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The map label for this gene is pyrC [H]

Identifier: 50084596

GI number: 50084596

Start: 1413752

End: 1415086

Strand: Reverse

Name: pyrC [H]

Synonym: ACIAD1419

Alternate gene names: 50084596

Gene position: 1415086-1413752 (Counterclockwise)

Preceding gene: 50084597

Following gene: 50084595

Centisome position: 39.32

GC content: 38.8

Gene sequence:

>1335_bases
TTGCCTGATATCATGATTCGTAATGCAAATATGATTAATGAAGGCCAGTCTAAATTTTGCGATGTGCTGATTAAAAATGG
CAGGATCGCCAAAATACAATCTTCAATTTCGAGTATTAACAATGCCAAGGAAATTGAGGCAAATGGGCGCTGGCTACTGC
CTGGGATGATTGATGATCAAGTTCATTTTCGAGATCCTGGCTCTCCTCACAAAGGCTGTATTGCCTCAGAATCTGCTGCG
GCAACCATTGGTGGAATTACCAGTTATATGGATATGCCAAATACTCAACCGCCAACCCTTGATCTTGATGCTTTACAAGC
CAAAAAGACTATTGCTTCACAAACCAGTATTGCCAACTATGCTTTTCATTTTGGTGTGAGCGCAGACAATCTAGAAATCA
TTAAACAACTTGACCCGACATTGGTCAGTGGCGTTAAGGTCTTTATGGGTGCGTCAACTGGTAATATGCTGGTTGATGAT
CCCAAAACACTTGGACTCTTATTTGCCAACGTACCCACCATTTTATTGAGCCATTGCGAGTCAAGTCCGATTATTTCTCA
GAATGAAAAATTGTTTAGGGAAAAATTTGGTGAAGATATTGATGCGTCCTGTCATCCTATTATTCGCAATGAAGAATGTT
GTTATCAAAGCTCAAAAATGGCTGTTGAGTTAGCAAAGAAATTTAATACCCAATTGCATGTACTGCATTTGACCACAGCA
CGTGAGCTAGCACTATTTGAAGATAAACCTTTACATGAGAAAAGGATTACTGCTGAGGTCTGTATTCATCATTTACATTT
TGATGATCGAGATTATAAACAGCTGAATCATCTGATTAAATGTAATCCGTCTATTAAAGCTGTCAGTGATAAAGAAGCAT
TGATTCAGGCAATCGCAAATACTAATTTACTGGATATTATTGGAACAGATCATGCACCCCATACATTGGATGAAAAGCAA
AGATCTTATTTTCAAGCTCCAGCAGGTTTACCACTGGTACAACATGCTTTGCCAGCCTTACTGGAGCTAGTTGCAGATCA
GAAAATGACGATTGAAAATGTTGTAAAAAAAACATCTCATCAGGTTGCTGATCTTTTTAGAATCAAAGAGCGTGGTTATA
TCCGTGAAGGCTATTGGGCAGATCTGGTATTAATTGATAAAAATCCTCTCATCGTTGCACAACAACCAAATTTTATGCGT
TGTGGATGGACACCATTTATCCATCAAACCTTTCGACATCAAGTGGCAACCACGATTGTTTCAGGACAAATCGCGTGGCA
TAACCAGCAGTTATTTTTAAATTGTAAAGGTCATGCTCTCGAAATTGATCGGTAA

Upstream 100 bases:

>100_bases
CCCATTGATATCTCCATTACAGAATTTTCAGAAAGTGTAATTACAACCAACATTGAACTGGTTCAGGGGTACAAGGCGCT
GTCCAATGAATTTTAATACC

Downstream 100 bases:

>100_bases
ATTATCTTCATCATGTATATTTAGATCAGGAAATACAGATTTATGCTGTTATTTCCTTATCTGTTTTGATGAAAATAAAC
ACATATTTATTTATAACTGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPDIMIRNANMINEGQSKFCDVLIKNGRIAKIQSSISSINNAKEIEANGRWLLPGMIDDQVHFRDPGSPHKGCIASESAA
ATIGGITSYMDMPNTQPPTLDLDALQAKKTIASQTSIANYAFHFGVSADNLEIIKQLDPTLVSGVKVFMGASTGNMLVDD
PKTLGLLFANVPTILLSHCESSPIISQNEKLFREKFGEDIDASCHPIIRNEECCYQSSKMAVELAKKFNTQLHVLHLTTA
RELALFEDKPLHEKRITAEVCIHHLHFDDRDYKQLNHLIKCNPSIKAVSDKEALIQAIANTNLLDIIGTDHAPHTLDEKQ
RSYFQAPAGLPLVQHALPALLELVADQKMTIENVVKKTSHQVADLFRIKERGYIREGYWADLVLIDKNPLIVAQQPNFMR
CGWTPFIHQTFRHQVATTIVSGQIAWHNQQLFLNCKGHALEIDR

Sequences:

