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The map label for this gene is acsA [H]

Identifier: 50084772

GI number: 50084772

Start: 1608592

End: 1610235

Strand: Direct

Name: acsA [H]

Synonym: ACIAD1611

Alternate gene names: 50084772

Gene position: 1608592-1610235 (Clockwise)

Preceding gene: 50084770

Following gene: 50084773

Centisome position: 44.7

GC content: 38.38

Gene sequence:

>1644_bases
ATGCAAACATTAGAGCAAGCATATCAAGCATTTGATTTGAATCAATTAATAGAGCAGCAATTGATAGGCCATCCCCAATC
GATCAATGCTTATGAAGAATGTTGTGGCCGTTATGTGGGACAAAATAAAATCGCATTGATTTGGGAAGGGCTTGAGGGTG
AGACAAAGCAATTCACCTTCGATGAGTTGGCAACTTATTCTGGTCAATTGGCAAATTATTTTAAGTCTCAAGGTGTGCAA
CCCGGACAATGCATTGCGGGTCTATTACCTCGTACTCCCGAATTGTTGATTACAATTTTAGCCACTTGGCGAATGGGAGC
TATTTATCAACCGTTATTTACTGCATTTGAATCAAAAGCAATTGAACATCGTTTGAGTGTAGCTCAGACACAACTGGTTG
TGACCAACAAAGAACAAGCGGCAAAATTAAATGCTGTGAACAATTTAAAAGTCTTAACAGTAGAAAAAGATTCATTTGAT
ATTTTAGATCAACCTGATTTTTGGAATGCACTTAAGCATTTTGATGCCCAATATCAATCTGAAATGATTACCTTTAATGA
TCATTTTTTGATGATGTTTACGTCTGGAACGACTGGTTTGGCTAAACCTGTGCCTGTGCCACTCAAAGCAATTTTATCTT
TTAAAGGCTATATGACGCACGCTGTTGGATTAAATCAGTCAGATTCTTTCTGGAATCTCGCAGATCCTGGCTGGGCCTAT
GGTTTGTACTACGGGATAACAGGGCCTTTAAGCCTGGGCCATAGCATCATTTTAGATGAACAAGGATTTAGTGTTGATCG
TGCAATTGAATTAATTAAAAAATACAAAGTCTCTAATTTGATTGGATCGCCTACTGCCTTTAGGATGTTCTTTGGATTTA
AAGAAAAATTTGATGCTGAAATTAAAGATTATTTACGTGTGGTGAGTAGTGCCGGAGAACCTTTAACACCAGAGGTCGTC
CATTGGTTTAAGAATGATTTAGACATCAATATTTATGATCAGTATGGTCAAACTGAACTGGGTATGGTCATCGCAAATCA
CCATGCACTTGAGCATCATGTAAAGATTGGCTCTGCTGGATATGCAATTCCTGGTTATCGTTTTGTCGTATTAGATGAAC
ATCATCAAGAACTATCATCTGATTCTATTGGTGTATTAGCAATAGATAGTGCTGCCTCTCCATTATTCTGGTTTACAGGG
TACGGCGAAAACAATCGAAGCGCATTTGTTGGTCAGTATTATATTACGGGTGATACTGTGAAAATGAATGCGTTTGGCAG
TATCGACTTTGTCGGGCGTATAGATGATGTAATTACAACATCGGGTTATCGTGTAGGGCCTTTTGATGTTGAAAGTACTT
TACTTGAGTGCCAAGAGGTTCTTGAATCTGCGGTGATTGGTAAGCCTGATGCAATCAGAACTGAAATTGTAAAAGCTTTT
GTTGTTTTAAAATCACAATACAAGTCTCAGGCTGATCAATCACTGAGCGAAAAACTTAAACAATATGTCCGCGGACGCCT
TTCAAAGCATGCTTATCCTAAAGAAATAGAATTTGTAGATCAATTACCTAAAACAGCCAGTGGCAAAATCCAGCGTGGAG
TTTTAAAACAACAGGAAATCTCCCGTATGCAGTTATCGGGTTAA

Upstream 100 bases:

>100_bases
GATATATAAGGGTTTAAAGGACTATAGATGATATAGGAAATACGATTTTTGTATTTGATACATCTATCAGAATAACAGGG
AAAAAAGGGAGAATAATGAA

Downstream 100 bases:

>100_bases
ATTTTTGATCATCAGGCAGAGCATTAAGGTATTCGTTCTTTAGAGATAGACAATGAACAATGAAGTTGTGATTTTGAGTG
CAATACGCACACCTATGGGT

Product: acetyl-CoA synthetase/AMP-(fatty) acid ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MQTLEQAYQAFDLNQLIEQQLIGHPQSINAYEECCGRYVGQNKIALIWEGLEGETKQFTFDELATYSGQLANYFKSQGVQ
PGQCIAGLLPRTPELLITILATWRMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVNNLKVLTVEKDSFD
ILDQPDFWNALKHFDAQYQSEMITFNDHFLMMFTSGTTGLAKPVPVPLKAILSFKGYMTHAVGLNQSDSFWNLADPGWAY
GLYYGITGPLSLGHSIILDEQGFSVDRAIELIKKYKVSNLIGSPTAFRMFFGFKEKFDAEIKDYLRVVSSAGEPLTPEVV
HWFKNDLDINIYDQYGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAIDSAASPLFWFTG
YGENNRSAFVGQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFDVESTLLECQEVLESAVIGKPDAIRTEIVKAF
VVLKSQYKSQADQSLSEKLKQYVRGRLSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQEISRMQLSG

Sequences:

>Translated_547_residues
MQTLEQAYQAFDLNQLIEQQLIGHPQSINAYEECCGRYVGQNKIALIWEGLEGETKQFTFDELATYSGQLANYFKSQGVQ
PGQCIAGLLPRTPELLITILATWRMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVNNLKVLTVEKDSFD
ILDQPDFWNALKHFDAQYQSEMITFNDHFLMMFTSGTTGLAKPVPVPLKAILSFKGYMTHAVGLNQSDSFWNLADPGWAY
GLYYGITGPLSLGHSIILDEQGFSVDRAIELIKKYKVSNLIGSPTAFRMFFGFKEKFDAEIKDYLRVVSSAGEPLTPEVV
HWFKNDLDINIYDQYGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAIDSAASPLFWFTG
YGENNRSAFVGQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFDVESTLLECQEVLESAVIGKPDAIRTEIVKAF
VVLKSQYKSQADQSLSEKLKQYVRGRLSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQEISRMQLSG
>Mature_547_residues
MQTLEQAYQAFDLNQLIEQQLIGHPQSINAYEECCGRYVGQNKIALIWEGLEGETKQFTFDELATYSGQLANYFKSQGVQ
PGQCIAGLLPRTPELLITILATWRMGAIYQPLFTAFESKAIEHRLSVAQTQLVVTNKEQAAKLNAVNNLKVLTVEKDSFD
ILDQPDFWNALKHFDAQYQSEMITFNDHFLMMFTSGTTGLAKPVPVPLKAILSFKGYMTHAVGLNQSDSFWNLADPGWAY
GLYYGITGPLSLGHSIILDEQGFSVDRAIELIKKYKVSNLIGSPTAFRMFFGFKEKFDAEIKDYLRVVSSAGEPLTPEVV
HWFKNDLDINIYDQYGQTELGMVIANHHALEHHVKIGSAGYAIPGYRFVVLDEHHQELSSDSIGVLAIDSAASPLFWFTG
YGENNRSAFVGQYYITGDTVKMNAFGSIDFVGRIDDVITTSGYRVGPFDVESTLLECQEVLESAVIGKPDAIRTEIVKAF
VVLKSQYKSQADQSLSEKLKQYVRGRLSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQEISRMQLSG

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI122937307, Length=513, Percent_Identity=33.1384015594542, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI42544132, Length=543, Percent_Identity=30.7550644567219, Blast_Score=245, Evalue=8e-65,
Organism=Homo sapiens, GI38505220, Length=513, Percent_Identity=32.3586744639376, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI115511026, Length=513, Percent_Identity=30.9941520467836, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI58082049, Length=508, Percent_Identity=30.7086614173228, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI157311624, Length=508, Percent_Identity=30.511811023622, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI157311622, Length=508, Percent_Identity=30.511811023622, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI28416953, Length=561, Percent_Identity=30.3030303030303, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI8923896, Length=562, Percent_Identity=28.4697508896797, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI253970489, Length=576, Percent_Identity=28.125, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI13375727, Length=535, Percent_Identity=28.5981308411215, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI42544134, Length=356, Percent_Identity=26.4044943820225, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI195947378, Length=411, Percent_Identity=25.7907542579075, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI156151445, Length=377, Percent_Identity=25.9946949602122, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1790505, Length=554, Percent_Identity=26.3537906137184, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786529, Length=524, Percent_Identity=28.8167938931298, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI145693145, Length=521, Percent_Identity=25.5278310940499, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788107, Length=554, Percent_Identity=23.826714801444, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786810, Length=531, Percent_Identity=22.2222222222222, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI221142682, Length=513, Percent_Identity=21.4424951267057, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=564, Percent_Identity=28.5460992907801, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71982997, Length=565, Percent_Identity=28.6725663716814, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17558820, Length=487, Percent_Identity=22.9979466119097, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=492, Percent_Identity=24.390243902439, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557194, Length=544, Percent_Identity=24.0808823529412, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17538037, Length=543, Percent_Identity=24.8618784530387, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17560308, Length=368, Percent_Identity=24.4565217391304, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=398, Percent_Identity=24.8743718592965, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71994690, Length=365, Percent_Identity=22.1917808219178, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=365, Percent_Identity=22.1917808219178, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=365, Percent_Identity=22.1917808219178, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531443, Length=517, Percent_Identity=23.21083172147, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=379, Percent_Identity=25.5936675461741, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71996755, Length=521, Percent_Identity=23.0326295585413, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560140, Length=293, Percent_Identity=24.2320819112628, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319264, Length=562, Percent_Identity=31.1387900355872, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323182, Length=563, Percent_Identity=30.0177619893428, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319699, Length=357, Percent_Identity=23.8095238095238, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24667955, Length=551, Percent_Identity=28.3121597096189, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI62472339, Length=540, Percent_Identity=27.962962962963, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24667959, Length=502, Percent_Identity=28.6852589641434, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21355225, Length=560, Percent_Identity=24.8214285714286, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24581924, Length=514, Percent_Identity=22.3735408560311, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356947, Length=504, Percent_Identity=22.0238095238095, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI18859661, Length=510, Percent_Identity=23.7254901960784, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648260, Length=495, Percent_Identity=21.4141414141414, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922652, Length=520, Percent_Identity=22.5, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648255, Length=498, Percent_Identity=25.1004016064257, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648253, Length=498, Percent_Identity=24.6987951807229, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24656500, Length=499, Percent_Identity=21.4428857715431, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355181, Length=500, Percent_Identity=23.6, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20130357, Length=356, Percent_Identity=24.438202247191, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356441, Length=494, Percent_Identity=22.2672064777328, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 61237; Mature: 61237

