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The map label for this gene is idh [H]

Identifier: 50084376

GI number: 50084376

Start: 1184683

End: 1186914

Strand: Direct

Name: idh [H]

Synonym: ACIAD1187

Alternate gene names: 50084376

Gene position: 1184683-1186914 (Clockwise)

Preceding gene: 50084375

Following gene: 50084379

Centisome position: 32.92

GC content: 42.43

Gene sequence:

>2232_bases
ATGGCTGGTGGAAAGTCAACAATCATTTACACACTGACCGATGAGGCGCCGCTATTAGCGACTTACTCACTGCTGCCGAT
CATTGAGACTTTTACTAAGCCTGCTGGCATAGAAATTGAGAAAAGTGATATTTCTGTTGCGACACGTGTGCTTGCAGAAT
TTCCTGAGTACTTGAGCGATGAGCAGAAAGTACCGAATAATTTGGCTGAACTTGGTCGTCTCACACAAGATCCAGATACA
AACATTATCAAGCTACCAAATATCAGTGCTTCAGTTGCACAGCTTACTGCTTGTATCAAAGAGCTTCAATCGAAAGGTTT
TGCGATTCCAGATTATCCAGAAAATCCTTCAACAGAAGAAGAAAAAGAGCTGAAAGCACGTTATGGTAAATGCTTGGGCT
CAGCAGTAAATCCTGTATTACGTGAAGGTAACTCTGATCGCCGTGCCCCAGCGGCAGTGAAAAACTATGCAAAAAAACAC
CCGCATTCAATGAGCGAGTGGAAGCAATGGTCACAAACGCATGTATCACATATGGAAGAAGGTGACTTCTATCATGGTGA
AAAATCAATGACACTTGATCGTGCACGTAACGTCAAAATGGAGTTGGTTACAAAAAGCGGTGAAACCATCGTGCTTAAAC
CAAAAGTAGCTTTGCTTGATGGTGAAATCATTGACTCAATGTTTATGAGCAAAAAAGCGCTTTGCGATTTTTATGAAAAG
CAGCTCGATGATTGCCGTGAAGCAGGCATTTTATTTTCGTTGCACGTGAAAGCAACTATGATGAAAGTGTCACATCCAAT
TGTATTTGGTCACTGTGTCAAAATTTACTATAAAGAAGCTTTTGAGAAACATGCCAAATTATTTGATGAGCTAGGCATCA
ATGTAAACAATGGTATGGCGGGTCTTTACGAGAAAATCGAAACTTTGCCAACTTCATTACGTGAAGAAATCATTGAAGAC
TTGCATGCTTGTCAAGAGCATCGTCCTGCACTTGCCATGGTCGATTCTGCAAAAGGAATCACCAACTTCCATTCTCCAAA
TGACATTATTGTTGATGCATCCATGCCAGCGATGATCCGTGCAGGCGGTAAAATGTGGGGTGCTGATGGCAAGCAATATG
ATGCTAAAGCCGTGATGCCAGAATCAACTTTCGCTCGTATTTACCAAGAAATGATTAATTTCTGTAAATGGCATGGTAAT
TTCGACCCGAAAACCATGGGTACTGTACCAAACGTAGGTTTGATGGCACAAAAAGCTGAAGAATACGGTTCTCACGATAA
GACGTTTGAAATTCCACAAGCAGGTGTTGCCAATATTACTGACCTTGAAACAGGTGAAGTGTTGCTTTCTCAAAATGTTG
AGGAAGGTGATATCTGGCGTATGTGTCAGGTGAAAGACGCACCGATTCGTGACTGGGTAAAACTTGCTGTAACTCGTGCA
CGTAACTCTGGTATGCCAGCCATTTTCTGGCTTGACCCGTACCGTCCACATGAAAATGAATTGATCAAGAAAGTACAAAC
TTACTTGAAAGAGCATGACACAACAGGTCTTGATATTGAAATCATGTCACAGGTTCGTGCAATGCGTTACACACTTGAAC
GTGTGGTACGTGGCTTAGATACGATTTCTGTCACAGGTAACATCTTGCGTGATTACCTCACAGATTTGTTCCCAATTATG
GAATTGGGTACTTCAGCCAAGATGCTATCTATTGTGCCACTCATGGCAGGTGGTGGAATGTACGAAACTGGTGCAGGCGG
TTCAGCACCAAAACACGTACAACAACTGGTAGAAGAAAACCACTTGCGTTGGGATTCTTTGGGTGAGTTCCTTGCGCTTG
CTGTATCTTTGGAAGAGTTAGGCATCAAAGAAGACAATGCACGTGCCAAGTTACTTGCAAAAACCTTAGATCAGGCAACA
GGCAAGCTACTTGACAATGATAAGTCTCCTTCACGTCGTACTGGCGAGCTGGATAACCGTGGTAGCCATTTCTATCTATC
ATTGTATTGGGCTGAAGCACTTGCAGCGCAAGATGAAGATGCAGAGTTGAAAGCCAAATTTGCACCACTTGCACAAGCTT
TAGCGGATAATGAAGAAAAAATTATTGCAGAGCTATCTCAAGTACAGGGTAGTGCGGCAGATATCGGTGGTTACTATGCA
ATTGATCCTGCAAAAGCAAATGCAGTGATGCGTCCAAGTGCAACATTTAATTCAACACTTGAAACTGTATAA

Upstream 100 bases:

>100_bases
AGGGCGGATACTCTCTGGGTTTTAAATAAGCTAATCGGTTCCAAGGAGTGAATCTTGATTCTCGCTCCTAAAAAAACTCA
ATCCAAAGCAGGAGAAATAT

Downstream 100 bases:

>100_bases
GTAAAGCTGATTGATTTTGAATAAAAAACGATGCCTAGGCATCGTTTTTTATTTGATTTTGCATCGTAATTGGGAACGTA
AAAAGCGCTCAAATTTAATT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MAGGKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIEKSDISVATRVLAEFPEYLSDEQKVPNNLAELGRLTQDPDT
NIIKLPNISASVAQLTACIKELQSKGFAIPDYPENPSTEEEKELKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKH
PHSMSEWKQWSQTHVSHMEEGDFYHGEKSMTLDRARNVKMELVTKSGETIVLKPKVALLDGEIIDSMFMSKKALCDFYEK
QLDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHAKLFDELGINVNNGMAGLYEKIETLPTSLREEIIED
LHACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIRAGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGN
FDPKTMGTVPNVGLMAQKAEEYGSHDKTFEIPQAGVANITDLETGEVLLSQNVEEGDIWRMCQVKDAPIRDWVKLAVTRA
RNSGMPAIFWLDPYRPHENELIKKVQTYLKEHDTTGLDIEIMSQVRAMRYTLERVVRGLDTISVTGNILRDYLTDLFPIM
ELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEELGIKEDNARAKLLAKTLDQAT
GKLLDNDKSPSRRTGELDNRGSHFYLSLYWAEALAAQDEDAELKAKFAPLAQALADNEEKIIAELSQVQGSAADIGGYYA
IDPAKANAVMRPSATFNSTLETV

Sequences:

>Translated_743_residues
MAGGKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIEKSDISVATRVLAEFPEYLSDEQKVPNNLAELGRLTQDPDT
NIIKLPNISASVAQLTACIKELQSKGFAIPDYPENPSTEEEKELKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKH
PHSMSEWKQWSQTHVSHMEEGDFYHGEKSMTLDRARNVKMELVTKSGETIVLKPKVALLDGEIIDSMFMSKKALCDFYEK
QLDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHAKLFDELGINVNNGMAGLYEKIETLPTSLREEIIED
LHACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIRAGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGN
FDPKTMGTVPNVGLMAQKAEEYGSHDKTFEIPQAGVANITDLETGEVLLSQNVEEGDIWRMCQVKDAPIRDWVKLAVTRA
RNSGMPAIFWLDPYRPHENELIKKVQTYLKEHDTTGLDIEIMSQVRAMRYTLERVVRGLDTISVTGNILRDYLTDLFPIM
ELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEELGIKEDNARAKLLAKTLDQAT
GKLLDNDKSPSRRTGELDNRGSHFYLSLYWAEALAAQDEDAELKAKFAPLAQALADNEEKIIAELSQVQGSAADIGGYYA
IDPAKANAVMRPSATFNSTLETV
>Mature_742_residues
AGGKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIEKSDISVATRVLAEFPEYLSDEQKVPNNLAELGRLTQDPDTN
IIKLPNISASVAQLTACIKELQSKGFAIPDYPENPSTEEEKELKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKHP
HSMSEWKQWSQTHVSHMEEGDFYHGEKSMTLDRARNVKMELVTKSGETIVLKPKVALLDGEIIDSMFMSKKALCDFYEKQ
LDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHAKLFDELGINVNNGMAGLYEKIETLPTSLREEIIEDL
HACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIRAGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGNF
DPKTMGTVPNVGLMAQKAEEYGSHDKTFEIPQAGVANITDLETGEVLLSQNVEEGDIWRMCQVKDAPIRDWVKLAVTRAR
NSGMPAIFWLDPYRPHENELIKKVQTYLKEHDTTGLDIEIMSQVRAMRYTLERVVRGLDTISVTGNILRDYLTDLFPIME
LGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEELGIKEDNARAKLLAKTLDQATG
KLLDNDKSPSRRTGELDNRGSHFYLSLYWAEALAAQDEDAELKAKFAPLAQALADNEEKIIAELSQVQGSAADIGGYYAI
DPAKANAVMRPSATFNSTLETV

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 82473; Mature: 82342

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGGKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIEKSDISVATRVLAEFPEYLSD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCC
EQKVPNNLAELGRLTQDPDTNIIKLPNISASVAQLTACIKELQSKGFAIPDYPENPSTEE
HHCCCHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
EKELKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKHPHSMSEWKQWSQTHVSHMEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GDFYHGEKSMTLDRARNVKMELVTKSGETIVLKPKVALLDGEIIDSMFMSKKALCDFYEK
CCCCCCCCCCCHHHHCCCEEEEEECCCCEEEECCCCEECCHHHHHHHHHHHHHHHHHHHH
QLDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHAKLFDELGINVNNGMA
HHHHHHHCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GLYEKIETLPTSLREEIIEDLHACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHH
AGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGNFDPKTMGTVPNVGLMAQKAE
CCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFEIPQAGVANITDLETGEVLLSQNVEEGDIWRMCQVKDAPIRDWVKLAVTRA
HHCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
RNSGMPAIFWLDPYRPHENELIKKVQTYLKEHDTTGLDIEIMSQVRAMRYTLERVVRGLD
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
TISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEELGIKEDNARAKLLAKTLDQATGKLLDNDKSPSRRTGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GSHFYLSLYWAEALAAQDEDAELKAKFAPLAQALADNEEKIIAELSQVQGSAADIGGYYA
CCEEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEE
IDPAKANAVMRPSATFNSTLETV
ECCCCCCEEECCCCCCCCHHCCC
>Mature Secondary Structure 
AGGKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIEKSDISVATRVLAEFPEYLSD
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCC
EQKVPNNLAELGRLTQDPDTNIIKLPNISASVAQLTACIKELQSKGFAIPDYPENPSTEE
HHCCCHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
EKELKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKHPHSMSEWKQWSQTHVSHMEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GDFYHGEKSMTLDRARNVKMELVTKSGETIVLKPKVALLDGEIIDSMFMSKKALCDFYEK
CCCCCCCCCCCHHHHCCCEEEEEECCCCEEEECCCCEECCHHHHHHHHHHHHHHHHHHHH
QLDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHAKLFDELGINVNNGMA
HHHHHHHCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GLYEKIETLPTSLREEIIEDLHACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHH
AGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGNFDPKTMGTVPNVGLMAQKAE
CCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFEIPQAGVANITDLETGEVLLSQNVEEGDIWRMCQVKDAPIRDWVKLAVTRA
HHCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
RNSGMPAIFWLDPYRPHENELIKKVQTYLKEHDTTGLDIEIMSQVRAMRYTLERVVRGLD
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
TISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEELGIKEDNARAKLLAKTLDQATGKLLDNDKSPSRRTGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GSHFYLSLYWAEALAAQDEDAELKAKFAPLAQALADNEEKIIAELSQVQGSAADIGGYYA
CCEEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEE
IDPAKANAVMRPSATFNSTLETV
ECCCCCCEEECCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]