIAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAAS
GGGGRGMRIVERVDTLLESVQAAQRDAEMWFGDDTVYMERFLQKPRHIEVQVLGDGNGHAVHLYDRDCSLQRRHQKVLEE
APAPNLPEQARADILEACVNACKLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEMVTGIDIIEQQLRIAAGLGLE
LQQEDIEVRGHAIECRINAEDPTTFLPSPGKIETFYAPGGAGIRLDSHIYSGYSIPPYYDSMIAKLISHGKDRETSMARM
RQALDETILTGVKTNIPLHKDLILQDKNFLKEAMDIHYLEKHLLKQLEAEKAAPAAETTEKA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=459, Percent_Identity=46.1873638344227, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=45.823927765237, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=45.823927765237, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=45.823927765237, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=47.2160356347439, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=47.2160356347439, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=47.2160356347439, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI38679971, Length=524, Percent_Identity=28.4351145038168, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679960, Length=524, Percent_Identity=28.4351145038168, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679977, Length=524, Percent_Identity=28.4351145038168, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI38679967, Length=524, Percent_Identity=28.4351145038168, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI38679974, Length=524, Percent_Identity=28.4351145038168, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI134142062, Length=523, Percent_Identity=28.8718929254302, Blast_Score=219, Evalue=6e-57,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=63.5955056179775, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1786216, Length=246, Percent_Identity=25.609756097561, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=465, Percent_Identity=44.0860215053763, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=45.2115812917595, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=43.7923250564334, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=28.4552845528455, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=450, Percent_Identity=29.1111111111111, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=450, Percent_Identity=29.1111111111111, Blast_Score=195, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=462, Percent_Identity=42.6406926406926, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=426, Percent_Identity=47.4178403755869, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=426, Percent_Identity=48.3568075117371, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6324343, Length=531, Percent_Identity=29.0018832391714, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6323863, Length=468, Percent_Identity=31.1965811965812, Blast_Score=223, Evalue=6e-59,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=49.2204899777283, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=49.2204899777283, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=49.2204899777283, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=49.2204899777283, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=49.2204899777283, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=49.2204899777283, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=49.2204899777283, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=49.2204899777283, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=49.2204899777283, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=49.2204899777283, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24651757, Length=426, Percent_Identity=47.1830985915493, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651759, Length=388, Percent_Identity=47.1649484536082, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI161076407, Length=517, Percent_Identity=28.4332688588008, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24586460, Length=517, Percent_Identity=28.4332688588008, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI161076409, Length=517, Percent_Identity=28.4332688588008, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24586458, Length=517, Percent_Identity=28.4332688588008, Blast_Score=221, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50945; Mature: 50945

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSY
CCCCEEECCCCCEEEEEEHHHHHCCCEEEEEECCCCCHHHHHEECCCEEEECCCCCCCCE
LNIPAIITAAEITGADAIHPGYGFLSENAEFAEIVETSGFIFIGPRPEHIRLMGNKVSAI
EECCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCEEEEECCCEEEE
IAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAASGGGGRGMRIVERVDTLLESV
EEEHHCCCCCCCCCCCEEHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
QAAQRDAEMWFGDDTVYMERFLQKPRHIEVQVLGDGNGHAVHLYDRDCSLQRRHQKVLEE
HHHHHCCHHEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHH
APAPNLPEQARADILEACVNACKLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEM
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHHH
VTGIDIIEQQLRIAAGLGLELQQEDIEVRGHAIECRINAEDPTTFLPSPGKIETFYAPGG
HHHHHHHHHHHHHHHCCCCEEECCCCEECCEEEEEEECCCCCCEECCCCCCEEEEECCCC
AGIRLDSHIYSGYSIPPYYDSMIAKLISHGKDRETSMARMRQALDETILTGVKTNIPLHK
CCEEECCEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
DLILQDKNFLKEAMDIHYLEKHLLKQLEAEKAAPAAETTEKA
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLQKVLIANRGEIALRITRACKTLGIKTVGIYSDADKDLMHLRFVDEAVCIGPGASSDSY
CCCCEEECCCCCEEEEEEHHHHHCCCEEEEEECCCCCHHHHHEECCCEEEECCCCCCCCE
LNIPAIITAAEITGADAIHPGYGFLSENAEFAEIVETSGFIFIGPRPEHIRLMGNKVSAI
EECCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCEEEEECCCEEEE
IAMKKAGVPTVPGCDHAVTIHNALAEAKEIGFPLIVKAASGGGGRGMRIVERVDTLLESV
EEEHHCCCCCCCCCCCEEHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
QAAQRDAEMWFGDDTVYMERFLQKPRHIEVQVLGDGNGHAVHLYDRDCSLQRRHQKVLEE
HHHHHCCHHEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHH
APAPNLPEQARADILEACVNACKLMQYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPVTEM
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHHH
VTGIDIIEQQLRIAAGLGLELQQEDIEVRGHAIECRINAEDPTTFLPSPGKIETFYAPGG
HHHHHHHHHHHHHHHCCCCEEECCCCEECCEEEEEEECCCCCCEECCCCCCEEEEECCCC
AGIRLDSHIYSGYSIPPYYDSMIAKLISHGKDRETSMARMRQALDETILTGVKTNIPLHK
CCEEECCEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
DLILQDKNFLKEAMDIHYLEKHLLKQLEAEKAAPAAETTEKA
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]