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLEQAYQAFDLNQLIEQQLIGHPQSINAYEECCGRYVGQNKIALIWEGLEGETKQFTF
CCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCEEH
DELATYSGQLANYFKSQGVQPGQCIAGLLPRTPELLITILATWRMGAIYQPLFTAFESKA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEHRLSVAQTQLVVTNKEQAAKLNAVNNLKVLTVEKDSFDILDQPDFWNALKHFDAQYQS
HHHHHHHHHHEEEEECCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHC
EMITFNDHFLMMFTSGTTGLAKPVPVPLKAILSFKGYMTHAVGLNQSDSFWNLADPGWAY
CEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEE
GLYYGITGPLSLGHSIILDEQGFSVDRAIELIKKYKVSNLIGSPTAFRMFFGFKEKFDAE
EEEECCCCCHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IKDYLRVVSSAGEPLTPEVVHWFKNDLDINIYDQYGQTELGMVIANHHALEHHVKIGSAG
HHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHEEEECCHHHHHHEEECCCC
YAIPGYRFVVLDEHHQELSSDSIGVLAIDSAASPLFWFTGYGENNRSAFVGQYYITGDTV
CCCCCEEEEEEECHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEEEEEECCEE
KMNAFGSIDFVGRIDDVITTSGYRVGPFDVESTLLECQEVLESAVIGKPDAIRTEIVKAF
EEECCCCEEEHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VVLKSQYKSQADQSLSEKLKQYVRGRLSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
SRMQLSG
HHHHCCC
>Mature Secondary Structure
MQTLEQAYQAFDLNQLIEQQLIGHPQSINAYEECCGRYVGQNKIALIWEGLEGETKQFTF
CCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCEEH
DELATYSGQLANYFKSQGVQPGQCIAGLLPRTPELLITILATWRMGAIYQPLFTAFESKA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEHRLSVAQTQLVVTNKEQAAKLNAVNNLKVLTVEKDSFDILDQPDFWNALKHFDAQYQS
HHHHHHHHHHEEEEECCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHC
EMITFNDHFLMMFTSGTTGLAKPVPVPLKAILSFKGYMTHAVGLNQSDSFWNLADPGWAY
CEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEE
GLYYGITGPLSLGHSIILDEQGFSVDRAIELIKKYKVSNLIGSPTAFRMFFGFKEKFDAE
EEEECCCCCHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IKDYLRVVSSAGEPLTPEVVHWFKNDLDINIYDQYGQTELGMVIANHHALEHHVKIGSAG
HHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHEEEECCHHHHHHEEECCCC
YAIPGYRFVVLDEHHQELSSDSIGVLAIDSAASPLFWFTGYGENNRSAFVGQYYITGDTV
CCCCCEEEEEEECHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEEEEEECCEE
KMNAFGSIDFVGRIDDVITTSGYRVGPFDVESTLLECQEVLESAVIGKPDAIRTEIVKAF
EEECCCCEEEHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VVLKSQYKSQADQSLSEKLKQYVRGRLSKHAYPKEIEFVDQLPKTASGKIQRGVLKQQEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
SRMQLSG
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]