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The map label for this gene is pepP [H]

Identifier: 50084320

GI number: 50084320

Start: 1113493

End: 1114818

Strand: Direct

Name: pepP [H]

Synonym: ACIAD1126

Alternate gene names: 50084320

Gene position: 1113493-1114818 (Clockwise)

Preceding gene: 50084319

Following gene: 50084321

Centisome position: 30.94

GC content: 43.67

Gene sequence:

>1326_bases
ATGAAATTGACTCAAGCTGATTTTGAACTACGCCGAGACCGCCTCGCTCAACAAATGGGGCCAAACAGTATTGCCATTAT
AGAAACCAGCCCAGTTGCTTATCGTAATCGTGATGCAGACTATAAATTTCGAGCAGATAGCAGTTTTTTTTATCTGACAG
GGTTTGCAGAACCAGAAGCTGTTGCTGTAATTGAAACCACAGATACGGTGGATGACTATACTTATAGTCTGTTTTGCCGT
GAGCGTAACCGTGAAATGGAAATCTGGAATGGCTATCGTGCAGGTATTGACGGTGCAATTGAAGATTTTGAAGCAGATGA
GGCTTATGCAATAGATTTACTGGATGAAGAAATCCTTGAAAAATTGCTCAATAAAGAACGTCTTTATTATCGCATTGGTC
ATCGTGCAGAATTTGATGCAAAGATTAGCCAGTGGATTAAACAGGCAGATGCCCAGCAACGCCGTGGTAATGGCTCACCT
TCACAGGTTTTGCAGTTAGATCGCATCGTTGATGAAATGCGCCTGATCAAATCTGATCAGGAAATTGAACTGATGCAAAT
TGCATCAAATATTAGTGCGGCTGCACACACACGAGCCATGCAGCAAGTGCGACCAGACATGATGGAGTATGCGCTTGAGG
CCGAGCTTAATTATGTGTTTGGTCAGCATGGGTGTGTACCCTCTTACAACAGTATTGTTGGCGGTGGTGAAAATGCCTGT
ATCTTGCATTATGTCGAAAACAATAAACCTTTAAACAGTGGGGATCTGGTTTTAATTGATGCTGCTTGTGAATATGAGTT
TTATGCCTCAGATATTACGCGTACTTTTCCAGTCAATGGAAAATTTAGCCCAGAGCAAAAAGCACTCTATGAAATTGTAT
TGGCTGCGCAGTATGCAGCTATAGATGCAGTTAGAATTGGAAACGCTTACCGAGAACCGCATGAGGTTGCAGTTCGGATC
TTGACGCAAGGACTGATTGACCTTGGATTGTTGAAAGGAGATTTGAACGAGCTGATTGAAACGGAGGCATTCCGACAGTT
TTATATGCATGGTACAGGCCACTGGTTAGGCATGGATGTGCATGATGTAGGTTCATACAAAGCTGACGGCGAATGGCGAG
CATACGAAGACGGTATGGTGGTGACTGTTGAGCCAGGACTATATATCGCACCTGATGATGAAAGTGTAGATCCAAAGTGG
CGTGGTATCGGAATCAGAATTGAAGATGATGTGGTTGCAACGCAGCAGGGACCATTGGTTCTGACCAAAGATGTGGTCAA
GGAAATCGCCGATATTGAACAGCTCATGGCTCAAGCAAAGTCATAA

Upstream 100 bases:

>100_bases
AGTATTGTTGAAATGTTTACACCACATCGTCCAAGCTAAGCTTGGGCGGTGTTTATCACACCGAATGACTTGATAACGAA
ATAGATAGACAAATAGCCTC

Downstream 100 bases:

>100_bases
CGATTAGAAAACGGGAGTAGATCACGTGCAACAGCAAGTCATTATTGTGGGTGGGGGAATGGTCGGACTGAGTCTGGCTT
TAATGTTGGCGAAGCAAAAA

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKLTQADFELRRDRLAQQMGPNSIAIIETSPVAYRNRDADYKFRADSSFFYLTGFAEPEAVAVIETTDTVDDYTYSLFCR
ERNREMEIWNGYRAGIDGAIEDFEADEAYAIDLLDEEILEKLLNKERLYYRIGHRAEFDAKISQWIKQADAQQRRGNGSP
SQVLQLDRIVDEMRLIKSDQEIELMQIASNISAAAHTRAMQQVRPDMMEYALEAELNYVFGQHGCVPSYNSIVGGGENAC
ILHYVENNKPLNSGDLVLIDAACEYEFYASDITRTFPVNGKFSPEQKALYEIVLAAQYAAIDAVRIGNAYREPHEVAVRI
LTQGLIDLGLLKGDLNELIETEAFRQFYMHGTGHWLGMDVHDVGSYKADGEWRAYEDGMVVTVEPGLYIAPDDESVDPKW
RGIGIRIEDDVVATQQGPLVLTKDVVKEIADIEQLMAQAKS

Sequences:

>Translated_441_residues
MKLTQADFELRRDRLAQQMGPNSIAIIETSPVAYRNRDADYKFRADSSFFYLTGFAEPEAVAVIETTDTVDDYTYSLFCR
ERNREMEIWNGYRAGIDGAIEDFEADEAYAIDLLDEEILEKLLNKERLYYRIGHRAEFDAKISQWIKQADAQQRRGNGSP
SQVLQLDRIVDEMRLIKSDQEIELMQIASNISAAAHTRAMQQVRPDMMEYALEAELNYVFGQHGCVPSYNSIVGGGENAC
ILHYVENNKPLNSGDLVLIDAACEYEFYASDITRTFPVNGKFSPEQKALYEIVLAAQYAAIDAVRIGNAYREPHEVAVRI
LTQGLIDLGLLKGDLNELIETEAFRQFYMHGTGHWLGMDVHDVGSYKADGEWRAYEDGMVVTVEPGLYIAPDDESVDPKW
RGIGIRIEDDVVATQQGPLVLTKDVVKEIADIEQLMAQAKS
>Mature_441_residues
MKLTQADFELRRDRLAQQMGPNSIAIIETSPVAYRNRDADYKFRADSSFFYLTGFAEPEAVAVIETTDTVDDYTYSLFCR
ERNREMEIWNGYRAGIDGAIEDFEADEAYAIDLLDEEILEKLLNKERLYYRIGHRAEFDAKISQWIKQADAQQRRGNGSP
SQVLQLDRIVDEMRLIKSDQEIELMQIASNISAAAHTRAMQQVRPDMMEYALEAELNYVFGQHGCVPSYNSIVGGGENAC
ILHYVENNKPLNSGDLVLIDAACEYEFYASDITRTFPVNGKFSPEQKALYEIVLAAQYAAIDAVRIGNAYREPHEVAVRI
LTQGLIDLGLLKGDLNELIETEAFRQFYMHGTGHWLGMDVHDVGSYKADGEWRAYEDGMVVTVEPGLYIAPDDESVDPKW
RGIGIRIEDDVVATQQGPLVLTKDVVKEIADIEQLMAQAKS

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=452, Percent_Identity=34.5132743362832, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI149589008, Length=485, Percent_Identity=30.9278350515464, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI260593665, Length=300, Percent_Identity=37, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI260593663, Length=480, Percent_Identity=28.75, Blast_Score=157, Evalue=3e-38,
Organism=Escherichia coli, GI1789275, Length=440, Percent_Identity=46.1363636363636, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1788728, Length=258, Percent_Identity=31.3953488372093, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1790282, Length=285, Percent_Identity=28.0701754385965, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508215, Length=471, Percent_Identity=30.1486199575372, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI71989583, Length=289, Percent_Identity=31.4878892733564, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6320922, Length=441, Percent_Identity=31.7460317460317, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6321118, Length=433, Percent_Identity=28.175519630485, Blast_Score=154, Evalue=4e-38,
Organism=Drosophila melanogaster, GI19920384, Length=413, Percent_Identity=33.6561743341404, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI21357079, Length=437, Percent_Identity=32.4942791762014, Blast_Score=195, Evalue=7e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49860; Mature: 49860

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTQADFELRRDRLAQQMGPNSIAIIETSPVAYRNRDADYKFRADSSFFYLTGFAEPEA
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCCCCCEEEECCCCEEEEEECCCCCE
VAVIETTDTVDDYTYSLFCRERNREMEIWNGYRAGIDGAIEDFEADEAYAIDLLDEEILE
EEEEEECCCCCCCEEEEEEECCCCCEEEECCCCCCCCCHHHCCCCCCEEEEHHHHHHHHH
KLLNKERLYYRIGHRAEFDAKISQWIKQADAQQRRGNGSPSQVLQLDRIVDEMRLIKSDQ
HHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
EIELMQIASNISAAAHTRAMQQVRPDMMEYALEAELNYVFGQHGCVPSYNSIVGGGENAC
CHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEE
ILHYVENNKPLNSGDLVLIDAACEYEFYASDITRTFPVNGKFSPEQKALYEIVLAAQYAA
EEEEECCCCCCCCCCEEEEEECCCCEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
IDAVRIGNAYREPHEVAVRILTQGLIDLGLLKGDLNELIETEAFRQFYMHGTGHWLGMDV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCH
HDVGSYKADGEWRAYEDGMVVTVEPGLYIAPDDESVDPKWRGIGIRIEDDVVATQQGPLV
HHCCCCCCCCCCEEECCCEEEEECCCEEECCCCCCCCCCEEEEEEEEECCEEECCCCCEE
LTKDVVKEIADIEQLMAQAKS
EEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLTQADFELRRDRLAQQMGPNSIAIIETSPVAYRNRDADYKFRADSSFFYLTGFAEPEA
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCCCCCEEEECCCCEEEEEECCCCCE
VAVIETTDTVDDYTYSLFCRERNREMEIWNGYRAGIDGAIEDFEADEAYAIDLLDEEILE
EEEEEECCCCCCCEEEEEEECCCCCEEEECCCCCCCCCHHHCCCCCCEEEEHHHHHHHHH
KLLNKERLYYRIGHRAEFDAKISQWIKQADAQQRRGNGSPSQVLQLDRIVDEMRLIKSDQ
HHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
EIELMQIASNISAAAHTRAMQQVRPDMMEYALEAELNYVFGQHGCVPSYNSIVGGGENAC
CHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCEE
ILHYVENNKPLNSGDLVLIDAACEYEFYASDITRTFPVNGKFSPEQKALYEIVLAAQYAA
EEEEECCCCCCCCCCEEEEEECCCCEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
IDAVRIGNAYREPHEVAVRILTQGLIDLGLLKGDLNELIETEAFRQFYMHGTGHWLGMDV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCH
HDVGSYKADGEWRAYEDGMVVTVEPGLYIAPDDESVDPKWRGIGIRIEDDVVATQQGPLV
HHCCCCCCCCCCEEECCCEEEEECCCEEECCCCCCCCCCEEEEEEEEECCEEECCCCCEE
LTKDVVKEIADIEQLMAQAKS
EEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]