>Translated_444_residues
MPDIMIRNANMINEGQSKFCDVLIKNGRIAKIQSSISSINNAKEIEANGRWLLPGMIDDQVHFRDPGSPHKGCIASESAA
ATIGGITSYMDMPNTQPPTLDLDALQAKKTIASQTSIANYAFHFGVSADNLEIIKQLDPTLVSGVKVFMGASTGNMLVDD
PKTLGLLFANVPTILLSHCESSPIISQNEKLFREKFGEDIDASCHPIIRNEECCYQSSKMAVELAKKFNTQLHVLHLTTA
RELALFEDKPLHEKRITAEVCIHHLHFDDRDYKQLNHLIKCNPSIKAVSDKEALIQAIANTNLLDIIGTDHAPHTLDEKQ
RSYFQAPAGLPLVQHALPALLELVADQKMTIENVVKKTSHQVADLFRIKERGYIREGYWADLVLIDKNPLIVAQQPNFMR
CGWTPFIHQTFRHQVATTIVSGQIAWHNQQLFLNCKGHALEIDR
>Mature_443_residues
PDIMIRNANMINEGQSKFCDVLIKNGRIAKIQSSISSINNAKEIEANGRWLLPGMIDDQVHFRDPGSPHKGCIASESAAA
TIGGITSYMDMPNTQPPTLDLDALQAKKTIASQTSIANYAFHFGVSADNLEIIKQLDPTLVSGVKVFMGASTGNMLVDDP
KTLGLLFANVPTILLSHCESSPIISQNEKLFREKFGEDIDASCHPIIRNEECCYQSSKMAVELAKKFNTQLHVLHLTTAR
ELALFEDKPLHEKRITAEVCIHHLHFDDRDYKQLNHLIKCNPSIKAVSDKEALIQAIANTNLLDIIGTDHAPHTLDEKQR
SYFQAPAGLPLVQHALPALLELVADQKMTIENVVKKTSHQVADLFRIKERGYIREGYWADLVLIDKNPLIVAQQPNFMRC
GWTPFIHQTFRHQVATTIVSGQIAWHNQQLFLNCKGHALEIDR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=384, Percent_Identity=26.0416666666667, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4503051, Length=409, Percent_Identity=23.4718826405868, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI62422571, Length=409, Percent_Identity=23.4718826405868, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI19923821, Length=469, Percent_Identity=22.1748400852878, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI4503379, Length=415, Percent_Identity=22.8915662650602, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI4503377, Length=405, Percent_Identity=21.4814814814815, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI190194363, Length=454, Percent_Identity=21.5859030837004, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786722, Length=450, Percent_Identity=26, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI87082175, Length=400, Percent_Identity=23.75, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=376, Percent_Identity=26.5957446808511, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71989490, Length=453, Percent_Identity=22.2958057395143, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17539558, Length=455, Percent_Identity=22.1978021978022, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24642586, Length=384, Percent_Identity=27.0833333333333, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 49606; Mature: 49474

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIMIRNANMINEGQSKFCDVLIKNGRIAKIQSSISSINNAKEIEANGRWLLPGMIDDQ
CCCEEEECCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHCCCCCEECCCCCEEECCCCCCC
VHFRDPGSPHKGCIASESAAATIGGITSYMDMPNTQPPTLDLDALQAKKTIASQTSIANY
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHE
AFHFGVSADNLEIIKQLDPTLVSGVKVFMGASTGNMLVDDPKTLGLLFANVPTILLSHCE
EEEECCCCCCHHHHHHCCHHHHHHHHHEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCC
SSPIISQNEKLFREKFGEDIDASCHPIIRNEECCYQSSKMAVELAKKFNTQLHVLHLTTA
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCH
RELALFEDKPLHEKRITAEVCIHHLHFDDRDYKQLNHLIKCNPSIKAVSDKEALIQAIAN
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHEECCCCCEECCHHHHHHHHHHC
TNLLDIIGTDHAPHTLDEKQRSYFQAPAGLPLVQHALPALLELVADQKMTIENVVKKTSH
CCEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QVADLFRIKERGYIREGYWADLVLIDKNPLIVAQQPNFMRCGWTPFIHQTFRHQVATTIV
HHHHHHHHHHCCCEECCCEEEEEEECCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHH
SGQIAWHNQQLFLNCKGHALEIDR
CCEEEEECCEEEEEECCCEEEECC
>Mature Secondary Structure 
PDIMIRNANMINEGQSKFCDVLIKNGRIAKIQSSISSINNAKEIEANGRWLLPGMIDDQ
CCEEEECCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHCCCCCEECCCCCEEECCCCCCC
VHFRDPGSPHKGCIASESAAATIGGITSYMDMPNTQPPTLDLDALQAKKTIASQTSIANY
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHE
AFHFGVSADNLEIIKQLDPTLVSGVKVFMGASTGNMLVDDPKTLGLLFANVPTILLSHCE
EEEECCCCCCHHHHHHCCHHHHHHHHHEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCC
SSPIISQNEKLFREKFGEDIDASCHPIIRNEECCYQSSKMAVELAKKFNTQLHVLHLTTA
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCH
RELALFEDKPLHEKRITAEVCIHHLHFDDRDYKQLNHLIKCNPSIKAVSDKEALIQAIAN
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHEECCCCCEECCHHHHHHHHHHC
TNLLDIIGTDHAPHTLDEKQRSYFQAPAGLPLVQHALPALLELVADQKMTIENVVKKTSH
CCEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QVADLFRIKERGYIREGYWADLVLIDKNPLIVAQQPNFMRCGWTPFIHQTFRHQVATTIV
HHHHHHHHHHCCCEECCCEEEEEEECCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHH
SGQIAWHNQQLFLNCKGHALEIDR
CCEEEEECCEEEEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA