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The map label for this gene is proY [C]

Identifier: 50084633

GI number: 50084633

Start: 1456611

End: 1458035

Strand: Direct

Name: proY [C]

Synonym: ACIAD1458

Alternate gene names: 50084633

Gene position: 1456611-1458035 (Clockwise)

Preceding gene: 50084629

Following gene: 50084634

Centisome position: 40.48

GC content: 44.91

Gene sequence:

>1425_bases
TTGAATACAATGAAAGATTCAGAATTAAGCCTAGACAATGGCGCAACTCGTGATGTTGATTATTTTGCAAAACGCCAGCT
CAAAAAGGGTGCAGTGGGCTGGTTATTATTGGTGGGTTTAGGAGTCTCTTATGTGATATCTGGAGACTTTGCGGGGTGGA
ACTTCGGTCTGGCTCAGGGCGGCTGGGGCGGTTTATTTATTGCAACGGTCATTGTGGCTTTAATGTACCTGTGCATGAGC
CTTTCTATGTCTGAAATGTCGACCATGTTGCCTACCGCAGGTGGTGGCTATAGTTTTGCACGTGTCGCGTTTGGCCCATT
AGGAGGCTACCTCACCGGAACCGCGATTTTAATTGAATATGCCATTGCACCGGCGGCGATTGCGGTGTTTATAGGCTCAT
ATTGTGAGTCACTGTTTGGGATTGGTGGCTGGAGCGTTTACTTACTATGCTATCTGGTCTTTATGGGTATTCATCTTAAA
GGTGCGGGAGAAGCCCTTAAAATCATGTTCATCATTACCGCAATTGCCTGTGTGGCTTTACTGGTATTTATTGTGGCCAT
GATTCCACATTTTGAAAGCGGTAAATTATTTGATATTGCGGTCAGCAATAACGTTGGGGCCAGTGCATTTTTACCACTCG
GTTATTTAGGAATTTGGGCAGCGGTACCCTATGCCATTTGGTTCTTTTTAGCTGTGGAGGGCGTTCCACTGGCGGCAGAA
GAAGCCAAAGATCCAGTTCGTTCTTTGCCACGTGGCCTCATTGGTTCGATGCTGATTTTGGCGGCATTTGCGCTATTGAT
TTTGTTTTTAAGTGCTGGTGCTGCGGGGTCAGATGCGTTAAAAGCCTCAGGTGCGCCTTTGGTTGATGCCTTGATTGCGG
TGTATGGGCAGCATACATGGTTGGCCAGTTTTGTTAATTTTGTTGGATTGGCTGGGCTTGTAGCGAGCTTCTTTTCGATT
ATTTATGCGTATTCGCGTCAGATTTTTGCACTTTCACGTGCCGGATATTTACCAAAAAGCTTGTCATTGACCAACAAAAA
CAAAGCACCTTTTCTTGCGATTATTATTCCGGGGATCATTGGCTTTTTGATGTCATTGACTCATGAAGGTGATTTGCTGA
TTTTAATGGCTGTCTTTGGTGCAACCATCTCTTATGTGCTCATGATGCTGTCACATATTAAATTGCGGATTTCACATCCA
AACCTTGCACGTCCGTATAAAACGCCGGGTGGTGTGGTTACTTCAAGTATTGCATTGGTTTTGGCTGCAATTGCAGTAGT
GGCTGGGTTAATGGTCAATCCGAAAGTATGGTTGCTCACCGCAATGATTTATGTGGCTTTTATTCTGTACTTTATTTTGT
ATAGCCGCTTTCATTTGGTGAAAGGAACGCCCGAAGAAGAGTTTGCGCGCGTGAACGAAGACTAA

Upstream 100 bases:

>100_bases
AATCAACTTGACTTCAAATGACCTTGCTCACAATTTGCGGTCAAGTTTTGAAATGGGCTTTTACGCAACATGAATGAAGT
CGGTTGGATCAATAGAGTGA

Downstream 100 bases:

>100_bases
CCACATTTAAGTGAAACCCAAAGGCATGGTATCTACTGATTCCATGCTTTTTTTATATCTGTCGCCTGTACTAGAAGGTG
TGTTTTTCTTAAAATTATGC

Product: transport protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNTMKDSELSLDNGATRDVDYFAKRQLKKGAVGWLLLVGLGVSYVISGDFAGWNFGLAQGGWGGLFIATVIVALMYLCMS
LSMSEMSTMLPTAGGGYSFARVAFGPLGGYLTGTAILIEYAIAPAAIAVFIGSYCESLFGIGGWSVYLLCYLVFMGIHLK
GAGEALKIMFIITAIACVALLVFIVAMIPHFESGKLFDIAVSNNVGASAFLPLGYLGIWAAVPYAIWFFLAVEGVPLAAE
EAKDPVRSLPRGLIGSMLILAAFALLILFLSAGAAGSDALKASGAPLVDALIAVYGQHTWLASFVNFVGLAGLVASFFSI
IYAYSRQIFALSRAGYLPKSLSLTNKNKAPFLAIIIPGIIGFLMSLTHEGDLLILMAVFGATISYVLMMLSHIKLRISHP
NLARPYKTPGGVVTSSIALVLAAIAVVAGLMVNPKVWLLTAMIYVAFILYFILYSRFHLVKGTPEEEFARVNED

Sequences:

>Translated_474_residues
MNTMKDSELSLDNGATRDVDYFAKRQLKKGAVGWLLLVGLGVSYVISGDFAGWNFGLAQGGWGGLFIATVIVALMYLCMS
LSMSEMSTMLPTAGGGYSFARVAFGPLGGYLTGTAILIEYAIAPAAIAVFIGSYCESLFGIGGWSVYLLCYLVFMGIHLK
GAGEALKIMFIITAIACVALLVFIVAMIPHFESGKLFDIAVSNNVGASAFLPLGYLGIWAAVPYAIWFFLAVEGVPLAAE
EAKDPVRSLPRGLIGSMLILAAFALLILFLSAGAAGSDALKASGAPLVDALIAVYGQHTWLASFVNFVGLAGLVASFFSI
IYAYSRQIFALSRAGYLPKSLSLTNKNKAPFLAIIIPGIIGFLMSLTHEGDLLILMAVFGATISYVLMMLSHIKLRISHP
NLARPYKTPGGVVTSSIALVLAAIAVVAGLMVNPKVWLLTAMIYVAFILYFILYSRFHLVKGTPEEEFARVNED
>Mature_474_residues
MNTMKDSELSLDNGATRDVDYFAKRQLKKGAVGWLLLVGLGVSYVISGDFAGWNFGLAQGGWGGLFIATVIVALMYLCMS
LSMSEMSTMLPTAGGGYSFARVAFGPLGGYLTGTAILIEYAIAPAAIAVFIGSYCESLFGIGGWSVYLLCYLVFMGIHLK
GAGEALKIMFIITAIACVALLVFIVAMIPHFESGKLFDIAVSNNVGASAFLPLGYLGIWAAVPYAIWFFLAVEGVPLAAE
EAKDPVRSLPRGLIGSMLILAAFALLILFLSAGAAGSDALKASGAPLVDALIAVYGQHTWLASFVNFVGLAGLVASFFSI
IYAYSRQIFALSRAGYLPKSLSLTNKNKAPFLAIIIPGIIGFLMSLTHEGDLLILMAVFGATISYVLMMLSHIKLRISHP
NLARPYKTPGGVVTSSIALVLAAIAVVAGLMVNPKVWLLTAMIYVAFILYFILYSRFHLVKGTPEEEFARVNED

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI7657683, Length=345, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786602, Length=350, Percent_Identity=23.7142857142857, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790653, Length=352, Percent_Identity=23.8636363636364, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786302, Length=372, Percent_Identity=25.5376344086022, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI2367353, Length=435, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=21.9114219114219, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=356, Percent_Identity=25.2808988764045, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221512776, Length=385, Percent_Identity=25.1948051948052, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666159, Length=385, Percent_Identity=25.1948051948052, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667468, Length=379, Percent_Identity=21.8997361477573, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161077963, Length=347, Percent_Identity=23.9193083573487, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50535; Mature: 50535

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMKDSELSLDNGATRDVDYFAKRQLKKGAVGWLLLVGLGVSYVISGDFAGWNFGLAQG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCHHHEEECCCCCCCCCCCCC
GWGGLFIATVIVALMYLCMSLSMSEMSTMLPTAGGGYSFARVAFGPLGGYLTGTAILIEY
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
AIAPAAIAVFIGSYCESLFGIGGWSVYLLCYLVFMGIHLKGAGEALKIMFIITAIACVAL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LVFIVAMIPHFESGKLFDIAVSNNVGASAFLPLGYLGIWAAVPYAIWFFLAVEGVPLAAE
HHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
EAKDPVRSLPRGLIGSMLILAAFALLILFLSAGAAGSDALKASGAPLVDALIAVYGQHTW
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCHHH
LASFVNFVGLAGLVASFFSIIYAYSRQIFALSRAGYLPKSLSLTNKNKAPFLAIIIPGII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHH
GFLMSLTHEGDLLILMAVFGATISYVLMMLSHIKLRISHPNLARPYKTPGGVVTSSIALV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHH
LAAIAVVAGLMVNPKVWLLTAMIYVAFILYFILYSRFHLVKGTPEEEFARVNED
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
>Mature Secondary Structure
MNTMKDSELSLDNGATRDVDYFAKRQLKKGAVGWLLLVGLGVSYVISGDFAGWNFGLAQG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCHHHEEECCCCCCCCCCCCC
GWGGLFIATVIVALMYLCMSLSMSEMSTMLPTAGGGYSFARVAFGPLGGYLTGTAILIEY
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
AIAPAAIAVFIGSYCESLFGIGGWSVYLLCYLVFMGIHLKGAGEALKIMFIITAIACVAL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LVFIVAMIPHFESGKLFDIAVSNNVGASAFLPLGYLGIWAAVPYAIWFFLAVEGVPLAAE
HHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
EAKDPVRSLPRGLIGSMLILAAFALLILFLSAGAAGSDALKASGAPLVDALIAVYGQHTW
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCHHH
LASFVNFVGLAGLVASFFSIIYAYSRQIFALSRAGYLPKSLSLTNKNKAPFLAIIIPGII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHH
GFLMSLTHEGDLLILMAVFGATISYVLMMLSHIKLRISHPNLARPYKTPGGVVTSSIALV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHH
LAAIAVVAGLMVNPKVWLLTAMIYVAFILYFILYSRFHLVKGTPEEEFARVNED
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]