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The map label for this gene is icd [H]

Identifier: 50084379

GI number: 50084379

Start: 1188428

End: 1189738

Strand: Direct

Name: icd [H]

Synonym: ACIAD1190

Alternate gene names: 50084379

Gene position: 1188428-1189738 (Clockwise)

Preceding gene: 50084376

Following gene: 50084380

Centisome position: 33.02

GC content: 42.41

Gene sequence:

>1311_bases
ATGTCCTTTGTGGCATACATTTATTCGCCAGTTACAAAAGGGAGTACCTGTACAATGGGTTATCAGAAGATCGTGGTGCC
TGTCGATGGTGACAGAATAAAAGTCAATGCAGACCTGTCACTTAACGTTCCAAACCATCCGATCATTCCTTTCATTGAGG
GTGACGGTATTGGTGTGGATATTACACCAGCTATGAAGGCAGTGGTAGATGCTGCGATTGTCAAAGCTTATGGCGGCAAA
CGTTCGATCGAATGGATGGAAGTATACTGCGGTGAAAAAGCAAATACTATCTATGGCAGCTATATGCCTGAAGAAACTTT
TGAAGCATTACGTGAATTTGTCATTTCAATTAAAGGGCCGCTTACCACGCCAGTGGGTGGAGGTATTCGTTCACTCAACG
TGGCTTTACGTCAAGAACTAGATTTATATGTTTGTGTCAGACCTGTACGCTGGTTTGAAGGTGTACCAAGTCCTGTACAA
CACCCTGAACTCACCGATATGGTGATTTTTCGTGAAAATTCAGAAGATATTTATGCTGGCATTGAGTGGAAAGCAGATTC
TCCAGAGGCAAAAAAAGTCATTCAGTTTTTACAAGAAGAAATGGGTGTTCAAAAAATCCGTTTTCCCGAACACTGTGGGA
TTGGAATTAAACCGGTCTCTAAAGAAGGAACCCAGCGTCTGGTACGAAAAGCGATTCAGTTCGCCATCGATAATGATAAG
CCAAGTGTTACTTTGGTACACAAAGGCAATATTATGAAATATACCGAAGGTGCTTTCAAAGAATGGGGTTATGAGCTTGC
AATCGAGCGTTTTGGAGGAGAGTTGATCGATGGTGGGCCATGGGTTCAAATTAAAAACCCCAAAACAGGCAAGGATATTG
TGATTAAAGATGTCATTGCAGACGCTTTCTTGCAGCAAATTTTAATGCGTCCAGCCGATTATTCAGTCATTGCAACCCTC
AATCTAAATGGTGATTATATTTCAGATGCACTTGCTGCTGAGGTGGGTGGAATTGGGATTGCACCAGGTGCCAATATTGG
TGGTGCAATTGCTGTTTATGAAGCAACCCATGGAACAGCACCGAAATATGCTGGGCAAGATAAAGTAAATCCAGGCTCTA
TTATTTTATCGGCAGAAATGATGCTACGCGATATGGGATGGACAGAAGCAGCTGATCTGATCATCAAAGGTATATCTGGT
GCGATTGAAGCCAAAACAGTGACTTACGATTTTGAGCGTTTAATGCCAGGCGCAACTCTATTAACCTGTTCAGAGTTTGG
GCAAGCCATCATTAAGCATATGGATGATTAA

Upstream 100 bases:

>100_bases
GATGTTTTTATTTAAATGAGAAATGTTGCTATTTTAGCTCAAAATCTCACCAACAACGATTTTTCAATTACACTGGTTTG
GCGTTAATAAAGTAGAAGGT

Downstream 100 bases:

>100_bases
CTGACATAATATGATCAAACCTCTCATATCGGGAGGTTTTTATCATTTTTTAAATATAAGTAATTGAATTAAAATTATAT
AAATAAAATAGTCACTTATA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSFVAYIYSPVTKGSTCTMGYQKIVVPVDGDRIKVNADLSLNVPNHPIIPFIEGDGIGVDITPAMKAVVDAAIVKAYGGK
RSIEWMEVYCGEKANTIYGSYMPEETFEALREFVISIKGPLTTPVGGGIRSLNVALRQELDLYVCVRPVRWFEGVPSPVQ
HPELTDMVIFRENSEDIYAGIEWKADSPEAKKVIQFLQEEMGVQKIRFPEHCGIGIKPVSKEGTQRLVRKAIQFAIDNDK
PSVTLVHKGNIMKYTEGAFKEWGYELAIERFGGELIDGGPWVQIKNPKTGKDIVIKDVIADAFLQQILMRPADYSVIATL
NLNGDYISDALAAEVGGIGIAPGANIGGAIAVYEATHGTAPKYAGQDKVNPGSIILSAEMMLRDMGWTEAADLIIKGISG
AIEAKTVTYDFERLMPGATLLTCSEFGQAIIKHMDD

Sequences:

>Translated_436_residues
MSFVAYIYSPVTKGSTCTMGYQKIVVPVDGDRIKVNADLSLNVPNHPIIPFIEGDGIGVDITPAMKAVVDAAIVKAYGGK
RSIEWMEVYCGEKANTIYGSYMPEETFEALREFVISIKGPLTTPVGGGIRSLNVALRQELDLYVCVRPVRWFEGVPSPVQ
HPELTDMVIFRENSEDIYAGIEWKADSPEAKKVIQFLQEEMGVQKIRFPEHCGIGIKPVSKEGTQRLVRKAIQFAIDNDK
PSVTLVHKGNIMKYTEGAFKEWGYELAIERFGGELIDGGPWVQIKNPKTGKDIVIKDVIADAFLQQILMRPADYSVIATL
NLNGDYISDALAAEVGGIGIAPGANIGGAIAVYEATHGTAPKYAGQDKVNPGSIILSAEMMLRDMGWTEAADLIIKGISG
AIEAKTVTYDFERLMPGATLLTCSEFGQAIIKHMDD
>Mature_435_residues
SFVAYIYSPVTKGSTCTMGYQKIVVPVDGDRIKVNADLSLNVPNHPIIPFIEGDGIGVDITPAMKAVVDAAIVKAYGGKR
SIEWMEVYCGEKANTIYGSYMPEETFEALREFVISIKGPLTTPVGGGIRSLNVALRQELDLYVCVRPVRWFEGVPSPVQH
PELTDMVIFRENSEDIYAGIEWKADSPEAKKVIQFLQEEMGVQKIRFPEHCGIGIKPVSKEGTQRLVRKAIQFAIDNDKP
SVTLVHKGNIMKYTEGAFKEWGYELAIERFGGELIDGGPWVQIKNPKTGKDIVIKDVIADAFLQQILMRPADYSVIATLN
LNGDYISDALAAEVGGIGIAPGANIGGAIAVYEATHGTAPKYAGQDKVNPGSIILSAEMMLRDMGWTEAADLIIKGISGA
IEAKTVTYDFERLMPGATLLTCSEFGQAIIKHMDD

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=394, Percent_Identity=30.7106598984772, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI28178816, Length=387, Percent_Identity=27.906976744186, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI28178821, Length=350, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI28178838, Length=366, Percent_Identity=26.5027322404372, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4758582, Length=360, Percent_Identity=26.6666666666667, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=30.939226519337, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1787381, Length=414, Percent_Identity=76.3285024154589, Blast_Score=663, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=347, Percent_Identity=27.6657060518732, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI87081683, Length=400, Percent_Identity=23.5, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71986051, Length=394, Percent_Identity=32.741116751269, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI25144293, Length=348, Percent_Identity=29.5977011494253, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=300, Percent_Identity=28.3333333333333, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17550882, Length=370, Percent_Identity=23.7837837837838, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324709, Length=392, Percent_Identity=30.8673469387755, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322097, Length=369, Percent_Identity=29.810298102981, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324291, Length=365, Percent_Identity=28.7671232876712, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24643268, Length=389, Percent_Identity=32.9048843187661, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24643270, Length=389, Percent_Identity=32.9048843187661, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24661184, Length=387, Percent_Identity=30.749354005168, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI161078635, Length=273, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI161078639, Length=273, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI161078637, Length=273, Percent_Identity=28.2051282051282, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI161078633, Length=273, Percent_Identity=28.2051282051282, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24650122, Length=273, Percent_Identity=28.2051282051282, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20130355, Length=384, Percent_Identity=24.21875, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281362242, Length=396, Percent_Identity=25.7575757575758, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24648872, Length=396, Percent_Identity=25.7575757575758, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 47596; Mature: 47465

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVAYIYSPVTKGSTCTMGYQKIVVPVDGDRIKVNADLSLNVPNHPIIPFIEGDGIGVD
CCEEEEEECCCCCCCEEEECCEEEEEEECCCEEEEEEEEEEECCCCCEEEEECCCCCCEE
ITPAMKAVVDAAIVKAYGGKRSIEWMEVYCGEKANTIYGSYMPEETFEALREFVISIKGP
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHCCCCC
LTTPVGGGIRSLNVALRQELDLYVCVRPVRWFEGVPSPVQHPELTDMVIFRENSEDIYAG
CCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEE
IEWKADSPEAKKVIQFLQEEMGVQKIRFPEHCGIGIKPVSKEGTQRLVRKAIQFAIDNDK
EEECCCCHHHHHHHHHHHHHCCCEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
PSVTLVHKGNIMKYTEGAFKEWGYELAIERFGGELIDGGPWVQIKNPKTGKDIVIKDVIA
CCEEEEECCCEEEECCCHHHHCCHHHHHHHHCCEEECCCCEEEECCCCCCCCHHHHHHHH
DAFLQQILMRPADYSVIATLNLNGDYISDALAAEVGGIGIAPGANIGGAIAVYEATHGTA
HHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCEECCCCCCCCCEEEEEECCCCCC
PKYAGQDKVNPGSIILSAEMMLRDMGWTEAADLIIKGISGAIEAKTVTYDFERLMPGATL
CCCCCCCCCCCCCEEEEHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEEEHHHHCCCCEE
LTCSEFGQAIIKHMDD
EEHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFVAYIYSPVTKGSTCTMGYQKIVVPVDGDRIKVNADLSLNVPNHPIIPFIEGDGIGVD
CEEEEEECCCCCCCEEEECCEEEEEEECCCEEEEEEEEEEECCCCCEEEEECCCCCCEE
ITPAMKAVVDAAIVKAYGGKRSIEWMEVYCGEKANTIYGSYMPEETFEALREFVISIKGP
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHCCCCC
LTTPVGGGIRSLNVALRQELDLYVCVRPVRWFEGVPSPVQHPELTDMVIFRENSEDIYAG
CCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEE
IEWKADSPEAKKVIQFLQEEMGVQKIRFPEHCGIGIKPVSKEGTQRLVRKAIQFAIDNDK
EEECCCCHHHHHHHHHHHHHCCCEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
PSVTLVHKGNIMKYTEGAFKEWGYELAIERFGGELIDGGPWVQIKNPKTGKDIVIKDVIA
CCEEEEECCCEEEECCCHHHHCCHHHHHHHHCCEEECCCCEEEECCCCCCCCHHHHHHHH
DAFLQQILMRPADYSVIATLNLNGDYISDALAAEVGGIGIAPGANIGGAIAVYEATHGTA
HHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCEECCCCCCCCCEEEEEECCCCCC
PKYAGQDKVNPGSIILSAEMMLRDMGWTEAADLIIKGISGAIEAKTVTYDFERLMPGATL
CCCCCCCCCCCCCEEEEHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEEEHHHHCCCCEE
LTCSEFGQAIIKHMDD
EEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112144; 8905232; 9278503; 9352899; 9298646; 2204109; 2682654; 10623532 [H]