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The map label for this gene is fadA [H]

Identifier: 50084731

GI number: 50084731

Start: 1560357

End: 1561520

Strand: Direct

Name: fadA [H]

Synonym: ACIAD1569

Alternate gene names: 50084731

Gene position: 1560357-1561520 (Clockwise)

Preceding gene: 50084730

Following gene: 50084732

Centisome position: 43.36

GC content: 45.36

Gene sequence:

>1164_bases
ATGAATGTTGCTTATATTGTAGATGCGGTGCGTACCGCAGGCGGTCGTCGTAACGGTAAACTGGCTAGCTGGCATCCTGT
TGATCTGGGTGCAGAAGTCATTAATGCCTTGCTGGATCGTACAGGTATTGATCCGAATGTGATTGATGATGCAGTTTTTG
GATGTGTCACTCAGGCAGGCGAACAAACTTTTGCATTTGCCCGAAATATTGTACTTGCTTCTAAATTACCGATTCATGTG
CCTGGCGTCACTATTGACAGGCAGTGCGGTAGTTCACAACAAGCTGTGCAATTTGCTGCCCAAGCGATTCTATCGGGCAT
GCAGGATGTGGTGATTGCAGGCGGTGTCGAAAGTATGTCGCGTGCCCCGATGTTGAGCAATGCGAGCTTACATGCCAAAG
CAGGACTCCCCGCAGATCCTTTAAGCCCACGCATTAAAGCACGGTTTGATGTTGATCAATTTAGCCAGTTTACAGGCGCT
GAAATGATGGCAAAAAAATATGGCTTTGATCGTGAGCAACTGGATCAATACGCTTTGTTGAGTCATCAACGCGCAATTCA
AGCTACCGAAACGGGTAATTTTGAAAATGAAATTGTTGTACTTGACGTAGATGGTGAAGCACATCGTATTGATGAAGGTA
TTCGTTTTGATGCTAATCTTGAATCTGTCTCAGGGCTTAAACCCTTAGTAGAAAATGGTGTGGTGACGGCGGCGAATGCC
AGTCAGATTTGTGATGGAGCAAGTGCTGTACTCATCGTCAGTGAGCGTGCGCTTAAAGCCTATGATCTGACTCCTAAAGC
ACGTCTAATACATATGAGTGTCAGTGCAGGTGACCCAGTGATGATGCTTGAAGAGCCAATTTTTGCTACACAAAAAGCCC
TAAAAAAAGCAGGACTTAAAATTACTGATATTGATTTATATGAAGTCAATGAAGCCTTTGCACCAGTGCCTCTGGCATGG
CTACAAGCGTTAGATGCAAACCCTGAAGCGCTGAATATTCATGGCGGTGCAATTGCATTGGGGCATCCATTAGGCGCATC
AGGAACCAAACTCATGACCACATTGATTCATGCATTACATACACAAGGTAAGCGTTATGGCCTACAAACCATGTGTGAAG
GTGGTGGTATGGCGAATGTTACGATTTTGGAGGCTTGCTCATGA

Upstream 100 bases:

>100_bases
CGCGCAGTATTGCAGCAATCAGTCTAGGTGAATCAGCCAAAGAAGGACTTGTGGCGTTTCTAGAAAAACGTGCAGCACAA
TTTAATCAGGATAGTGAAAT

Downstream 100 bases:

>100_bases
AATTACAAACGCGTGTTACTGAATTACTTGGAATTGAATATCCGATTATTCAAGGTGGGATGATGTGGGTCGGACGTGCT
GAACTAGCGAGTGCAGTCTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNVAYIVDAVRTAGGRRNGKLASWHPVDLGAEVINALLDRTGIDPNVIDDAVFGCVTQAGEQTFAFARNIVLASKLPIHV
PGVTIDRQCGSSQQAVQFAAQAILSGMQDVVIAGGVESMSRAPMLSNASLHAKAGLPADPLSPRIKARFDVDQFSQFTGA
EMMAKKYGFDREQLDQYALLSHQRAIQATETGNFENEIVVLDVDGEAHRIDEGIRFDANLESVSGLKPLVENGVVTAANA
SQICDGASAVLIVSERALKAYDLTPKARLIHMSVSAGDPVMMLEEPIFATQKALKKAGLKITDIDLYEVNEAFAPVPLAW
LQALDANPEALNIHGGAIALGHPLGASGTKLMTTLIHALHTQGKRYGLQTMCEGGGMANVTILEACS

Sequences:

>Translated_387_residues
MNVAYIVDAVRTAGGRRNGKLASWHPVDLGAEVINALLDRTGIDPNVIDDAVFGCVTQAGEQTFAFARNIVLASKLPIHV
PGVTIDRQCGSSQQAVQFAAQAILSGMQDVVIAGGVESMSRAPMLSNASLHAKAGLPADPLSPRIKARFDVDQFSQFTGA
EMMAKKYGFDREQLDQYALLSHQRAIQATETGNFENEIVVLDVDGEAHRIDEGIRFDANLESVSGLKPLVENGVVTAANA
SQICDGASAVLIVSERALKAYDLTPKARLIHMSVSAGDPVMMLEEPIFATQKALKKAGLKITDIDLYEVNEAFAPVPLAW
LQALDANPEALNIHGGAIALGHPLGASGTKLMTTLIHALHTQGKRYGLQTMCEGGGMANVTILEACS
>Mature_387_residues
MNVAYIVDAVRTAGGRRNGKLASWHPVDLGAEVINALLDRTGIDPNVIDDAVFGCVTQAGEQTFAFARNIVLASKLPIHV
PGVTIDRQCGSSQQAVQFAAQAILSGMQDVVIAGGVESMSRAPMLSNASLHAKAGLPADPLSPRIKARFDVDQFSQFTGA
EMMAKKYGFDREQLDQYALLSHQRAIQATETGNFENEIVVLDVDGEAHRIDEGIRFDANLESVSGLKPLVENGVVTAANA
SQICDGASAVLIVSERALKAYDLTPKARLIHMSVSAGDPVMMLEEPIFATQKALKKAGLKITDIDLYEVNEAFAPVPLAW
LQALDANPEALNIHGGAIALGHPLGASGTKLMTTLIHALHTQGKRYGLQTMCEGGGMANVTILEACS

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=382, Percent_Identity=39.5287958115183, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=37.4045801526718, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=36.3867684478371, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=35.2941176470588, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4504327, Length=419, Percent_Identity=33.890214797136, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI194353979, Length=381, Percent_Identity=27.5590551181102, Blast_Score=118, Evalue=9e-27,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=41.1471321695761, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=38.6934673366834, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=40.8163265306122, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=37.4045801526718, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=33.3333333333333, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=38.0462724935733, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=32.7365728900256, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=32.5699745547074, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.1596244131455, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=390, Percent_Identity=29.7435897435897, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=35.8585858585859, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322031, Length=343, Percent_Identity=32.0699708454811, Blast_Score=156, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=36.5239294710327, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=37.8516624040921, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=33.1658291457286, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=32.2274881516588, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24585051, Length=361, Percent_Identity=24.6537396121884, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921506, Length=361, Percent_Identity=24.3767313019391, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41124; Mature: 41124

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVAYIVDAVRTAGGRRNGKLASWHPVDLGAEVINALLDRTGIDPNVIDDAVFGCVTQAG
CCHHHEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
EQTFAFARNIVLASKLPIHVPGVTIDRQCGSSQQAVQFAAQAILSGMQDVVIAGGVESMS
CHHHHHHHHHHEECCCCEECCCEEEECCCCCHHHHHHHHHHHHHHCHHHEEEECCHHHHH
RAPMLSNASLHAKAGLPADPLSPRIKARFDVDQFSQFTGAEMMAKKYGFDREQLDQYALL
CCCCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SHQRAIQATETGNFENEIVVLDVDGEAHRIDEGIRFDANLESVSGLKPLVENGVVTAANA
HHHHHHHHHCCCCCCCEEEEEEECCCHHHCCCCCEECCCHHHHHCCHHHHHCCEEEECCH
SQICDGASAVLIVSERALKAYDLTPKARLIHMSVSAGDPVMMLEEPIFATQKALKKAGLK
HHHCCCCCEEEEEECCCHHHCCCCCCCEEEEEEECCCCCEEEECCCHHHHHHHHHHCCCE
ITDIDLYEVNEAFAPVPLAWLQALDANPEALNIHGGAIALGHPLGASGTKLMTTLIHALH
EEEEEHEECCCCCCCCHHHHHHHHCCCCCEEEECCCEEEECCCCCCCCHHHHHHHHHHHH
TQGKRYGLQTMCEGGGMANVTILEACS
HCCHHCCHHHHHCCCCCCEEEEEEECC
>Mature Secondary Structure
MNVAYIVDAVRTAGGRRNGKLASWHPVDLGAEVINALLDRTGIDPNVIDDAVFGCVTQAG
CCHHHEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
EQTFAFARNIVLASKLPIHVPGVTIDRQCGSSQQAVQFAAQAILSGMQDVVIAGGVESMS
CHHHHHHHHHHEECCCCEECCCEEEECCCCCHHHHHHHHHHHHHHCHHHEEEECCHHHHH
RAPMLSNASLHAKAGLPADPLSPRIKARFDVDQFSQFTGAEMMAKKYGFDREQLDQYALL
CCCCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SHQRAIQATETGNFENEIVVLDVDGEAHRIDEGIRFDANLESVSGLKPLVENGVVTAANA
HHHHHHHHHCCCCCCCEEEEEEECCCHHHCCCCCEECCCHHHHHCCHHHHHCCEEEECCH
SQICDGASAVLIVSERALKAYDLTPKARLIHMSVSAGDPVMMLEEPIFATQKALKKAGLK
HHHCCCCCEEEEEECCCHHHCCCCCCCEEEEEEECCCCCEEEECCCHHHHHHHHHHCCCE
ITDIDLYEVNEAFAPVPLAWLQALDANPEALNIHGGAIALGHPLGASGTKLMTTLIHALH
EEEEEHEECCCCCCCCHHHHHHHHCCCCCEEEECCCEEEECCCCCCCCHHHHHHHHHHHH
TQGKRYGLQTMCEGGGMANVTILEACS
HCCHHCCHHHHHCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA