Click here to switch to the map view.

The map label for this gene is fabR [H]

Identifier: 50084395

GI number: 50084395

Start: 1207854

End: 1208546

Strand: Reverse

Name: fabR [H]

Synonym: ACIAD1206

Alternate gene names: 50084395

Gene position: 1208546-1207854 (Counterclockwise)

Preceding gene: 50084398

Following gene: 50084394

Centisome position: 33.58

GC content: 39.97

Gene sequence:

>693_bases
ATGGCGCCATCTTCTCTTTCTCAATCATTCGATCACGCTGCCCAGACTCCTGAGATTTTTGAGAAAGTGCCTAGCCGTAC
TGTGGGTAGAAAAGCAACCATTACCAAAGAAGAACTGTTTCAGGCAGCACTTAATCTGATTGGCCCAGAAAAAAGCATTT
CTTCATTAAGTTTAAGAGAAGTTGCTCGTGAAGCTGGAATTGCTCCAAATAGTTTTTATCGCCACTTTAGAGATATCGAT
GAGCTTGCAATTGATTTGATTAATCGTGCAGGTTTAGTGTTACGCCATATTATTCGTGAATCTCGTCTGCAAGCTTCAAA
ACAAAACAGTATTATTCGAAGCTCGGTTGAAGTATTTATTCAACAACTTGATGCAGATGAAGGTAACTTAAGTTTGTTAC
TTAGAGAAGCTTATACAGGCTCTAAATCATATAAAGAAGCTGTAGAGCGCCAACTTAACTTTTTTCAACAAGAGCTTCAA
GAAGATTTAATCCGTTTAGAACGTTTGAACCATAGTCGCTTGTCACATCCAGATTTAGTCGCGCGCGCCATTACCCAATT
GGTGTTTACCATGGGTGCCAAAGTTCTGGATTTACCAATCAATCAACGTACTGCTGTTGCCGAACAAACCATGATTATGA
TTCGTATGATACTTGAGGGCGCTCGCCATCTGGATGAATCTAAAATTCGTTAG

Upstream 100 bases:

>100_bases
ATGTATATAAATTTGTATATACACCTGTACTTTTATTTACGTTTCAAATCGTAAGCAGCTATGGTTATAATGAGACATAT
CTAACAATCATTTGAAAAAT

Downstream 100 bases:

>100_bases
TCCTTCTATCACATGTTGTGACGTTGTGTATATCGAACCTATACAAAAACTTTAACAACCTAAACAGGCAACGTGTGCTT
CTTAATTTACTCTATTGTTT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MAPSSLSQSFDHAAQTPEIFEKVPSRTVGRKATITKEELFQAALNLIGPEKSISSLSLREVAREAGIAPNSFYRHFRDID
ELAIDLINRAGLVLRHIIRESRLQASKQNSIIRSSVEVFIQQLDADEGNLSLLLREAYTGSKSYKEAVERQLNFFQQELQ
EDLIRLERLNHSRLSHPDLVARAITQLVFTMGAKVLDLPINQRTAVAEQTMIMIRMILEGARHLDESKIR

Sequences:

>Translated_230_residues
MAPSSLSQSFDHAAQTPEIFEKVPSRTVGRKATITKEELFQAALNLIGPEKSISSLSLREVAREAGIAPNSFYRHFRDID
ELAIDLINRAGLVLRHIIRESRLQASKQNSIIRSSVEVFIQQLDADEGNLSLLLREAYTGSKSYKEAVERQLNFFQQELQ
EDLIRLERLNHSRLSHPDLVARAITQLVFTMGAKVLDLPINQRTAVAEQTMIMIRMILEGARHLDESKIR
>Mature_229_residues
APSSLSQSFDHAAQTPEIFEKVPSRTVGRKATITKEELFQAALNLIGPEKSISSLSLREVAREAGIAPNSFYRHFRDIDE
LAIDLINRAGLVLRHIIRESRLQASKQNSIIRSSVEVFIQQLDADEGNLSLLLREAYTGSKSYKEAVERQLNFFQQELQE
DLIRLERLNHSRLSHPDLVARAITQLVFTMGAKVLDLPINQRTAVAEQTMIMIRMILEGARHLDESKIR

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=190, Percent_Identity=41.0526315789474, Blast_Score=148, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26074; Mature: 25943

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPSSLSQSFDHAAQTPEIFEKVPSRTVGRKATITKEELFQAALNLIGPEKSISSLSLRE
CCCHHHHHHHHHHCCCHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
VAREAGIAPNSFYRHFRDIDELAIDLINRAGLVLRHIIRESRLQASKQNSIIRSSVEVFI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQLDADEGNLSLLLREAYTGSKSYKEAVERQLNFFQQELQEDLIRLERLNHSRLSHPDLV
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ARAITQLVFTMGAKVLDLPINQRTAVAEQTMIMIRMILEGARHLDESKIR
HHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
APSSLSQSFDHAAQTPEIFEKVPSRTVGRKATITKEELFQAALNLIGPEKSISSLSLRE
CCHHHHHHHHHHCCCHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
VAREAGIAPNSFYRHFRDIDELAIDLINRAGLVLRHIIRESRLQASKQNSIIRSSVEVFI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQLDADEGNLSLLLREAYTGSKSYKEAVERQLNFFQQELQEDLIRLERLNHSRLSHPDLV
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ARAITQLVFTMGAKVLDLPINQRTAVAEQTMIMIRMILEGARHLDESKIR
HHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA