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The map label for this gene is areB [H]

Identifier: 50084606

GI number: 50084606

Start: 1425343

End: 1426458

Strand: Reverse

Name: areB [H]

Synonym: ACIAD1429

Alternate gene names: 50084606

Gene position: 1426458-1425343 (Counterclockwise)

Preceding gene: 50084607

Following gene: 50084605

Centisome position: 39.64

GC content: 46.77

Gene sequence:

>1116_bases
ATGACAAAGTTTACCGAAATCACAGCAGCAGTGACCGAATGCAAAGGCGCAGACTTTGAGCTCAAACAGCTCAAAATTCG
TGAACCTCAAAACGATGAAGTATTGGTTAAAATTGTGGCAACGGGAATGTGCCATACCGATCTGATTGTGCGTGATCAGT
ATTATCCTGTTCCATTACCAGCGGTACTTGGTCACGAGGGTTCAGGCATCATTGAAGCCATTGGCCCGAATGTCAAAGAT
TTGGCTGTAGGTGATCACGTGGTGCTCAGCTATGGCTTTTGTGGAAGCTGTGAGCAGTGTAGCAGCGGACAACCAGCCTA
CTGTCAGGATTTTTTTGGACGAAACTTCAGTGGTGGAGATCCAGATGGGCATTCTGCCGTATGCTCGCACGATCATCATA
AAATTCATGATCATTTCTTTGCGCAATCTTCGTTTGCAACCTACGCCATCAGCCGTGAAAATAATGCCGTAAAAGTGAGT
AAAGATGTACCGCTTGAACTTTTGGGGCCACTCGGCTGCGGCATACAAACTGGTGCAGGTGCTGCAATCAATGCGCTGAA
AGTCGCGCCTGCCAGTAGCTTTGTCACTTGGGGTGCAGGCGCAGTCGGACTCAGTGCACTTCTTGCTGCAAAAGTATGTG
GTGCGACCACTATTATTGCAGTGGATATTGTCGAGTCTCGTTTGGCGTTAGCCAAAGAACTTGGTGCGACCCATGTTATC
AACAGTAAAACGCAAGATCCCGTCGAAGCCATCAAGGAAATCACAGGCGGTGGTGTAAAGTTTGCTCTTGAATCGACTGG
ACGCCCAGAAATTTTGAAACAAGGGATCGATGCGCTCGGTATTCTTGGCAGCATTGCAGTGGTAGGTGCTCCGCCTTTAG
GAACGACCGCAGCATTTGACGTGAATGATTTATTGCTTGGCGGCAAATCGATTATCGGCGTTGTAGAAGGCAGCGGCGTA
CCGAAAAAGTTTATTCCGGCTTTGGTTTCGCTGTATCAGCAAGGTAAGTTTCCGTTCGACAAACTGGTTAAGTTCTATGA
TTTTAAAGATATTAATCAGGCTGCAATTGATAGCCATAAAGGCATCACGCTCAAACCCATTTTAAAAATTGGTTAA

Upstream 100 bases:

>100_bases
AGCAAATCCAGATGAATTTACTCAGTGGCAATGGATGACCATTCAGGCTGAGGCCCCACACTATCCATTTTAATTTTTTT
CTCATACAGGATGTATAGAA

Downstream 100 bases:

>100_bases
GCATTGAGAAGTTATGTCTTGAACAATACATAACTTCTCAAATCGTAAATAAATCAAAAAGATTTAAAAAGGATTTTTAA
TACATGTTACAGAGTTTAGA

Product: aryl-alcohol dehydrogenase

Products: NA

Alternate protein names: Benzyl alcohol dehydrogenase; BADH [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTKFTEITAAVTECKGADFELKQLKIREPQNDEVLVKIVATGMCHTDLIVRDQYYPVPLPAVLGHEGSGIIEAIGPNVKD
LAVGDHVVLSYGFCGSCEQCSSGQPAYCQDFFGRNFSGGDPDGHSAVCSHDHHKIHDHFFAQSSFATYAISRENNAVKVS
KDVPLELLGPLGCGIQTGAGAAINALKVAPASSFVTWGAGAVGLSALLAAKVCGATTIIAVDIVESRLALAKELGATHVI
NSKTQDPVEAIKEITGGGVKFALESTGRPEILKQGIDALGILGSIAVVGAPPLGTTAAFDVNDLLLGGKSIIGVVEGSGV
PKKFIPALVSLYQQGKFPFDKLVKFYDFKDINQAAIDSHKGITLKPILKIG

Sequences:

>Translated_371_residues
MTKFTEITAAVTECKGADFELKQLKIREPQNDEVLVKIVATGMCHTDLIVRDQYYPVPLPAVLGHEGSGIIEAIGPNVKD
LAVGDHVVLSYGFCGSCEQCSSGQPAYCQDFFGRNFSGGDPDGHSAVCSHDHHKIHDHFFAQSSFATYAISRENNAVKVS
KDVPLELLGPLGCGIQTGAGAAINALKVAPASSFVTWGAGAVGLSALLAAKVCGATTIIAVDIVESRLALAKELGATHVI
NSKTQDPVEAIKEITGGGVKFALESTGRPEILKQGIDALGILGSIAVVGAPPLGTTAAFDVNDLLLGGKSIIGVVEGSGV
PKKFIPALVSLYQQGKFPFDKLVKFYDFKDINQAAIDSHKGITLKPILKIG
>Mature_370_residues
TKFTEITAAVTECKGADFELKQLKIREPQNDEVLVKIVATGMCHTDLIVRDQYYPVPLPAVLGHEGSGIIEAIGPNVKDL
AVGDHVVLSYGFCGSCEQCSSGQPAYCQDFFGRNFSGGDPDGHSAVCSHDHHKIHDHFFAQSSFATYAISRENNAVKVSK
DVPLELLGPLGCGIQTGAGAAINALKVAPASSFVTWGAGAVGLSALLAAKVCGATTIIAVDIVESRLALAKELGATHVIN
SKTQDPVEAIKEITGGGVKFALESTGRPEILKQGIDALGILGSIAVVGAPPLGTTAAFDVNDLLLGGKSIIGVVEGSGVP
KKFIPALVSLYQQGKFPFDKLVKFYDFKDINQAAIDSHKGITLKPILKIG

Specific function: Oxidizes primary alcohols with an aromatic or cyclohex- 1-ene ring. It is highly specific for benzyl alcohol [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=35.6756756756757, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=35.9459459459459, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=34.6774193548387, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=33.6898395721925, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=32.6975476839237, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI156523966, Length=374, Percent_Identity=31.8181818181818, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=32.2222222222222, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI262073058, Length=379, Percent_Identity=31.9261213720317, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI71743840, Length=376, Percent_Identity=31.9148936170213, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI156627571, Length=283, Percent_Identity=28.9752650176678, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=29.1891891891892, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788073, Length=352, Percent_Identity=28.4090909090909, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI87081918, Length=313, Percent_Identity=28.4345047923323, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788407, Length=273, Percent_Identity=28.9377289377289, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790045, Length=303, Percent_Identity=25.0825082508251, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788075, Length=301, Percent_Identity=30.2325581395349, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082125, Length=306, Percent_Identity=26.1437908496732, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787863, Length=284, Percent_Identity=26.056338028169, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=313, Percent_Identity=26.8370607028754, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786825, Length=304, Percent_Identity=26.6447368421053, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=34.5844504021448, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=34.4, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17565904, Length=347, Percent_Identity=34.5821325648415, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17562584, Length=317, Percent_Identity=29.0220820189274, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=262, Percent_Identity=30.5343511450382, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=357, Percent_Identity=27.4509803921569, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=224, Percent_Identity=31.6964285714286, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=363, Percent_Identity=31.9559228650138, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323729, Length=284, Percent_Identity=28.169014084507, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=305, Percent_Identity=25.5737704918033, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=305, Percent_Identity=25.5737704918033, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=306, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=314, Percent_Identity=26.1146496815287, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322619, Length=283, Percent_Identity=26.1484098939929, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=283, Percent_Identity=26.1484098939929, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=291, Percent_Identity=25.4295532646048, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737895, Length=360, Percent_Identity=32.7777777777778, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI17737897, Length=246, Percent_Identity=30.8943089430894, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137530, Length=253, Percent_Identity=29.6442687747036, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.90 [H]

Molecular weight: Translated: 38879; Mature: 38748

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFTEITAAVTECKGADFELKQLKIREPQNDEVLVKIVATGMCHTDLIVRDQYYPVPLP
CCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEHHCCCCCEEEEECCCCCCCCH
AVLGHEGSGIIEAIGPNVKDLAVGDHVVLSYGFCGSCEQCSSGQPAYCQDFFGRNFSGGD
HHHCCCCCCCCEECCCCCCEEECCCEEEEEECCCCCHHHCCCCCCHHHHHHCCCCCCCCC
PDGHSAVCSHDHHKIHDHFFAQSSFATYAISRENNAVKVSKDVPLELLGPLGCGIQTGAG
CCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHCCCCCCCCCCCC
AAINALKVAPASSFVTWGAGAVGLSALLAAKVCGATTIIAVDIVESRLALAKELGATHVI
CHHHEEEECCCCCHHCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCEEE
NSKTQDPVEAIKEITGGGVKFALESTGRPEILKQGIDALGILGSIAVVGAPPLGTTAAFD
CCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEC
VNDLLLGGKSIIGVVEGSGVPKKFIPALVSLYQQGKFPFDKLVKFYDFKDINQAAIDSHK
HHHHEECCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHCCC
GITLKPILKIG
CEEEECEEECC
>Mature Secondary Structure 
TKFTEITAAVTECKGADFELKQLKIREPQNDEVLVKIVATGMCHTDLIVRDQYYPVPLP
CCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEHHCCCCCEEEEECCCCCCCCH
AVLGHEGSGIIEAIGPNVKDLAVGDHVVLSYGFCGSCEQCSSGQPAYCQDFFGRNFSGGD
HHHCCCCCCCCEECCCCCCEEECCCEEEEEECCCCCHHHCCCCCCHHHHHHCCCCCCCCC
PDGHSAVCSHDHHKIHDHFFAQSSFATYAISRENNAVKVSKDVPLELLGPLGCGIQTGAG
CCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHCCCCCCCCCCCC
AAINALKVAPASSFVTWGAGAVGLSALLAAKVCGATTIIAVDIVESRLALAKELGATHVI
CHHHEEEECCCCCHHCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCEEE
NSKTQDPVEAIKEITGGGVKFALESTGRPEILKQGIDALGILGSIAVVGAPPLGTTAAFD
CCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEC
VNDLLLGGKSIIGVVEGSGVPKKFIPALVSLYQQGKFPFDKLVKFYDFKDINQAAIDSHK
HHHHEECCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHCCC
GITLKPILKIG
CEEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8496150; 1989592 [H]