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The map label for this gene is catR

Identifier: 50084620

GI number: 50084620

Start: 1443680

End: 1444591

Strand: Reverse

Name: catR

Synonym: ACIAD1445

Alternate gene names: 50084620

Gene position: 1444591-1443680 (Counterclockwise)

Preceding gene: 50084628

Following gene: 50084611

Centisome position: 40.14

GC content: 43.97

Gene sequence:

>912_bases
ATGGAACTAAGACACCTCAGATATTTTGTGACCGTGGTTGAAGAGCAAAGCATTTCCAAAGCTGCTGAAAAGTTGTGTAT
TGCCCAGCCGCCCCTCAGCCGACAAATTCAAAAACTCGAAGAAGAATTGGGAATTCAGCTATTTGAACGCGGCTTCAGAC
CGGCTAAAGTGACTGAAGCAGGCATGTTTTTTTATCAGCATGCTGTGCAGATTTTGACTCATACTGCACAAGCGTCCTCA
ATGGCAAAACGGATTGCAACGGTCAGTCAAACCTTGAGAATTGGTTACGTCAGCTCCTTACTGTATGGTTTGTTACCTGA
AATTATTTATCTGTTTCGTCAACAAAATCCTGAAATTCACATCGAACTCATCGAATGCGGCACCAAAGATCAAATTAATG
CCCTTAAGCAGGGAAAAATCGATCTGGGTTTTGGTCGGCTCAAAATTACCGATCCTGCAATTCGACGTATCGTGTTGCAT
AAAGAACAGCTCAAACTTGCAATCCATAAGCATCATCACCTCAATCAGTTTGCAGCAACAGGGGTTCATCTCTCTCAAAT
TATTGATGAACCGATGCTGCTGTACCCAGTCTCTCAAAAGCCCAATTTTGCGACCTTTATTCAGTCACTCTTTACCGAAC
TAGGCCTAGTACCATCCAAACTCACCGAAATTCGAGAAATTCAACTGGCACTCGGCTTGGTGGCAGCAGGTGAAGGCGTC
TGCATCGTACCGGCGTCTGCCATGGATATTGGGGTGAAGAATCTACTTTATATTCCAATTTTAGATGATGATGCCTATAG
CCCAATTTCACTCGCGGTGCGAAATATGGACCACAGTAATTACATTCCTAAAATTCTCGCCTGTGTACAGGAGGTGTTTG
CAACGCACCATATCAGGCCACTCATCGAATAA

Upstream 100 bases:

>100_bases
TACTATTTACATACCTTAAATTAATGTAATAATAAAAAAGATAAACAATTTGGTATTTTTGCATACTAAAAAGGTATATA
AAACCAATTAGGGCGTATAA

Downstream 100 bases:

>100_bases
AATATGTCTGAAAAATTTACTGCTCTTTATTCAATGCGTAGCGCTTGGCTGAGTTGATCGAGTGCTGCGCTGTAATCGAT
GAAGGTTTCATCGAGTGTTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cat operon transcriptional regulator

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MELRHLRYFVTVVEEQSISKAAEKLCIAQPPLSRQIQKLEEELGIQLFERGFRPAKVTEAGMFFYQHAVQILTHTAQASS
MAKRIATVSQTLRIGYVSSLLYGLLPEIIYLFRQQNPEIHIELIECGTKDQINALKQGKIDLGFGRLKITDPAIRRIVLH
KEQLKLAIHKHHHLNQFAATGVHLSQIIDEPMLLYPVSQKPNFATFIQSLFTELGLVPSKLTEIREIQLALGLVAAGEGV
CIVPASAMDIGVKNLLYIPILDDDAYSPISLAVRNMDHSNYIPKILACVQEVFATHHIRPLIE

Sequences:

>Translated_303_residues
MELRHLRYFVTVVEEQSISKAAEKLCIAQPPLSRQIQKLEEELGIQLFERGFRPAKVTEAGMFFYQHAVQILTHTAQASS
MAKRIATVSQTLRIGYVSSLLYGLLPEIIYLFRQQNPEIHIELIECGTKDQINALKQGKIDLGFGRLKITDPAIRRIVLH
KEQLKLAIHKHHHLNQFAATGVHLSQIIDEPMLLYPVSQKPNFATFIQSLFTELGLVPSKLTEIREIQLALGLVAAGEGV
CIVPASAMDIGVKNLLYIPILDDDAYSPISLAVRNMDHSNYIPKILACVQEVFATHHIRPLIE
>Mature_303_residues
MELRHLRYFVTVVEEQSISKAAEKLCIAQPPLSRQIQKLEEELGIQLFERGFRPAKVTEAGMFFYQHAVQILTHTAQASS
MAKRIATVSQTLRIGYVSSLLYGLLPEIIYLFRQQNPEIHIELIECGTKDQINALKQGKIDLGFGRLKITDPAIRRIVLH
KEQLKLAIHKHHHLNQFAATGVHLSQIIDEPMLLYPVSQKPNFATFIQSLFTELGLVPSKLTEIREIQLALGLVAAGEGV
CIVPASAMDIGVKNLLYIPILDDDAYSPISLAVRNMDHSNYIPKILACVQEVFATHHIRPLIE

Specific function: Positively regulates the expression of catA, catBCIJFD and benPK in response to cis,cis-muconate. It binds to the catB- catM intercistronic region, to a specific sequence upstream of catA and to the benPK promoter region. Can also repress pca genes

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787879, Length=274, Percent_Identity=33.2116788321168, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1788887, Length=300, Percent_Identity=29.6666666666667, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87081904, Length=283, Percent_Identity=30.0353356890459, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI2367136, Length=266, Percent_Identity=27.4436090225564, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI157672245, Length=246, Percent_Identity=28.8617886178862, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790399, Length=277, Percent_Identity=28.158844765343, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1787601, Length=143, Percent_Identity=35.6643356643357, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI145693105, Length=251, Percent_Identity=27.0916334661355, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082132, Length=263, Percent_Identity=26.9961977186312, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=37.3983739837398, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787806, Length=250, Percent_Identity=25.2, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786401, Length=153, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788296, Length=233, Percent_Identity=26.1802575107296, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788297, Length=131, Percent_Identity=38.9312977099237, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=142, Percent_Identity=29.5774647887324, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790208, Length=146, Percent_Identity=31.5068493150685, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790262, Length=317, Percent_Identity=23.0283911671924, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787530, Length=309, Percent_Identity=23.3009708737864, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788748, Length=254, Percent_Identity=23.6220472440945, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1787589, Length=151, Percent_Identity=31.7880794701987, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): CATM_ACIAD (P07774)

Other databases:

- EMBL:   AF009224
- EMBL:   CR543861
- RefSeq:   YP_046130.1
- PDB:   2F7B
- PDB:   2F7C
- PDB:   2H98
- PDB:   3GLB
- PDBsum:   2F7B
- PDBsum:   2F7C
- PDBsum:   2H98
- PDBsum:   3GLB
- ProteinModelPortal:   P07774
- SMR:   P07774
- STRING:   P07774
- GeneID:   2879926
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1445
- NMPDR:   fig|62977.3.peg.802
- eggNOG:   COG0583
- HOGENOM:   HBG685425
- OMA:   HIELIEC
- PhylomeDB:   P07774
- ProtClustDB:   CLSK736889
- BioCyc:   ASP62977:ACIAD1445-MONOMER
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00039

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate

EC number: NA

Molecular weight: Translated: 34084; Mature: 34084

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFVTVVEEQSISKAAEKLCIAQPPLSRQIQKLEEELGIQLFERGFRPAKVTEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHCCCCCCHHHHH
GMFFYQHAVQILTHTAQASSMAKRIATVSQTLRIGYVSSLLYGLLPEIIYLFRQQNPEIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IELIECGTKDQINALKQGKIDLGFGRLKITDPAIRRIVLHKEQLKLAIHKHHHLNQFAAT
EEEEECCCHHHHHHHHCCCEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVHLSQIIDEPMLLYPVSQKPNFATFIQSLFTELGLVPSKLTEIREIQLALGLVAAGEGV
CHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCE
CIVPASAMDIGVKNLLYIPILDDDAYSPISLAVRNMDHSNYIPKILACVQEVFATHHIRP
EEEECHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHH
LIE
CCC
>Mature Secondary Structure
MELRHLRYFVTVVEEQSISKAAEKLCIAQPPLSRQIQKLEEELGIQLFERGFRPAKVTEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHCCCCCCHHHHH
GMFFYQHAVQILTHTAQASSMAKRIATVSQTLRIGYVSSLLYGLLPEIIYLFRQQNPEIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IELIECGTKDQINALKQGKIDLGFGRLKITDPAIRRIVLHKEQLKLAIHKHHHLNQFAAT
EEEEECCCHHHHHHHHCCCEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVHLSQIIDEPMLLYPVSQKPNFATFIQSLFTELGLVPSKLTEIREIQLALGLVAAGEGV
CHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCE
CIVPASAMDIGVKNLLYIPILDDDAYSPISLAVRNMDHSNYIPKILACVQEVFATHHIRP
EEEECHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHH
LIE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2793826; 7592340; 11932465; 12620848