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The map label for this gene is yedX [H]

Identifier: 50084377

GI number: 50084377

Start: 1187009

End: 1187407

Strand: Reverse

Name: yedX [H]

Synonym: ACIAD1188

Alternate gene names: 50084377

Gene position: 1187407-1187009 (Counterclockwise)

Preceding gene: 50084378

Following gene: 50084374

Centisome position: 33.0

GC content: 40.85

Gene sequence:

>399_bases
ATGCTTAAAATATTACTTCCACTGGTTGGACTAGGTTTCTCCACATTTTGCCTTGCTCAGAATCCATTAAGTGTGCATGT
ACTTAGCCTCGAAACGGGCTTACCCTCTGCCAATGTAAACGTTACCCTAGAAGCTCAGCAAAAAGATAAATGGGTCGAGA
TTAATCACGGTACAACAGATGATAATGGCCGTATTGCAGCATTGTATCCCGAAGATAAACCCCTAGATAAAGGCATTTAT
CGGGTGACGTTTAAAACGGGTGAGTGGTTTCGGCAGAAAAACCAACGTTCATTTTTTCCAGAAGTTCCTGTGGTTTTCGT
GATTGATGGATCGCTCGAACACTACCATATTCCACTATTAATTAGTCCTTATGGCTATTCAACTTATCGTGGTAATTAA

Upstream 100 bases:

>100_bases
ACGCAGAGCCCGCTAATCAATTGATAGATTACATTTTTTAAACCTATGATTTTTAATCAATTGGTTAACATAATGGTTTC
TAAATTCTGGAGACCATTTA

Downstream 100 bases:

>100_bases
ATTTGAGCGCTTTTTACGTTCCCAATTACGATGCAAAATCAAATAAAAAACGATGCCTAGGCATCGTTTTTTATTCAAAA
TCAATCAGCTTTACTTATAC

Product: transthyretin-like protein

Products: NA

Alternate protein names: HIU hydrolase; HIUHase; Transthyretin-like protein; TLP [H]

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MLKILLPLVGLGFSTFCLAQNPLSVHVLSLETGLPSANVNVTLEAQQKDKWVEINHGTTDDNGRIAALYPEDKPLDKGIY
RVTFKTGEWFRQKNQRSFFPEVPVVFVIDGSLEHYHIPLLISPYGYSTYRGN

Sequences:

>Translated_132_residues
MLKILLPLVGLGFSTFCLAQNPLSVHVLSLETGLPSANVNVTLEAQQKDKWVEINHGTTDDNGRIAALYPEDKPLDKGIY
RVTFKTGEWFRQKNQRSFFPEVPVVFVIDGSLEHYHIPLLISPYGYSTYRGN
>Mature_132_residues
MLKILLPLVGLGFSTFCLAQNPLSVHVLSLETGLPSANVNVTLEAQQKDKWVEINHGTTDDNGRIAALYPEDKPLDKGIY
RVTFKTGEWFRQKNQRSFFPEVPVVFVIDGSLEHYHIPLLISPYGYSTYRGN

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=138, Percent_Identity=50, Blast_Score=134, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI115532920, Length=110, Percent_Identity=43.6363636363636, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI115532922, Length=110, Percent_Identity=43.6363636363636, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI115534555, Length=110, Percent_Identity=40, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24652571, Length=111, Percent_Identity=37.8378378378378, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 14893; Mature: 14893

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKILLPLVGLGFSTFCLAQNPLSVHVLSLETGLPSANVNVTLEAQQKDKWVEINHGTTD
CEEEEEEHHCCCCEEEEEECCCCEEEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCC
DNGRIAALYPEDKPLDKGIYRVTFKTGEWFRQKNQRSFFPEVPVVFVIDGSLEHYHIPLL
CCCEEEEECCCCCCCCCCEEEEEEECCHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEE
ISPYGYSTYRGN
ECCCCCCEECCC
>Mature Secondary Structure
MLKILLPLVGLGFSTFCLAQNPLSVHVLSLETGLPSANVNVTLEAQQKDKWVEINHGTTD
CEEEEEEHHCCCCEEEEEECCCCEEEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCC
DNGRIAALYPEDKPLDKGIYRVTFKTGEWFRQKNQRSFFPEVPVVFVIDGSLEHYHIPLL
CCCEEEEECCCCCCCCCCEEEEEEECCHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEE
ISPYGYSTYRGN
ECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]