Click here to switch to the map view.

The map label for this gene is mmuM [H]

Identifier: 50084595

GI number: 50084595

Start: 1412698

End: 1413576

Strand: Reverse

Name: mmuM [H]

Synonym: ACIAD1418

Alternate gene names: 50084595

Gene position: 1413576-1412698 (Counterclockwise)

Preceding gene: 50084596

Following gene: 50084594

Centisome position: 39.28

GC content: 43.0

Gene sequence:

>879_bases
ATGAAAATTTTAGATGGTGGATTTGGACGCGAGCTTGCACGCAGAGGTGCACCCTTTAGACAACCAGAATGGTCTGCTCT
AGCACTCACAGAGGCACCAGAAATTGTAAAAGAAGTACATCTGGACTTTATTCGTGCTGGTGCACAAGTCATTACCACCA
ATAATTATGCTGTTGTACCCTTTCATATTGGTCAGGAACGTTTTGATCGTGAAGTCACGCAACTTGTAAAAGTTGCCACC
AGTCAAGCCAGACTTGCCGTTCAGGAAAGTGGTCAACCTGTTCAAATTGCAGGCTGTCTACCGCCTTTATTTGGCTCTTA
TCGTGCAGATTTGTTTGATCAATCTAAGGCAGAAGCTTTAGCAAAACCCATTATTGAAGCACTCTCTCCAGACGTAGACT
TTTGGCTTGCAGAAACACAATCTTGTCTTGCAGAAGTAAGAACGATTCATCAGTTATTACCCAAAGACGGCCGTGAATTT
TGGGTATCATTTACCTTACAAGACGAACAAGCTCTGACTGAAGCAAAATTACGTTCTGGTGAAAATATCCAACAAGCTGC
TCAGCTTGTACACGAACTCGGTGCAAATGCAATTTTATTTAATTGCTGCCAGCCAGAAGTCATTTTACAAGCCATTGAAG
AAATCCGTAGTCTACTCCCGTCTGGTGTCAAGATTGGTGCTTATGCAAATGCCTTCCCACCACAAAACAGTGATGCAACA
GCCAATGATGGTCTGGATGAAGTTCGTAAAGATCTAGATCCGGATGCTTATCTAACATTTGCAAAACAGTGGCAACACGC
TGGTGCATCCATGATTGGTGGCTGCTGTGGCATAGGTCCTGAGCACATTCAGAAACTTTCTCAGTTTTTTCAAGAATAA

Upstream 100 bases:

>100_bases
TAAACACATATTTATTTATAACTGGCAAGCTAACTGAAAGTTTTTTGCACAGGCATTTGATGATAGATCCTCTATAATCG
ACATTTTTTACAGACTTCTT

Downstream 100 bases:

>100_bases
TTTTTATGTCAACTTCTAAAATTGGCTTGCTATCCTTAACCGCACTCGTGTTTAGCTCGATGGTCGGTTCTGGTGTGTTT
AGTTTGCCACAAAATATGGC

Product: homocysteine S-methyltransferase family protein

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKILDGGFGRELARRGAPFRQPEWSALALTEAPEIVKEVHLDFIRAGAQVITTNNYAVVPFHIGQERFDREVTQLVKVAT
SQARLAVQESGQPVQIAGCLPPLFGSYRADLFDQSKAEALAKPIIEALSPDVDFWLAETQSCLAEVRTIHQLLPKDGREF
WVSFTLQDEQALTEAKLRSGENIQQAAQLVHELGANAILFNCCQPEVILQAIEEIRSLLPSGVKIGAYANAFPPQNSDAT
ANDGLDEVRKDLDPDAYLTFAKQWQHAGASMIGGCCGIGPEHIQKLSQFFQE

Sequences:

>Translated_292_residues
MKILDGGFGRELARRGAPFRQPEWSALALTEAPEIVKEVHLDFIRAGAQVITTNNYAVVPFHIGQERFDREVTQLVKVAT
SQARLAVQESGQPVQIAGCLPPLFGSYRADLFDQSKAEALAKPIIEALSPDVDFWLAETQSCLAEVRTIHQLLPKDGREF
WVSFTLQDEQALTEAKLRSGENIQQAAQLVHELGANAILFNCCQPEVILQAIEEIRSLLPSGVKIGAYANAFPPQNSDAT
ANDGLDEVRKDLDPDAYLTFAKQWQHAGASMIGGCCGIGPEHIQKLSQFFQE
>Mature_292_residues
MKILDGGFGRELARRGAPFRQPEWSALALTEAPEIVKEVHLDFIRAGAQVITTNNYAVVPFHIGQERFDREVTQLVKVAT
SQARLAVQESGQPVQIAGCLPPLFGSYRADLFDQSKAEALAKPIIEALSPDVDFWLAETQSCLAEVRTIHQLLPKDGREF
WVSFTLQDEQALTEAKLRSGENIQQAAQLVHELGANAILFNCCQPEVILQAIEEIRSLLPSGVKIGAYANAFPPQNSDAT
ANDGLDEVRKDLDPDAYLTFAKQWQHAGASMIGGCCGIGPEHIQKLSQFFQE

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786456, Length=302, Percent_Identity=29.8013245033113, Blast_Score=95, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324982, Length=320, Percent_Identity=23.4375, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 32126; Mature: 32126

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILDGGFGRELARRGAPFRQPEWSALALTEAPEIVKEVHLDFIRAGAQVITTNNYAVVP
CCCCCCCCHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEE
FHIGQERFDREVTQLVKVATSQARLAVQESGQPVQIAGCLPPLFGSYRADLFDQSKAEAL
EECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
AKPIIEALSPDVDFWLAETQSCLAEVRTIHQLLPKDGREFWVSFTLQDEQALTEAKLRSG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHCC
ENIQQAAQLVHELGANAILFNCCQPEVILQAIEEIRSLLPSGVKIGAYANAFPPQNSDAT
CCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCC
ANDGLDEVRKDLDPDAYLTFAKQWQHAGASMIGGCCGIGPEHIQKLSQFFQE
CCCCHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKILDGGFGRELARRGAPFRQPEWSALALTEAPEIVKEVHLDFIRAGAQVITTNNYAVVP
CCCCCCCCHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEE
FHIGQERFDREVTQLVKVATSQARLAVQESGQPVQIAGCLPPLFGSYRADLFDQSKAEAL
EECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
AKPIIEALSPDVDFWLAETQSCLAEVRTIHQLLPKDGREFWVSFTLQDEQALTEAKLRSG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHCC
ENIQQAAQLVHELGANAILFNCCQPEVILQAIEEIRSLLPSGVKIGAYANAFPPQNSDAT
CCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCC
ANDGLDEVRKDLDPDAYLTFAKQWQHAGASMIGGCCGIGPEHIQKLSQFFQE
CCCCHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]