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The map label for this gene is lrp [H]

Identifier: 50084805

GI number: 50084805

Start: 1645929

End: 1646432

Strand: Direct

Name: lrp [H]

Synonym: ACIAD1648

Alternate gene names: 50084805

Gene position: 1645929-1646432 (Clockwise)

Preceding gene: 50084799

Following gene: 50084811

Centisome position: 45.74

GC content: 40.08

Gene sequence:

>504_bases
ATGAGTGGGGGTTTTTCTACACTTGATCGCGTGGATATTAAAATTCTTGATATTCTTCAAAGAGATGGAAGAATTTCAAA
CAGCAAATTAGCTGAAGAAGTAAGCCTGTCTGCGACTGCTGTGTTGGCTCGTGTACAGAAGCTGAGCAAAGAGGGTTTTA
TTGTTGGTTATGAGGCCAAACTAAATCCTGAAAAATTAAATGCCAGCTTTTTGGTGTTTGTAGAAGTGTTACTTGATAAA
ACGACCACCAATGGATTAGAAGAATTCATTGAAGCTGTGGCCCAGTATCCCGAAATTGTAGAATGCCATATGACCAGCGG
CGGTTTTGACTTTCTCATGAAGATTCGTAGTGCCAGTATGGAAGAATATCGAAAATTTGCGGGACAAACCTTGTGGCAAT
TGCCAGGTGTTAAAGAAACGCGAAGTTATCCTGTGATGCAAGTCGTAAAAGAGACTTCGCAAATTAAACTGGTAAAACGC
AGTGTAAAAAAAGGGGCTTCTTAA

Upstream 100 bases:

>100_bases
CTAAGGTATATTGTTTAAAGGGGTTTAGATAATTTATCATTACAGAATAATTACCAAATAACTGACTATAATTGATTCAT
TTTTTAGAGGAAAATTTTGT

Downstream 100 bases:

>100_bases
AGCCCCTGATGAATGCCTTGATCTCTCTAAATTTTATTTTGAGCTATGATACAAGCGATCTGCTTCTTCAAAACGCTCAG
TCACTTCTTTACTTGGCTGT

Product: leucine-responsive regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MSGGFSTLDRVDIKILDILQRDGRISNSKLAEEVSLSATAVLARVQKLSKEGFIVGYEAKLNPEKLNASFLVFVEVLLDK
TTTNGLEEFIEAVAQYPEIVECHMTSGGFDFLMKIRSASMEEYRKFAGQTLWQLPGVKETRSYPVMQVVKETSQIKLVKR
SVKKGAS

Sequences:

>Translated_167_residues
MSGGFSTLDRVDIKILDILQRDGRISNSKLAEEVSLSATAVLARVQKLSKEGFIVGYEAKLNPEKLNASFLVFVEVLLDK
TTTNGLEEFIEAVAQYPEIVECHMTSGGFDFLMKIRSASMEEYRKFAGQTLWQLPGVKETRSYPVMQVVKETSQIKLVKR
SVKKGAS
>Mature_166_residues
SGGFSTLDRVDIKILDILQRDGRISNSKLAEEVSLSATAVLARVQKLSKEGFIVGYEAKLNPEKLNASFLVFVEVLLDKT
TTNGLEEFIEAVAQYPEIVECHMTSGGFDFLMKIRSASMEEYRKFAGQTLWQLPGVKETRSYPVMQVVKETSQIKLVKRS
VKKGAS

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=148, Percent_Identity=50.6756756756757, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=29.3333333333333, Blast_Score=88, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18626; Mature: 18495

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGGFSTLDRVDIKILDILQRDGRISNSKLAEEVSLSATAVLARVQKLSKEGFIVGYEAK
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
LNPEKLNASFLVFVEVLLDKTTTNGLEEFIEAVAQYPEIVECHMTSGGFDFLMKIRSASM
CCHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHEEHHCCCCCHHHHHHHHHCCH
EEYRKFAGQTLWQLPGVKETRSYPVMQVVKETSQIKLVKRSVKKGAS
HHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGGFSTLDRVDIKILDILQRDGRISNSKLAEEVSLSATAVLARVQKLSKEGFIVGYEAK
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
LNPEKLNASFLVFVEVLLDKTTTNGLEEFIEAVAQYPEIVECHMTSGGFDFLMKIRSASM
CCHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHEEHHCCCCCHHHHHHHHHCCH
EEYRKFAGQTLWQLPGVKETRSYPVMQVVKETSQIKLVKRSVKKGAS
HHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]