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The map label for this gene is argF

Identifier: 50084545

GI number: 50084545

Start: 1361806

End: 1362726

Strand: Reverse

Name: argF

Synonym: ACIAD1366

Alternate gene names: 50084545

Gene position: 1362726-1361806 (Counterclockwise)

Preceding gene: 50084546

Following gene: 50084544

Centisome position: 37.87

GC content: 41.59

Gene sequence:

>921_bases
ATGGCTCTACGGCATTTTCTCACTTTACGAGACCTCTCTTCTTTGGAACTCAATTCCATCCTTGATCGAGCAAGCGAACT
TAAACGTCAGCAACATGCTAATCAAGTATACCAGCCATTTAAAGGCAAAGTATTAGGAATGATTTTTGAAAAATCGAGCA
CACGTACTCGTATTTCATTCGAAGCTGGAATATGCCAATTTGGAGGAAGTGCCATTTTTCTTTCTCCTCGTGATACTCAA
CTTGGCCGTGGCGAACCGATTGAAGATTCTGCTCGTGTAATCTCCAGTATGCTTGATATTGTCATGATCCGCACTTTTGG
ACATAATATTGTTGAACGTTTTGCTTCATTCTCTAAAGTTCCAGTGATTAATGGTTTAACCGATGATCATCACCCCTGTC
AGCTTCTTGCCGACCTGCAAACCTATCAAGAGCATCGTGGTAGCATTAAAGGTAAAACTGTGGCATGGATTGGCGATGGG
AATAATATGTGCAACTCCTATATGGAAGCTGCACACATGATGGGTTTCAAGCTTAAAGTTGGCTCTCCAAAAGGCTATGA
ACCAAAGCCTGAATTTCTTGCAGAGTTTGCGCATTGCGTGGAAGTCTTCAATAGCGCTGAAGATGCAGCTGTAAATGCTG
ACCTAATTGTCACTGACGTATGGGCAAGTATGGGACAGGAAGAAGAGCAAAAGTTACGTGAAAAAGCATTTTTAACCTTT
CAAGTAAATGAAGCATTAATGGCGCTTGCACATCCTGAATGCTTATTCATGCATTGCCTTCCTGCACATCGCGGTGAAGA
AATCTCTGAAAATATGCTAGATCACAAGAACTCCGTGGTTTGGGATGAAGCAGAAAATCGGCTCCATGCACAGAAAGCAT
TGATGGAATTTTTATTAAATGAAAATGCCAAAAGAGCCTAA

Upstream 100 bases:

>100_bases
TTTTTTTGCATTTTCTTTGACATATAGTATATTAATCGATTGTTTTTTTCGTTCATCAACCAACAACTAATTGTTGTAAA
ACAATTATTGTGGAGTAACC

Downstream 100 bases:

>100_bases
AATCTTTTTAAACATTTTAAAAAGCCCCTAGCCAAGCACTATGGGCTTTTTTATTTCATAACGTCTTTATAATAATCCAA
AATCAATATATTCATACGAA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MALRHFLTLRDLSSLELNSILDRASELKRQQHANQVYQPFKGKVLGMIFEKSSTRTRISFEAGICQFGGSAIFLSPRDTQ
LGRGEPIEDSARVISSMLDIVMIRTFGHNIVERFASFSKVPVINGLTDDHHPCQLLADLQTYQEHRGSIKGKTVAWIGDG
NNMCNSYMEAAHMMGFKLKVGSPKGYEPKPEFLAEFAHCVEVFNSAEDAAVNADLIVTDVWASMGQEEEQKLREKAFLTF
QVNEALMALAHPECLFMHCLPAHRGEEISENMLDHKNSVVWDEAENRLHAQKALMEFLLNENAKRA

Sequences:

>Translated_306_residues
MALRHFLTLRDLSSLELNSILDRASELKRQQHANQVYQPFKGKVLGMIFEKSSTRTRISFEAGICQFGGSAIFLSPRDTQ
LGRGEPIEDSARVISSMLDIVMIRTFGHNIVERFASFSKVPVINGLTDDHHPCQLLADLQTYQEHRGSIKGKTVAWIGDG
NNMCNSYMEAAHMMGFKLKVGSPKGYEPKPEFLAEFAHCVEVFNSAEDAAVNADLIVTDVWASMGQEEEQKLREKAFLTF
QVNEALMALAHPECLFMHCLPAHRGEEISENMLDHKNSVVWDEAENRLHAQKALMEFLLNENAKRA
>Mature_305_residues
ALRHFLTLRDLSSLELNSILDRASELKRQQHANQVYQPFKGKVLGMIFEKSSTRTRISFEAGICQFGGSAIFLSPRDTQL
GRGEPIEDSARVISSMLDIVMIRTFGHNIVERFASFSKVPVINGLTDDHHPCQLLADLQTYQEHRGSIKGKTVAWIGDGN
NMCNSYMEAAHMMGFKLKVGSPKGYEPKPEFLAEFAHCVEVFNSAEDAAVNADLIVTDVWASMGQEEEQKLREKAFLTFQ
VNEALMALAHPECLFMHCLPAHRGEEISENMLDHKNSVVWDEAENRLHAQKALMEFLLNENAKRA

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=306, Percent_Identity=40.1960784313725, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI18105007, Length=305, Percent_Identity=26.5573770491803, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1786469, Length=331, Percent_Identity=38.6706948640483, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1790703, Length=325, Percent_Identity=38.7692307692308, Blast_Score=212, Evalue=2e-56,
Organism=Escherichia coli, GI2367364, Length=318, Percent_Identity=27.6729559748428, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI48994908, Length=373, Percent_Identity=24.1286863270777, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193204318, Length=161, Percent_Identity=31.055900621118, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322373, Length=321, Percent_Identity=34.5794392523364, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322331, Length=283, Percent_Identity=28.2685512367491, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24642586, Length=199, Percent_Identity=31.1557788944724, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_ACIAD (Q6FCH8)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046055.1
- ProteinModelPortal:   Q6FCH8
- SMR:   Q6FCH8
- STRING:   Q6FCH8
- GeneID:   2877978
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1366
- NMPDR:   fig|62977.3.peg.599
- eggNOG:   COG0078
- HOGENOM:   HBG579429
- OMA:   FTVAMYQ
- PhylomeDB:   Q6FCH8
- ProtClustDB:   PRK00779
- BioCyc:   ASP62977:ACIAD1366-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34469; Mature: 34338

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 104-104 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRHFLTLRDLSSLELNSILDRASELKRQQHANQVYQPFKGKVLGMIFEKSSTRTRISF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEE
EAGICQFGGSAIFLSPRDTQLGRGEPIEDSARVISSMLDIVMIRTFGHNIVERFASFSKV
ECCHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVINGLTDDHHPCQLLADLQTYQEHRGSIKGKTVAWIGDGNNMCNSYMEAAHMMGFKLKV
CEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHCEEEEE
GSPKGYEPKPEFLAEFAHCVEVFNSAEDAAVNADLIVTDVWASMGQEEEQKLREKAFLTF
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHEEEE
QVNEALMALAHPECLFMHCLPAHRGEEISENMLDHKNSVVWDEAENRLHAQKALMEFLLN
EHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHC
ENAKRA
CCCCCC
>Mature Secondary Structure 
ALRHFLTLRDLSSLELNSILDRASELKRQQHANQVYQPFKGKVLGMIFEKSSTRTRISF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEE
EAGICQFGGSAIFLSPRDTQLGRGEPIEDSARVISSMLDIVMIRTFGHNIVERFASFSKV
ECCHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVINGLTDDHHPCQLLADLQTYQEHRGSIKGKTVAWIGDGNNMCNSYMEAAHMMGFKLKV
CEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHCEEEEE
GSPKGYEPKPEFLAEFAHCVEVFNSAEDAAVNADLIVTDVWASMGQEEEQKLREKAFLTF
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHEEEE
QVNEALMALAHPECLFMHCLPAHRGEEISENMLDHKNSVVWDEAENRLHAQKALMEFLLN
EHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHC
ENAKRA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA