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The map label for this gene is hemL

Identifier: 50084390

GI number: 50084390

Start: 1201571

End: 1202869

Strand: Direct

Name: hemL

Synonym: ACIAD1201

Alternate gene names: 50084390

Gene position: 1201571-1202869 (Clockwise)

Preceding gene: 50084389

Following gene: 50084391

Centisome position: 33.39

GC content: 43.96

Gene sequence:

>1299_bases
ATGAGTTTATCTCCAAAACAAGTGCAATTATTTGAGCAAGCCAGCAAACATATTCCAGGGGGTGTGAACTCACCTGTACG
TGCATTTAATGGTGTAGGCGGAACTCCGGTATTTATCAAAAAGGCGCAAGGCGCTTATCTTTGGGACGAAGACGATAAAC
GCTATGTCGATTATGTTGGTTCCTGGGGGCCAATGATCTTGGGGCATGCTCATCCAGATATTATTCAAGCCGTGCAAACT
GCTGCTGTAGATGGTTTGAGCTTTGGTGCGCCCACTGTGCACGAAACCACGCTAGCCGACATCATTTGCGACATCATGCC
ATCTATCGAGATGGTGCGTATGACCAATTCTGGTACAGAAGCCACGATGACTGCAATTCGTCTGGCACGTGGTTATACGG
GACGAGACAAGATTGTTAAGTTTGAAGGGTGTTATCACGGACATTCAGATTCGCTATTAGTCAAAGCAGGTTCGGGGCTT
TTAACTTTGGGTGAAGGTGAACCAACTTCGAAAGGTGTACCTGTCGACTTTGCCAAACATACATTGACACTGCCTTACAA
TAATATTGAAGCACTTAAAGAATGTTTCGCAAAGTTTGGTCATGAAATTGCAGGTGTGATTGTAGAACCTGTTGCAGGCA
ACATGAATTTGGTCACACCAATTGATGGATTCTTGCAAGCAATCCGCGATGTATGTGACGAATATGGTTCAGTCTTTATC
ATTGATGAAGTGATGACAGGTTTTCGTGTGGCATTGGGCGGAGCGCAGTCTGTTTACCAAGTAAAACCAGATTTGACCAC
CTTAGGTAAAATTATTGGTGCAGGACTTCCAGTGGGTGCATTTGGTGGTAAGCGCGAGATTATGGAATGTATTGCACCTT
TAGGCGGTGTTTATCAGGCGGGTACTTTATCTGGTAATCCACTGGCGATGCGTGCAGGTATTACCATGTTCAAGCATTTA
CGCGAACCCGATTTCTATAGCAAGCTTGAGGCCAAACTCCAAAAATTGCTTACAGGTTTACAGGCTGCTGCGAATGAAGC
AGGGATTGCATTTAAAACTCAGCAAGTAGGTGGTATGTTTGGTCTTTACTTTACAGATCAGGAAGATATCACCAGTTTTG
ATTCCATGCTGGCTTGTGATACAGACGCATTTAAGAAATTTTTCCATGGTATGTTAGAGCGTGGAGTCAATCTTGCACCT
TCTGCATTTGAGGCAGGTTTCATCTCATCCGCTCATAGCGATGAAGATATTGAGTTGACCATTCAAGCTGCAAAAGAAAC
ATTTGCAGAAATGAAATAG

Upstream 100 bases:

>100_bases
AGGATATTCCTACGCGAATCAATGCGTGGGCTGCTTTATTTGCAGAGACTTCATCTGCTGTAAATGTATAGTTAAAGTTA
TATAGATATCGAGAGTATTC

Downstream 100 bases:

>100_bases
CAGATCATCTGAAGAAGCCCGATTTCGGGCTTTTTTTATTGGAGTTAGGCTTATGAAAACCAAACATTATTTAACACTAG
CAGATGCTGAAATTCTTATG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSLSPKQVQLFEQASKHIPGGVNSPVRAFNGVGGTPVFIKKAQGAYLWDEDDKRYVDYVGSWGPMILGHAHPDIIQAVQT
AAVDGLSFGAPTVHETTLADIICDIMPSIEMVRMTNSGTEATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGL
LTLGEGEPTSKGVPVDFAKHTLTLPYNNIEALKECFAKFGHEIAGVIVEPVAGNMNLVTPIDGFLQAIRDVCDEYGSVFI
IDEVMTGFRVALGGAQSVYQVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQAGTLSGNPLAMRAGITMFKHL
REPDFYSKLEAKLQKLLTGLQAAANEAGIAFKTQQVGGMFGLYFTDQEDITSFDSMLACDTDAFKKFFHGMLERGVNLAP
SAFEAGFISSAHSDEDIELTIQAAKETFAEMK

Sequences:

>Translated_432_residues
MSLSPKQVQLFEQASKHIPGGVNSPVRAFNGVGGTPVFIKKAQGAYLWDEDDKRYVDYVGSWGPMILGHAHPDIIQAVQT
AAVDGLSFGAPTVHETTLADIICDIMPSIEMVRMTNSGTEATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGL
LTLGEGEPTSKGVPVDFAKHTLTLPYNNIEALKECFAKFGHEIAGVIVEPVAGNMNLVTPIDGFLQAIRDVCDEYGSVFI
IDEVMTGFRVALGGAQSVYQVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQAGTLSGNPLAMRAGITMFKHL
REPDFYSKLEAKLQKLLTGLQAAANEAGIAFKTQQVGGMFGLYFTDQEDITSFDSMLACDTDAFKKFFHGMLERGVNLAP
SAFEAGFISSAHSDEDIELTIQAAKETFAEMK
>Mature_431_residues
SLSPKQVQLFEQASKHIPGGVNSPVRAFNGVGGTPVFIKKAQGAYLWDEDDKRYVDYVGSWGPMILGHAHPDIIQAVQTA
AVDGLSFGAPTVHETTLADIICDIMPSIEMVRMTNSGTEATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGLL
TLGEGEPTSKGVPVDFAKHTLTLPYNNIEALKECFAKFGHEIAGVIVEPVAGNMNLVTPIDGFLQAIRDVCDEYGSVFII
DEVMTGFRVALGGAQSVYQVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQAGTLSGNPLAMRAGITMFKHLR
EPDFYSKLEAKLQKLLTGLQAAANEAGIAFKTQQVGGMFGLYFTDQEDITSFDSMLACDTDAFKKFFHGMLERGVNLAPS
AFEAGFISSAHSDEDIELTIQAAKETFAEMK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=303, Percent_Identity=30.3630363036304, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI24119277, Length=305, Percent_Identity=26.8852459016393, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI13994255, Length=362, Percent_Identity=25.9668508287293, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI284507298, Length=251, Percent_Identity=30.2788844621514, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=61.0328638497653, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1789016, Length=390, Percent_Identity=28.2051282051282, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1789759, Length=319, Percent_Identity=29.4670846394984, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI145693181, Length=410, Percent_Identity=27.3170731707317, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788044, Length=335, Percent_Identity=27.4626865671642, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787560, Length=343, Percent_Identity=27.9883381924198, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786991, Length=388, Percent_Identity=26.8041237113402, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=298, Percent_Identity=27.8523489932886, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=419, Percent_Identity=24.1050119331742, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=203, Percent_Identity=28.0788177339901, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=336, Percent_Identity=28.5714285714286, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=331, Percent_Identity=24.773413897281, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357415, Length=299, Percent_Identity=28.4280936454849, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356575, Length=317, Percent_Identity=28.391167192429, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_ACIAD (Q6FCY1)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045900.1
- ProteinModelPortal:   Q6FCY1
- SMR:   Q6FCY1
- STRING:   Q6FCY1
- GeneID:   2879994
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1201
- NMPDR:   fig|62977.3.peg.164
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   DKVIKFE
- PhylomeDB:   Q6FCY1
- ProtClustDB:   PRK00062
- BioCyc:   ASP62977:ACIAD1201-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46364; Mature: 46232

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSPKQVQLFEQASKHIPGGVNSPVRAFNGVGGTPVFIKKAQGAYLWDEDDKRYVDYVG
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEECCCCEEECCCCCHHHHHHC
SWGPMILGHAHPDIIQAVQTAAVDGLSFGAPTVHETTLADIICDIMPSIEMVRMTNSGTE
CCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCH
ATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGLLTLGEGEPTSKGVPVDFAKH
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCEECCC
TLTLPYNNIEALKECFAKFGHEIAGVIVEPVAGNMNLVTPIDGFLQAIRDVCDEYGSVFI
EEECCCCCHHHHHHHHHHHCHHHHHHEEECCCCCCEEECCHHHHHHHHHHHHHHHCCEEE
IDEVMTGFRVALGGAQSVYQVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQA
EHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEC
GTLSGNPLAMRAGITMFKHLREPDFYSKLEAKLQKLLTGLQAAANEAGIAFKTQQVGGMF
CCCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCEE
GLYFTDQEDITSFDSMLACDTDAFKKFFHGMLERGVNLAPSAFEAGFISSAHSDEDIELT
EEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCEEEE
IQAAKETFAEMK
HHHHHHHHHHCC
>Mature Secondary Structure 
SLSPKQVQLFEQASKHIPGGVNSPVRAFNGVGGTPVFIKKAQGAYLWDEDDKRYVDYVG
CCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEECCCCEEECCCCCHHHHHHC
SWGPMILGHAHPDIIQAVQTAAVDGLSFGAPTVHETTLADIICDIMPSIEMVRMTNSGTE
CCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCH
ATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGLLTLGEGEPTSKGVPVDFAKH
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCEECCC
TLTLPYNNIEALKECFAKFGHEIAGVIVEPVAGNMNLVTPIDGFLQAIRDVCDEYGSVFI
EEECCCCCHHHHHHHHHHHCHHHHHHEEECCCCCCEEECCHHHHHHHHHHHHHHHCCEEE
IDEVMTGFRVALGGAQSVYQVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQA
EHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEC
GTLSGNPLAMRAGITMFKHLREPDFYSKLEAKLQKLLTGLQAAANEAGIAFKTQQVGGMF
CCCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCEE
GLYFTDQEDITSFDSMLACDTDAFKKFFHGMLERGVNLAPSAFEAGFISSAHSDEDIELT
EEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCEEEE
IQAAKETFAEMK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA